Detailed information for compound 1040708

Basic information

Technical information
  • TDR Targets ID: 1040708
  • Name: 2-(4-methoxyphenyl)sulfanyl-N-(5-methyl-1H-py razol-3-yl)quinazolin-4-amine
  • MW: 363.436 | Formula: C19H17N5OS
  • H donors: 2 H acceptors: 3 LogP: 4.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Sc1nc(Nc2n[nH]c(c2)C)c2c(n1)cccc2
  • InChi: 1S/C19H17N5OS/c1-12-11-17(24-23-12)21-18-15-5-3-4-6-16(15)20-19(22-18)26-14-9-7-13(25-2)8-10-14/h3-11H,1-2H3,(H2,20,21,22,23,24)
  • InChiKey: KJVHTJKPBZOBPJ-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(4-methoxyphenyl)thio]-N-(5-methyl-1H-pyrazol-3-yl)-4-quinazolinamine
  • [2-[(4-methoxyphenyl)thio]quinazolin-4-yl]-(5-methyl-1H-pyrazol-3-yl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0307 0.3505
Brugia malayi nuclear receptor NHR-88 0.0038 0.0151 0.03
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0184 0.2104
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0074 0.0412 0.471
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0151 0.0151
Onchocerca volvulus 0.0074 0.0412 0.2167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0307 0.3505
Schistosoma mansoni hypothetical protein 0.0144 0.0928 0.0928
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0307 0.1505
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0412
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0142 0.0695
Brugia malayi TATA binding protein associated factor 0.0074 0.0412 0.0817
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0151 0.03
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0074 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0412
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0742 0.0742
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.006 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1785 0.8764
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.0565 0.0565
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1128 0.5538
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0088 0.0515 0.0515
Schistosoma mansoni nuclear receptor 0.0018 0.0005 0.0005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0005 0.0025
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0151 0.0151
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0151 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0208 0.0208
Brugia malayi proteasome subunit beta type 1 0.0068 0.0372 0.0738
Echinococcus multilocularis proteasome (prosome, macropain) 0.0088 0.0515 0.0515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0151 0.0151
Brugia malayi hypothetical protein 0.0707 0.5042 1
Brugia malayi jmjC domain containing protein 0.0025 0.006 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0208 0.0208
Echinococcus granulosus GPCR family 2 0.0094 0.0565 0.0565
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0142 0.1618
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0066 0.036 0.036
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0005 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0095 0.057 0.057
Brugia malayi latrophilin 2 splice variant baaae 0.0204 0.1367 0.2711
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0074 0.0412 0.471
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0465 0.0465
Schistosoma mansoni jumonji domain containing protein 0.0025 0.006 0.006
Toxoplasma gondii aurora kinase 0.0137 0.0875 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0412 0.471
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0068 0.0372 0.4255
Loa Loa (eye worm) DR-78 0.0018 0.0005 0.0005
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Giardia lamblia Proteasome subunit beta type 2 0.0042 0.0183 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0151 0.03
Brugia malayi serine/threonine protein kinase 6 0.0137 0.0875 0.1735
Brugia malayi nuclear hormone receptor 0.0018 0.0005 0.0009
Echinococcus granulosus peregrin 0.0033 0.0116 0.0116
Onchocerca volvulus 0.0081 0.0465 0.2445
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0151 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0005 0.0005
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0412 0.471
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0151 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0208 0.0208
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0412 0.2022
Schistosoma mansoni protein kinase 0.0137 0.0875 0.0875
Leishmania major proteasome beta 2 subunit, putative 0.0042 0.0183 0.2089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Schistosoma mansoni hypothetical protein 0.0508 0.3593 0.3593
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.002 0.002
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.009 0.009
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0307 0.0307
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0299 0.2058 0.4081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0005 0.0005
Echinococcus granulosus tar DNA binding protein 0.0063 0.0335 0.0335
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0042 0.0183 0.0897
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1384 1 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0137 0.0875 0.0875
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0307 0.0307
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.006 0.0683
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1128 0.5538
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0335 0.0664
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0151 0.0151
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0142 0.0142
Plasmodium vivax proteasome subunit beta type-2, putative 0.0042 0.0183 0.2089
Onchocerca volvulus 0.0036 0.0138 0.0724
Toxoplasma gondii proteasome subunit beta type, putative 0.0088 0.0515 0.5891
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0074 0.0412 0.471
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0783 0.0783
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.002 0.004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0042 0.0183 0.0897
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0316 0.0316
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0316 0.3609
Giardia lamblia PHD finger protein 15 0.0029 0.009 0.0441
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0158 0.1809
Entamoeba histolytica hypothetical protein 0.0036 0.0136 0.0666
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Brugia malayi RNA binding protein 0.0063 0.0335 0.0664
Brugia malayi nuclear receptor NHR-67 0.0018 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0094 0.0565 0.0565
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0151 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0138 0.0138
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.5773 0.5773
Brugia malayi jmjC domain containing protein 0.0099 0.0595 0.1179
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0875 0.4294
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0595 0.0595
Echinococcus granulosus lamin dm0 0.0081 0.0465 0.0465
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0142 0.0142
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0144 0.0928 0.1841
Loa Loa (eye worm) hypothetical protein 0.0058 0.0295 0.0295
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.002 0.002
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0042 0.0183 0.2089
Schistosoma mansoni zinc finger protein 0.0018 0.0005 0.0005
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0191 0.0378
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0151 0.0795
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0068 0.0372 0.1827
Entamoeba histolytica protein kinase, putative 0.0059 0.0307 0.1505
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.006 0.0683
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0119 0.0119
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.006 0.0683
Toxoplasma gondii aminopeptidase N protein 0.0074 0.0412 0.471
Brugia malayi nuclear receptor RXR 0.002 0.002 0.004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0142 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0158 0.0777
Echinococcus multilocularis peregrin 0.0033 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.006
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.006 0.006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0151 0.03
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0151 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0151 0.0151
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0174 0.0174
Plasmodium falciparum serine/threonine protein kinase, putative 0.0137 0.0875 1
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0068 0.0372 0.4255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0151 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0138 0.0138
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1384 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0465 0.0922
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0138 0.1573
Echinococcus granulosus proteasome prosome macropain 0.0088 0.0515 0.0515
Brugia malayi hypothetical protein 0.0036 0.0136 0.0269
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0316 0.3609
Brugia malayi intermediate filament protein 0.0081 0.0465 0.0922
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1785 0.8764
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0151 0.03
Echinococcus multilocularis lamin 0.0081 0.0465 0.0465
Giardia lamblia Proteasome subunit beta type 1 0.0068 0.0372 0.1827
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0151 0.03
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0068 0.0372 0.4255
Brugia malayi ecdysone receptor 0.0018 0.0005 0.0009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.108 0.2141
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0335 0.0335
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0068 0.0372 0.0372
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0084 0.0084
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0005 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0742 0.0742
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0246 0.1676 0.1676
Echinococcus granulosus tumor protein p63 0.0394 0.2753 0.2753
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1196 0.5869
Schistosoma mansoni phd/f-box containing protein 0.0025 0.006 0.006
Brugia malayi hypothetical protein 0.0074 0.0412 0.0817
Schistosoma mansoni intermediate filament proteins 0.0081 0.0465 0.0465
Onchocerca volvulus 0.0018 0.0005 0.0025
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0307 0.1505
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0142 0.1618
Schistosoma mansoni alpha glucosidase 0.0037 0.0142 0.0142
Schistosoma mansoni lamin 0.0081 0.0465 0.0465
Toxoplasma gondii aminopeptidase N, putative 0.0074 0.0412 0.471
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0298 0.0298
Brugia malayi serine/threonine-protein kinase 6 0.0137 0.0875 0.1735
Echinococcus granulosus geminin 0.0508 0.3593 0.3593
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0184 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0138 0.0138
Onchocerca volvulus 0.0058 0.0295 0.1553
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0036 0.0136 0.0666
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0088 0.0515 0.5891
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0412 0.471
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0316 0.3392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0299 0.2058 0.2058
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0094 0.0565 0.0565
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0074 0.0412 0.0412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0136 0.0136
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0931 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0074 0.0412 0.0412
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0412 0.4427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0151 0.0151
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0412 0.2022
Plasmodium falciparum phd finger protein, putative 0.0029 0.009 0.1026
Echinococcus granulosus dnaJ subfamily B 0.0825 0.5912 0.5912
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.006 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0307 0.1505
Schistosoma mansoni nuclear receptor 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.009 0.1026
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0005 0.0005
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0412 0.471
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0412 0.471
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0151 0.0151
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0042 0.0183 0.2089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0335 0.0335
Brugia malayi Pre-SET motif family protein 0.0036 0.0138 0.0273
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.006 0.006
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0151 0.0151
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0151 0.0151
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0151 0.03
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0137 0.0875 0.4294
Onchocerca volvulus Alhambra homolog 0.0029 0.009 0.0472
Schistosoma mansoni lamin 0.0081 0.0465 0.0465
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0412 0.471
Brugia malayi hypothetical protein 0.0018 0.0005 0.0009
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0335 0.0335
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0088 0.0515 0.253
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.009 0.009
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0068 0.0372 0.0372
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0335 0.0335
Brugia malayi serine/threonine kinase 12 0.0137 0.0875 0.1735
Brugia malayi hypothetical protein 0.0636 0.4529 0.8984
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0307 0.3505
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0151 0.0151
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0074 0.0412 0.471
Brugia malayi proteasome subunit beta type 2 0.0042 0.0183 0.0362
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0184 0.0904
Echinococcus multilocularis dnaJ subfamily B 0.0825 0.5912 0.5912
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0042 0.0183 0.0183
Trypanosoma brucei aminopeptidase, putative 0.0074 0.0412 0.471
Leishmania major hypothetical protein, conserved 0.0025 0.006 0.0683
Loa Loa (eye worm) hypothetical protein 0.0094 0.0565 0.0565
Brugia malayi jmjC domain containing protein 0.0025 0.006 0.0118
Brugia malayi hypothetical protein 0.002 0.002 0.004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.2037 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0084 0.0084
Brugia malayi hypothetical protein 0.002 0.002 0.004
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0875 0.0875
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0074 0.0412 0.0412
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0307 0.0307
Echinococcus granulosus survival motor neuron protein 1 0.0707 0.5042 0.5042
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0005 0.0005
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0412 0.471
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0137 0.0875 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0307 0.0307
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0208 0.0208
Loa Loa (eye worm) TATA binding protein associated factor 0.0074 0.0412 0.0412
Echinococcus multilocularis geminin 0.0508 0.3593 0.3593
Entamoeba histolytica aminopeptidase, putative 0.0074 0.0412 0.2022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0151 0.0151
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0307 0.0307
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0088 0.0515 0.0515
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0083 0.0165
Schistosoma mansoni protein phosphatase 2C 0.0025 0.006 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0208 0.0208
Onchocerca volvulus 0.0081 0.0465 0.2445
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0151 0.03
Schistosoma mansoni hypothetical protein 0.0029 0.009 0.009
Brugia malayi Bromodomain containing protein 0.0033 0.0116 0.0229
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0042 0.0183 0.0183
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0074 0.0412 0.0412
Onchocerca volvulus 0.0074 0.0412 0.2167
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.2037 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0142 0.0695
Plasmodium vivax hypothetical protein, conserved 0.0029 0.009 0.1026
Brugia malayi tailless protein 0.0018 0.0005 0.0009
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0871 0.0871
Loa Loa (eye worm) proteasome subunit beta type 2 0.0042 0.0183 0.0183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0094 0.0565 0.112
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0142 0.0695
Echinococcus granulosus cpg binding protein 0.0061 0.0322 0.0322
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0307 0.1505
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0005 0.0005
Brugia malayi jmjC domain containing protein 0.0025 0.006 0.0118
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0412 0.471
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0875 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0151 0.03
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Brugia malayi Latrophilin receptor protein 2 0.0094 0.0565 0.112
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0151 0.0151
Echinococcus multilocularis lamin dm0 0.0081 0.0465 0.0465
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0307 0.3505
Schistosoma mansoni hypothetical protein 0.0825 0.5912 0.5912
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.108 0.108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.002 0.002
Leishmania major protein kinase, putative 0.0137 0.0875 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0039 0.0159 0.0159
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0712 0.8144
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0088 0.0515 0.5891
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0707 0.5042 0.5042
Trypanosoma cruzi 20S proteasome subunit 0.0042 0.0183 0.2089
Onchocerca volvulus 0.0277 0.1901 1
Onchocerca volvulus Huntingtin homolog 0.0246 0.1676 0.8813
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0005 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0151 0.03
Entamoeba histolytica protein kinase, putative 0.0137 0.0875 0.4294
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0148
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0042 0.0183 0.2089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0005 0.0009
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0088 0.0515 0.253
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0142 0.1618
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0307 0.3505
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0142 0.0142
Trypanosoma brucei proteasome beta 6 subunit 0.0068 0.0372 0.4255
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0005 0.0009
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0928 0.0928
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Leishmania major proteasome beta 5 subunit, putative 0.0088 0.0515 0.5891
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0074 0.0412 0.471
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1128 0.5538
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0335 0.0335
Echinococcus multilocularis aminopeptidase N 0.0074 0.0412 0.0412
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.1785 0.1785
Plasmodium falciparum proteasome subunit beta type-5 0.0088 0.0515 0.5891
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1785 0.8764
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0088 0.0515 0.5891
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1128 0.5538
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0137 0.0875 0.4294
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0074 0.0412 0.471
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0307 0.1505
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0142 0.0695
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.1128 0.5932
Echinococcus granulosus phd:f box containing protein 0.0025 0.006 0.006
Brugia malayi PHD-finger family protein 0.0029 0.009 0.0178
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0151 0.0151
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0316 0.0316
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0151 0.0151
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.006 0.006
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0875 0.0875
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0151 0.0151
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0138 0.0138
Brugia malayi intracellular kinase 0.0059 0.0307 0.0608
Brugia malayi TAR-binding protein 0.0063 0.0335 0.0664
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0151 0.0795
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0151 0.0151
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0931 1
Brugia malayi nuclear receptor RXR 0.0018 0.0005 0.0009
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0005 0.0005
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0015 0.0015
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0088 0.0515 0.253
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0151 0.0795
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1785 0.8764
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0151 0.03
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0151 0.0151
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0137 0.0875 0.4294
Onchocerca volvulus 0.0038 0.0151 0.0795
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0151 0.0151
Loa Loa (eye worm) acetyltransferase 0.0144 0.0928 0.0928
Onchocerca volvulus 0.0018 0.0005 0.0025
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0088 0.0515 0.5537
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0137 0.0875 0.0875
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0042 0.0183 0.0183
Echinococcus multilocularis survival motor neuron protein 1 0.0707 0.5042 0.5042
Echinococcus multilocularis GPCR, family 2 0.0094 0.0565 0.0565
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Brugia malayi CXXC zinc finger family protein 0.0058 0.0298 0.0591
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0151 0.03
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.1785 0.3541
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.006 0.006
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0042 0.0183 0.2089
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0246 0.1676 0.1676
Mycobacterium ulcerans proteasome PrcB 0.0088 0.0515 0.5537
Brugia malayi Pre-SET motif family protein 0.0244 0.1656 0.3286
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0335 0.0335
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0875 0.4294
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0019 0.0012 0.006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0142 0.0695
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0316 0.3392
Onchocerca volvulus 0.0074 0.0412 0.2167
Echinococcus multilocularis cpg binding protein 0.0061 0.0322 0.0322
Plasmodium vivax proteasome subunit beta type-5, putative 0.0088 0.0515 0.5891
Schistosoma mansoni hypothetical protein 0.0094 0.0565 0.0565
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0151 0.0151
Trypanosoma brucei glucosidase, putative 0.0037 0.0142 0.1618
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1128 0.5538
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0151 0.0151
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0142 0.0695
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0158 0.0777
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1196 0.5869
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0184 0.2104
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0137 0.0875 0.4294
Schistosoma mansoni cpg binding protein 0.0061 0.0322 0.0322
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0142 0.0695
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0059 0.0059
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0151 0.0151
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0138 0.0138
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0151 0.0151
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0017 0 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Brugia malayi hypothetical protein 0.0074 0.0412 0.0817
Loa Loa (eye worm) latrophilin receptor protein 2 0.0094 0.0565 0.0565
Brugia malayi ecdysteroid receptor 0.0038 0.0151 0.03
Brugia malayi hypothetical protein 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0412
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0412 0.471
Echinococcus granulosus protein kinase shaggy 0.0059 0.0307 0.0307
Trypanosoma cruzi aurora B kinase, putative 0.0137 0.0875 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0412 0.471
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0899 0.0899
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0335 0.0335
Schistosoma mansoni alpha-glucosidase 0.0142 0.0912 0.0912
Schistosoma mansoni hypothetical protein 0.0094 0.0565 0.0565
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0412 0.4427
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0151 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1128 0.5538
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.1656 0.1656
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0005 0.0005
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0928 0.0928
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0005 0.0005
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0068 0.0372 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0151 0.0151
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0412 0.0817
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0142 0.0695
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0412 0.471
Plasmodium vivax JmjC domain containing protein 0.0025 0.006 0.0683
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0094 0.0565 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0204 0.1367 0.1367
Schistosoma mansoni hypothetical protein 0.0094 0.0565 0.0565
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0005 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0875 0.4294
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0875 0.4294
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0015 0.0015
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0142 0.0695
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.108 0.108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0038 0.0151 0.03
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0138 0.0138
Brugia malayi MH2 domain containing protein 0.0119 0.0742 0.1472
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1785 0.8764
Plasmodium vivax proteasome subunit beta type-1, putative 0.0068 0.0372 0.4255
Onchocerca volvulus 0.0059 0.0307 0.1612
Echinococcus granulosus lamin 0.0081 0.0465 0.0465
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.2037 0.5
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0412 0.471
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.009 0.009
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.006 0.006
Echinococcus granulosus aminopeptidase N 0.0074 0.0412 0.0412
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0412 0.0817
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0875 0.0875
Brugia malayi Calcitonin receptor-like protein seb-1 0.0299 0.2058 0.4081
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0151 0.03
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0151 0.03
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0151 0.03
Entamoeba histolytica hypothetical protein 0.0036 0.0136 0.0666
Schistosoma mansoni survival motor neuron protein 0.0144 0.0928 0.0928
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0151 0.03
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0316 0.3392
Brugia malayi hypothetical protein 0.0246 0.1676 0.3324
Trypanosoma cruzi Aminopeptidase M1, putative 0.0074 0.0412 0.471
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0412 0.0817
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0465 0.0465
Echinococcus multilocularis tumor protein p63 0.0394 0.2753 0.2753
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0068 0.0372 0.1827
Loa Loa (eye worm) RNA binding protein 0.0063 0.0335 0.0335
Trypanosoma brucei aurora B kinase 0.0137 0.0875 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.1367 0.1367
Schistosoma mansoni aminopeptidase A (M01 family) 0.0074 0.0412 0.0412
Echinococcus granulosus intermediate filament protein 0.0081 0.0465 0.0465
Schistosoma mansoni coup transcription factor 0.0038 0.0151 0.0151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.2037 1
Schistosoma mansoni cpg binding protein 0.0061 0.0322 0.0322
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0081 0.0465 0.0465
Trichomonas vaginalis set domain proteins, putative 0.0277 0.1901 0.9335
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1128 0.5538
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0005 0.0005
Brugia malayi conserved hypotetical protein 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Onchocerca volvulus 0.0058 0.0298 0.1567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0208 0.0208
Onchocerca volvulus 0.0144 0.0928 0.4881
Echinococcus granulosus aurora kinase A 0.0137 0.0875 0.0875
Entamoeba histolytica hypothetical protein 0.0036 0.0136 0.0666
Toxoplasma gondii aminopeptidase n, putative 0.0074 0.0412 0.471
Schistosoma mansoni alpha-glucosidase 0.0142 0.0912 0.0912
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0595 0.0595
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0875 0.4294
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.006 0.0683
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0931 1
Echinococcus multilocularis aurora kinase A 0.0137 0.0875 0.0875
Brugia malayi nuclear receptor NHR-88 0.0018 0.0005 0.0009
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0928 0.1841
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0088 0.0515 0.5537
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0208 0.0413
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0159 0.0159
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0191 0.0191
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0208 0.0208
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0151 0.0151
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0068 0.0372 0.4255
Loa Loa (eye worm) aminopeptidase N 0.0074 0.0412 0.0412
Schistosoma mansoni hypothetical protein 0.0036 0.0136 0.0136
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0136 0.0136
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0307 0.1505
Brugia malayi Proteasome A-type and B-type family protein 0.0088 0.0515 0.1022
Echinococcus multilocularis phd:f box containing protein 0.0025 0.006 0.006
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0005 0.0009
Onchocerca volvulus Huntingtin homolog 0.0246 0.1676 0.8813
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0142 0.1618
Echinococcus multilocularis musashi 0.0081 0.0465 0.0465
Schistosoma mansoni cpg binding protein 0.0058 0.0298 0.0298
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.108 0.108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi steroid hormone receptor 0.0038 0.0151 0.03
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0184 0.2104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0151 0.0151
Brugia malayi jmjC domain containing protein 0.0156 0.1016 0.2015
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0174 0.0174
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0151 0.0151
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0142 0.0695
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0151 0.0151
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0295 0.0295
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.009 0.1026
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.002 0.004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0156 0.1016 0.1016
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0316 0.3392
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0156 0.1016 0.1016
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0042 0.0183 0.0897
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0151 0.0151
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.0565 0.0565
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0151 0.0151
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.006 0.006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0184 0.0904
Schistosoma mansoni hypothetical protein 0.0508 0.3593 0.3593
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0148
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1384 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.006
Trypanosoma brucei protein kinase, putative 0.0059 0.0307 0.3505
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1785 0.8764
Loa Loa (eye worm) hypothetical protein 0.0036 0.0138 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0138 0.0138
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.006 0.0683
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0412 0.2022
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Plasmodium vivax SET domain protein, putative 0.0036 0.0138 0.1573
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0005 0.0009
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0042 0.0183 0.0183
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Onchocerca volvulus 0.0095 0.0571 0.3005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0015 0.0015
Brugia malayi jmjC domain containing protein 0.0025 0.006 0.0118
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.006 0.006
Giardia lamblia Aurora kinase 0.0137 0.0875 0.4294
Loa Loa (eye worm) proteasome subunit beta type 1 0.0068 0.0372 0.0372
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.2037 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0142 0.0695
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0299 0.2058 0.2058
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0307 0.0307
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0005 0.0005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.006 0.006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0316 0.0316
Entamoeba histolytica protein kinase , putative 0.0137 0.0875 0.4294
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.006 0.0683
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0005 0.0009
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0068 0.0372 0.4255
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.108 0.108
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0412 0.0412

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 9 nM Inhibition of Aurora-A by coupled assay ChEMBL. 19447622
Ki (binding) = 124 nM Inhibition of GSK3-beta ChEMBL. 19447622
Ki (binding) = 575 nM Inhibition of Aurora-B ChEMBL. 19447622

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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