Detailed information for compound 1039902

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.342 | Formula: C22H13F5N2O3
  • H donors: 2 H acceptors: 3 LogP: 4.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)Cn1c2ccc(cc2c(c1C(=O)O)c1ccc[nH]c1=O)C(F)(F)F
  • InChi: 1S/C22H13F5N2O3/c23-13-5-3-11(16(24)9-13)10-29-17-6-4-12(22(25,26)27)8-15(17)18(19(29)21(31)32)14-2-1-7-28-20(14)30/h1-9H,10H2,(H,28,30)(H,31,32)
  • InChiKey: SLVJPWXSVAXIPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1394 1
Onchocerca volvulus 0.0025 0.0335 0.0614
Schistosoma mansoni DNA polymerase eta 0.0019 0.0205 0.0606
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0161 0.0219
Brugia malayi Carboxylesterase family protein 0.0146 0.2985 0.5633
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0422 0.3032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Schistosoma mansoni neuroligin 3 (S09 family) 0.0025 0.0335 0.0991
Toxoplasma gondii ABC1 family protein 0.0073 0.1394 1
Trypanosoma brucei glucose transporter 2A 0.0011 0.0027 0.0143
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0178 0.0525
Echinococcus multilocularis para nitrobenzyl esterase 0.0025 0.0335 0.0456
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.1645 0.3103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0655 0.1235
Schistosoma mansoni hypothetical protein 0.0017 0.0161 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0035 0.0048
Echinococcus granulosus expressed protein 0.0036 0.0582 0.0792
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0289 0.0546
Echinococcus granulosus bloom syndrome protein 0.0022 0.0289 0.0394
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0335 0.0309
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0186 0.0549
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1805 1
Schistosoma mansoni hypothetical protein 0.0017 0.0161 0.0475
Schistosoma mansoni hypothetical protein 0.0029 0.0422 0.1249
Giardia lamblia PHD finger protein 15 0.0029 0.0422 0.234
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0161 0.0303
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0011 0.0027 0.008
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0025 0.0335 0.0614
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0083
Trichomonas vaginalis set domain proteins, putative 0.024 0.5048 1
Loa Loa (eye worm) carboxylesterase 0.0146 0.2985 0.5633
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1805 0.3406
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0582 0.1098
Schistosoma mansoni hypothetical protein 0.0164 0.3384 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0422 0.1249
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0409 0.2261
Toxoplasma gondii sugar transporter ST3 0.0011 0.0027 0.0194
Loa Loa (eye worm) hypothetical protein 0.0041 0.0688 0.1299
Loa Loa (eye worm) hypothetical protein 0.005 0.0902 0.1702
Echinococcus multilocularis musashi 0.0084 0.1645 0.2238
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0289 0.0523
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0205 0.1002
Echinococcus multilocularis acetylcholinesterase 0.0146 0.2985 0.4063
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0205 0.0279
Schistosoma mansoni rotamase 0.0036 0.0582 0.1721
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1805 1
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0597 0.0812
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Brugia malayi PHD-finger family protein 0.0025 0.0353 0.0667
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1425 0.4212
Loa Loa (eye worm) hypothetical protein 0.0073 0.1394 0.2629
Echinococcus multilocularis solute carrier family 22 0.0011 0.0027 0.0037
Echinococcus multilocularis lamin dm0 0.0084 0.1645 0.2238
Echinococcus granulosus GPCR family 2 0.0017 0.0161 0.0219
Brugia malayi beta-lactamase family protein 0.0073 0.1394 0.2629
Echinococcus granulosus BC026374 protein S09 family 0.0025 0.0335 0.0456
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0205 0.0606
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0205 0.1002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0205 0.0179
Loa Loa (eye worm) hypothetical protein 0.0073 0.1394 0.2629
Loa Loa (eye worm) hypothetical protein 0.0073 0.1394 0.2629
Toxoplasma gondii exonuclease III APE 0.0019 0.0208 0.1496
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0205 0.0832
Brugia malayi major facilitator superfamily protein 0.0011 0.0027 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0161 0.0303
Loa Loa (eye worm) hypothetical protein 0.0029 0.0422 0.0797
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1394 0.4119
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0668 0.0909
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0208 0.0182
Schistosoma mansoni hypothetical protein 0.0017 0.0161 0.0475
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0068 0.0129
Mycobacterium tuberculosis Carboxylesterase LipT 0.0025 0.0335 0.0309
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0409 0.0557
Schistosoma mansoni lamin 0.0084 0.1645 0.486
Schistosoma mansoni kinase 0.0047 0.0817 0.2416
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0839 0.1142
Brugia malayi hypothetical protein 0.0025 0.0335 0.0633
Schistosoma mansoni glucose transport protein 0.0011 0.0027 0.008
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.006 0.0065
Brugia malayi major facilitator superfamily protein 0.0011 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0335 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.06 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1805 0.3542
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0458 0.0624
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0027 0.0051
Echinococcus granulosus dna polymerase kappa 0.0019 0.0205 0.0279
Schistosoma mansoni hypothetical protein 0.0021 0.0258 0.0762
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0208 0.102
Trypanosoma brucei THT1 - hexose transporter, putative 0.0011 0.0027 0.0143
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1394 0.137
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0011 0.0027 0.0037
Trypanosoma brucei polo-like protein kinase 0.0092 0.1805 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0335 0.0633
Loa Loa (eye worm) hypothetical protein 0.0072 0.1377 0.2598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0335 0.0633
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0178 0.0242
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0161 0.0219
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1805 0.3542
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0948 0.1788
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0208 0.0284
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0011 0.0027 0.0639
Plasmodium vivax hexose transporter 0.0011 0.0027 0.0186
Trypanosoma cruzi ISWI complex protein 0.0016 0.0138 0.0627
Brugia malayi hypothetical protein 0.0011 0.0027 0.0051
Brugia malayi Sugar transporter family protein 0.0011 0.0027 0.0051
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Trypanosoma cruzi ISWI complex protein 0.0016 0.0138 0.0627
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1394 0.5
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0409 0.0772
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0025 0.0075
Onchocerca volvulus 0.0084 0.1645 0.3222
Echinococcus granulosus tumor protein p63 0.0345 0.7348 1
Onchocerca volvulus 0.0025 0.0335 0.0614
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0011 0.0027 0.0037
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1805 0.2457
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.006 0.0325
Brugia malayi intermediate filament protein 0.0084 0.1645 0.3103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0458 0.1355
Plasmodium falciparum flap endonuclease 1 0.0028 0.0409 0.9684
Loa Loa (eye worm) hypothetical protein 0.0042 0.0707 0.1334
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0205 0.0279
Echinococcus multilocularis GPCR, family 2 0.0017 0.0161 0.0219
Onchocerca volvulus 0.0073 0.1394 0.2722
Echinococcus granulosus neuroligin 0.0025 0.0335 0.0456
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0146 0.2985 0.8823
Trypanosoma brucei ISWI complex protein 0.0016 0.0138 0.0761
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0178 0.0242
Echinococcus multilocularis neuroligin 0.0025 0.0335 0.0456
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0041 0.0056
Echinococcus multilocularis carboxylesterase 5A 0.0146 0.2985 0.4063
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0208 0.0851
Schistosoma mansoni sugar transporter 0.0011 0.0027 0.008
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0409 0.2149
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0205 0.1131
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0011 0.0027 0.0037
Echinococcus multilocularis zinc finger protein 0.002 0.0234 0.0319
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0335 0.0309
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.06 0.0816
Loa Loa (eye worm) carboxylesterase 0.0025 0.0335 0.0633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0205 0.1002
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Loa Loa (eye worm) hypothetical protein 0.0146 0.2985 0.5633
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0434 0.0591
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0839 0.1142
Schistosoma mansoni sugar transporter 0.0011 0.0027 0.008
Loa Loa (eye worm) hypothetical protein 0.0146 0.2985 0.5633
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0205 0.0387
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.1131 0.1539
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1394 0.2722
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0205 0.1303
Trypanosoma brucei THT1 - hexose transporter, putative 0.0011 0.0027 0.0143
Echinococcus multilocularis dna polymerase eta 0.0019 0.0205 0.0279
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1805 0.2457
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0011 0.0027 0.0037
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1394 0.2629
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0208 0.1155
Brugia malayi Carboxylesterase family protein 0.0025 0.0335 0.0633
Loa Loa (eye worm) hypothetical protein 0.0025 0.0335 0.0633
Echinococcus multilocularis synaptic vesicle 2 protein 0.0011 0.0027 0.0037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1394 0.2629
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1394 0.137
Loa Loa (eye worm) hypothetical protein 0.0083 0.1611 0.3039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0335 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1805 0.3542
Schistosoma mansoni zinc finger protein 0.0016 0.0138 0.0409
Schistosoma mansoni hypothetical protein 0.0016 0.0138 0.0409
Echinococcus granulosus geminin 0.0164 0.3384 0.4605
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1805 1
Echinococcus granulosus solute carrier family 22 0.0011 0.0027 0.0037
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0289 0.0394
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.023 0.5433
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0409 0.2936
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0208 0.4934
Loa Loa (eye worm) major facilitator superfamily transporter 0.0011 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1394 0.137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0161 0.0303
Brugia malayi Pre-SET motif family protein 0.0211 0.441 0.8321
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0597 0.1764
Brugia malayi jmjC domain containing protein 0.0037 0.0597 0.1126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0205 0.1002
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0688 0.0937
Onchocerca volvulus Alhambra homolog 0.0029 0.0422 0.0788
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0205 0.1303
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0458 0.3289
Echinococcus multilocularis solute carrier family 22 0.0011 0.0027 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Trypanosoma brucei unspecified product 0.0019 0.0205 0.1131
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0791 0.1521
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Echinococcus granulosus para nitrobenzyl esterase 0.0025 0.0335 0.0456
Brugia malayi beta-lactamase 0.0073 0.1394 0.2629
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1089 0.2054
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0409 0.2001
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.006 0.0185
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1394 0.2722
Brugia malayi Sugar transporter family protein 0.0011 0.0027 0.0051
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0205 0.0355
Onchocerca volvulus 0.0073 0.1394 0.2722
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0161 0.0219
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1394 0.1897
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0335 0.0991
Loa Loa (eye worm) sugar transporter 0.0011 0.0027 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0948 0.1788
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1394 0.137
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0205 0.0387
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0084 0.1645 0.3103
Echinococcus granulosus intermediate filament protein 0.0084 0.1645 0.2238
Trichomonas vaginalis rotamase, putative 0.0035 0.0564 0.1069
Echinococcus granulosus synaptic vesicle 2 protein 0.0011 0.0027 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.1106
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0422 0.3026
Mycobacterium tuberculosis Conserved protein 0.0073 0.1394 0.137
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2324 0.4384
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0027 0.0051
Echinococcus multilocularis geminin 0.0164 0.3384 0.4605
Loa Loa (eye worm) carboxylesterase 0.0025 0.0335 0.0633
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0597 0.1126
Brugia malayi Carboxylesterase family protein 0.0146 0.2985 0.5633
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Echinococcus granulosus Sugar transporter ERD6 protein 0.0011 0.0027 0.0037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.000000000092643 0.00000000066476
Onchocerca volvulus 0.024 0.5048 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0335 0.0633
Trichomonas vaginalis esterase, putative 0.0073 0.1394 0.2722
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0787 0.1484
Brugia malayi PHD-finger family protein 0.0029 0.0422 0.0797
Schistosoma mansoni lamin 0.0084 0.1645 0.486
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0422 0.0575
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0205 0.0179
Echinococcus granulosus acetylcholinesterase 0.0146 0.2985 0.4063
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0422 0.0575
Echinococcus granulosus dna polymerase eta 0.0019 0.0205 0.0279
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0035 0.0048
Brugia malayi hypothetical protein 0.0011 0.0027 0.0051
Loa Loa (eye worm) major facilitator superfamily transporter 0.0011 0.0027 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0205 0.0387
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1394 0.7686
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1394 0.4119
Brugia malayi beta-lactamase family protein 0.0073 0.1394 0.2629
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0205 0.1131
Brugia malayi Bromodomain containing protein 0.0039 0.0653 0.1231
Toxoplasma gondii sugar transporter ST1 0.0011 0.0027 0.0194
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0582 0.1098
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.03 0.0888
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1394 0.137
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0205 0.0279
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0161 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1805 0.5335
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1805 0.3406
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0948 0.1788
Mycobacterium ulcerans beta-lactamase 0.0073 0.1394 1
Onchocerca volvulus 0.0025 0.0335 0.0614
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Onchocerca volvulus 0.0025 0.0335 0.0614
Loa Loa (eye worm) hypothetical protein 0.0018 0.019 0.0358
Brugia malayi jmjC domain containing protein 0.0094 0.1847 0.3484
Schistosoma mansoni ap endonuclease 0.0019 0.0208 0.0616
Onchocerca volvulus 0.005 0.0902 0.1742
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.1131 0.1539
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0208 0.0361
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0902 0.2665
Schistosoma mansoni zinc finger protein 0.002 0.0234 0.0692
Echinococcus granulosus lamin 0.0084 0.1645 0.2238
Mycobacterium tuberculosis Conserved protein 0.0073 0.1394 0.137
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1394 0.137
Schistosoma mansoni ap endonuclease 0.0019 0.0208 0.0616
Schistosoma mansoni hypothetical protein 0.0036 0.0584 0.1725
Echinococcus multilocularis peregrin 0.0031 0.0475 0.0647
Trypanosoma brucei glucose transporter, putative 0.0011 0.0027 0.0143
Echinococcus granulosus peregrin 0.0031 0.0475 0.0647
Plasmodium falciparum phd finger protein, putative 0.0029 0.0422 1
Brugia malayi AF-10 protein 0.0009 0.0001 0.0002
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0564 0.2887
Brugia malayi Bromodomain containing protein 0.0076 0.1473 0.2778
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0564 0.3018
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.013 0.0924
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0205 0.1002
Loa Loa (eye worm) hypothetical protein 0.0049 0.087 0.1641
Brugia malayi follicle stimulating hormone receptor 0.0251 0.53 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0564 0.3018
Trypanosoma brucei sugar transporter, putative 0.0011 0.0027 0.0143
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0035 0.019
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1394 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Brugia malayi Bromodomain containing protein 0.0031 0.0475 0.0897
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0003
Brugia malayi hypothetical protein 0.0011 0.0027 0.0051
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2324 0.4384
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0035 0.0048
Brugia malayi Pre-SET motif family protein 0.003 0.0458 0.0865
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0329 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0025 0.0335 0.0456
Loa Loa (eye worm) RecQ helicase 0.0022 0.0289 0.0546
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Giardia lamblia Kinase, PLK 0.0092 0.1805 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0564 0.3018
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1394 0.7686
Toxoplasma gondii facilitative glucose transporter GT1 0.0011 0.0027 0.0194
Toxoplasma gondii sugar transporter ST2 0.0011 0.0027 0.0194
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0554 0.0754
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Mycobacterium ulcerans hypothetical protein 0.0073 0.1394 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0025 0.0335 0.0991
Toxoplasma gondii transporter, major facilitator family protein 0.0011 0.0027 0.0194
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0208 0.1328
Schistosoma mansoni intermediate filament proteins 0.0084 0.1645 0.486
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0126 0.0903
Giardia lamblia Sugar-proton symporter 0.0011 0.0027 0.015
Loa Loa (eye worm) hypothetical protein 0.0073 0.1394 0.2629
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0839 0.2481
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0035 0.0254
Echinococcus granulosus solute carrier family 22 0.0011 0.0027 0.0037
Echinococcus multilocularis solute carrier family 22 0.0011 0.0027 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0208 1
Echinococcus multilocularis acetylcholinesterase 0.0146 0.2985 0.4063
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0422 0.0797
Schistosoma mansoni bromodomain containing protein 0.0065 0.1211 0.3578
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1394 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0839 0.1584
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1847 0.2513
Loa Loa (eye worm) sugar transporter 0.0011 0.0027 0.0051
Echinococcus granulosus solute carrier family 22 0.0011 0.0027 0.0037
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0208 0.0393
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0208 0.0361
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0335 0.0991
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0409 0.2149
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0787 0.1484
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0205 0.1131
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Schistosoma mansoni acetylcholinesterase 0.0025 0.0335 0.0991
Mycobacterium ulcerans lipase LipD 0.0073 0.1394 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0205 0.1131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0458 0.1355
Loa Loa (eye worm) hypothetical protein 0.0019 0.0205 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0839 0.2481
Schistosoma mansoni glucose transport protein 0.0011 0.0027 0.008
Echinococcus granulosus acetylcholinesterase 0.0146 0.2985 0.4063
Brugia malayi Carboxylesterase family protein 0.0025 0.0335 0.0633
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0208 0.0284
Giardia lamblia DINP protein human, muc B family 0.0019 0.0205 0.1136
Schistosoma mansoni gliotactin 0.0025 0.0335 0.0991
Trichomonas vaginalis spcc417.12 protein, putative 0.0025 0.0335 0.0614
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0409 0.293
Echinococcus multilocularis tumor protein p63 0.0345 0.7348 1
Leishmania major hypothetical protein, conserved 0.0073 0.1394 0.7686
Trypanosoma brucei unspecified product 0.0013 0.0078 0.0428
Trypanosoma brucei THT1 - hexose transporter, putative 0.0011 0.0027 0.0143
Loa Loa (eye worm) acetylcholinesterase 1 0.0146 0.2985 0.5633
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.441 0.8321
Plasmodium vivax sugar transporter, putative 0.0011 0.0027 0.0186
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0001 0.0008
Schistosoma mansoni glucose transporter 0.0011 0.0027 0.008
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0258 0.0486
Loa Loa (eye worm) intermediate filament protein 0.0084 0.1645 0.3103
Schistosoma mansoni sugar transporter 0.0011 0.0027 0.008
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1805 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0655 0.1235
Loa Loa (eye worm) hypothetical protein 0.0036 0.0584 0.1101
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0208 0.0393
Leishmania major DNA polymerase eta, putative 0.0019 0.0205 0.1002
Brugia malayi Flap endonuclease-1 0.0028 0.0409 0.0772
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0035 0.0466
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1394 0.2722
Echinococcus granulosus carboxylesterase 5A 0.0146 0.2985 0.4063
Onchocerca volvulus 0.003 0.0458 0.0859
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0791 0.1521
Echinococcus granulosus jumonji domain containing protein 0.004 0.0668 0.0909
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0001 0.0008
Trypanosoma brucei unspecified product 0.0013 0.0078 0.0428
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0335 0.0991
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0078 0.0428
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0011 0.0027 0.0143
Onchocerca volvulus 0.0073 0.1394 0.2722
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0208 0.102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Schistosoma mansoni hypothetical protein 0.0011 0.0027 0.008
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0409 0.0761
Echinococcus multilocularis expressed protein 0.0036 0.0582 0.0792
Brugia malayi MH2 domain containing protein 0.0115 0.2324 0.4384
Echinococcus granulosus zinc finger protein 0.002 0.0234 0.0319
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0161 0.0303
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0191 0.0361
Trichomonas vaginalis rotamase, putative 0.0036 0.0582 0.1106
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.03 0.0409
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0178 0.0525
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1394 0.2722
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1805 0.3542
Echinococcus granulosus flap endonuclease 1 0.0028 0.0409 0.0557
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0011 0.0027 0.0037
Onchocerca volvulus 0.0025 0.0335 0.0614
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.1645 0.3103
Schistosoma mansoni hypothetical protein 0.0017 0.0161 0.0475
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0041 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0597 0.1764
Loa Loa (eye worm) beta-lactamase 0.0073 0.1394 0.2629
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0208 0.5
Brugia malayi Carboxylesterase family protein 0.0025 0.0335 0.0633
Plasmodium vivax SET domain protein, putative 0.003 0.0458 0.3283
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1394 0.1897
Schistosoma mansoni hypothetical protein 0.0164 0.3384 1
Giardia lamblia Hexose transporter 0.0011 0.0027 0.015
Echinococcus multilocularis lamin 0.0084 0.1645 0.2238
Echinococcus granulosus solute carrier family 22 0.0011 0.0027 0.0037
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0409 0.2266
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1394 0.137
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0289 0.0523
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0078 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1805 0.3542
Echinococcus granulosus lamin dm0 0.0084 0.1645 0.2238
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.03 0.0409
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1394 0.7719
Mycobacterium ulcerans carboxylesterase, LipT 0.0025 0.0335 0.2257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.53 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0335 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0205 0.1131
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.006 0.0185
Mycobacterium leprae Probable lipase LipE 0.0073 0.1394 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0011 0.0027 0.0037
Trypanosoma brucei glucose transporter 1E 0.0011 0.0027 0.0143
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0011 0.0027 0.0037
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0208 0.1489
Schistosoma mansoni glucose transport protein 0.0011 0.0027 0.008
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1805 0.3542
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0208 0.1149
Leishmania major hypothetical protein, conserved 0.0016 0.0138 0.0627
Leishmania major DNA polymerase kappa, putative 0.0019 0.0205 0.1002
Loa Loa (eye worm) hypothetical protein 0.0053 0.0948 0.1788
Plasmodium falciparum hexose transporter 0.0011 0.0027 0.0639
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1847 0.2513
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Brugia malayi Cytochrome P450 family protein 0.0024 0.0329 0.062
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0688 0.0937
Echinococcus multilocularis solute carrier family 22 0.0011 0.0027 0.0037
Mycobacterium tuberculosis Conserved protein 0.0073 0.1394 0.137
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0564 0.3118
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0205 0.0606
Onchocerca volvulus 0.0084 0.1645 0.3222
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0051
Brugia malayi Sugar transporter family protein 0.0011 0.0027 0.0051
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0564 0.4045
Schistosoma mansoni sugar transporter 0.0011 0.0027 0.008
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0205 0.0355
Brugia malayi PHD-finger family protein 0.0011 0.0044 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0584 0.1101
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0025 0.0335 0.0456
Loa Loa (eye worm) hypothetical protein 0.0073 0.1394 0.2629
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0208 0.102
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1805 0.3542
Echinococcus multilocularis BC026374 protein (S09 family) 0.0025 0.0335 0.0456
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0011 0.0027 0.0037
Schistosoma mansoni flap endonuclease-1 0.0025 0.035 0.1035
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1805 0.3542
Loa Loa (eye worm) hypothetical protein 0.0043 0.075 0.1414
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0078 0.0428
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0422 0.3032
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0027 0.0051
Brugia malayi Carboxylesterase family protein 0.0025 0.0335 0.0633
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0009 0.0001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0654 0.1234
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0011 0.0027 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0205 0.1002
Loa Loa (eye worm) hypothetical protein 0.0073 0.1394 0.2629
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1394 0.2722

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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