Detailed information for compound 103894

Basic information

Technical information
  • TDR Targets ID: 103894
  • Name: 4-cyclohexyl-N-(diaminomethylidene)-3-methyls ulfonylbenzamide
  • MW: 323.411 | Formula: C15H21N3O3S
  • H donors: 2 H acceptors: 3 LogP: 2.61 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=NC(=O)c1ccc(c(c1)S(=O)(=O)C)C1CCCCC1)N
  • InChi: 1S/C15H21N3O3S/c1-22(20,21)13-9-11(14(19)18-15(16)17)7-8-12(13)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H4,16,17,18,19)
  • InChiKey: DZRKOSXZXKLSDC-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 4-cyclohexyl-N-(diaminomethylene)-3-methylsulfonyl-benzamide
  • 4-cyclohexyl-N-(diaminomethylene)-3-methylsulfonylbenzamide
  • N-[bis(azanyl)methylidene]-4-cyclohexyl-3-methylsulfonyl-benzamide
  • 4-cyclohexyl-N-(diaminomethylene)-3-mesyl-benzamide
  • 4-cyclohexyl-N-(diaminomethylidene)-3-methylsulfonyl-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Sodium/hydrogen exchanger Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K03316 monovalent cation:H+ antiporter, CPA1 family, putative Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Giardia lamblia Sodium/hydrogen exchanger 3 Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) NHE-3 Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma mansoni sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Brugia malayi sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0028 0.0166
Leishmania major trypanothione reductase 0.0104 0.0333 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0013 0.0271
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0028 0.047
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0028 0.0199
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.031 0.177
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0096 0.9835
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0028 0.1777
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.031 0.1823
Leishmania major hypothetical protein, conserved 0.0044 0.0028 0.0652
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0028 0.0166
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0028 0.0652
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0028 0.0103
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.031 0.188
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.1145 0.022
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0151 0.4328
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus granulosus dna polymerase kappa 0.0041 0.0013 0.0014
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0044 0.0028 0.0171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0091 0.0551
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0098 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0566 0.2678 0.2669
Loa Loa (eye worm) hypothetical protein 0.0044 0.0028 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0013 0.0191
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0319 0.1424 0.8638
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1442 0.7126 1
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.031 0.177
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0363 0.1648 0.97
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0169 0.0992
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.0096 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0028 0.0652
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.031 0.5
Brugia malayi RNA binding protein 0.0072 0.0169 0.1184
Echinococcus multilocularis dna polymerase eta 0.0068 0.0151 0.0833
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.031 0.177
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.031 0.1823
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0044 0.0028 0.0103
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0044 0.0028 0.0652
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0096 0.9835
Toxoplasma gondii thioredoxin reductase 0.0104 0.0333 0.1219
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0044 0.0028 0.0103
Loa Loa (eye worm) hypothetical protein 0.0057 0.0091 0.0551
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.0096 1
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.031 0.177
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0169 0.0992
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Plasmodium vivax glutathione reductase, putative 0.0104 0.0333 1
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0011 0.0064
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 0.5
Leishmania major DNA polymerase kappa, putative 0.0041 0.0013 0.0191
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0169 0.1023
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0028 0.0166
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0013 0.0014
Mycobacterium tuberculosis Probable dehydrogenase 0.0238 0.101 0.1402
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0363 0.1648 0.9698
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0028 0.0652
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0096 0.9835
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0013 0.0078
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.0096 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0238 0.101 0.1402
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 0.5
Loa Loa (eye worm) glutathione reductase 0.0104 0.0333 0.2018
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0044 0.0028 0.0103
Loa Loa (eye worm) hypothetical protein 0.0068 0.0151 0.0919
Loa Loa (eye worm) RNA binding protein 0.0072 0.0169 0.1023
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0319 0.1424 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.031 0.2176
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0028 0.047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0238 0.101 0.1402
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0013 0.0191
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0044 0.0028 0.047
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0028 0.0199
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0028 0.0652
Schistosoma mansoni hypothetical protein 0.0041 0.0011 0.0064
Plasmodium falciparum glutathione reductase 0.0104 0.0333 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0028 0.0652
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trichomonas vaginalis MYB72, putative 0.0058 0.0096 0.9835
Mycobacterium tuberculosis Probable reductase 0.0238 0.101 0.1402
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0169 0.1184
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0028 0.0103
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0319 0.1424 0.8368
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.1145 0.1591
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus multilocularis geminin 0.0373 0.1699 1
Giardia lamblia hypothetical protein 0.0044 0.0028 0.0092
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0028 0.0652
Brugia malayi TAR-binding protein 0.0072 0.0169 0.1184
Loa Loa (eye worm) hypothetical protein 0.0363 0.1648 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0098 1
Trichomonas vaginalis MYB3r3, putative 0.0058 0.0096 0.9835
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0028 0.0199
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0058 0.0098 0.0339
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0013 0.008
Brugia malayi glutathione reductase 0.0104 0.0333 0.2337
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Loa Loa (eye worm) PDE1B protein 0.0044 0.0028 0.0171
Loa Loa (eye worm) hypothetical protein 0.01 0.031 0.188
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0028 0.0166
Echinococcus granulosus thioredoxin glutathione reductase 0.0104 0.0333 0.1906
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0028 0.1777
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.031 0.188
Loa Loa (eye worm) NHE-3 0.01 0.031 0.188
Echinococcus granulosus dna polymerase eta 0.0068 0.0151 0.0833
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.031 0.177
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0028 0.0103
Brugia malayi MH2 domain containing protein 0.0263 0.1139 0.8002
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.1139 0.6912
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0169 0.0933
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0044 0.0028 0.0166
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0044 0.0028 0.0166
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.0096 1
Plasmodium falciparum thioredoxin reductase 0.0104 0.0333 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0096 0.9835
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0566 0.2678 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1442 0.7126 1
Schistosoma mansoni DNA polymerase eta 0.0068 0.0151 0.0892
Loa Loa (eye worm) hypothetical protein 0.01 0.031 0.188
Loa Loa (eye worm) hypothetical protein 0.0044 0.0028 0.0171
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0013 0.0014
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0028 0.1777
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0028 0.0166
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.1139 0.6912
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0013 0.0093
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.031 0.177
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0151 0.4436
Loa Loa (eye worm) hypothetical protein 0.0044 0.0028 0.0171
Plasmodium vivax thioredoxin reductase, putative 0.0104 0.0333 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0044 0.0028 0.0652
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0363 0.1648 1
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.031 0.177
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0028 0.0652
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0151 0.1064
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0104 0.0333 0.0449
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0013 0.0191
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.031 0.177
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0213 0.1199
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0028 0.0166
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0028 0.0103
Brugia malayi hypothetical protein 0.0041 0.0011 0.0077
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0096 0.9835
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0044 0.0028 0.0103
Loa Loa (eye worm) hypothetical protein 0.01 0.031 0.188
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.0096 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0028 0.0103
Loa Loa (eye worm) thioredoxin reductase 0.0104 0.0333 0.2018
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0044 0.0028 0.0103
Trichomonas vaginalis pc-MYB2, putative 0.0058 0.0096 0.9835
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0238 0.101 0.1402
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0028 0.1777
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis MYB, putative 0.0058 0.0098 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Leishmania major cAMP-specific phosphodiesterase, putative 0.0044 0.0028 0.0652
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0044 0.0028 0.0166
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.1145 0.1591
Trichomonas vaginalis C-MYB, putative 0.0058 0.0096 0.9835
Echinococcus granulosus geminin 0.0373 0.1699 1
Schistosoma mansoni hypothetical protein 0.0373 0.1699 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0363 0.1648 0.9698
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0028 0.0652
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0566 0.2678 0.2728
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0013 0.0191
Trichomonas vaginalis pc-MYB2, putative 0.0058 0.0096 0.9835
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0044 0.0028 0.0199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trichomonas vaginalis C-MYB, putative 0.0058 0.0096 0.9835
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.031 0.177
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0028 0.0652
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0044 0.0028 0.0199
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.047
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.031 0.1814
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0169 0.0992
Echinococcus granulosus tar DNA binding protein 0.0072 0.0169 0.0933
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0028 0.0652
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.031 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0013 0.0078
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0013 0.0014
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0363 0.1648 0.9698
Giardia lamblia Myb 1-like protein 0.0058 0.0098 0.0516
Leishmania major hypothetical protein, conserved 0.0044 0.0028 0.0652
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.031 0.177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Giardia lamblia Hypothetical protein 0.0044 0.0028 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0091 0.0638
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.1145 0.1591
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0028 0.0652
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0044 0.0028 0.0652
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0028 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0363 0.1648 0.6143
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0363 0.1648 0.9698
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0028 0.1777
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0013 0.0191
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.031 0.5
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0169 0.0992
Leishmania major DNA polymerase eta, putative 0.0068 0.0151 0.4436
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0044 0.0028 0.0166
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0238 0.101 0.1402
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0028 0.1777
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0213 0.1199
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0044 0.0028 0.0199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0169 0.1023
Trypanosoma cruzi trypanothione reductase, putative 0.0104 0.0333 1
Brugia malayi Thioredoxin reductase 0.0104 0.0333 0.2337
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0169 0.0992
Trypanosoma brucei trypanothione reductase 0.0104 0.0333 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0091 0.0638
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0044 0.0028 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0028 0.047
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.0096 0.9835
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0028 0.0079
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.047
Schistosoma mansoni hypothetical protein 0.0373 0.1699 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0104 0.0333 0.1906
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0028 0.1777
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0028 0.0652
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0319 0.1424 0.8368
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0044 0.0028 0.047

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 340 nM Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes. ChEMBL. 9207943
IC50 (functional) = 340 nM Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes. ChEMBL. 9207943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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