TDR Targets

Basic information

Technical information

TDR Targets ID: 1040708
Name: 2-(4-methoxyphenyl)sulfanyl-N-(5-methyl-1H-py razol-3-yl)quinazolin-4-amine
MW: 363.436 | Formula: C19H17N5OS
H donors: 2 H acceptors: 3 LogP: 4.82 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Sc1nc(Nc2n[nH]c(c2)C)c2c(n1)cccc2
InChi: 1S/C19H17N5OS/c1-12-11-17(24-23-12)21-18-15-5-3-4-6-16(15)20-19(22-18)26-14-9-7-13(25-2)8-10-14/h3-11H,1-2H3,(H2,20,21,22,23,24)
InChiKey: KJVHTJKPBZOBPJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(4-methoxyphenyl)thio]-N-(5-methyl-1H-pyrazol-3-yl)-4-quinazolinamine
[2-[(4-methoxyphenyl)thio]quinazolin-4-yl]-(5-methyl-1H-pyrazol-3-yl)amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0059	0.0307	0.3505
Brugia malayi	nuclear receptor NHR-88	0.0038	0.0151	0.03
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0184	0.2104
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0074	0.0412	0.471
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0038	0.0151	0.0151
Onchocerca volvulus		0.0074	0.0412	0.2167
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Plasmodium falciparum	glycogen synthase kinase 3	0.0059	0.0307	0.3505
Schistosoma mansoni	hypothetical protein	0.0144	0.0928	0.0928
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0018	0.0005	0.0005
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0307	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0412	0.0412
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0142	0.0695
Brugia malayi	TATA binding protein associated factor	0.0074	0.0412	0.0817
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0038	0.0151	0.03
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0074	0.0412	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0412	0.0412
Loa Loa (eye worm)	jmjC domain-containing protein	0.0099	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0742	0.0742
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.006	0.006
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1785	0.8764
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0094	0.0565	0.0565
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1128	0.5538
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0088	0.0515	0.0515
Schistosoma mansoni	nuclear receptor	0.0018	0.0005	0.0005
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0018	0.0005	0.0025
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0038	0.0151	0.0151
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0038	0.0151	0.0151
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0208	0.0208
Brugia malayi	proteasome subunit beta type 1	0.0068	0.0372	0.0738
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0088	0.0515	0.0515
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0038	0.0151	0.0151
Brugia malayi	hypothetical protein	0.0707	0.5042	1
Brugia malayi	jmjC domain containing protein	0.0025	0.006	0.0118
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0208	0.0208
Echinococcus granulosus	GPCR family 2	0.0094	0.0565	0.0565
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0142	0.1618
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0038	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0066	0.036	0.036
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0018	0.0005	0.0005
Echinococcus multilocularis	lysine specific demethylase 5A	0.0095	0.057	0.057
Brugia malayi	latrophilin 2 splice variant baaae	0.0204	0.1367	0.2711
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0074	0.0412	0.471
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	intermediate filament protein	0.0081	0.0465	0.0465
Schistosoma mansoni	jumonji domain containing protein	0.0025	0.006	0.006
Toxoplasma gondii	aurora kinase	0.0137	0.0875	1
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0074	0.0412	0.471
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0068	0.0372	0.4255
Loa Loa (eye worm)	DR-78	0.0018	0.0005	0.0005
Echinococcus granulosus	lysine specific demethylase 5A	0.0099	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Giardia lamblia	Proteasome subunit beta type 2	0.0042	0.0183	0.0897
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0038	0.0151	0.03
Brugia malayi	serine/threonine protein kinase 6	0.0137	0.0875	0.1735
Brugia malayi	nuclear hormone receptor	0.0018	0.0005	0.0009
Echinococcus granulosus	peregrin	0.0033	0.0116	0.0116
Onchocerca volvulus		0.0081	0.0465	0.2445
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0038	0.0151	0.03
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0005	0.0005
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0412	0.471
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0038	0.0151	0.0151
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0208	0.0208
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0074	0.0412	0.2022
Schistosoma mansoni	protein kinase	0.0137	0.0875	0.0875
Leishmania major	proteasome beta 2 subunit, putative	0.0042	0.0183	0.2089
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Schistosoma mansoni	hypothetical protein	0.0508	0.3593	0.3593
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.002	0.002	0.002
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.009	0.009
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0307	0.0307
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0299	0.2058	0.4081
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0005	0.0005
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0335	0.0335
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0042	0.0183	0.0897
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1384	1	1
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0137	0.0875	0.0875
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0307	0.0307
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0025	0.006	0.0683
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.002
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1128	0.5538
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0335	0.0664
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0038	0.0151	0.0151
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0142	0.0142
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0042	0.0183	0.2089
Onchocerca volvulus		0.0036	0.0138	0.0724
Toxoplasma gondii	proteasome subunit beta type, putative	0.0088	0.0515	0.5891
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0074	0.0412	0.471
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.0783	0.0783
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.002	0.004
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0042	0.0183	0.0897
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0316	0.0316
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0316	0.3609
Giardia lamblia	PHD finger protein 15	0.0029	0.009	0.0441
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0158	0.1809
Entamoeba histolytica	hypothetical protein	0.0036	0.0136	0.0666
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Brugia malayi	RNA binding protein	0.0063	0.0335	0.0664
Brugia malayi	nuclear receptor NHR-67	0.0018	0.0005	0.0009
Schistosoma mansoni	hypothetical protein	0.0094	0.0565	0.0565
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0038	0.0151	0.0151
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0138	0.0138
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0806	0.5773	0.5773
Brugia malayi	jmjC domain containing protein	0.0099	0.0595	0.1179
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0875	0.4294
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0099	0.0595	0.0595
Echinococcus granulosus	lamin dm0	0.0081	0.0465	0.0465
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0142	0.0142
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0144	0.0928	0.1841
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0295	0.0295
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.002	0.002	0.002
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0042	0.0183	0.2089
Schistosoma mansoni	zinc finger protein	0.0018	0.0005	0.0005
Brugia malayi	cytoplasmic intermediate filament protein	0.0043	0.0191	0.0378
Onchocerca volvulus	Protein ultraspiracle homolog	0.0038	0.0151	0.0795
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0372	0.1827
Entamoeba histolytica	protein kinase, putative	0.0059	0.0307	0.1505
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0025	0.006	0.0683
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0119	0.0119
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0025	0.006	0.0683
Toxoplasma gondii	aminopeptidase N protein	0.0074	0.0412	0.471
Brugia malayi	nuclear receptor RXR	0.002	0.002	0.004
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0142	0.0281
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0158	0.0777
Echinococcus multilocularis	peregrin	0.0033	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0025	0.006	0.006
Echinococcus granulosus	lysine specific demethylase 6a	0.0025	0.006	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0038	0.0151	0.03
Loa Loa (eye worm)	steroid hormone receptor	0.0038	0.0151	0.0151
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0038	0.0151	0.0151
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0174	0.0174
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0137	0.0875	1
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0068	0.0372	0.4255
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0151	0.0151
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0138	0.0138
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1384	1	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0081	0.0465	0.0922
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0138	0.1573
Echinococcus granulosus	proteasome prosome macropain	0.0088	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0036	0.0136	0.0269
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0316	0.3609
Brugia malayi	intermediate filament protein	0.0081	0.0465	0.0922
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1785	0.8764
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0038	0.0151	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0038	0.0151	0.03
Echinococcus multilocularis	lamin	0.0081	0.0465	0.0465
Giardia lamblia	Proteasome subunit beta type 1	0.0068	0.0372	0.1827
Brugia malayi	photoreceptor-specific nuclear receptor	0.0038	0.0151	0.03
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.0372	0.4255
Brugia malayi	ecdysone receptor	0.0018	0.0005	0.0009
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0165	0.108	0.2141
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0335	0.0335
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0068	0.0372	0.0372
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0029	0.0084	0.0084
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0018	0.0005	0.0005
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0742	0.0742
Echinococcus granulosus	JmjC domain containing protein 4	0.0025	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0454	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1676	0.1676
Echinococcus granulosus	tumor protein p63	0.0394	0.2753	0.2753
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.1196	0.5869
Schistosoma mansoni	phd/f-box containing protein	0.0025	0.006	0.006
Brugia malayi	hypothetical protein	0.0074	0.0412	0.0817
Schistosoma mansoni	intermediate filament proteins	0.0081	0.0465	0.0465
Onchocerca volvulus		0.0018	0.0005	0.0025
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.0307	0.1505
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0142	0.1618
Schistosoma mansoni	alpha glucosidase	0.0037	0.0142	0.0142
Schistosoma mansoni	lamin	0.0081	0.0465	0.0465
Toxoplasma gondii	aminopeptidase N, putative	0.0074	0.0412	0.471
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0298	0.0298
Brugia malayi	serine/threonine-protein kinase 6	0.0137	0.0875	0.1735
Echinococcus granulosus	geminin	0.0508	0.3593	0.3593
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0184	0.0184
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0138	0.0138
Onchocerca volvulus		0.0058	0.0295	0.1553
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.002	0.002	0.002
Entamoeba histolytica	hypothetical protein	0.0036	0.0136	0.0666
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0088	0.0515	0.5891
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0412	0.471
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0316	0.3392
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0299	0.2058	0.2058
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0094	0.0565	0.0565
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0074	0.0412	0.0412
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0136	0.0136
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0144	0.0931	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0074	0.0412	0.0412
Mycobacterium ulcerans	aminopeptidase N PepN	0.0074	0.0412	0.4427
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0038	0.0151	0.0151
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0074	0.0412	0.2022
Plasmodium falciparum	phd finger protein, putative	0.0029	0.009	0.1026
Echinococcus granulosus	dnaJ subfamily B	0.0825	0.5912	0.5912
Echinococcus multilocularis	JmjC domain containing protein 4	0.0025	0.006	0.006
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0307	0.1505
Schistosoma mansoni	nuclear receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.009	0.1026
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.0005	0.0005
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0074	0.0412	0.471
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0412	0.471
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0151	0.0151
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0042	0.0183	0.2089
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0335	0.0335
Brugia malayi	Pre-SET motif family protein	0.0036	0.0138	0.0273
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.006	0.006
Echinococcus multilocularis	FTZ F1 alpha	0.0038	0.0151	0.0151
Echinococcus multilocularis	ecdysone induced protein 78C	0.0038	0.0151	0.0151
Brugia malayi	Steroid receptor seven-up type 2	0.0038	0.0151	0.03
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0137	0.0875	0.4294
Onchocerca volvulus	Alhambra homolog	0.0029	0.009	0.0472
Schistosoma mansoni	lamin	0.0081	0.0465	0.0465
Trypanosoma cruzi	aminopeptidase, putative	0.0074	0.0412	0.471
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0009
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0335	0.0335
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0088	0.0515	0.253
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.009	0.009
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0068	0.0372	0.0372
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0335	0.0335
Brugia malayi	serine/threonine kinase 12	0.0137	0.0875	0.1735
Brugia malayi	hypothetical protein	0.0636	0.4529	0.8984
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0059	0.0307	0.3505
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0038	0.0151	0.0151
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0074	0.0412	0.471
Brugia malayi	proteasome subunit beta type 2	0.0042	0.0183	0.0362
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0184	0.0904
Echinococcus multilocularis	dnaJ subfamily B	0.0825	0.5912	0.5912
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0042	0.0183	0.0183
Trypanosoma brucei	aminopeptidase, putative	0.0074	0.0412	0.471
Leishmania major	hypothetical protein, conserved	0.0025	0.006	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0565	0.0565
Brugia malayi	jmjC domain containing protein	0.0025	0.006	0.0118
Brugia malayi	hypothetical protein	0.002	0.002	0.004
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0296	0.2037	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0029	0.0084	0.0084
Brugia malayi	hypothetical protein	0.002	0.002	0.004
Loa Loa (eye worm)	AUR protein kinase	0.0137	0.0875	0.0875
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0074	0.0412	0.0412
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0059	0.0307	0.0307
Echinococcus granulosus	survival motor neuron protein 1	0.0707	0.5042	0.5042
Loa Loa (eye worm)	nuclear hormone receptor	0.0018	0.0005	0.0005
Trypanosoma brucei	Aminopeptidase M1, putative	0.0074	0.0412	0.471
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0137	0.0875	1
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0059	0.0307	0.0307
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0208	0.0208
Loa Loa (eye worm)	TATA binding protein associated factor	0.0074	0.0412	0.0412
Echinococcus multilocularis	geminin	0.0508	0.3593	0.3593
Entamoeba histolytica	aminopeptidase, putative	0.0074	0.0412	0.2022
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0038	0.0151	0.0151
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0059	0.0307	0.0307
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0088	0.0515	0.0515
Brugia malayi	F/Y-rich N-terminus family protein	0.0029	0.0083	0.0165
Schistosoma mansoni	protein phosphatase 2C	0.0025	0.006	0.006
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0208	0.0208
Onchocerca volvulus		0.0081	0.0465	0.2445
Brugia malayi	Nuclear hormone receptor-like 1	0.0038	0.0151	0.03
Schistosoma mansoni	hypothetical protein	0.0029	0.009	0.009
Brugia malayi	Bromodomain containing protein	0.0033	0.0116	0.0229
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0042	0.0183	0.0183
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0074	0.0412	0.0412
Onchocerca volvulus		0.0074	0.0412	0.2167
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0296	0.2037	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0142	0.0695
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.009	0.1026
Brugia malayi	tailless protein	0.0018	0.0005	0.0009
Schistosoma mansoni	jumonji domain containing protein	0.0136	0.0871	0.0871
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0042	0.0183	0.0183
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0094	0.0565	0.112
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0142	0.0695
Echinococcus granulosus	cpg binding protein	0.0061	0.0322	0.0322
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.0307	0.1505
Echinococcus multilocularis	nuclear receptor nhr 48	0.0018	0.0005	0.0005
Brugia malayi	jmjC domain containing protein	0.0025	0.006	0.0118
Trypanosoma brucei	Aminopeptidase M1, putative	0.0074	0.0412	0.471
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	AUR protein kinase	0.0137	0.0875	0.0875
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0038	0.0151	0.03
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Brugia malayi	Latrophilin receptor protein 2	0.0094	0.0565	0.112
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0038	0.0151	0.0151
Echinococcus multilocularis	lamin dm0	0.0081	0.0465	0.0465
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0059	0.0307	0.3505
Schistosoma mansoni	hypothetical protein	0.0825	0.5912	0.5912
Echinococcus granulosus	lysosomal alpha glucosidase	0.0165	0.108	0.108
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.002	0.002
Leishmania major	protein kinase, putative	0.0137	0.0875	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0159	0.0159
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0115	0.0712	0.8144
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0088	0.0515	0.5891
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0707	0.5042	0.5042
Trypanosoma cruzi	20S proteasome subunit	0.0042	0.0183	0.2089
Onchocerca volvulus		0.0277	0.1901	1
Onchocerca volvulus	Huntingtin homolog	0.0246	0.1676	0.8813
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0018	0.0005	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0038	0.0151	0.03
Entamoeba histolytica	protein kinase, putative	0.0137	0.0875	0.4294
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0148	0.0148
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0042	0.0183	0.2089
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0018	0.0005	0.0009
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0088	0.0515	0.253
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0142	0.1618
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0059	0.0307	0.3505
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0142	0.0142
Trypanosoma brucei	proteasome beta 6 subunit	0.0068	0.0372	0.4255
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.002
Brugia malayi	nuclear hormone receptor family member odr-7	0.0018	0.0005	0.0009
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0928	0.0928
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0018	0.0005	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Leishmania major	proteasome beta 5 subunit, putative	0.0088	0.0515	0.5891
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0074	0.0412	0.471
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1128	0.5538
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0335	0.0335
Echinococcus multilocularis	aminopeptidase N	0.0074	0.0412	0.0412
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0261	0.1785	0.1785
Plasmodium falciparum	proteasome subunit beta type-5	0.0088	0.0515	0.5891
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1785	0.8764
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0088	0.0515	0.5891
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1128	0.5538
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0137	0.0875	0.4294
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0074	0.0412	0.471
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0307	0.1505
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0142	0.0695
Onchocerca volvulus	Glucosylceramidase homolog	0.0171	0.1128	0.5932
Echinococcus granulosus	phd:f box containing protein	0.0025	0.006	0.006
Brugia malayi	PHD-finger family protein	0.0029	0.009	0.0178
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.002	0.002	0.002
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Echinococcus granulosus	FTZ F1 alpha	0.0038	0.0151	0.0151
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0316	0.0316
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.0151	0.0151
Echinococcus multilocularis	lysine specific demethylase 6a	0.0025	0.006	0.006
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0039	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0137	0.0875	0.0875
Schistosoma mansoni	thyroid hormone receptor	0.0038	0.0151	0.0151
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0138	0.0138
Brugia malayi	intracellular kinase	0.0059	0.0307	0.0608
Brugia malayi	TAR-binding protein	0.0063	0.0335	0.0664
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0038	0.0151	0.0795
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0038	0.0151	0.0151
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0144	0.0931	1
Brugia malayi	nuclear receptor RXR	0.0018	0.0005	0.0009
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0018	0.0005	0.0005
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0015	0.0015
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0088	0.0515	0.253
Onchocerca volvulus	Bile acid receptor homolog	0.0038	0.0151	0.0795
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1785	0.8764
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0038	0.0151	0.03
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0038	0.0151	0.0151
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0137	0.0875	0.4294
Onchocerca volvulus		0.0038	0.0151	0.0795
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0151	0.0151
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0928	0.0928
Onchocerca volvulus		0.0018	0.0005	0.0025
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0088	0.0515	0.5537
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0137	0.0875	0.0875
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0042	0.0183	0.0183
Echinococcus multilocularis	survival motor neuron protein 1	0.0707	0.5042	0.5042
Echinococcus multilocularis	GPCR, family 2	0.0094	0.0565	0.0565
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0298	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0038	0.0151	0.03
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0261	0.1785	0.3541
Echinococcus granulosus	jumonji domain containing 1A	0.0025	0.006	0.006
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0042	0.0183	0.2089
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1676	0.1676
Mycobacterium ulcerans	proteasome PrcB	0.0088	0.0515	0.5537
Brugia malayi	Pre-SET motif family protein	0.0244	0.1656	0.3286
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0335	0.0335
Entamoeba histolytica	protein kinase domain containing protein	0.0137	0.0875	0.4294
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0019	0.0012	0.006
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0142	0.0695
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0316	0.3392
Onchocerca volvulus		0.0074	0.0412	0.2167
Echinococcus multilocularis	cpg binding protein	0.0061	0.0322	0.0322
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0088	0.0515	0.5891
Schistosoma mansoni	hypothetical protein	0.0094	0.0565	0.0565
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0038	0.0151	0.0151
Trypanosoma brucei	glucosidase, putative	0.0037	0.0142	0.1618
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1128	0.5538
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0038	0.0151	0.0151
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0142	0.0695
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0158	0.0777
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.1196	0.5869
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0184	0.2104
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0018	0.0005	0.0005
Entamoeba histolytica	protein kinase, putative	0.0137	0.0875	0.4294
Schistosoma mansoni	cpg binding protein	0.0061	0.0322	0.0322
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0142	0.0695
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0025	0.0059	0.0059
Schistosoma mansoni	thyroid hormone receptor	0.0038	0.0151	0.0151
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0138	0.0138
Schistosoma mansoni	RAR-like nuclear receptor	0.0038	0.0151	0.0151
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0017	0	0.5
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Brugia malayi	hypothetical protein	0.0074	0.0412	0.0817
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0094	0.0565	0.0565
Brugia malayi	ecdysteroid receptor	0.0038	0.0151	0.03
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0412	0.0412
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0412	0.471
Echinococcus granulosus	protein kinase shaggy	0.0059	0.0307	0.0307
Trypanosoma cruzi	aurora B kinase, putative	0.0137	0.0875	1
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0074	0.0412	0.471
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.0899	0.0899
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0335	0.0335
Schistosoma mansoni	alpha-glucosidase	0.0142	0.0912	0.0912
Schistosoma mansoni	hypothetical protein	0.0094	0.0565	0.0565
Mycobacterium ulcerans	aminopeptidase N PepN	0.0074	0.0412	0.4427
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0038	0.0151	0.0151
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1128	0.5538
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0244	0.1656	0.1656
Schistosoma mansoni	nuclear receptor nhr-48	0.0018	0.0005	0.0005
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0928	0.0928
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0018	0.0005	0.0005
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0068	0.0372	0.0372
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0038	0.0151	0.0151
Brugia malayi	Peptidase family M1 containing protein	0.0074	0.0412	0.0817
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0142	0.0695
Trypanosoma cruzi	aminopeptidase, putative	0.0074	0.0412	0.471
Plasmodium vivax	JmjC domain containing protein	0.0025	0.006	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0094	0.0565	0.0565
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0038	0.0151	0.0151
Schistosoma mansoni	hypothetical protein	0.0204	0.1367	0.1367
Schistosoma mansoni	hypothetical protein	0.0094	0.0565	0.0565
Echinococcus granulosus	thyroid hormone receptor alpha	0.0018	0.0005	0.0005
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0875	0.4294
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0875	0.4294
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0015	0.0015
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0142	0.0695
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0165	0.108	0.108
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	nuclear hormone receptor	0.0038	0.0151	0.03
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0138	0.0138
Brugia malayi	MH2 domain containing protein	0.0119	0.0742	0.1472
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1785	0.8764
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0068	0.0372	0.4255
Onchocerca volvulus		0.0059	0.0307	0.1612
Echinococcus granulosus	lamin	0.0081	0.0465	0.0465
Treponema pallidum	fructose-bisphosphate aldolase	0.0296	0.2037	0.5
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0074	0.0412	0.471
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.009	0.009
Schistosoma mansoni	phosphatidylserine receptor	0.0025	0.006	0.006
Echinococcus granulosus	aminopeptidase N	0.0074	0.0412	0.0412
Brugia malayi	Peptidase family M1 containing protein	0.0074	0.0412	0.0817
Loa Loa (eye worm)	AUR protein kinase	0.0137	0.0875	0.0875
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0299	0.2058	0.4081
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0038	0.0151	0.03
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0038	0.0151	0.03
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0038	0.0151	0.03
Entamoeba histolytica	hypothetical protein	0.0036	0.0136	0.0666
Schistosoma mansoni	survival motor neuron protein	0.0144	0.0928	0.0928
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0038	0.0151	0.03
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0316	0.3392
Brugia malayi	hypothetical protein	0.0246	0.1676	0.3324
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0074	0.0412	0.471
Brugia malayi	Peptidase family M1 containing protein	0.0074	0.0412	0.0817
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0081	0.0465	0.0465
Echinococcus multilocularis	tumor protein p63	0.0394	0.2753	0.2753
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0068	0.0372	0.1827
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0335	0.0335
Trypanosoma brucei	aurora B kinase	0.0137	0.0875	1
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1367	0.1367
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0074	0.0412	0.0412
Echinococcus granulosus	intermediate filament protein	0.0081	0.0465	0.0465
Schistosoma mansoni	coup transcription factor	0.0038	0.0151	0.0151
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.2037	1
Schistosoma mansoni	cpg binding protein	0.0061	0.0322	0.0322
Echinococcus granulosus	nuclear receptor nhr 48	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0465	0.0465
Trichomonas vaginalis	set domain proteins, putative	0.0277	0.1901	0.9335
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1128	0.5538
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0018	0.0005	0.0005
Brugia malayi	conserved hypotetical protein	0.0018	0.0005	0.0009
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.002
Onchocerca volvulus		0.0058	0.0298	0.1567
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0208	0.0208
Onchocerca volvulus		0.0144	0.0928	0.4881
Echinococcus granulosus	aurora kinase A	0.0137	0.0875	0.0875
Entamoeba histolytica	hypothetical protein	0.0036	0.0136	0.0666
Toxoplasma gondii	aminopeptidase n, putative	0.0074	0.0412	0.471
Schistosoma mansoni	alpha-glucosidase	0.0142	0.0912	0.0912
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0099	0.0595	0.0595
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0875	0.4294
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0025	0.006	0.0683
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0144	0.0931	1
Echinococcus multilocularis	aurora kinase A	0.0137	0.0875	0.0875
Brugia malayi	nuclear receptor NHR-88	0.0018	0.0005	0.0009
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0928	0.1841
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0088	0.0515	0.5537
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0208	0.0413
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0039	0.0159	0.0159
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0043	0.0191	0.0191
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0018	0.0005	0.0005
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0208	0.0208
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0038	0.0151	0.0151
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0068	0.0372	0.4255
Loa Loa (eye worm)	aminopeptidase N	0.0074	0.0412	0.0412
Schistosoma mansoni	hypothetical protein	0.0036	0.0136	0.0136
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0136	0.0136
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0307	0.1505
Brugia malayi	Proteasome A-type and B-type family protein	0.0088	0.0515	0.1022
Echinococcus multilocularis	phd:f box containing protein	0.0025	0.006	0.006
Brugia malayi	orphan nuclear receptor NR2E1	0.0018	0.0005	0.0009
Onchocerca volvulus	Huntingtin homolog	0.0246	0.1676	0.8813
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0142	0.1618
Echinococcus multilocularis	musashi	0.0081	0.0465	0.0465
Schistosoma mansoni	cpg binding protein	0.0058	0.0298	0.0298
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.108	0.108
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	steroid hormone receptor	0.0038	0.0151	0.03
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0184	0.2104
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0038	0.0151	0.0151
Brugia malayi	jmjC domain containing protein	0.0156	0.1016	0.2015
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0174	0.0174
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0038	0.0151	0.0151
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0142	0.0695
Schistosoma mansoni	retinoic acid receptor RXR	0.0038	0.0151	0.0151
Schistosoma mansoni	cellular tumor antigen P53	0.0058	0.0295	0.0295
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.009	0.1026
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.002	0.004
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0156	0.1016	0.1016
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0316	0.3392
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0156	0.1016	0.1016
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0042	0.0183	0.0897
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0151	0.0151
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0094	0.0565	0.0565
Echinococcus granulosus	ecdysone induced protein 78C	0.0038	0.0151	0.0151
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0025	0.006	0.006
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0184	0.0904
Schistosoma mansoni	hypothetical protein	0.0508	0.3593	0.3593
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0148	0.0148
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1384	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0025	0.006	0.006
Trypanosoma brucei	protein kinase, putative	0.0059	0.0307	0.3505
Loa Loa (eye worm)	hypothetical protein	0.0029	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.002
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1785	0.8764
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0138	0.0138
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0138	0.0138
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0025	0.006	0.0683
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0074	0.0412	0.2022
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Plasmodium vivax	SET domain protein, putative	0.0036	0.0138	0.1573
Brugia malayi	Nuclear hormone receptor E75	0.0018	0.0005	0.0009
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0042	0.0183	0.0183
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Onchocerca volvulus		0.0095	0.0571	0.3005
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0015	0.0015
Brugia malayi	jmjC domain containing protein	0.0025	0.006	0.0118
Echinococcus multilocularis	jumonji domain containing 1A	0.0025	0.006	0.006
Giardia lamblia	Aurora kinase	0.0137	0.0875	0.4294
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0068	0.0372	0.0372
Giardia lamblia	Fructose-bisphosphate aldolase	0.0296	0.2037	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0142	0.0695
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0299	0.2058	0.2058
Echinococcus multilocularis	protein kinase shaggy	0.0059	0.0307	0.0307
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0018	0.0005	0.0005
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.006	0.006
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0316	0.0316
Entamoeba histolytica	protein kinase , putative	0.0137	0.0875	0.4294
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0025	0.006	0.0683
Brugia malayi	Nuclear hormone receptor E75	0.0018	0.0005	0.0009
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.0372	0.4255
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.108	0.108
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0412	0.0412

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 9 nM	Inhibition of Aurora-A by coupled assay	ChEMBL.	19447622
Ki (binding)	= 124 nM	Inhibition of GSK3-beta	ChEMBL.	19447622
Ki (binding)	= 575 nM	Inhibition of Aurora-B	ChEMBL.	19447622

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL552500

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1040708