Detailed information for compound 1040262

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.51 | Formula: C23H21N5O2S
  • H donors: 1 H acceptors: 1 LogP: 6.95 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: [N-]=[N+]=NCCCOc1ccc(cc1)CNc1nc2c(s1)cc(cc2)Oc1ccccc1
  • InChi: 1S/C23H21N5O2S/c24-28-26-13-4-14-29-18-9-7-17(8-10-18)16-25-23-27-21-12-11-20(15-22(21)31-23)30-19-5-2-1-3-6-19/h1-3,5-12,15H,4,13-14,16H2,(H,25,27)
  • InChiKey: AGOMXYARYODWGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0313 0.6302 0.7511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.2654 0.3163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0312 0.06
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0902 0.1084
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0902 0.1084
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0051 0.0106
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0301 0.0574
Echinococcus granulosus dna polymerase eta 0.0021 0.01 0.0063
Echinococcus multilocularis importin subunit beta 1 0.003 0.0301 0.0318
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0281 0.0529
Loa Loa (eye worm) hypothetical protein 0.0037 0.045 0.0428
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0131 0.0102
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.01 0.0063
Plasmodium falciparum importin beta, putative 0.003 0.0301 0.0675
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.01 0.012
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.01 0.0113
Plasmodium falciparum basic transcription factor 3b, putative 0.0223 0.4397 1
Echinococcus granulosus zinc finger protein 0.0128 0.2387 0.2977
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0751 0.0895
Brugia malayi beta-lactamase family protein 0.0037 0.045 0.045
Brugia malayi hypothetical protein 0.0091 0.1596 0.1596
Leishmania major importin beta-1 subunit, putative 0.0025 0.0179 0.0295
Schistosoma mansoni eyes absent homolog 0.0091 0.1596 0.1902
Toxoplasma gondii histone lysine methyltransferase SET1 0.008 0.1361 0.3014
Loa Loa (eye worm) hypothetical protein 0.0091 0.1596 0.1658
Trichomonas vaginalis set domain proteins, putative 0.0239 0.4739 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.045 0.0428
Entamoeba histolytica cysteine protease, putative 0.0019 0.0051 0.0106
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0751 0.0891
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0131 0.1696
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.045 0.0757
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0179 0.0273
Brugia malayi PHD-finger family protein 0.0029 0.0281 0.0281
Onchocerca volvulus 0.0019 0.0051 0.0108
Echinococcus granulosus dna polymerase kappa 0.0021 0.01 0.0063
Entamoeba histolytica hypothetical protein 0.0223 0.4397 1
Leishmania major cathepsin L-like protease 0.0071 0.1157 0.2544
Leishmania major hypothetical protein, conserved 0.0099 0.1759 0.393
Trypanosoma brucei ISWI complex protein 0.0099 0.1759 0.3861
Loa Loa (eye worm) hypothetical protein 0.016 0.3064 0.3232
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.045 0.0757
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.01 0.0063
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.111 0.1137
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.3965 0.4987
Schistosoma mansoni cpg binding protein 0.0048 0.0676 0.0806
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.045 0.085
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0131 0.0102
Plasmodium vivax vivapain-2 0.0019 0.0051 0.0067
Trypanosoma cruzi transcription factor btf3, putative 0.0223 0.4397 1
Schistosoma mansoni hypothetical protein 0.0133 0.2492 0.297
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.045 0.0917
Onchocerca volvulus 0.0034 0.0373 0.0787
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0312 0.0372
Schistosoma mansoni myst-related protein 0.0016 0.0004 0.0005
Onchocerca volvulus 0.0019 0.0051 0.0108
Onchocerca volvulus 0.0019 0.0051 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0068 0.111 0.1323
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0232 0.4593 0.5788
Echinococcus granulosus peregrin 0.0045 0.0606 0.0708
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0268
Mycobacterium ulcerans hypothetical protein 0.0037 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0281 0.0247
Loa Loa (eye worm) bromodomain containing protein 0.0114 0.2084 0.2181
Leishmania major hypothetical protein, conserved 0.0037 0.045 0.0917
Schistosoma mansoni jumonji/arid domain-containing protein 0.005 0.0716 0.0853
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0162 0.0141
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0051 0.0106
Brugia malayi mbt repeat family protein 0.0051 0.0751 0.0751
Schistosoma mansoni DNA polymerase eta 0.0021 0.01 0.012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0312 0.0332
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.01 0.0218
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0141 0.2654 0.3317
Brugia malayi Cathepsin L-like precursor 0.0019 0.0051 0.0051
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0902 0.1075
Loa Loa (eye worm) hypothetical protein 0.003 0.0286 0.0252
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.01 0.01
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.023 0.0301
Entamoeba histolytica hypothetical protein 0.0025 0.0179 0.0398
Loa Loa (eye worm) hypothetical protein 0.0457 0.9372 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.01 0.0113
Schistosoma mansoni jumonji/arid domain-containing protein 0.005 0.0716 0.0853
Plasmodium falciparum phd finger protein, putative 0.0029 0.0281 0.063
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.045 0.0508
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0751 0.1584
Leishmania major DNA polymerase kappa, putative 0.0021 0.01 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.045 0.0536
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0051 0.0108
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.4717 1
Brugia malayi hypothetical protein 0.0017 0.0027 0.0027
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0131 0.0086
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0131 0.0184
Plasmodium vivax basic transcription factor 3b, putative 0.0223 0.4397 1
Brugia malayi Bromodomain containing protein 0.0045 0.0606 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Brugia malayi Pre-SET motif family protein 0.0031 0.0312 0.0312
Brugia malayi beta-lactamase 0.0037 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0027 0.023 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0068 0.111 0.1323
Loa Loa (eye worm) beta-lactamase 0.0037 0.045 0.0428
Trichomonas vaginalis ran, putative 0.0022 0.0131 0.017
Mycobacterium ulcerans beta-lactamase 0.0037 0.045 1
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1157 0.2544
Echinococcus multilocularis methyl CpG binding domain protein 2 0.011 0.2 0.2484
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0366 0.0366
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0751 0.0891
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0131 0.0184
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1157 0.2544
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.4397 0.927
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.023 0.0513
Trypanosoma cruzi ISWI complex protein 0.0099 0.1759 0.393
Schistosoma mansoni jumonji domain containing protein 0.0076 0.128 0.1526
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0666 0.0784
Loa Loa (eye worm) hypothetical protein 0.0278 0.5556 0.5907
Brugia malayi hypothetical protein 0.0027 0.023 0.023
Schistosoma mansoni tar DNA-binding protein 0.0068 0.111 0.1323
Echinococcus granulosus fetal alzheimer antigen falz 0.0148 0.2795 0.3496
Loa Loa (eye worm) hypothetical protein 0.005 0.0727 0.0725
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.01 0.0113
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0179 0.0295
Brugia malayi CXXC zinc finger family protein 0.0034 0.0373 0.0373
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.01 0.0053
Brugia malayi jmjC domain containing protein 0.0096 0.17 0.17
Loa Loa (eye worm) hypothetical protein 0.0037 0.045 0.0428
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.17 0.2101
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.4397 0.927
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.045 0.0917
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0051 0.0106
Brugia malayi beta-NAC-like protein 0.0223 0.4397 0.4397
Loa Loa (eye worm) hypothetical protein 0.0091 0.1596 0.1658
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.045 0.085
Schistosoma mansoni hypothetical protein 0.0348 0.706 0.8415
Brugia malayi Cathepsin L-like precursor 0.0019 0.0051 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0666 0.0666
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.01 0.01
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0131 0.0249
Onchocerca volvulus 0.016 0.3064 0.6465
Echinococcus granulosus importin subunit beta 1 0.003 0.0301 0.0318
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1157 0.2544
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0525 0.0604
Leishmania major GTP-binding protein, putative 0.0022 0.0131 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0312 0.0372
Loa Loa (eye worm) PHD-finger family protein 0.0133 0.2492 0.2619
Loa Loa (eye worm) hypothetical protein 0.0248 0.4928 0.5232
Entamoeba histolytica transcription factor BTF3, putative 0.0223 0.4397 1
Brugia malayi Importin beta-1 subunit 0.003 0.0301 0.0301
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0131 0.0071
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0051 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.1198 0.1428
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.045 0.0428
Toxoplasma gondii ABC1 family protein 0.0037 0.045 0.0917
Echinococcus granulosus histone lysine methyltransferase setb 0.0141 0.2654 0.3317
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0122
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0273 0.0282
Leishmania major DNA polymerase eta, putative 0.0021 0.01 0.0113
Schistosoma mansoni methyl-cpg binding protein mbd 0.011 0.2 0.2384
Schistosoma mansoni tar DNA-binding protein 0.0068 0.111 0.1323
Leishmania major basic transcription factor 3a, putative 0.0223 0.4397 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0051 0.0106
Mycobacterium tuberculosis Conserved protein 0.0037 0.045 0.0757
Echinococcus multilocularis geminin 0.0348 0.706 0.8932
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Schistosoma mansoni importin beta-1 0.003 0.0301 0.0358
Onchocerca volvulus Alhambra homolog 0.0029 0.0281 0.0593
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.023 0.0513
Entamoeba histolytica Ran family GTPase 0.0022 0.0131 0.0288
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0281 0.0293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0666 0.0784
Schistosoma mansoni myst-related protein 0.0016 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0348 0.706 0.8415
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0281 0.0293
Onchocerca volvulus 0.0019 0.0051 0.0108
Loa Loa (eye worm) hypothetical protein 0.005 0.0724 0.0722
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.045 0.0508
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.023 0.0411
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.01 0.0113
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0902 0.0902
Echinococcus granulosus transcription factor btf3 0.0223 0.4397 0.5538
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.045 0.0757
Echinococcus granulosus lysine specific demethylase 5A 0.005 0.0716 0.0847
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.3965 0.4987
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0131 0.0288
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0301 0.0467
Brugia malayi Cathepsin L-like precursor 0.0019 0.0051 0.0051
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0051 0.0108
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0301 0.0467
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.01 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Brugia malayi hypothetical protein 0.016 0.3064 0.3064
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0179 0.0273
Echinococcus granulosus geminin 0.0348 0.706 0.8932
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.045 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.1026 0.2244
Mycobacterium leprae Probable lipase LipE 0.0037 0.045 0.5
Mycobacterium tuberculosis Conserved protein 0.0037 0.045 0.0757
Leishmania major cathepsin L-like protease 0.0071 0.1157 0.2544
Toxoplasma gondii NAC domain-containing protein 0.0223 0.4397 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0666 0.0794
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.045 0.0757
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0131 0.0184
Giardia lamblia PHD finger protein 15 0.0029 0.0281 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.01 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0666 0.0794
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.023 0.0411
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.045 0.045
Plasmodium vivax importin-beta 2, putative 0.003 0.0301 0.0637
Loa Loa (eye worm) RNA binding protein 0.0068 0.111 0.1137
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0945 0.0959
Echinococcus multilocularis zinc finger protein 0.0128 0.2387 0.2977
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0666 0.066
Schistosoma mansoni ran 0.0022 0.0131 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0053
Echinococcus multilocularis cpg binding protein 0.0048 0.0676 0.0796
Onchocerca volvulus 0.0019 0.0051 0.0108
Schistosoma mansoni bromodomain containing protein 0.003 0.0286 0.0341
Echinococcus multilocularis snurportin 1 0.0323 0.6522 0.8246
Echinococcus multilocularis dna polymerase kappa 0.0021 0.01 0.0063
Schistosoma mansoni hypothetical protein 0.0029 0.0281 0.0335
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0412 0.046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0373 0.0345
Schistosoma mansoni hypothetical protein 0.0099 0.1759 0.2097
Onchocerca volvulus 0.0037 0.045 0.0949
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.045 0.085
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0051 0.0061
Brugia malayi Bromodomain containing protein 0.0248 0.4918 0.4918
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.111 0.111
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0751 0.0751
Brugia malayi beta-lactamase family protein 0.0037 0.045 0.045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0666 0.0784
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.045 0.0757
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.6522 0.6943
Echinococcus multilocularis transcription factor btf3 0.0223 0.4397 0.5538
Echinococcus granulosus cpg binding protein 0.0048 0.0676 0.0796
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.045 0.0757
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.045 0.0813
Mycobacterium tuberculosis Conserved protein 0.0037 0.045 0.0757
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0724 0.0724
Onchocerca volvulus 0.0037 0.045 0.0949
Plasmodium vivax SET domain protein, putative 0.0031 0.0312 0.0662
Plasmodium vivax hypothetical protein, conserved 0.0037 0.045 0.0978
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0751 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Schistosoma mansoni bromodomain containing protein 0.0411 0.839 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.111 0.135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0232 0.4593 0.5788
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0179 0.0273
Mycobacterium ulcerans lipase LipD 0.0037 0.045 1
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0751 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.045 0.0757
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0388 0.7899 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0902 0.0913
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1157 0.2544
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.045 1
Schistosoma mansoni zinc finger protein 0.0128 0.2387 0.2845
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.01 0.0113
Brugia malayi RNA binding protein 0.0068 0.111 0.111
Brugia malayi Cathepsin L-like precursor 0.0019 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0323 0.6522 0.7773
Loa Loa (eye worm) hypothetical protein 0.0263 0.5253 0.5581
Leishmania major hypothetical protein, conserved 0.0027 0.023 0.0411
Brugia malayi Cathepsin L-like precursor 0.0019 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Echinococcus granulosus methyl CpG binding domain protein 2 0.011 0.2 0.2484
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0063 0.0075
Onchocerca volvulus 0.0051 0.0751 0.1584
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.4397 0.927
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.2654 0.3163
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0051 0.0061
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0902 0.1084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0148 0.2795 0.3496
Brugia malayi Pre-SET motif family protein 0.021 0.4124 0.4124
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0051 0.0106
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0836 0.1805
Echinococcus multilocularis tar DNA binding protein 0.0068 0.111 0.135
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.023 0.0411
Plasmodium vivax vivapain-2 0.0019 0.0051 0.0067
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0162 0.0141
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0281 0.0335
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0131 0.0131
Schistosoma mansoni ran 0.0022 0.0131 0.0156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0724 0.0724
Onchocerca volvulus 0.0037 0.045 0.0949
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.01 0.0105
Schistosoma mansoni transcription factor btf3 0.0223 0.4397 0.524
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.01 0.012
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0751 0.0895
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0388 0.7899 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.17 0.2101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0666 0.0794
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.045 0.085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0666 0.0784
Loa Loa (eye worm) hypothetical protein 0.0037 0.045 0.0428
Onchocerca volvulus 0.0031 0.0312 0.0658
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0148 0.2795 0.3331
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.045 0.0536
Echinococcus multilocularis peregrin 0.0045 0.0606 0.0708
Brugia malayi PHD-finger family protein 0.0024 0.0165 0.0165
Trypanosoma cruzi ISWI complex protein 0.0099 0.1759 0.393
Loa Loa (eye worm) hypothetical protein 0.0051 0.0751 0.0751
Trypanosoma brucei transcription factor BTF3, putative 0.0223 0.4397 1
Schistosoma mansoni cpg binding protein 0.0048 0.0676 0.0806
Loa Loa (eye worm) hypothetical protein 0.0037 0.045 0.0428
Echinococcus granulosus snurportin 1 0.0323 0.6522 0.8246
Onchocerca volvulus 0.0019 0.0051 0.0108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0724 0.0722
Echinococcus multilocularis dna polymerase eta 0.0021 0.01 0.0063
Schistosoma mansoni methyl-cpg binding protein mbd 0.011 0.2 0.2384
Loa Loa (eye worm) hypothetical protein 0.0037 0.045 0.0428
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0902 0.1084
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0525 0.0604
Brugia malayi jmjC domain containing protein 0.005 0.0716 0.0716
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.023 0.0474
Onchocerca volvulus 0.0239 0.4739 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.111 0.1323
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0716 0.0713
Brugia malayi RNA, U transporter 1 0.0086 0.1486 0.1486
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0281 0.0529
Trypanosoma cruzi transcription factor btf3, putative 0.0223 0.4397 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0281 0.0247
Loa Loa (eye worm) MBCTL1 0.0059 0.0902 0.0913
Mycobacterium leprae conserved hypothetical protein 0.0037 0.045 0.5
Schistosoma mansoni zinc finger protein 0.0099 0.1759 0.2097
Loa Loa (eye worm) ICD-1 protein 0.0223 0.4397 0.4663
Loa Loa (eye worm) hypothetical protein 0.0141 0.2654 0.2793
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0751 0.0895
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.4124 0.437
Leishmania major cathepsin L-like protease 0.0071 0.1157 0.2544
Loa Loa (eye worm) hypothetical protein 0.0034 0.0387 0.036
Brugia malayi Cathepsin L-like precursor 0.0019 0.0051 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0387 0.0387
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.045 0.085
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0281 0.0592
Trichomonas vaginalis esterase, putative 0.0037 0.045 0.085
Brugia malayi PHD-finger family protein 0.0163 0.312 0.312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1157 0.2458
Schistosoma mansoni cpg binding protein 0.0034 0.0373 0.0444
Schistosoma mansoni hypothetical protein 0.0034 0.0387 0.0461
Loa Loa (eye worm) TAR-binding protein 0.0068 0.111 0.1137
Brugia malayi mbt repeat family protein 0.0051 0.0751 0.0751
Onchocerca volvulus 0.0019 0.0051 0.0108
Brugia malayi TAR-binding protein 0.0068 0.111 0.111

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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