Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.1272 | 0.1272 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0084 | 0.0524 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0037 | 0.0243 | 0.1023 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0611 | 0.6767 | 0.6767 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0219 | 0.0691 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0287 | 0.091 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0016 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.2158 | 0.2158 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0084 | 0.0524 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0219 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0018 | 0.0018 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0156 | 0.0266 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0343 | 0.283 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0084 | 0.0524 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.1413 | 0.1412 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0219 | 0.0874 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.1012 | 0.4282 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0155 | 0.0155 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0343 | 0.0343 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0343 | 0.1088 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0084 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0243 | 0.2002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0132 | 0.0416 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.1145 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0355 | 0.3859 | 0.3858 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0037 | 0.0243 | 0.0243 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0132 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.3859 | 0.3859 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0149 | 0.0149 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0084 | 0.0524 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.006 | 0.0503 | 0.2125 |
Loa Loa (eye worm) | carboxylesterase | 0.006 | 0.0503 | 0.0503 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.1012 | 0.4282 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0018 | 0.0066 |
Schistosoma mansoni | acetylcholinesterase | 0.006 | 0.0503 | 0.0865 |
Onchocerca volvulus | 0.006 | 0.0503 | 0.1749 | |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0018 | 0.0099 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0287 | 0.091 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.1413 | 0.1412 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0219 | 0.0219 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.0503 | 0.0503 |
Echinococcus granulosus | muscleblind protein | 0.0896 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.0219 | 0.0562 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0219 | 0.0219 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0243 | 0.077 |
Echinococcus multilocularis | smad | 0.0016 | 0.0007 | 0.0005 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.006 | 0.0503 | 0.2022 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0084 | 0.0524 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0105 | 0.1012 | 0.8747 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1219 | 0.1219 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.1413 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.006 | 0.0503 | 0.1749 | |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0007 | 0.0009 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0122 | 0.1208 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.1145 | 0.4845 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0007 | 0.0007 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0243 | 0.0417 |
Brugia malayi | Smad1 | 0.0016 | 0.0007 | 0.0007 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0343 | 0.283 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0037 | 0.0243 | 0.1542 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0155 | 0.0153 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.006 | 0.0503 | 0.0501 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.2361 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0016 | 0.0007 | 0.0007 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0037 | 0.0243 | 0.077 |
Brugia malayi | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0219 | 0.1384 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0007 | 0.0007 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0016 | 0.0007 | 0.0005 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0343 | 0.0341 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0241 | 0.2556 | 0.2556 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0018 | 0.0129 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0219 | 0.0918 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0219 | 0.1384 |
Schistosoma mansoni | hypothetical protein | 0.0526 | 0.5796 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0156 | 0.0266 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0611 | 0.6767 | 0.6767 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0372 | 0.0372 |
Echinococcus multilocularis | acetylcholinesterase | 0.0355 | 0.3859 | 0.3858 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.006 | 0.0503 | 0.0501 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0155 | 0.0153 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0122 | 0.1208 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0132 | 0.0132 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0007 | 0.002 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0343 | 0.0343 |
Schistosoma mansoni | hypothetical protein | 0.0526 | 0.5796 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0155 | 0.0153 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0122 | 0.1208 | 1 |
Onchocerca volvulus | 0.006 | 0.0503 | 0.1749 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.1145 | 0.4845 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0132 | 0.1081 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | Smad1 | 0.0016 | 0.0007 | 0.0007 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0084 | 0.0262 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.1568 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0355 | 0.3859 | 0.3859 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0156 | 0.0156 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0156 | 0.1279 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0287 | 0.091 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0144 | 0.0142 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0219 | 0.0918 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.1145 | 0.4845 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0037 | 0.0243 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0355 | 0.3859 | 0.3859 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0343 | 0.0343 |
Brugia malayi | MH2 domain containing protein | 0.0241 | 0.2556 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1219 | 0.1219 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0219 | 0.1269 |
Onchocerca volvulus | 0.0029 | 0.0155 | 0.0296 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.1413 | 0.2436 |
Echinococcus multilocularis | neuroligin | 0.006 | 0.0503 | 0.0501 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.1272 | 0.1272 |
Echinococcus multilocularis | muscleblind protein | 0.0896 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.1012 | 0.4282 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0155 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0292 | 0.3137 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.1012 | 0.4282 |
Echinococcus multilocularis | geminin | 0.0526 | 0.5796 | 0.5795 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0355 | 0.3859 | 0.6656 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0084 | 0.0084 |
Echinococcus granulosus | geminin | 0.0526 | 0.5796 | 0.5795 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0018 | 0.0129 |
Loa Loa (eye worm) | carboxylesterase | 0.0355 | 0.3859 | 0.3859 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.1219 | 0.4736 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.006 | 0.0503 | 0.2125 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.1413 | 0.1413 |
Schistosoma mansoni | lamin | 0.0029 | 0.0155 | 0.0264 |
Schistosoma mansoni | Smad4 | 0.0016 | 0.0007 | 0.0009 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0219 | 0.0691 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.1272 | 0.2192 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0022 | 0.0022 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.1012 | 0.4282 |
Toxoplasma gondii | cathepsin CPC1 | 0.0122 | 0.1208 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.1413 | 0.1412 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0156 | 0.0154 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.006 | 0.0503 | 0.3202 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3137 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0219 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0018 | 0.0018 |
Echinococcus granulosus | Smad4 | 0.0016 | 0.0007 | 0.0005 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.3859 | 0.3859 |
Schistosoma mansoni | lamin | 0.0029 | 0.0155 | 0.0264 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0219 | 0.1269 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0219 | 0.0874 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.1413 | 0.2436 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0037 | 0.0243 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0243 | 0.0974 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0122 | 0.1208 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0219 | 0.0217 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0037 | 0.0243 | 0.2002 |
Echinococcus granulosus | neuroligin | 0.006 | 0.0503 | 0.0501 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0243 | 0.0417 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0219 | 0.0219 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0219 | 0.0918 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0219 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0018 | 0.0018 |
Brugia malayi | RNA binding protein | 0.0128 | 0.1272 | 0.1272 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0007 | 0.002 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0016 | 0.0007 | 0.0005 |
Schistosoma mansoni | gliotactin | 0.006 | 0.0503 | 0.0865 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0219 | 0.0918 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0155 | 0.0155 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0219 | 0.0219 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0018 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0016 | 0.0007 | 0.0009 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0007 | 0.002 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0241 | 0.2556 | 0.2556 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.006 | 0.0503 | 0.0865 |
Echinococcus granulosus | BC026374 protein S09 family | 0.006 | 0.0503 | 0.0501 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.2158 | 0.2158 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0343 | 0.283 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0372 | 0.0372 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.1413 | 0.1412 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0156 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0122 | 0.1208 | 0.4864 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0219 | 0.0918 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0219 | 0.0219 |
Brugia malayi | hypothetical protein | 0.0123 | 0.1219 | 0.1219 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.1219 | 0.4736 |
Onchocerca volvulus | 0.006 | 0.0503 | 0.1749 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0219 | 0.0374 |
Echinococcus multilocularis | Smad4 | 0.0016 | 0.0007 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0156 | 0.0266 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0219 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0343 | 0.283 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0219 | 0.0874 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.1272 | 0.2192 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.006 | 0.0503 | 0.0865 |
Onchocerca volvulus | 0.0029 | 0.0155 | 0.0296 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0219 | 0.0918 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0084 | 0.0348 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0219 | 0.1384 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0007 | 0.002 |
Onchocerca volvulus | 0.0035 | 0.0219 | 0.0562 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.006 | 0.0503 | 0.0865 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.1413 | 0.2436 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0018 | 0.0018 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 0.3137 | 1 |
Schistosoma mansoni | smad | 0.0016 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0372 | 0.0372 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0084 | 0.0262 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0219 | 0.0219 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.1272 | 0.2192 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.006 | 0.0503 | 0.0501 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0356 | 0.2935 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0219 | 0.1384 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.1012 | 0.4282 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0372 | 0.0372 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0156 | 0.0266 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0084 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0219 | 0.0219 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0219 | 0.1384 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0355 | 0.3859 | 0.3858 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0219 | 0.0918 |
Onchocerca volvulus | 0.006 | 0.0503 | 0.1749 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0355 | 0.3859 | 0.3859 |
Onchocerca volvulus | 0.0029 | 0.0156 | 0.0301 | |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.139 | 0.4429 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.1272 | 0.127 |
Echinococcus multilocularis | acetylcholinesterase | 0.0355 | 0.3859 | 0.3858 |
Echinococcus granulosus | smad | 0.0016 | 0.0007 | 0.0005 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.0343 | 0.1446 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0007 | 0.0009 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0219 | 0.1797 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.2481 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0156 | 0.0154 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0343 | 0.1088 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0197 | 0.0197 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.139 | 0.4429 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0155 | 0.0155 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0037 | 0.0243 | 0.0241 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0197 | 0.0337 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0896 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0788 | 0.8776 | 0.8775 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0219 | 0.0691 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.006 | 0.0503 | 0.2125 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.006 | 0.0503 | 0.2022 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0084 | 0.0524 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.006 | 0.0503 | 0.0501 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0132 | 0.1081 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.1272 | 0.1272 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0016 | 0.0007 | 0.0005 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0219 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0155 | 0.0155 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0132 | 0.0416 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0122 | 0.1208 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0155 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0018 | 0.0018 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0.0243 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0.0243 | 0.2002 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0219 | 0.0217 |
Loa Loa (eye worm) | carboxylesterase | 0.006 | 0.0503 | 0.0503 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0084 | 0.0348 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.006 | 0.0503 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0156 | 0.0156 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.1272 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0503 | 0.0503 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0343 | 0.1088 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0132 | 0.1081 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0287 | 0.091 |
Echinococcus granulosus | carboxylesterase 5A | 0.0355 | 0.3859 | 0.3858 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0084 | 0.0084 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0219 | 0.0374 |
Onchocerca volvulus | 0.0035 | 0.0219 | 0.0562 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0219 | 0.0219 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0219 | 0.1797 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0007 | 0.0009 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0219 | 0.0918 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0037 | 0.0243 | 0.0243 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0037 | 0.0243 | 0.077 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.1272 | 0.1272 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0016 | 0.0007 | 0.0005 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0132 | 0.1081 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.1272 | 0.1272 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0084 | 0.0524 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.1568 | 0.6637 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0084 | 0.0084 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.0234 | 0.2481 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.1272 | 0.2192 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0343 | 0.0341 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.0503 | 0.0503 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.006 | 0.0503 | 0.0501 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0343 | 0.0343 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0197 | 0.0197 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3137 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0037 | 0.0243 | 0.0241 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0156 | 0.0154 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0243 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0219 | 0.0219 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0122 | 0.1208 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0122 | 0.1208 | 0.2081 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0219 | 0.0918 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.1272 | 0.2192 |
Echinococcus granulosus | acetylcholinesterase | 0.0355 | 0.3859 | 0.3858 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.139 | 0.4429 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0243 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0219 | 0.0219 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0155 | 0.0153 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0132 | 0.0416 |
Echinococcus granulosus | lamin | 0.0029 | 0.0155 | 0.0153 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0243 | 0.077 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0343 | 0.283 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.006 | 0.0503 | 0.0865 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0389 | 0.1235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC90 (functional) | = 8 ng/ml | Antimalarial activity against chloroquine-sensitive and mefloquine-resistant Plasmodium falciparum D6 by SYBR Green I-based fluorescence assay | ChEMBL. | 21854078 |
IC90 (functional) | = 11 ng/ml | Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation by liquid scintillation spectrometry | ChEMBL. | 21854078 |
IC90 (functional) | = 39 ng/ml | Antimalarial activity against chloroquine-sensitive and mefloquine-resistant Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation by liquid scintillation spectrometry | ChEMBL. | 21854078 |
IC90 (functional) | = 55 ng/ml | Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM91C235 by SYBR Green I-based fluorescence assay | ChEMBL. | 21854078 |
IC90 (functional) | = 71 ng/ml | Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM90C2A assessed as inhibition of [3H]hypoxanthine incorporation by liquid scintillation spectrometry | ChEMBL. | 21854078 |
IC90 (functional) | = 79 ng/ml | Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation by liquid scintillation spectrometry | ChEMBL. | 21854078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.