Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.2932 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1121 | 0.3788 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1121 | 0.3788 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0071 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1121 | 0.3788 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1121 | 0.3788 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1121 | 0.3788 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2932 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2932 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2932 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2932 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1121 | 0.3788 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2932 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2932 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0032 | 0.0032 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2932 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0071 | 0.0071 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0071 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2932 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0071 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0071 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.