Detailed information for compound 1038434

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 267.758 | Formula: C12H18ClN5
  • H donors: 1 H acceptors: 2 LogP: 2.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cnc(c2n1c(C)cn2)N1CCNCC1.Cl
  • InChi: 1S/C12H17N5.ClH/c1-9-7-14-11(16-5-3-13-4-6-16)12-15-8-10(2)17(9)12;/h7-8,13H,3-6H2,1-2H3;1H
  • InChiKey: YBCJZAJRABKCTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Beta-1 adrenergic receptor Starlite/ChEMBL References
Bos taurus Alpha-2a adrenergic receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus alpha 1A adrenergic receptor Alpha-2a adrenergic receptor   452 aa 456 aa 21.1 %
Echinococcus multilocularis alpha 1A adrenergic receptor Alpha-2a adrenergic receptor   452 aa 452 aa 20.6 %
Loa Loa (eye worm) TYRA-2 protein Alpha-2a adrenergic receptor   452 aa 491 aa 24.4 %
Schistosoma mansoni amine GPCR Alpha-2a adrenergic receptor   452 aa 440 aa 29.1 %
Onchocerca volvulus Alpha-2a adrenergic receptor   452 aa 426 aa 18.3 %
Echinococcus multilocularis fmrfamide receptor Alpha-2a adrenergic receptor   452 aa 453 aa 19.2 %
Onchocerca volvulus Alpha-2a adrenergic receptor   452 aa 471 aa 27.4 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Alpha-2a adrenergic receptor   452 aa 381 aa 21.8 %
Echinococcus granulosus biogenic amine 5HT receptor Alpha-2a adrenergic receptor   452 aa 420 aa 32.6 %
Echinococcus multilocularis serotonin receptor Alpha-2a adrenergic receptor   452 aa 421 aa 33.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.4403 0.619
Schistosoma mansoni rab6-interacting 0.0022 0.0202 0.0173
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4517 0.6351
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0202 1
Schistosoma mansoni lamin 0.0027 0.0353 0.0324
Mycobacterium tuberculosis Conserved protein 0.0042 0.078 0.0848
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.7113 1
Schistosoma mansoni hypothetical protein 0.0053 0.1095 0.1069
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.1351 0.1325
Schistosoma mansoni ap endonuclease 0.0021 0.0173 0.0143
Echinococcus granulosus intermediate filament protein 0.0027 0.0353 0.0324
Brugia malayi RNA binding protein 0.0207 0.5575 0.7838
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0734 0.1032
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.7113 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.5256 0.739
Echinococcus multilocularis RUN 0.0022 0.0202 0.0173
Echinococcus granulosus GPCR family 2 0.0053 0.1095 0.1069
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.078 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0734 0.1032
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0202 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5575 0.5562
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0173 0.0243
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0734 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.5575 0.7838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.5256 0.5242
Echinococcus granulosus lamin 0.0027 0.0353 0.0324
Onchocerca volvulus 0.0027 0.0353 0.0781
Trypanosoma brucei glucosidase, putative 0.004 0.0734 0.9413
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0734 0.0706
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.07 0.0672
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0786 0.1105
Loa Loa (eye worm) beta-lactamase 0.0042 0.078 0.1096
Loa Loa (eye worm) hypothetical protein 0.0042 0.078 0.1096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.078 0.0752
Mycobacterium ulcerans lipase LipD 0.0042 0.078 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0734 0.1032
Toxoplasma gondii ABC1 family protein 0.0042 0.078 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.5256 0.5242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.1095 0.154
Echinococcus multilocularis GPCR, family 2 0.0053 0.1095 0.1069
Schistosoma mansoni thyroid hormone receptor 0.0131 0.3388 0.3368
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.078 0.0848
Brugia malayi MH2 domain containing protein 0.0138 0.3595 0.5054
Brugia malayi Doublecortin family protein 0.0022 0.0202 0.0284
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.1095 0.1069
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0202 0.0173
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0173 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.078 0.1096
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.7113 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.4836 0.482
Schistosoma mansoni alpha glucosidase 0.004 0.0734 0.0706
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0202 0.0173
Mycobacterium ulcerans beta-lactamase 0.0042 0.078 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.5256 0.739
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.5256 0.5242
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.7113 1
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5575 0.5562
Schistosoma mansoni hypothetical protein 0.0359 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.078 0.0752
Brugia malayi hypothetical protein 0.0039 0.07 0.0984
Schistosoma mansoni hypothetical protein 0.0114 0.2872 0.2851
Schistosoma mansoni hypothetical protein 0.0039 0.07 0.0672
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0353 0.0496
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0734 0.1032
Loa Loa (eye worm) hypothetical protein 0.0114 0.2872 0.4038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.4403 0.619
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.078 0.0848
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.078 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.07 0.0672
Schistosoma mansoni intermediate filament proteins 0.0027 0.0353 0.0324
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.5575 0.7838
Echinococcus multilocularis musashi 0.0027 0.0353 0.0324
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.07 0.0672
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.4836 0.482
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0353 0.0496
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0559 0.0785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.5256 0.5242
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0786 0.1105
Loa Loa (eye worm) hypothetical protein 0.02 0.5373 0.7554
Echinococcus multilocularis lamin 0.0027 0.0353 0.0324
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0353 0.0496
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.003 0.0042
Onchocerca volvulus 0.0042 0.078 0.1726
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.1095 0.1069
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0173 0.2216
Onchocerca volvulus 0.0105 0.2613 0.5785
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.1351 0.1325
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.3595 0.5054
Echinococcus multilocularis thyroid hormone receptor alpha 0.0131 0.3388 0.3368
Schistosoma mansoni loxhd1 0.0022 0.0202 0.0173
Mycobacterium leprae conserved hypothetical protein 0.0042 0.078 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.078 0.1096
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0786 0.0758
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0734 0.9413
Leishmania major hypothetical protein, conserved 0.0042 0.078 1
Entamoeba histolytica hypothetical protein 0.0039 0.07 0.9531
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0202 0.0173
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0173 0.0143
Onchocerca volvulus 0.0042 0.078 0.1726
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0202 0.0284
Onchocerca volvulus 0.0022 0.0202 0.0448
Brugia malayi TAR-binding protein 0.0207 0.5575 0.7838
Loa Loa (eye worm) hypothetical protein 0.0027 0.0353 0.0496
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.4836 0.6798
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.078 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.5256 0.5242
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0734 0.0706
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.078 0.1096
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.078 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0173 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0192 0.5146 0.7235
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5575 0.5562
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0173 0.5
Echinococcus granulosus RUN 0.0022 0.0202 0.0173
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.078 1
Schistosoma mansoni hypothetical protein 0.0359 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.078 0.0752
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.078 0.1096
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.078 0.0848
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.078 0.0848
Loa Loa (eye worm) hypothetical protein 0.0042 0.078 0.1096
Echinococcus multilocularis lamin dm0 0.0027 0.0353 0.0324
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0173 0.2354
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4517 0.6351
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.078 0.1096
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0734 0.1032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0734 0.1032
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0884 0.0856
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4517 0.6351
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0202 0.0485
Schistosoma mansoni lipoxygenase 0.0022 0.0202 0.0173
Schistosoma mansoni alpha-glucosidase 0.0156 0.4102 0.4084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0173 0.2216
Echinococcus multilocularis geminin 0.0359 1 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.7113 1
Loa Loa (eye worm) RNA binding protein 0.0207 0.5575 0.7838
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.4403 0.619
Brugia malayi Latrophilin receptor protein 2 0.0053 0.1095 0.154
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.078 0.1096
Schistosoma mansoni polycystin 1-related 0.0022 0.0202 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5575 0.5562
Entamoeba histolytica hypothetical protein 0.0039 0.07 0.9531
Mycobacterium tuberculosis Conserved protein 0.0042 0.078 0.0848
Brugia malayi beta-lactamase 0.0042 0.078 0.1096
Echinococcus granulosus tar DNA binding protein 0.0207 0.5575 0.5562
Onchocerca volvulus 0.0027 0.0353 0.0781
Plasmodium vivax hypothetical protein, conserved 0.0042 0.078 1
Brugia malayi hypothetical protein 0.0022 0.0202 0.0284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0338 0.0475
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0734 0.9413
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.3104 0.3083
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4517 0.6351
Schistosoma mansoni rab6-interacting 0.0022 0.0202 0.0173
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.078 0.1096
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4517 0.6351
Brugia malayi hypothetical protein 0.0022 0.0202 0.0284
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0173 0.0243
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0173 0.0243
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4517 0.6351
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0734 0.1032
Loa Loa (eye worm) TAR-binding protein 0.0207 0.5575 0.7838
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0173 0.0143
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.02 0.5373 0.7554
Entamoeba histolytica hypothetical protein 0.0039 0.07 0.9531
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.7113 1
Schistosoma mansoni lipoxygenase 0.0061 0.1351 0.1325
Brugia malayi intermediate filament protein 0.0027 0.0353 0.0496
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0202 0.0173
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.2872 0.4038
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.3595 0.5054
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.4836 0.482
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0734 0.9246
Mycobacterium leprae Probable lipase LipE 0.0042 0.078 0.5
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5575 0.5562
Onchocerca volvulus 0.0022 0.0202 0.0448
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.078 0.1096
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0786 0.0758
Schistosoma mansoni hypothetical protein 0.0053 0.1095 0.1069
Echinococcus multilocularis tar DNA binding protein 0.0207 0.5575 0.5562
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0884 0.0856
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.4517 0.6351
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.733 1
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.7113 1
Schistosoma mansoni hypothetical protein 0.0022 0.0202 0.0173
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.3104 0.3083
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4784 0.6726
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0173 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.078 0.0848
Schistosoma mansoni ap endonuclease 0.0021 0.0173 0.0143
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4784 0.6726
Schistosoma mansoni hypothetical protein 0.0122 0.3104 0.3083
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.1095 0.1069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.1095 0.154
Trichomonas vaginalis esterase, putative 0.0042 0.078 0.1096
Echinococcus granulosus lamin dm0 0.0027 0.0353 0.0324
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0734 0.1032
Schistosoma mansoni lamin 0.0027 0.0353 0.0324
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.4517 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0202 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.5256 0.5242
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.078 0.0752
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0734 0.1032
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0734 0.1032
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.7113 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.078 0.1096
Entamoeba histolytica hypothetical protein 0.0039 0.07 0.9531
Schistosoma mansoni hypothetical protein 0.0053 0.1095 0.1069
Schistosoma mansoni thyroid hormone receptor 0.0131 0.3388 0.3368
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0734 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.078 0.1096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0173 0.2216
Onchocerca volvulus 0.0042 0.078 0.1726
Schistosoma mansoni hypothetical protein 0.0053 0.1095 0.1069
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.078 0.0848
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0734 0.9413
Brugia malayi beta-lactamase family protein 0.0042 0.078 0.1096
Loa Loa (eye worm) hypothetical protein 0.0022 0.0202 0.0284
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.078 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0559 0.0785
Loa Loa (eye worm) hypothetical protein 0.0037 0.0645 0.0907
Schistosoma mansoni alpha-glucosidase 0.0156 0.4102 0.4084
Loa Loa (eye worm) hypothetical protein 0.0166 0.4403 0.619
Loa Loa (eye worm) hypothetical protein 0.0022 0.0202 0.0284
Loa Loa (eye worm) hypothetical protein 0.0042 0.078 0.1096
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.1095 0.1069
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0734 0.1032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0173 0.2216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.5256 0.5242
Brugia malayi beta-lactamase family protein 0.0042 0.078 0.1096
Loa Loa (eye worm) hypothetical protein 0.0053 0.1095 0.154
Mycobacterium ulcerans hypothetical protein 0.0042 0.078 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.4836 0.6798
Mycobacterium tuberculosis Conserved protein 0.0042 0.078 0.0848

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 72 % Ability to lower blood glucose in insulin-resistant hyperglycemic ob/ob mice after 30 mg/kg p.o. administration. ChEMBL. 1359141
Ki (binding) = 340 nM Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]-clonidine displacement. ChEMBL. 1359141
Ki (binding) = 400 nM Binding affinity at Beta-1 adrenergic receptor in guinea pigs by [125I]-CYP displacement ChEMBL. 1359141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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