Detailed information for compound 1038520

Basic information

Technical information
  • TDR Targets ID: 1038520
  • Name: 1-ethylpyridin-1-ium iodide
  • MW: 235.065 | Formula: C7H10IN
  • H donors: 0 H acceptors: 0 LogP: 2.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[n+]1ccccc1.[I-]
  • InChi: 1S/C7H10N.HI/c1-2-8-6-4-3-5-7-8;/h3-7H,2H2,1H3;1H/q+1;/p-1
  • InChiKey: FSRVQSSHFLOXGR-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 872-90-2
  • NSC35668

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0048 0.008
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0048 0.0048
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0048 0.008
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.1064 0.1064
Echinococcus multilocularis ferritin 0.0009 0.0169 0.0169
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0048 0.008
Entamoeba histolytica hypothetical protein 0.0036 0.1365 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.1064 0.1064
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0051 0.1992 0.1992
Schistosoma mansoni coup transcription factor 0.0011 0.0243 0.0409
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0482 0.0482
Echinococcus multilocularis GPCR, family 2 0.0016 0.0482 0.0482
Schistosoma mansoni ferritin 0.0009 0.0169 0.0284
Schistosoma mansoni DNA helicase recq1 0.002 0.0655 0.1102
Schistosoma mansoni hypothetical protein 0.0016 0.0482 0.0812
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0243 0.0409
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0227 0.0054
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0048 0.0048
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0243 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0063 0.252 0.4243
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0243 0.0243
Entamoeba histolytica recQ family helicase, putative 0.001 0.021 0.1236
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0048 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.256 0.7542
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0227 0.0185
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0048 0.0048
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0655 0.0655
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0048 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0655 0.142
Schistosoma mansoni tar DNA-binding protein 0.0063 0.252 0.4243
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.021 0.0354
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0243 0.0243
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.2114 0.6136
Trichomonas vaginalis ferritin, putative 0.0009 0.0169 0.1995
Brugia malayi CXXC zinc finger family protein 0.003 0.1089 0.1089
Brugia malayi hypothetical protein 0.0006 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0378 0.0378
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.1009 0.255
Schistosoma mansoni apoferritin-2 0.0009 0.0169 0.0284
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0243 0.0243
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.334 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.256 0.431
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0079 0.0519
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0482 0.0482
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0655 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1992 0.1992
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0108 0.0108
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0243 0.0243
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0026 0.0026
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0243 0.0243
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.334 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.594 0.594
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0243 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0063 0.252 0.4243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.594 0.594
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0243 0.0243
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.1365 0.2299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0243 0.0243
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0048 0.0048
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0187 0.0187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.1009 0.2648
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.2114 0.8136
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.334 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0026 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0243 0.0243
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0048 0.0048
Echinococcus granulosus tar DNA binding protein 0.0063 0.252 0.252
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.594 0.594
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.252 0.252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0079 0.0519
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0108 0.0108
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0227 0.0383
Echinococcus multilocularis expressed protein 0.0009 0.0169 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.1365 0.1365
Echinococcus multilocularis tar DNA binding protein 0.0063 0.252 0.252
Loa Loa (eye worm) hypothetical protein 0.001 0.0227 0.0227
Echinococcus granulosus intermediate filament protein 0.0029 0.1064 0.1064
Schistosoma mansoni hypothetical protein 0.0035 0.1293 0.2177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0482 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0243 0.0243
Onchocerca volvulus 0.0006 0.0048 0.0255
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0048 0.008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0014 0.0378 0.0378
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0048 0.0048
Onchocerca volvulus 0.0029 0.1064 0.5698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.594 1
Schistosoma mansoni lamin 0.0029 0.1064 0.1791
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0048 0.0048
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0187 0.0187
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0655 0.142
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0048 0.0048
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0243 0.0409
Loa Loa (eye worm) hypothetical protein 0.0029 0.1064 0.1064
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0482 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0243 0.0243
Schistosoma mansoni lamin 0.0029 0.1064 0.1791
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0655 1
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.2114 0.2114
Brugia malayi nuclear hormone receptor 0.0011 0.0243 0.0243
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.2258 0.6542
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1293 0.1293
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0048 0.008
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0655 0.0655
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0243 0.0409
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.1064 0.1064
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.2114 0.2114
Loa Loa (eye worm) hypothetical protein 0.0234 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0243 0.0409
Schistosoma mansoni cpg binding protein 0.0032 0.1164 0.1959
Brugia malayi G-protein alpha subunit 0.0006 0.0048 0.0048
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.334 1
Echinococcus granulosus ferritin 0.0009 0.0169 0.0169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0243 0.0243
Schistosoma mansoni hypothetical protein 0.0016 0.0482 0.0812
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0243 0.0243
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.2554 0.4299
Schistosoma mansoni hypothetical protein 0.0048 0.1867 0.3143
Brugia malayi nuclear receptor RXR 0.0006 0.0026 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0243 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0243 0.0243
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0227 0.0227
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.334 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0227 0.0054
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0048
Brugia malayi hypothetical protein 0.0006 0.0048 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0036 0.1365 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0026
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.256 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0243 0.0243
Brugia malayi Probable ClpP-like protease 0.0081 0.334 0.334
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0469 0.0469
Toxoplasma gondii hypothetical protein 0.0028 0.1009 0.255
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.334 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0048 0.008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0655 0.0655
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.256 0.7542
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0243 0.0243
Schistosoma mansoni DNA helicase recq5 0.002 0.0655 0.1102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0243 0.0243
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.334 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0243 0.0243
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0108 0.0181
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0036 0.1365 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0048 0.008
Onchocerca volvulus 0.0048 0.1867 1
Echinococcus granulosus GPCR family 2 0.0016 0.0482 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0243 0.0243
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Loa Loa (eye worm) RecQ helicase 0.002 0.0655 0.0655
Onchocerca volvulus 0.0006 0.0048 0.0255
Schistosoma mansoni ferritin light chain 0.0009 0.0169 0.0284
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0243 0.0409
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0243 0.0243
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.334 0.5623
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0048 0.008
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.256 0.7509
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0655 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0655 0.0655
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.1009 0.2648
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0048
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.334 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0048 0.008
Schistosoma mansoni ferritin 0.0009 0.0169 0.0284
Echinococcus granulosus survival motor neuron protein 1 0.0234 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0243 0.0243
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0655 0.0655
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0048 0.008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0187 0.0187
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0482 0.0482
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0026 0.0044
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0482 0.0482
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0048 0.008
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.1009 0.1318
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0243 0.1301
Brugia malayi TAR-binding protein 0.0063 0.252 0.252
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0243 0.0409
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.594 0.594
Schistosoma mansoni hypothetical protein 0.0036 0.1365 0.2299
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0243 0.0409
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0482 0.0482
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0243 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0243 0.0243
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0081 0.334 0.334
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0026
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.334 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.594 0.594
Brugia malayi ecdysteroid receptor 0.0011 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0243 0.0243
Brugia malayi hypothetical protein 0.0036 0.1365 0.1365
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0243 0.0243
Entamoeba histolytica recQ family DNA helicase 0.001 0.0227 0.1364
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.334 0.334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0401 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0243 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0048 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0048 0.0048
Echinococcus granulosus lamin 0.0029 0.1064 0.1064
Onchocerca volvulus 0.0029 0.1064 0.5698
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0655 1
Echinococcus multilocularis bloom syndrome protein 0.002 0.0655 0.0655
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0655 0.0655
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.256 0.256
Brugia malayi hypothetical protein 0.0006 0.0026 0.0026
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1992 0.1992
Echinococcus granulosus cpg binding protein 0.0032 0.1164 0.1164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0079 0.0519
Echinococcus multilocularis cpg binding protein 0.0032 0.1164 0.1164
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0655 0.5
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0006 0.0048 0.0048
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0048 0.0048
Schistosoma mansoni cpg binding protein 0.0032 0.1164 0.1959
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0006 0.0048 0.0048
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0243 0.0409
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0655 0.0655
Schistosoma mansoni ferritin 0.0009 0.0169 0.0284
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.256 0.431
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0655 0.0655
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.256 0.7542
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0048 0.0048
Echinococcus multilocularis survival motor neuron protein 1 0.0234 1 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0655 0.0655
Brugia malayi nuclear receptor NHR-88 0.0011 0.0243 0.0243
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.1365 0.1365
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0243 0.1301
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Brugia malayi intermediate filament protein 0.0029 0.1064 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0243 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0243 0.0243
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0048 0.008
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0243 0.0243
Schistosoma mansoni ferritin light chain 0.0009 0.0169 0.0284
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0048 0.0048
Echinococcus multilocularis lamin dm0 0.0029 0.1064 0.1064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0243 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.594 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.252 0.4243
Schistosoma mansoni survival motor neuron protein 0.0048 0.1867 0.3143
Echinococcus multilocularis lamin 0.0029 0.1064 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0079 0.0519
Onchocerca volvulus 0.003 0.1089 0.5834
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0079 0.0519
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0048
Loa Loa (eye worm) TAR-binding protein 0.0063 0.252 0.252
Echinococcus multilocularis expressed protein 0.0006 0.0048 0.0048
Entamoeba histolytica recQ family helicase, putative 0.002 0.0655 0.4607
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.256 0.256
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0026
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1867 0.1867
Trichomonas vaginalis helicase, putative 0.0007 0.0079 0.0519
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0048 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0035 0.1293 0.1293
Schistosoma mansoni hypothetical protein 0.0016 0.0482 0.0812
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0243 0.0243
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0243 0.0409
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0079 0.0519
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0048 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1089 0.1089
Schistosoma mansoni intermediate filament proteins 0.0029 0.1064 0.1791
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0401 0.0401
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.256 1
Brugia malayi steroid hormone receptor 0.0011 0.0243 0.0243
Echinococcus multilocularis musashi 0.0029 0.1064 0.1064
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0048 0.008
Schistosoma mansoni hypothetical protein 0.0016 0.0482 0.0812
Loa Loa (eye worm) RNA binding protein 0.0063 0.252 0.252
Schistosoma mansoni ferritin 0.0009 0.0169 0.0284
Onchocerca volvulus 0.0011 0.0243 0.1301
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0026 0.0044
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.252 0.252
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0401 0.0401
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0243 0.0243
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0048 0.0048
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.334 0.334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.594 0.594
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.2114 0.8136
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0079 0.0519
Loa Loa (eye worm) hypothetical protein 0.0029 0.1041 0.1041
Onchocerca volvulus 0.0006 0.0048 0.0255
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0243 0.0243
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0469 0.0469
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.334 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0243 0.0243
Echinococcus granulosus lamin dm0 0.0029 0.1064 0.1064
Schistosoma mansoni apoferritin-2 0.0009 0.0169 0.0284
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0482 0.0482
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0243 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0079 0.0519
Echinococcus granulosus bloom syndrome protein 0.002 0.0655 0.0655
Brugia malayi RNA binding protein 0.0063 0.252 0.252
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0243 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0063 0.252 0.4243
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.334 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0079 0.0519
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0243 0.1301
Entamoeba histolytica hypothetical protein 0.0036 0.1365 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.594 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0243 0.0243
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0243 0.0409
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1992 0.1992
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0243 0.0243
Echinococcus granulosus expressed protein 0.0006 0.0048 0.0048
Echinococcus granulosus expressed protein 0.0009 0.0169 0.0169
Schistosoma mansoni cpg binding protein 0.003 0.1089 0.1834

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 61.3171 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.8259 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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