Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0772 | 0.0967 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.0887 | 0.0125 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.2707 | 0.4187 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0887 | 0.1371 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0887 | 0.1371 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0772 | 0.2087 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0098 | 0.3698 | 0.4345 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.3399 | 0.5258 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.0887 | 0.2398 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0786 | 0.2126 |
Brugia malayi | hypothetical protein | 0.0179 | 0.7506 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0098 | 0.3698 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.0887 | 0.0393 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.0887 | 0.0393 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.3399 | 0.4491 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0772 | 0.1194 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0098 | 0.3698 | 0.572 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0143 | 0.0386 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0887 | 0.0393 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.0887 | 0.2388 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2572 | 0.5994 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.1929 | 0.5216 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.2572 | 0.3978 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0772 | 0.2087 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0772 | 0.0967 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0772 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1109 | 0.1419 |
Giardia lamblia | Kinase, PLK | 0.0098 | 0.3698 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.1381 | 0.4456 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.1929 | 0.5216 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.3399 | 0.9192 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0887 | 0.0393 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3698 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.3399 | 0.4335 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2572 | 0.5994 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0772 | 0.1194 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.7506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2458 | 0.3229 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.2707 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.1381 | 0.4456 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0887 | 0.1121 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.145 | 0.0735 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0098 | 0.3698 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0112 | 0.4356 | 0.3884 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.3399 | 0.9192 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0772 | 0.0711 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.3399 | 0.5258 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.4947 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3698 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.0887 | 0.2398 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0098 | 0.3698 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0887 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0732 | 0.0914 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0772 | 0.1907 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0772 | 0.1907 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.2664 | 0.3321 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0772 | 0.0984 |
Schistosoma mansoni | kinase | 0.005 | 0.1416 | 0.2191 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.145 | 0.3921 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.2572 | 0.3978 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.1381 | 0.3735 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0887 | 0.2388 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.1381 | 0.4456 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.3698 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0143 | 0.0386 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1507 | 0.1953 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0039 | 0.0887 | 0.0594 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0112 | 0.4356 | 0.3884 |
Trypanosoma brucei | polo-like protein kinase | 0.0098 | 0.3698 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3698 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3698 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0772 | 0.0967 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1507 | 0.1725 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.4947 | 0.4524 |
Leishmania major | trypanothione reductase | 0.0049 | 0.1381 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2707 | 0.3562 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 0.732 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0112 | 0.4356 | 0.3884 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0051 | 0.0079 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.1381 | 0.1784 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.3399 | 0.9192 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0772 | 0.0711 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0772 | 0.0984 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.3399 | 0.9192 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.145 | 0.2449 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.2707 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.1381 | 0.1551 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0887 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0772 | 0.0967 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0732 | 0.1133 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1017 | 0.1296 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.145 | 0.3921 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0786 | 0.2126 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.09 | 0.0888 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.2572 | 0.6955 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.1355 | 0.1995 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.0887 | 0.2388 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.2707 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0112 | 0.4356 | 0.8724 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.1381 | 0.2083 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0098 | 0.3698 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0772 | 0.0711 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0772 | 0.0967 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.1381 | 0.066 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2572 | 0.5994 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.2707 | 0.338 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.1355 | 0.1995 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1507 | 0.1725 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.1381 | 0.3735 |
Brugia malayi | hypothetical protein | 0.0074 | 0.2572 | 0.3193 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.4947 | 0.4524 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0112 | 0.4356 | 0.3884 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.1381 | 0.1551 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0772 | 0.0967 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0112 | 0.4356 | 0.3884 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0887 | 0.2388 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.1381 | 0.4456 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3698 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0903 | 0.1144 |
Mycobacterium tuberculosis | Probable reductase | 0.0112 | 0.4356 | 0.3884 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1507 | 0.1953 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.2572 | 0.6955 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.3399 | 0.5258 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.2101 | 0.325 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0098 | 0.3698 | 0.4747 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3698 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0887 | 0.0393 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.1381 | 0.1784 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.3698 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0772 | 0.0711 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2572 | 0.5994 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0732 | 0.0657 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0772 | 0.0967 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.1381 | 0.2083 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.145 | 0.0735 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0098 | 0.3698 | 0.4892 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.4947 | 0.4524 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3698 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.2707 | 0.5163 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0143 | 0.0221 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 0.732 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.1381 | 0.4456 |
Onchocerca volvulus | 0.0179 | 0.7506 | 1 | |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2707 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 38 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.