Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.3855 | 0.3855 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0069 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.3855 | 0.3855 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3855 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3855 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.3855 | 0.3855 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3855 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.3855 | 0.3855 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3855 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.3855 | 0.3855 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.211 uM | Cytotoxicity against human SiHa cells after 48 hrs by MTT assay | ChEMBL. | 21733601 |
IC50 (functional) | = 0.3 uM | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 21733601 |
IC50 (functional) | = 0.802 uM | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 21733601 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21733601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.