Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0264 | 0.307 | 0.3067 |
Trypanosoma cruzi | cysteine protease, putative | 0.0136 | 0.1217 | 0.1504 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1807 | 0.3096 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0742 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0177 | 0.1807 | 0.3102 |
Entamoeba histolytica | cysteine protease, putative | 0.0264 | 0.307 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0177 | 0.1807 | 0.3102 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1807 | 0.3096 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0136 | 0.1217 | 0.2089 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Onchocerca volvulus | 0.0177 | 0.1807 | 0.3102 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0136 | 0.1217 | 0.1504 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.0005 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0264 | 0.307 | 0.3067 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0136 | 0.1217 | 0.1461 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Onchocerca volvulus | 0.0264 | 0.307 | 0.527 | |
Loa Loa (eye worm) | cysteine protease | 0.0264 | 0.307 | 0.5266 |
Onchocerca volvulus | Cathepsin L homolog | 0.0264 | 0.307 | 0.527 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0136 | 0.1217 | 0.1461 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Brugia malayi | Cathepsin L-like precursor | 0.0087 | 0.0512 | 0.0879 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0177 | 0.1807 | 0.1807 |
Echinococcus granulosus | cathepsin l1 | 0.0177 | 0.1807 | 0.1803 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0512 | 0.0871 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0177 | 0.1807 | 0.5878 |
Echinococcus multilocularis | Protein lozenge | 0.0057 | 0.0074 | 0.0068 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Plasmodium vivax | vivapain-2 | 0.0264 | 0.307 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0264 | 0.307 | 0.5266 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0087 | 0.0512 | 0.0879 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0087 | 0.0512 | 0.0629 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Plasmodium vivax | unspecified product | 0.0136 | 0.1217 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.1217 | 0.3954 |
Leishmania major | cathepsin L-like protease | 0.0609 | 0.8063 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0512 | 0.0871 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Onchocerca volvulus | 0.0264 | 0.307 | 0.527 | |
Brugia malayi | hypothetical protein | 0.0254 | 0.2933 | 0.5035 |
Leishmania major | cathepsin L-like protease | 0.0264 | 0.307 | 0.3804 |
Schistosoma mansoni | lozenge | 0.0057 | 0.0074 | 0.0074 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0114 | 0.09 | 0.09 |
Loa Loa (eye worm) | runx1 | 0.0057 | 0.0074 | 0.0118 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0087 | 0.0512 | 0.0871 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0136 | 0.1217 | 0.2089 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0136 | 0.1217 | 0.1504 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.1217 | 0.1504 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.1217 | 0.3954 |
Onchocerca volvulus | 0.0264 | 0.307 | 0.527 | |
Brugia malayi | Cathepsin L-like precursor | 0.0264 | 0.307 | 0.527 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Onchocerca volvulus | 0.0264 | 0.307 | 0.527 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0264 | 0.307 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.1217 | 0.1504 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.1084 | 0.1854 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Leishmania major | cathepsin L-like protease | 0.0609 | 0.8063 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0177 | 0.1807 | 0.4178 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Echinococcus granulosus | cysteine protease | 0.0136 | 0.1217 | 0.1213 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.1084 | 0.1861 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0087 | 0.0512 | 0.0629 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0264 | 0.307 | 0.3804 |
Brugia malayi | Cathepsin L-like precursor | 0.0177 | 0.1807 | 0.3102 |
Leishmania major | cysteine peptidase A (CPA) | 0.0264 | 0.307 | 0.3804 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Brugia malayi | Cathepsin L-like precursor | 0.0264 | 0.307 | 0.527 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0264 | 0.307 | 0.5266 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0609 | 0.8063 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0264 | 0.307 | 0.3067 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0136 | 0.1217 | 0.1217 |
Loa Loa (eye worm) | fibroinase | 0.0264 | 0.307 | 0.5266 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.1084 | 0.1854 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2933 | 0.503 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Onchocerca volvulus | 0.0454 | 0.5825 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Brugia malayi | hypothetical protein | 0.0454 | 0.5825 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0087 | 0.0512 | 0.0879 |
Onchocerca volvulus | 0.0264 | 0.307 | 0.527 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0136 | 0.1217 | 0.1217 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0254 | 0.2933 | 0.2929 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0264 | 0.307 | 0.307 |
Leishmania major | cathepsin L-like protease | 0.0264 | 0.307 | 0.3804 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0136 | 0.1217 | 0.1504 |
Onchocerca volvulus | Cathepsin F homolog | 0.0264 | 0.307 | 0.527 |
Onchocerca volvulus | Cathepsin L homolog | 0.0264 | 0.307 | 0.527 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0512 | 0.0871 |
Plasmodium vivax | vivapain-2 | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0177 | 0.1807 | 0.5878 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.09 | 0.09 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0136 | 0.1217 | 0.1461 |
Leishmania major | cathepsin L-like protease | 0.0264 | 0.307 | 0.3804 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0264 | 0.307 | 0.3067 |
Schistosoma mansoni | cathepsin s | 0.0087 | 0.0512 | 0.0512 |
Echinococcus multilocularis | cathepsin L | 0.0136 | 0.1217 | 0.1213 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0254 | 0.2933 | 0.2929 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.0005 | 0.0009 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0609 | 0.8063 | 1 |
Leishmania major | cathepsin L-like protease | 0.0264 | 0.307 | 0.3804 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0264 | 0.307 | 0.3067 |
Plasmodium vivax | vivapain-3 | 0.0136 | 0.1217 | 0.2757 |
Plasmodium vivax | vivapain-1 | 0.0136 | 0.1217 | 0.2757 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0136 | 0.1217 | 0.1461 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0264 | 0.307 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0609 | 0.8063 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0264 | 0.307 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0264 | 0.307 | 0.307 |
Echinococcus multilocularis | cysteine protease | 0.0264 | 0.307 | 0.3067 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0264 | 0.307 | 0.527 |
Loa Loa (eye worm) | ctsf protein | 0.0264 | 0.307 | 0.5266 |
Leishmania major | cathepsin L-like protease | 0.0264 | 0.307 | 0.3804 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Leishmania major | cathepsin L-like protease | 0.0609 | 0.8063 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.307 | 0.5266 |
Onchocerca volvulus | 0.0264 | 0.307 | 0.527 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0136 | 0.1217 | 0.1217 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0136 | 0.1217 | 0.1213 |
Brugia malayi | Cathepsin L-like precursor | 0.0264 | 0.307 | 0.527 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0136 | 0.1217 | 0.1504 |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.5825 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0177 | 0.1807 | 0.3102 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1807 | 0.3096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0264 | 0.307 | 1 |
Echinococcus granulosus | cathepsin L | 0.0136 | 0.1217 | 0.1213 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0393 | 0.4946 | 0.6132 |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.5825 | 1 |
Brugia malayi | hypothetical protein | 0.0114 | 0.09 | 0.1545 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0264 | 0.307 | 0.527 |
Brugia malayi | Cathepsin L-like precursor | 0.0264 | 0.307 | 0.527 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0114 | 0.09 | 0.0895 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0264 | 0.307 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0609 | 0.8063 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0005 | 0.0005 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0136 | 0.1217 | 0.1461 |
Echinococcus multilocularis | cysteine protease | 0.0264 | 0.307 | 0.3067 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0136 | 0.1217 | 0.1461 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0264 | 0.307 | 0.3067 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.1217 | 0.1461 |
Brugia malayi | Cathepsin L-like precursor | 0.0264 | 0.307 | 0.527 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0264 | 0.307 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0114 | 0.09 | 0.0895 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0742 | 1 | 1 |
Onchocerca volvulus | 0.0264 | 0.307 | 0.527 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0609 | 0.8063 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0521 | 0.6799 | 0.8432 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0264 | 0.307 | 0.3067 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -7 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.