TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.866 | Formula: C19H24ClN3O2
H donors: 2 H acceptors: 3 LogP: 3.91 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N#CCNC(=O)[C@@H](NC(=O)C1CCCCCC1)Cc1cccc(c1)Cl
InChi: 1S/C19H24ClN3O2/c20-16-9-5-6-14(12-16)13-17(19(25)22-11-10-21)23-18(24)15-7-3-1-2-4-8-15/h5-6,9,12,15,17H,1-4,7-8,11,13H2,(H,22,25)(H,23,24)/t17-/m0/s1
InChiKey: LOYNXKUDTAAJJS-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin V	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	0.1083	0.1083
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0113	0.1821	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0213	0.0505
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.0738	0.2216
Brugia malayi	mbt repeat family protein	0.0048	0.0485	0.1116
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0485	0.0485
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0075	0.103	0.3093
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0623	0.0623
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.1205	0.3675
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0223	0.0513
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0213	0.0505
Entamoeba histolytica	cysteine proteinase 2	0.0061	0.0738	0.4054
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.2317	0.2317
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.1821	0.4311
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0158	0.2766	0.6365
Toxoplasma gondii	ABC1 family protein	0.0074	0.1026	0.3128
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0342	0.0809
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0183	0.3279	1
Echinococcus granulosus	peptidase Clp S14 family	0.0054	0.0612	0.0612
Onchocerca volvulus		0.0048	0.0485	0.1148
Echinococcus granulosus	cathepsin b	0.0186	0.3331	0.3331
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0036	0.0223	0.0513
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Trypanosoma cruzi	cruzipain precursor, putative	0.0036	0.0223	0.067
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.1026	0.1026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0213	0.117
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.044	0.044
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.3648	0.8393
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1026	0.236
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1821	0.4189
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.023	0.053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.3331	0.3331
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0183	0.3279	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0223	0.0513
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.0738	0.2216
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0213	0.049
Echinococcus multilocularis	cathepsin b	0.0186	0.3331	0.3331
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1205	0.1928
Onchocerca volvulus		0.0113	0.1821	0.4311
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0213	0.0505
Brugia malayi	Pre-SET motif family protein	0.0201	0.3648	0.8393
Brugia malayi	Pre-SET motif family protein	0.0029	0.0082	0.0189
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0623	0.0623
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.0738	0.1698
Brugia malayi	Probable ClpP-like protease	0.0083	0.1205	0.2772
Loa Loa (eye worm)	ctsf protein	0.0113	0.1821	0.4189
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.044	0.044
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0213	0.0505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Schistosoma mansoni	ap endonuclease	0.0059	0.0709	0.0709
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.1026	0.8409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.0738	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0113	0.1821	1
Leishmania major	cysteine peptidase A (CPA)	0.0113	0.1821	0.5244
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Schistosoma mansoni	hypothetical protein	0.0306	0.581	0.581
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0485	0.0485
Onchocerca volvulus		0.0113	0.1821	0.4311
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0485	0.0485
Mycobacterium ulcerans	hypothetical protein	0.0074	0.1026	0.123
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0213	0.0213
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Plasmodium vivax	vivapain-2	0.0113	0.1821	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0158	0.2766	0.2766
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1821	0.5467
Echinococcus multilocularis	geminin	0.0508	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Echinococcus multilocularis	cathepsin L	0.0061	0.0738	0.0738
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0113	0.1821	0.1821
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.0738	0.2216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Mycobacterium tuberculosis	Conserved protein	0.0074	0.1026	0.0474
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.1026	0.5054
Loa Loa (eye worm)	beta-lactamase	0.0074	0.1026	0.236
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1821	0.4189
Schistosoma mansoni	peptidase Clp (S14 family)	0.0083	0.1205	0.1205
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1821	0.4189
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.1026	0.236
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.044	0.044
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0059	0.0709	0.213
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0183	0.3279	0.3279
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1205	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Trypanosoma cruzi	cruzipain precursor, putative	0.0113	0.1821	0.5467
Toxoplasma gondii	cathepsin CPL	0.0113	0.1821	0.5553
Mycobacterium tuberculosis	Conserved protein	0.0074	0.1026	0.0474
Schistosoma mansoni	hypothetical protein	0.0036	0.023	0.023
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0738	0.3266
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.0738	0.4054
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0202	0.3672	0.3672
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.1026	0.3079
Giardia lamblia	Cathepsin B precursor	0.0075	0.103	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.2398	0.5518
Entamoeba histolytica	hypothetical protein	0.0073	0.0992	0.5447
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0059	0.0709	0.3896
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0082	0.0082
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1821	0.4189
Onchocerca volvulus		0.0113	0.1821	0.4311
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0083	0.1205	0.6617
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.1026	0.0474
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0213	0.0213
Entamoeba histolytica	cysteine proteinase, putative	0.0077	0.1083	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1205	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0183	0.3279	0.306
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0059	0.0709	0.1632
Schistosoma mansoni	hypothetical protein	0.0508	1	1
Echinococcus granulosus	cathepsin l1	0.0077	0.1083	0.1083
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.4223	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Giardia lamblia	Cathepsin B precursor	0.0075	0.103	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Mycobacterium ulcerans	lipase LipD	0.0074	0.1026	0.123
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Trichomonas vaginalis	ap endonuclease, putative	0.0059	0.0709	0.168
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.2398	0.2398
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	0.3331	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1821	0.5467
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.2398	0.2398
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.1821	0.4311
Plasmodium vivax	SET domain protein, putative	0.0029	0.0082	0.0451
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.1026	0.2428
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.0189
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.027	0.1485
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1205	0.6617
Loa Loa (eye worm)	transcription factor SMAD2	0.0235	0.4346	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0059	0.0709	0.3896
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0223	0.0513
Onchocerca volvulus		0.0074	0.1026	0.2428
Echinococcus multilocularis	cysteine protease	0.0113	0.1821	0.1821
Brugia malayi	Papain family cysteine protease containing protein	0.0113	0.1821	0.4189
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0077	0.1083	0.2491
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1026	0.236
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0083	0.1205	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.1083	0.2564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0082	0.0082
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0082	0.0082
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1821	0.4189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0342	0.1042
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0075	0.103	0.2665
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.1821	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0213	0.0505
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.1026	0.1026
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0059	0.0709	0.0709
Loa Loa (eye worm)	MBCTL1	0.0055	0.0623	0.1434
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.2766	0.2766
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.1821	0.1821
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.0738	0.0738
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0061	0.0738	0.0738
Mycobacterium ulcerans	beta-lactamase	0.0074	0.1026	0.123
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.1026	0.1026
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.1026	0.123
Onchocerca volvulus		0.0077	0.1083	0.2564
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.0223	0.0513
Onchocerca volvulus		0.0074	0.1026	0.2428
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.1026	0.123
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0213	0.064
Plasmodium vivax	unspecified product	0.0036	0.0223	0.1225
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0059	0.0709	0.3087
Brugia malayi	cathepsin B-like cysteine proteinase	0.0186	0.3331	0.7663
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0576	0.1324
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0213	0.065
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1821	0.5467
Schistosoma mansoni	hypothetical protein	0.0073	0.0992	0.0992
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0342	0.1877
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0075	0.103	0.103
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0059	0.0709	0.1619
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0992	0.0992
Brugia malayi	exodeoxyribonuclease III family protein	0.0059	0.0709	0.1632
Onchocerca volvulus		0.0113	0.1821	0.4311
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0992	0.0992
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0082	0.0082
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0083	0.1205	0.1205
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1821	0.4189
Onchocerca volvulus		0.0029	0.0082	0.0194
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0576	0.1324
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1205	0.5
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0059	0.0709	0.0709
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0082	0.0082
Loa Loa (eye worm)	fibroinase	0.0113	0.1821	0.4189
Onchocerca volvulus		0.0113	0.1821	0.4311
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0113	0.1821	0.4189
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0113	0.1821	0.1821
Mycobacterium leprae	Probable lipase LipE	0.0074	0.1026	0.8409
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0061	0.0738	0.2216
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.044	0.044
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0213	0.049
Schistosoma mansoni	aldehyde dehydrogenase	0.0183	0.3279	0.3279
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0083	0.1205	0.1205
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0075	0.103	0.2439
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Onchocerca volvulus	Cathepsin F homolog	0.0113	0.1821	0.4311
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.1026	0.5633
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0082	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0738	0.1748
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0213	0.0505
Leishmania major	hypothetical protein, conserved	0.0074	0.1026	0.265
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.1026	0.1026
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0183	0.3279	0.3279
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0059	0.0709	0.3896
Schistosoma mansoni	hypothetical protein	0.0508	1	1
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0485	0.1116
Trichomonas vaginalis	esterase, putative	0.0074	0.1026	0.2428
Loa Loa (eye worm)	hypothetical protein	0.0186	0.3331	0.7663
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.1026	0.0474
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Toxoplasma gondii	exonuclease III APE	0.0059	0.0709	0.2163
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0077	0.1083	0.325
Entamoeba histolytica	cysteine proteinase 1, putative	0.0061	0.0738	0.4054
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.1026	0.0474
Brugia malayi	beta-lactamase family protein	0.0074	0.1026	0.236
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.3331	0.3331
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.1821	0.1821
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.0738	0.4054
Mycobacterium tuberculosis	Conserved protein	0.0074	0.1026	0.0474
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0082	0.0082
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.044	0.1012
Schistosoma mansoni	alpha-glucosidase	0.0136	0.2309	0.2309
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0342	0.0809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0485	0.1148
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0036	0.023	0.053
Onchocerca volvulus		0.0092	0.1383	0.3275
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.044	0.044
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0059	0.0709	0.5605
Echinococcus granulosus	cathepsin L	0.0061	0.0738	0.0738
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0342	0.1042
Toxoplasma gondii	aldehyde dehydrogenase	0.0183	0.3279	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0183	0.3279	0.3279
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0623	0.1434
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0075	0.103	0.5082
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.1026	0.0474
Echinococcus granulosus	cysteine protease	0.0061	0.0738	0.0738
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.1821	0.1821
Loa Loa (eye worm)	cathepsin B	0.0075	0.103	0.237
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0202	0.3672	0.3672
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.1026	0.0474
Echinococcus granulosus	cathepsin l1	0.0113	0.1821	0.1821
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.1026	0.0474
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.1821	0.1821
Loa Loa (eye worm)	cysteine protease	0.0113	0.1821	0.4189
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.1026	0.2428
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.1083	0.2564
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Plasmodium vivax	vivapain-1	0.0061	0.0738	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1083	0.2491
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0576	0.1324
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0158	0.2766	0.6365
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.0738	0.0738
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.1026	0.0474
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0054	0.0612	0.4744
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.027	0.1485
Brugia malayi	cathepsin L-like precursor	0.0077	0.1083	0.2491
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.1026	0.2428
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Trichomonas vaginalis	ap endonuclease, putative	0.0059	0.0709	0.168
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.0738	0.0738
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0183	0.3279	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0113	0.1821	0.4189
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.1205	0.3675
Plasmodium vivax	vivapain-2	0.0113	0.1821	1
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1205	0.5
Brugia malayi	MH2 domain containing protein	0.0235	0.4346	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0213	0.0505
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0342	0.0342
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.1026	0.3079
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	0.3331	0.3331
Schistosoma mansoni	alpha-glucosidase	0.0136	0.2309	0.2309
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0059	0.0709	0.6887
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.1026	0.236
Onchocerca volvulus		0.0113	0.1821	0.4311
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.044	0.044
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0623	0.0623
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.1821	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0475	0.9327	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0054	0.0612	0.0612
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.3331	0.3331
Brugia malayi	beta-lactamase family protein	0.0074	0.1026	0.236
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0061	0.0738	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1026	0.236
Entamoeba histolytica	hypothetical protein	0.0073	0.0992	0.5447
Echinococcus multilocularis	cysteine protease	0.0113	0.1821	0.1821
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0485	0.0485
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0213	0.117
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.044	0.1012
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0078	0.0426
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.1821	0.1821
Toxoplasma gondii	hypothetical protein	0.0029	0.0078	0.0236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0738	0.3266
Echinococcus granulosus	cathepsin b	0.0186	0.3331	0.3331
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.0078	0.0426
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0213	0.0505
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.1821	0.1821
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0485	0.0485
Plasmodium vivax	vivapain-3	0.0061	0.0738	0.4054
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0213	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0485	0.1116
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0623	0.0623
Plasmodium vivax	unspecified product	0.0061	0.0738	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0623	0.1434
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Schistosoma mansoni	ap endonuclease	0.0059	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.1821	0.4311
Onchocerca volvulus		0.0113	0.1821	0.4311
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0576	0.1324
Entamoeba histolytica	cysteine protease, putative	0.0113	0.1821	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0113	0.1821	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0059	0.0709	0.0111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1821	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1821	0.4189
Toxoplasma gondii	cathepsin B	0.0075	0.103	0.3142
Entamoeba histolytica	hypothetical protein	0.0073	0.0992	0.5447
Brugia malayi	hypothetical protein	0.0073	0.0992	0.2282
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0485	0.0485
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0223	0.067
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1205	0.1928
Trypanosoma cruzi	cysteine protease, putative	0.0061	0.0738	0.2216
Onchocerca volvulus		0.0229	0.4223	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.006	0.006
Schistosoma mansoni	cathepsin s	0.0036	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1083	0.2491
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1026	0.236
Brugia malayi	Cathepsin L-like precursor	0.0077	0.1083	0.2491
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0223	0.0513
Loa Loa (eye worm)	MH2 domain-containing protein	0.0235	0.4346	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Onchocerca volvulus		0.0074	0.1026	0.2428
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0223	0.0513
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.1821	0.4311
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1026	0.236
Loa Loa (eye worm)	acetyltransferase	0.0141	0.2398	0.5518
Brugia malayi	mbt repeat family protein	0.0048	0.0485	0.1116
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0082	0.0082
Leishmania major	cathepsin L-like protease	0.0113	0.1821	0.5244
Brugia malayi	beta-lactamase	0.0074	0.1026	0.236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0738	0.1748
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.2766	0.2766
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0485	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1026	0.236
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.027	0.2624
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.1026	0.2428
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1205	0.2772
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0623	0.0623
Schistosoma mansoni	alpha glucosidase	0.0035	0.0213	0.0213
Giardia lamblia	Cathepsin B precursor	0.0075	0.103	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0738	0.4054
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0059	0.0709	0.213
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1083	0.2491
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.1026	0.2428
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0183	0.3279	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1821	0.4311
Entamoeba histolytica	hypothetical protein	0.0073	0.0992	0.5447
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1821	0.5467
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0213	0.064
Echinococcus multilocularis	cathepsin b	0.0186	0.3331	0.3331
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1821	0.4311
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.0738	0.1698
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.0738	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0077	0.1083	0.2491

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 5	Inhibition of cathepsin B	ChEMBL.	19515558
IC50 (binding)	= 5.2	Inhibition of cathepsin L2	ChEMBL.	19515558
IC50 (binding)	= 5.3	Inhibition of cathepsin K	ChEMBL.	19515558
IC50 (binding)	= 5.6	Inhibition of cathepsin S	ChEMBL.	19515558
IC50 (binding)	= 6.5	Inhibition of cathepsin L	ChEMBL.	19515558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL550247

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1040425