Detailed information for compound 1038161

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.956 | Formula: C23H30ClN3O2
  • H donors: 0 H acceptors: 2 LogP: 3.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1CC[C@@H]([C@H]2N(C(=O)Cc1ccncc1)C)N1CCCC1.Cl
  • InChi: 1S/C23H29N3O2.ClH/c1-25(22(27)16-17-10-12-24-13-11-17)23-19-6-5-7-21(28-2)18(19)8-9-20(23)26-14-3-4-15-26;/h5-7,10-13,20,23H,3-4,8-9,14-16H2,1-2H3;1H/t20-,23-;/m0./s1
  • InChiKey: NLYNZWFSXHKDSM-WCRWPNQISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0052 0.0162 0.1057
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0008 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0119 0.0111
Plasmodium vivax importin-beta 2, putative 0.0061 0.0203 0.3227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0129 0.0126
Echinococcus granulosus zinc finger protein 0.0032 0.007 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.0178 0.073 0.0754
Schistosoma mansoni lipoxygenase 0.0055 0.0173 0.0173
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0153 0.0996
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0119 0.0777
Brugia malayi acetyltransferase, GNAT family protein 0.0454 0.1973 0.6868
Loa Loa (eye worm) hypothetical protein 0.0094 0.0351 0.1194
Echinococcus granulosus lysosomal alpha glucosidase 0.0192 0.0794 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0076 0.0237
Loa Loa (eye worm) steroid hormone receptor 0.0178 0.073 0.2514
Plasmodium falciparum histone acetyltransferase GCN5 0.0122 0.0475 0.7802
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0202 0.1318
Schistosoma mansoni thyroid hormone receptor 0.0178 0.073 0.073
Echinococcus granulosus lamin 0.0027 0.0047 0.0039
Schistosoma mansoni polycystin 1-related 0.002 0.0015 0.0015
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.004 0.0258
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0119 0.1939
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0084 0.0306 0.0306
Echinococcus granulosus histone acetyltransferase KAT2B 0.0438 0.1905 0.1898
Schistosoma mansoni biogenic amine receptor 0.0018 0.0008 0.0008
Echinococcus granulosus geminin 0.0511 0.2231 0.2225
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0515 0.6608
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.004 0.0377
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.0687 0.4481
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0515 0.6608
Loa Loa (eye worm) nuclear receptor NHR-67 0.0084 0.0306 0.1036
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0019 0.0122
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0008 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0178 0.073 0.2523
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0084 0.0306 0.1036
Schistosoma mansoni histamine h1 receptor 0.0018 0.0008 0.0008
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0035 0.0035
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0203 0.2892
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0099 0.0095
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0178 0.073 0.2523
Onchocerca volvulus Protein ultraspiracle homolog 0.0178 0.073 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0119 0.1939
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0119 0.0116
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0007
Entamoeba histolytica hypothetical protein 0.005 0.0151 0.2897
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0093 0.0608
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0129 0.0129
Schistosoma mansoni alpha-glucosidase 0.0165 0.0673 0.0673
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.1036 0.358
Echinococcus granulosus dna polymerase eta 0.002 0.0019 0.0011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0119 0.0388
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0101 0.0574
Loa Loa (eye worm) hypothetical protein 0.0048 0.0145 0.0476
Echinococcus granulosus thyroid hormone receptor alpha 0.0084 0.0306 0.0298
Echinococcus multilocularis lysosomal alpha glucosidase 0.0192 0.0794 0.0821
Brugia malayi conserved hypotetical protein 0.0084 0.0306 0.104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi hypothetical protein 0.002 0.0015 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Schistosoma mansoni ran 0.0045 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0101 0.1592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0178 0.073 0.2514
Trypanosoma brucei glucosidase, putative 0.0043 0.0119 0.0777
Schistosoma mansoni RAR-like nuclear receptor 0.0178 0.073 0.073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0101 0.066
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0454 0.1973 0.2054
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.004 0.0262
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0093 0.0297
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0101 0.066
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0035 0.0028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0019 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0178 0.073 0.073
Schistosoma mansoni zinc finger protein 0.0084 0.0306 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.2139 0.9576 1
Loa Loa (eye worm) nuclear hormone receptor 0.0084 0.0306 0.1036
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0019 0.0122
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0382 0.1649 1
Plasmodium vivax glutathione reductase, putative 0.0151 0.0606 1
Trichomonas vaginalis importin beta-1, putative 0.005 0.0151 0.2555
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0047 0.0137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0178 0.073 0.2523
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0008 0.0008
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0093 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0019 0.0122
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0119 0.0387
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0145 0.0478
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Trypanosoma brucei unspecified product 0.002 0.0019 0.0122
Loa Loa (eye worm) hypothetical protein 0.0033 0.0076 0.0236
Loa Loa (eye worm) bromodomain containing protein 0.003 0.0061 0.0185
Brugia malayi tailless protein 0.0084 0.0306 0.104
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0112
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0084 0.0306 0.0311
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0052 0.0162 0.1057
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0052 0.0162 0.2533
Brugia malayi AMP-binding enzyme family protein 0.0025 0.004 0.0113
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0093 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0178 0.073 0.2514
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0101 0.1805
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0008 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis geminin 0.0511 0.2231 0.2324
Onchocerca volvulus 0.0027 0.0047 0.0543
Toxoplasma gondii NADPH-glutathione reductase 0.0052 0.0162 0.2165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0178 0.073 0.0754
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.004 0.0377
Leishmania major DNA polymerase kappa, putative 0.002 0.0019 0.0122
Trypanosoma brucei trypanothione reductase 0.0151 0.0606 0.3951
Brugia malayi Bromodomain containing protein 0.0091 0.0336 0.1145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0178 0.073 0.2514
Brugia malayi nuclear hormone receptor family member nhr-6 0.0084 0.0306 0.104
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0178 0.073 0.2514
Schistosoma mansoni adenoreceptor 0.0018 0.0008 0.0008
Echinococcus granulosus thioredoxin glutathione reductase 0.0151 0.0609 0.0601
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0178 0.073 0.0754
Brugia malayi AMP-binding enzyme family protein 0.0025 0.004 0.0113
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0162 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0178 0.073 0.2523
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.004 0.0262
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0178 0.073 0.0754
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.004 0.0471
Brugia malayi hypothetical protein 0.0094 0.0351 0.1199
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.004 0.047
Schistosoma mansoni hypothetical protein 0.0511 0.2231 0.2231
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.0351 0.1199
Brugia malayi photoreceptor-specific nuclear receptor 0.0178 0.073 0.2523
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Echinococcus multilocularis tumor protein p63 0.0358 0.1544 0.1605
Echinococcus granulosus RUN 0.002 0.0015 0.0007
Loa Loa (eye worm) hypothetical protein 0.0094 0.0351 0.1194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0178 0.073 0.0722
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Echinococcus multilocularis snurportin 1 0.0655 0.2879 0.3001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0306 0.0298
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Loa Loa (eye worm) acetyltransferase 0.0454 0.1973 0.6844
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0093 0.0089
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0052 0.0162 0.2533
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.0306 0.4122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0129 0.0422
Schistosoma mansoni hypothetical protein 0.0655 0.2879 0.2879
Loa Loa (eye worm) hypothetical protein 0.0094 0.0351 0.1194
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0019 0.0122
Echinococcus multilocularis dna polymerase kappa 0.002 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.0094 0.0351 0.1194
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0178 0.073 0.073
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0093 0.0608
Brugia malayi nuclear hormone receptor 0.0084 0.0306 0.104
Echinococcus granulosus lamin dm0 0.0027 0.0047 0.0039
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0178 0.073 0.0754
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0178 0.073 0.2523
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0052 0.0162 1
Schistosoma mansoni thyroid hormone receptor 0.0178 0.073 0.073
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0151 0.0606 0.3648
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.004 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.0178 0.073 0.2523
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0101 0.0097
Leishmania major trypanothione reductase 0.0151 0.0606 0.3951
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0037
Echinococcus multilocularis dna polymerase eta 0.002 0.0019 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0356 0.1534 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0052 0.0162 0.1057
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0093 0.0085
Schistosoma mansoni nuclear hormone receptor 0.0084 0.0306 0.0306
Brugia malayi nuclear hormone receptor family member odr-7 0.0084 0.0306 0.104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Onchocerca volvulus 0.002 0.0015 0.0095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0343 0.1476 0.8947
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0306 0.0311
Schistosoma mansoni biogenic amine receptor 0.0018 0.0008 0.0008
Brugia malayi RNA, U transporter 1 0.0174 0.0713 0.2465
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0052 0.0162 0.1057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0181 0.0601
Echinococcus granulosus histone acetyltransferase KAT2B 0.0135 0.0537 0.0529
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0052 0.0162 0.1057
Leishmania major GTP-binding protein, putative 0.0045 0.013 0.085
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.0306 0.0311
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0129 0.0121
Plasmodium falciparum importin beta, putative 0.0061 0.0203 0.3227
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis zinc finger protein 0.0032 0.007 0.0065
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0203 0.1326
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.013 0.1998
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.2233 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.0687 0.4481
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0052 0.0162 0.2533
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0343 0.1476 0.8947
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.004 0.0377
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0019 0.0072
Schistosoma mansoni alpha-glucosidase 0.0165 0.0673 0.0673
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0178 0.073 0.2523
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0119 0.1939
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0203 0.1326
Trichomonas vaginalis bromodomain-containing protein, putative 0.0135 0.0537 1
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0026 0.0061
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0454 0.1973 0.1973
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0101 0.0325
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0019 0.0122
Schistosoma mansoni intermediate filament proteins 0.0027 0.0047 0.0047
Schistosoma mansoni steroid hormone receptor ad4bp 0.0178 0.073 0.073
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0052 0.0162 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.004 0.0377
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0112
Loa Loa (eye worm) hypothetical protein 0.0652 0.2869 0.9964
Plasmodium falciparum thioredoxin reductase 0.0052 0.0162 0.2533
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0094 0.0351 0.0343
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0052 0.0162 0.2533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0178 0.073 0.2514
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0515 0.6608
Loa Loa (eye worm) DR-78 0.0084 0.0306 0.1036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0008 0.0008
Giardia lamblia Histone acetyltransferase GCN5 0.0122 0.0475 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0119 0.2199
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0178 0.073 0.0754
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0012 0.0028
Brugia malayi ecdysteroid receptor 0.0178 0.073 0.2523
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Schistosoma mansoni nuclear receptor nhr-48 0.0084 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0093 0.1439
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0356 0.1534 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0119 0.1939
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0019 0.0011
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0052 0.0162 0.0162
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0169 0.0687 0.4481
Echinococcus granulosus FTZ F1 alpha 0.0178 0.073 0.0722
Brugia malayi nuclear receptor RXR 0.0084 0.0306 0.104
Schistosoma mansoni opsin-like receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0129 0.0421
Schistosoma mansoni zinc finger protein 0.0032 0.007 0.007
Toxoplasma gondii thioredoxin reductase 0.0151 0.0606 1
Schistosoma mansoni ap endonuclease 0.0039 0.0101 0.0101
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.013 0.085
Brugia malayi AMP-binding enzyme family protein 0.0025 0.004 0.0113
Giardia lamblia NADH oxidase lateral transfer candidate 0.0052 0.0162 0.314
Schistosoma mansoni biogenic amine receptor 0.0018 0.0008 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0019 0.0122
Schistosoma mansoni ap endonuclease 0.0039 0.0101 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0188 0.0773 0.4667
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0178 0.073 0.2523
Brugia malayi steroid hormone receptor 0.0178 0.073 0.2523
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Echinococcus multilocularis ecdysone induced protein 78C 0.0178 0.073 0.0754
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0203 0.0204
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0145 0.0478
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0178 0.073 1
Brugia malayi nuclear receptor NHR-67 0.0084 0.0306 0.104
Echinococcus multilocularis musashi 0.0027 0.0047 0.0041
Brugia malayi intermediate filament protein 0.0027 0.0047 0.0137
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0019 0.0019
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0084 0.0306 0.104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0137
Echinococcus granulosus dna polymerase kappa 0.002 0.0019 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0151 0.2555
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0178 0.073 0.0754
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0496 0.1699
Echinococcus multilocularis thyroid hormone receptor alpha 0.0178 0.073 0.0754
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0038 0.01 0.032
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0129 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0178 0.073 0.2523
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0052 0.0162 0.1977
Trichomonas vaginalis mercuric reductase, putative 0.0052 0.0162 0.2769
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0019 0.0122
Loa Loa (eye worm) hypothetical protein 0.0094 0.0351 0.1194
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0119 0.1939
Mycobacterium tuberculosis Probable dehydrogenase 0.0343 0.1476 0.8947
Onchocerca volvulus 0.0084 0.0306 0.4122
Echinococcus granulosus nuclear receptor nhr 48 0.0084 0.0306 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0119 0.0777
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.073 0.2523
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0356 0.1534 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0084 0.0306 0.0298
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.004 0.0258
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0008 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0008 0.0008
Brugia malayi nuclear receptor NHR-88 0.0084 0.0306 0.104
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0178 0.073 0.2514
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0119 0.1406
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0515 0.0515
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0008 0.0008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0052 0.0162 0.1977
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0008 0.0008
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0008 0.0008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0052 0.0162 0.1057
Schistosoma mansoni opsin-like receptor 0.0018 0.0008 0.0008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0153 0.0996
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0178 0.073 0.2523
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0101 0.1508
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0093 0.0298
Brugia malayi ecdysone receptor 0.0084 0.0306 0.104
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0151 0.0985
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Schistosoma mansoni loxhd1 0.002 0.0015 0.0015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0655 0.2879 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0094 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0192 0.0794 0.2746
Loa Loa (eye worm) glutathione reductase 0.0151 0.0606 0.2082
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0015 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi nuclear hormone receptor 0.0178 0.073 0.2523
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0052 0.0162 0.1057
Loa Loa (eye worm) hypothetical protein 0.0041 0.011 0.0356
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0038 0.01 0.032
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0262 0.0255
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Trichomonas vaginalis ran, putative 0.0045 0.013 0.2155
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0135 0.0537 1
Onchocerca volvulus 0.0025 0.004 0.0446
Echinococcus multilocularis thioredoxin glutathione reductase 0.0151 0.0609 0.0628
Onchocerca volvulus 0.0052 0.0163 0.2153
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0178 0.073 0.0722
Loa Loa (eye worm) hypothetical protein 0.0061 0.0203 0.068
Entamoeba histolytica Ran family GTPase 0.0045 0.013 0.2444
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0119 0.1939
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0178 0.073 0.073
Schistosoma mansoni lamin 0.0027 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0178 0.073 0.2523
Schistosoma mansoni bromodomain containing protein 0.0078 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0075 0.0265 0.0896
Brugia malayi glutathione reductase 0.0151 0.0606 0.209
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0008 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0008 0.0008
Onchocerca volvulus 0.0111 0.0428 0.5821
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.013 0.0122
Schistosoma mansoni myosin xvIII 0.0018 0.0008 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.0052 0.0162 0.2769
Schistosoma mansoni nuclear hormone receptor 0.0084 0.0306 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0515 0.8393
Leishmania major DNA polymerase eta, putative 0.002 0.0019 0.0122
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0047 0.0137
Leishmania major importin beta-1 subunit, putative 0.005 0.0151 0.0985
Schistosoma mansoni importin beta-1 0.0061 0.0203 0.0203
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0101 0.1176
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0084 0.0306 0.104
Brugia malayi nuclear receptor NHR-88 0.0178 0.073 0.2523
Schistosoma mansoni hypothetical protein 0.0511 0.2231 0.2231
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0047 0.0137
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0135 0.0537 0.8774
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0178 0.073 0.2523
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0015 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.004 0.0377
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0052 0.0162 0.2165
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0008 0.0008
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0153 0.0996
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.013 0.085
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0192 0.0794 0.2736
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0007
Echinococcus granulosus tumor protein p63 0.0358 0.1544 0.1537
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0019 0.0037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0262 0.0266
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0119 0.2199
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0093 0.1632
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0052 0.0162 0.0161
Brugia malayi MH2 domain containing protein 0.0126 0.0496 0.1705
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0052 0.0162 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.013 0.0427
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.013 0.1603
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0015 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0019 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0496 0.1699
Entamoeba histolytica acetyltransferase, GNAT family 0.0122 0.0475 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0129 0.0126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0178 0.073 0.073
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0119 0.1939
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Brugia malayi hypothetical protein 0.0652 0.2869 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0515 0.3357
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0145 0.0476
Schistosoma mansoni nuclear receptor 0.0084 0.0306 0.0306
Echinococcus granulosus intermediate filament protein 0.0027 0.0047 0.0039
Brugia malayi hypothetical protein 0.0084 0.0306 0.104
Toxoplasma gondii hypothetical protein 0.0057 0.0186 0.2586
Mycobacterium ulcerans hypothetical protein 0.0188 0.0773 1
Brugia malayi hypothetical protein 0.0084 0.0306 0.104
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0101 0.1805
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0178 0.073 0.0722
Onchocerca volvulus Bile acid receptor homolog 0.0178 0.073 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0178 0.073 0.0722
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0052 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0178 0.073 0.2523
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.004 0.0471
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0019 0.0095
Brugia malayi Doublecortin family protein 0.002 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0012
Schistosoma mansoni ran 0.0045 0.013 0.013
Schistosoma mansoni coup transcription factor 0.0178 0.073 0.073
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0135 0.0537 0.8832
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0008 0.0008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0099 0.0091
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0101 0.1508
Loa Loa (eye worm) hypothetical protein 0.0054 0.0172 0.057
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0112
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0052 0.0162 0.1057
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.004 0.0258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.004 0.047
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.013 0.1998
Onchocerca volvulus 0.0178 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0515 0.0507
Plasmodium falciparum glutathione reductase 0.0052 0.0162 0.2533
Leishmania major mitochondrial DNA polymerase beta 0.0356 0.1534 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0093 0.0949
Brugia malayi Nuclear hormone receptor E75 0.0084 0.0306 0.104
Echinococcus multilocularis lamin 0.0027 0.0047 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.0306 0.0298
Brugia malayi orphan nuclear receptor NR2E1 0.0084 0.0306 0.104
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0135 0.0537 0.8774
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0093 0.0608
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0129 0.0129
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.013 0.2444
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.0306 0.4122
Brugia malayi hypothetical protein 0.0094 0.0351 0.1199
Echinococcus multilocularis nuclear receptor nhr 48 0.0084 0.0306 0.0311
Loa Loa (eye worm) thioredoxin reductase 0.0151 0.0606 0.2082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0178 0.073 0.2514
Schistosoma mansoni nuclear receptor 0.0084 0.0306 0.0306
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0101 0.0093
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.004 0.0377
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.004 0.0203
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Schistosoma mansoni alpha glucosidase 0.0043 0.0119 0.0119
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.013 0.085
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0178 0.073 0.073
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0178 0.073 0.073
Echinococcus granulosus importin subunit beta 1 0.0061 0.0203 0.0195
Brugia malayi follicle stimulating hormone receptor 0.0246 0.1036 0.3593
Plasmodium vivax thioredoxin reductase, putative 0.0151 0.0606 1
Mycobacterium tuberculosis Probable reductase 0.0343 0.1476 0.8947
Trypanosoma cruzi trypanothione reductase, putative 0.0151 0.0606 0.3951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0008 0.0008
Brugia malayi Thioredoxin reductase 0.0151 0.0606 0.209
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0119 0.1939
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0343 0.1476 0.8925
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0151 0.2555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.0351 0.1199
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0024
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0153 0.0996
Brugia malayi hypothetical protein 0.0025 0.004 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.1057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.004 0.0203
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0052 0.0162 0.0945
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0012
Onchocerca volvulus 0.0084 0.0306 0.4122
Leishmania major hypothetical protein, conserved 0.0025 0.004 0.0258
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.013 0.0426
Schistosoma mansoni DNA polymerase eta 0.002 0.0019 0.0019
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.004 0.0471
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Plasmodium falciparum thioredoxin reductase 0.0151 0.0606 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0035 0.0027
Loa Loa (eye worm) hypothetical protein 0.0178 0.073 0.2514
Mycobacterium tuberculosis Probable oxidoreductase 0.0382 0.1649 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0101 0.0324
Loa Loa (eye worm) hypothetical protein 0.0052 0.0163 0.0541
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0306 0.1036
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0382 0.1649 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.004 0.047
Schistosoma mansoni lamin 0.0027 0.0047 0.0047
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0019 0.0122
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0093 0.1375
Plasmodium falciparum glutathione reductase 0.0151 0.0606 1
Schistosoma mansoni opsin-like receptor 0.0018 0.0008 0.0008
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0008 0.0008
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0052 0.0162 0.0539
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.0306 0.0298
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.0306 0.0311
Brugia malayi Importin beta-1 subunit 0.0061 0.0203 0.0683
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0101 0.066
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0515 0.053
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0008 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0019 0.0122
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0093 0.0608
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0094 0.0351 0.0351
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0093 0.1375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0382 0.1649 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0178 0.073 0.2523
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0019 0.0095
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0019 0.0019
Echinococcus multilocularis RUN 0.002 0.0015 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0129 0.0129
Brugia malayi hypothetical protein 0.002 0.0015 0.0024
Schistosoma mansoni hypothetical protein 0.0033 0.0076 0.0076
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0173 0.0173
Brugia malayi sulfakinin receptor protein 0.0652 0.2869 1
Echinococcus multilocularis lamin dm0 0.0027 0.0047 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0178 0.073 0.0722
Treponema pallidum NADH oxidase 0.0052 0.0162 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0119 0.0777
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0019 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0094 0.0351 0.1194
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0119 0.1939
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0101 0.066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.0178 0.073 0.0722
Schistosoma mansoni hypothetical protein 0.0022 0.0026 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0178 0.073 0.0722
Brugia malayi Bromodomain containing protein 0.0052 0.016 0.0531
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0093 0.1439
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0343 0.1476 0.8947
Loa Loa (eye worm) doublecortin family protein 0.002 0.0015 0.0024
Schistosoma mansoni lipoxygenase 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0101 0.1592
Echinococcus granulosus snurportin 1 0.0655 0.2879 0.2874
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0343 0.1476 0.8947
Toxoplasma gondii exonuclease III APE 0.0039 0.0101 0.1088
Echinococcus multilocularis lysosomal alpha glucosidase 0.0192 0.0794 0.0821
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0515 0.3094
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0173 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0019 0.0122
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.004 0.0262
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0052 0.0162 0.1977
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.013 0.0128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0178 0.073 0.073
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0015 0.0007
Onchocerca volvulus 0.0027 0.0047 0.0543
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0019 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0515 0.0515
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0084 0.0306 0.0306
Mycobacterium ulcerans hypothetical protein 0.0025 0.004 0.0377
Onchocerca volvulus 0.002 0.0015 0.0095
Brugia malayi nuclear receptor RXR 0.0094 0.0351 0.1199
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0163 0.0163
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0019 0.0072
Brugia malayi PHD-finger family protein 0.0037 0.0096 0.0307
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0094 0.0351 0.0358

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 15263 nM In vitro binding property against kappa opioid receptor ChEMBL. No reference
Activity (binding) = 33480 nM In vitro binding property against mu opioid receptor ChEMBL. No reference
ED50 (functional) > 81 mg kg-1 Antagonistic effect on mouse phenylquinone writhing (PQW ) test, subcutaneous administration ChEMBL. No reference
ED50 (functional) > 81 mg kg-1 Antagonistic effect on mouse phenylquinone writhing (PQW ) test, peroral administration ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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