TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 661.697 | Formula: C38H33F2N5O4
H donors: 1 H acceptors: 4 LogP: 6.21 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)c1cn(Cc2c(F)cccc2F)c2n(c1=O)c(CN(Cc1ccccc1)C)c(n2)c1ccc(cc1)NC(=O)c1ccccc1
InChi: 1S/C38H33F2N5O4/c1-3-49-37(48)30-23-44(22-29-31(39)15-10-16-32(29)40)38-42-34(26-17-19-28(20-18-26)41-35(46)27-13-8-5-9-14-27)33(45(38)36(30)47)24-43(2)21-25-11-6-4-7-12-25/h4-20,23H,3,21-22,24H2,1-2H3,(H,41,46)
InChiKey: IAPQVOLLBFCQRK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gonadotropin-releasing hormone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GnHR receptor homolog	Get druggable targets OG5_131719	All targets in OG5_131719

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0022
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Brugia malayi	hypothetical protein	0.0309	0.1472	0.147
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.002	0.001	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Schistosoma mansoni	tyrosine kinase	0.0115	0.0493	0.0805
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0078	0.0045
Loa Loa (eye worm)	hypothetical protein	0.003	0.0062	0.0062
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0022
Giardia lamblia	Tenascin-like	0.003	0.0062	0.021
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Leishmania major	hypothetical protein, conserved	0.0077	0.0302	1
Toxoplasma gondii	subtilisin SUB5	0.0053	0.0177	0.4816
Entamoeba histolytica	protein kinase, putative	0.0031	0.0068	0.836
Loa Loa (eye worm)	hypothetical protein	0.011	0.0468	0.0468
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0068	0.0068
Brugia malayi	hypothetical protein	0.0022	0.0022	0.0021
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.075	0.3692	1
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0053	0.0177	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0115	0.0493	0.0672
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0313	0.1491	0.1491
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0026	0.164
Echinococcus multilocularis	enteropeptidase	0.002	0.001	0.0014
Schistosoma mansoni	hypothetical protein	0.0421	0.2037	0.3321
Loa Loa (eye worm)	hypothetical protein	0.002	0.001	0.001
Brugia malayi	Trypsin family protein	0.002	0.001	0.0009
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0127	0.0553	0.0754
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Toxoplasma gondii	subtilisin SUB11	0.0053	0.0177	0.4816
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.0026	0.036
Schistosoma mansoni	integrin alpha	0.0149	0.0665	0.1084
Echinococcus granulosus	integrin alpha ps	0.0067	0.0249	0.0339
Echinococcus granulosus	enteropeptidase	0.002	0.001	0.0014
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.075	0.3692	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0503	0.0503
Echinococcus granulosus	integrin alpha ps	0.0032	0.0073	0.01
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0053	0.0177	0.5
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0057	0.0196	1
Loa Loa (eye worm)	hypothetical protein	0.0484	0.2351	0.2351
Echinococcus multilocularis	Mastin	0.002	0.001	0.0014
Schistosoma mansoni	hypothetical protein	0.0032	0.0073	0.0119
Echinococcus granulosus	dnaJ subfamily B	0.0421	0.2037	0.2775
Plasmodium vivax	subtilisin-like protease 2, putative	0.0053	0.0177	0.5657
Onchocerca volvulus		0.0053	0.0177	0.3643
Loa Loa (eye worm)	subtilase	0.0053	0.0177	0.0177
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0053	0.0177	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0022
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Echinococcus multilocularis	Furin 1	0.0291	0.1381	0.1881
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.002	0.001	0.0017
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.002	0.001	0.0017
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0053	0.0177	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Brugia malayi	celfurPC protein	0.0995	0.4929	0.4928
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1234	0.6132	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0014	0.0019
Brugia malayi	EGF-like domain containing protein	0.003	0.0062	0.006
Brugia malayi	endoprotease bli-4 precursor	0.1234	0.6132	0.6132
Echinococcus granulosus	fibrillin 1	0.003	0.0062	0.0084
Echinococcus granulosus	Furin 1	0.0291	0.1381	0.1881
Loa Loa (eye worm)	integrin alpha pat-2	0.023	0.1073	0.1073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Echinococcus multilocularis	nervana 2	0.002	0.0014	0.0019
Toxoplasma gondii	subtilisin SUB8	0.0053	0.0177	0.4816
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0053	0.0177	0.0242
Echinococcus granulosus	disintegrin and metalloproteinase	0.0018	0.0002	0.0002
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0239	0.1115	0.29
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Schistosoma mansoni	growth factor receptor-bound protein	0.0127	0.0553	0.0903
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0302	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0078	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0077	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.002	0.001	0.001
Trypanosoma brucei	subtilisin peptidase	0.0053	0.0177	0.8374
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0053	0.0177	1
Plasmodium vivax	subtilisin-like serine protease, putative	0.0053	0.0177	0.5657
Brugia malayi	Subtilase family protein	0.0053	0.0177	0.0176
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.002	0.001	0.0017
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0053	0.0177	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0309	0.1472	0.1472
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0291	0.1381	0.2251
Giardia lamblia	Tenascin-37	0.003	0.0062	0.021
Toxoplasma gondii	subtilisin SUB10	0.0053	0.0177	0.4816
Toxoplasma gondii	subtilisin SUB1	0.0053	0.0177	0.4816
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0078	0.0045
Echinococcus granulosus	furin	0.1234	0.6132	0.8357
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.011	0.0468	0.0764
Toxoplasma gondii	subtilisin SUB4	0.0053	0.0177	0.4816
Echinococcus granulosus	MAM	0.0022	0.0022	0.0031
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0015	0.0021
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Toxoplasma gondii	AGC kinase	0.0031	0.0068	0.0254
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0026	0.0042
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Echinococcus multilocularis	neuroendocrine convertase 2	0.0775	0.3821	0.5206
Echinococcus granulosus	transmembrane protease serine 3	0.002	0.001	0.0014
Toxoplasma gondii	subtilisin SUB6	0.0053	0.0177	0.4816
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0129	0.0129
Onchocerca volvulus		0.0048	0.0156	0.3177
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Giardia lamblia	Neurogenic locus notch-like protein	0.003	0.0062	0.021
Giardia lamblia	High cysteine protein	0.003	0.0062	0.021
Echinococcus granulosus	nervana 2	0.002	0.0014	0.0019
Onchocerca volvulus		0.0022	0.0022	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0177	0.0318
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0018	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.002	0.001	0.001
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0053	0.0177	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0078	0.0045
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0026	0.0042
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0015	0.0021
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0053	0.0177	0.0289
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0057	0.0196	0.6329
Loa Loa (eye worm)	reprolysin	0.0043	0.0129	0.0129
Brugia malayi	Trypsin family protein	0.011	0.0468	0.0467
Plasmodium falciparum	subtilisin-like protease 2	0.0053	0.0177	0.5657
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0026	0.0035
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0113	0.0481	0.0479
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0114	0.0487	0.0795
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Brugia malayi	Trypsin family protein	0.002	0.001	0.0009
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Brugia malayi	neuroendocrine convertase 1 precursor	0.0775	0.3821	0.382
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0291	0.1381	0.3633
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Giardia lamblia	High cysteine membrane protein Group 2	0.0458	0.2223	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0468	0.0468
Echinococcus multilocularis	integrin alpha ps	0.0067	0.0249	0.0339
Echinococcus granulosus	epidermal growth factor receptor	0.0115	0.0493	0.0672
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0291	0.1381	0.3633
Brugia malayi	EGF-like domain containing protein	0.003	0.0062	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0177	0.0318
Echinococcus multilocularis	transmembrane protease serine 3	0.002	0.001	0.0014
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0002	0.0002
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0078	0.0045
Onchocerca volvulus		0.0091	0.0369	0.7835
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0239	0.1115	0.29
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Echinococcus multilocularis	adam	0.0086	0.0347	0.0473
Brugia malayi	ADAMTS-like protease	0.0025	0.0039	0.0037
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.002	0.001	0.0014
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0014	0.0019
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0053	0.0177	0.5
Echinococcus granulosus	adam	0.0086	0.0347	0.0473
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.003	0.0048
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0053	0.0177	0.0176
Loa Loa (eye worm)	TK/ALK protein kinase	0.0022	0.0022	0.0022
Schistosoma mansoni	dihydroceramide desaturase	0.0018	0.0002	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0177	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0014	0.0019
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0053	0.0177	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0302	0.0302
Entamoeba histolytica	protein kinase, putative	0.0033	0.0078	1
Onchocerca volvulus		0.0077	0.0302	0.6358
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0327	0.0327
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.075	0.3692	0.5031
Schistosoma mansoni	integrin beta subunit	0.1163	0.5778	0.9422
Onchocerca volvulus		0.011	0.0468	1
Plasmodium vivax	subtilisin-like protease 1	0.0053	0.0177	0.5657
Plasmodium falciparum	subtilisin-like protease 3	0.0053	0.0177	0.5657
Toxoplasma gondii	subtilisin SUB2	0.0053	0.0177	0.4816
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0043	0.0129	0.0176
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0291	0.1381	0.3633
Echinococcus granulosus	glycoprotein Antigen 5	0.002	0.001	0.0014
Loa Loa (eye worm)	hypothetical protein	0.003	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0039	0.0039
Echinococcus multilocularis	fibrillin 1	0.0044	0.0131	0.0179
Echinococcus granulosus	nervana 2	0.002	0.0014	0.0019
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0291	0.1381	0.3633
Brugia malayi	GnHR receptor homolog	0.0566	0.2763	0.2762
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0057	0.0196	0.6329
Trypanosoma cruzi	subtilisin peptidase	0.0053	0.0177	0.5657
Toxoplasma gondii	subtilisin SUB9	0.0053	0.0177	0.4816
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0032	0.0032
Echinococcus granulosus	membrane bound transcription factor site 1	0.0053	0.0177	0.0242
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0053	0.0177	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0039	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Brugia malayi	Furin-like cysteine rich region family protein	0.0115	0.0493	0.0492
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0177	0.0318
Echinococcus granulosus	integrin alpha 3	0.0115	0.0489	0.0666
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0026	0.164
Trypanosoma cruzi	Protein kinase B	0.0023	0.0026	0.036
Brugia malayi	angiogenesis inhibito	0.0025	0.0039	0.0037
Echinococcus multilocularis	fibrillin 2	0.003	0.0062	0.0084
Toxoplasma gondii	subtilisin SUB7	0.0053	0.0177	0.4816
Brugia malayi	Kringle domain containing protein	0.0077	0.0302	0.03
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Brugia malayi	Sex muscle abnormal protein 5	0.0127	0.0553	0.0552
Schistosoma mansoni	furin-1 (S08 family)	0.0537	0.2617	0.4268
Mycobacterium leprae	Possible secreted protease	0.0053	0.0177	0.5
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0068	0.0066
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0043	0.0129	0.0211
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0026	0.0035
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Onchocerca volvulus		0.003	0.0062	0.1121
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.002	0.001	0.0009
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0018	0.0002	0.0002
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0078	0.0045
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0025	0.0039	0.0037
Brugia malayi	hypothetical protein	0.0057	0.0197	0.0195
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.002	0.001	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0078	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Loa Loa (eye worm)	hypothetical protein	0.1234	0.6132	0.6132
Toxoplasma gondii	kringle domain-containing protein	0.0077	0.0302	1
Giardia lamblia	Neurogenic locus Notch protein precursor	0.003	0.0062	0.021
Schistosoma mansoni	hypothetical protein	0.002	0.001	0.0017
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Brugia malayi	Kelch motif family protein	0.0313	0.1491	0.1489
Loa Loa (eye worm)	hypothetical protein	0.002	0.001	0.001
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.002	0.001	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Loa Loa (eye worm)	integrin beta-2	0.2001	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0062	0.0062
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0053	0.0177	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0481	0.0481
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0053	0.0177	0.5657
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0043	0.0129	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0087	0.0087
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0053	0.0177	0.0176
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0239	0.1115	0.29
Loa Loa (eye worm)	hypothetical protein	0.003	0.0062	0.0062
Onchocerca volvulus		0.0022	0.0022	0.026
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Echinococcus multilocularis	glycoprotein Antigen 5	0.002	0.001	0.0014
Toxoplasma gondii	subtilisin SUB12	0.0067	0.0251	0.7903
Echinococcus multilocularis	dnaJ subfamily B	0.0421	0.2037	0.2775
Schistosoma mansoni	hypothetical protein	0.0022	0.0022	0.0037
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Brugia malayi	Reprolysin	0.0025	0.0039	0.0037
Giardia lamblia	Tenascin-X	0.003	0.0062	0.021
Echinococcus multilocularis	MAM	0.0022	0.0022	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0177	0.0318
Loa Loa (eye worm)	trypsin family protein	0.002	0.001	0.001
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0078	0.0045
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Echinococcus multilocularis	tissue type plasminogen activator	0.0077	0.0302	0.0411
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0053	0.0177	1
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0302	0.03
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Echinococcus multilocularis		0.0995	0.4929	0.6717
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0291	0.1381	0.3633
Trichomonas vaginalis	hypothetical protein	0.0239	0.1115	0.29
Schistosoma mansoni	growth factor receptor-bound protein	0.0127	0.0553	0.0903
Echinococcus multilocularis	protein jagged 2	0.003	0.0062	0.0084
Echinococcus granulosus	tissue type plasminogen activator	0.0077	0.0302	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0073	0.0073
Echinococcus granulosus	growth factor receptor bound protein 2	0.0127	0.0553	0.0754
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0077	0.0302	1
Echinococcus granulosus	fibrillin 2	0.003	0.0062	0.0084
Schistosoma mansoni	hypothetical protein	0.002	0.001	0.0017
Schistosoma mansoni	hypothetical protein	0.0077	0.0302	0.0492
Brugia malayi	EGF-like domain containing protein	0.003	0.0062	0.006
Echinococcus granulosus	adam 17 protease	0.0018	0.0002	0.0002
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0078	0.0045
Giardia lamblia	High cysteine protein	0.003	0.0062	0.021
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0014	0.0019
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Brugia malayi	hypothetical protein	0.002	0.001	0.0009
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0291	0.1381	0.3633
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Brugia malayi	Integrin alpha pat-2 precursor	0.0149	0.0665	0.0663
Brugia malayi	Trypsin family protein	0.002	0.001	0.0009
Echinococcus multilocularis	nervana 2	0.002	0.0014	0.0019
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.002	0.001	0.0014
Echinococcus multilocularis	integrin beta 2	0.1473	0.7338	1
Echinococcus multilocularis	integrin alpha ps	0.0032	0.0073	0.01
Loa Loa (eye worm)	proprotein convertase 2	0.0291	0.1381	0.1381
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0015	0.0021
Giardia lamblia	Furin precursor putative serine protease	0.0239	0.1115	0.498
Schistosoma mansoni	hypothetical protein	0.0239	0.1115	0.1818
Schistosoma mansoni	integrin alpha-ps	0.0035	0.0087	0.0142
Plasmodium falciparum	subtilisin-like protease 1	0.0053	0.0177	0.5657
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.075	0.3692	0.5031
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0057	0.0197	0.0321
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0022	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Echinococcus multilocularis	integrin alpha ps	0.0067	0.0249	0.0339
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Brugia malayi	proprotein convertase 2	0.0775	0.3821	0.382
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Schistosoma mansoni	integrin alpha-ps	0.0067	0.0249	0.0406
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0053	0.0177	0.0318
Echinococcus granulosus	Mastin	0.002	0.001	0.0014
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0053	0.0177	1
Echinococcus multilocularis	disintegrin and metalloproteinase	0.0018	0.0002	0.0002
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0127	0.0553	0.0553
Brugia malayi	Trypsin-like protease protein 5	0.002	0.001	0.0009
Echinococcus multilocularis	integrin alpha 3	0.0115	0.0489	0.0666
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.002	0.001	0.0014
Schistosoma mansoni	hypothetical protein	0.0022	0.0022	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.1115	0.29
Echinococcus granulosus	integrin beta 2	0.1473	0.7338	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0115	0.0493	0.0493
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0043	0.0129	0.0176
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0078	0.0078
Giardia lamblia	Tenascin precursor	0.003	0.0062	0.021
Plasmodium falciparum	cysteine repeat modular protein 1	0.0077	0.0302	1
Loa Loa (eye worm)	endoprotease bli-4	0.1234	0.6132	0.6132
Brugia malayi	EGF-like domain containing protein	0.003	0.0062	0.006
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0177	0.0177
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0053	0.0177	0.0289
Schistosoma mansoni	cercarial elastase (S01 family)	0.002	0.001	0.0017
Giardia lamblia	hypothetical protein	0.003	0.0062	0.021
Echinococcus granulosus	neuroendocrine convertase 2	0.0775	0.3821	0.5206
Loa Loa (eye worm)	hypothetical protein	0.002	0.001	0.001

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 20 nM	In vitro inhibition of specific [125I]-leuprorelin binding to the cloned human LHRH receptor expressed in chinese hamster ovary cells	ChEMBL.	12127507
IC50 (binding)	= 20 nM	In vitro inhibition of specific [125I]-leuprorelin binding to the cloned human LHRH receptor expressed in chinese hamster ovary cells	ChEMBL.	12127507

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 104092