Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0082 | 0.4891 | 0.4891 |
Echinococcus granulosus | hexokinase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.6815 | 0.6815 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.2115 | 0.2115 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3168 | 0.3168 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.2115 | 0.2115 |
Toxoplasma gondii | hexokinase | 0.0167 | 1 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.0086 | 0.5157 | 0.5157 |
Echinococcus granulosus | CREB binding protein | 0.0086 | 0.5157 | 0.5157 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.2115 | 0.2115 |
Brugia malayi | TAZ zinc finger family protein | 0.0086 | 0.5157 | 0.5157 |
Echinococcus multilocularis | hexokinase type 2 | 0.0167 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0167 | 1 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0093 | 0.5581 | 0.5581 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0093 | 0.5581 | 0.5581 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.4891 | 0.4891 |
Echinococcus multilocularis | CREB binding protein | 0.0086 | 0.5157 | 0.5157 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0082 | 0.4891 | 0.4891 |
Leishmania major | hexokinase, putative | 0.0167 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4891 | 0.4891 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0093 | 0.5581 | 0.5581 |
Entamoeba histolytica | hexokinase 2 | 0.0167 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0167 | 1 | 1 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0093 | 0.5596 | 0.5596 |
Loa Loa (eye worm) | hexokinase | 0.0105 | 0.6267 | 0.6267 |
Brugia malayi | Hexokinase family protein | 0.0052 | 0.3082 | 0.3082 |
Treponema pallidum | hexokinase (hxk) | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.2115 | 0.2115 |
Schistosoma mansoni | apoptosis regulator bax | 0.0082 | 0.4891 | 0.4891 |
Brugia malayi | Hexokinase family protein | 0.0105 | 0.6267 | 0.6267 |
Plasmodium vivax | hexokinase, putative | 0.0167 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.0167 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0167 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0167 | 1 | 0.5 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0082 | 0.4891 | 0.4891 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0082 | 0.4891 | 0.4891 |
Trypanosoma brucei | hexokinase, putative | 0.0167 | 1 | 0.5 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0082 | 0.4891 | 0.4891 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.4891 | 0.4891 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0082 | 0.4891 | 0.4891 |
Echinococcus multilocularis | hexokinase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0167 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0167 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0167 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0086 | 0.5157 | 0.5157 |
Brugia malayi | hypothetical protein | 0.0035 | 0.2115 | 0.2115 |
Schistosoma mansoni | hexokinase | 0.0167 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3168 | 0.3168 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.5596 | 0.5596 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.4891 | 0.4891 |
Echinococcus multilocularis | hexokinase | 0.0167 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0167 | 1 | 0.5 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0093 | 0.5581 | 0.5581 |
Loa Loa (eye worm) | CBP-B | 0.0086 | 0.5157 | 0.5157 |
Loa Loa (eye worm) | hexokinase type II | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0093 | 0.5581 | 0.5581 |
Trypanosoma cruzi | hexokinase, putative | 0.0167 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0086 | 0.5157 | 0.5157 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0082 | 0.4891 | 0.4891 |
Brugia malayi | hexokinase type II | 0.0053 | 0.3168 | 0.3168 |
Loa Loa (eye worm) | hexokinase | 0.0052 | 0.3082 | 0.3082 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -7 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.