Detailed information for compound 1041171

Basic information

Technical information
  • TDR Targets ID: 1041171
  • Name: N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyri midin-2-yl]sulfanylphenyl]acetamide
  • MW: 340.403 | Formula: C16H16N6OS
  • H donors: 3 H acceptors: 4 LogP: 2.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)Sc1nccc(n1)Nc1n[nH]c(c1)C
  • InChi: 1S/C16H16N6OS/c1-10-9-15(22-21-10)19-14-7-8-17-16(20-14)24-13-5-3-12(4-6-13)18-11(2)23/h3-9H,1-2H3,(H,18,23)(H2,17,19,20,21,22)
  • InChiKey: BGNRYQCGVJJPRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]acetamide
  • N-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]acetamide
  • N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0014 0.002
Onchocerca volvulus 0.0029 0.0086 0.0147
Echinococcus multilocularis protein kinase c eta type 0.0132 0.0737 0.0736
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0286 0.1702 0.3352
Echinococcus granulosus lamin 0.0032 0.0106 0.0208
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.02
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0014 0.002
Schistosoma mansoni rac gtpase activating protein 0.0132 0.0737 0.1451
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0064 0.0182
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0014 0.0034
Entamoeba histolytica protein kinase, putative 0.0144 0.0811 0.4587
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0014 0.002
Giardia lamblia Kinase, NEK 0.0171 0.0977 0.5244
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0079 0.0124
Brugia malayi Protein kinase domain containing protein 0.0037 0.0137 0.0393
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0037 0.0137 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0086 0.017
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0286 0.1702 0.4325
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.0318
Echinococcus multilocularis Diacylglycerol kinase theta 0.0132 0.0737 0.0736
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0123 0.0311
Echinococcus multilocularis protein kinase c iota type 0.0448 0.2718 0.2718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0068 0.0325
Schistosoma mansoni protein kinase C mu 0.0384 0.232 0.457
Echinococcus multilocularis raf serine:threonine protein kinase 0.0132 0.0737 0.0736
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0014 0.002
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0046 0.0196 0.0453
Echinococcus multilocularis serine threonine protein kinase 0.0399 0.2413 0.2413
Brugia malayi intermediate filament protein 0.0032 0.0106 0.0303
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0037 0.0137 0.0271
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0086 0.017
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0064 0.0298
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0132 0.0737 0.0736
Brugia malayi Uncoordinated protein 44 0.0028 0.0079 0.0226
Brugia malayi Pleckstrin Homology Domain 0.0141 0.0788 0.2256
Toxoplasma gondii protein kinase domain-containing protein 0.0017 0.0013 0.0076
Mycobacterium tuberculosis Conserved protein 0.0059 0.0273 0.0418
Loa Loa (eye worm) raf kinase 0.0132 0.0737 0.1708
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.008 0.0156
Mycobacterium ulcerans hypothetical protein 0.0059 0.0273 0.0398
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0179 0.1049
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0177 0.0409
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0286 0.1702 0.3352
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0179 0.0178
Echinococcus granulosus NDR protein kinase 0.0151 0.0852 0.1679
Loa Loa (eye worm) AGC/PKA protein kinase 0.0286 0.1702 0.3948
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0414 0.2505 0.382
Entamoeba histolytica protein kinase, putative 0.0144 0.0811 0.4587
Leishmania major protein kinase A catalytic subunit isoform 2 0.0286 0.1702 1
Echinococcus granulosus axis inhibition protein axin 0.0037 0.0137 0.027
Trichomonas vaginalis AGC family protein kinase 0.0151 0.0852 0.497
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0636
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0017 0.0013 0.0033
Schistosoma mansoni z-protein (S1r protein) 0.0037 0.0137 0.0271
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0179 0.0952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.0563
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.1516
Echinococcus granulosus regulator of G protein signaling 3 0.0037 0.0137 0.027
Echinococcus granulosus serine/threonine protein kinase 0.0017 0.0013 0.0025
Schistosoma mansoni protein kinase C mu 0.0132 0.0737 0.1451
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0179 0.0352
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Echinococcus multilocularis Rac GTPase activating protein 1 0.0132 0.0737 0.0736
Echinococcus granulosus axis inhibition protein axin 0.0037 0.0137 0.027
Loa Loa (eye worm) cytochrome P450 0.0018 0.0014 0.0031
Brugia malayi hypothetical protein 0.0037 0.0137 0.0393
Entamoeba histolytica PH domain containing protein kinase, putative 0.0294 0.1753 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0072
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0079 0.0079
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0286 0.1702 0.1702
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.0137 0.027
Toxoplasma gondii diacylglycerol kinase, putative 0.0132 0.0737 0.4327
Loa Loa (eye worm) AUR protein kinase 0.0144 0.0811 0.1882
Echinococcus multilocularis protein kinase c epsilon type 0.0571 0.3493 0.3493
Trichomonas vaginalis AGC family protein kinase 0.0286 0.1702 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0068 0.0325
Echinococcus granulosus intermediate filament protein 0.0032 0.0106 0.0208
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0286 0.1702 1
Echinococcus multilocularis axis inhibition protein axin 0.0037 0.0137 0.0137
Echinococcus granulosus expressed protein 0.0724 0.4457 0.8779
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0252 0.1487 0.3449
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.0318
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0636
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.0737 0.4157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0315
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0286 0.1702 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0144 0.0811 0.4587
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0231 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0137 0.0736
Giardia lamblia Kinase, AGC PKA 0.0286 0.1702 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0315
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0852 0.1679
Onchocerca volvulus 0.0243 0.1429 0.4185
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0046 0.0196 0.056
Brugia malayi Protein kinase c protein 2 0.039 0.2355 0.6743
Brugia malayi Cytochrome P450 family protein 0.0043 0.0177 0.0506
Mycobacterium tuberculosis Possible conserved lipoprotein LppH 0.0059 0.0273 0.0418
Brugia malayi hypothetical protein 0.0119 0.0654 0.1872
Brugia malayi hypothetical protein 0.0037 0.0137 0.0393
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0014 0.0034
Mycobacterium ulcerans lipoprotein 0.0059 0.0273 0.0398
Loa Loa (eye worm) hypothetical protein 0.0132 0.0737 0.1708
Mycobacterium tuberculosis Probable lipoprotein LprH 0.0059 0.0273 0.0418
Echinococcus granulosus serine:threonine protein kinase N2 0.0151 0.0852 0.1679
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0021 0.0034 0.0077
Loa Loa (eye worm) hypothetical protein 0.0243 0.1429 0.3314
Echinococcus granulosus beta-adrenergic receptor kinase 0.0046 0.0196 0.0385
Mycobacterium ulcerans lipoprotein LppR 0.0059 0.0273 0.0398
Leishmania major protein kinase A catalytic subunit 0.0286 0.1702 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0286 0.1702 0.1702
Schistosoma mansoni atypical protein kinase C 0.046 0.2794 0.5504
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0137 0.0271
Echinococcus multilocularis regulator of G protein signaling 3 0.0037 0.0137 0.0137
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.0737 0.4157
Mycobacterium tuberculosis Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H) 0.023 0.1347 0.2061
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0014 0.002
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0811 0.4726
Echinococcus multilocularis musashi 0.0032 0.0106 0.0105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1178 0.2733
Mycobacterium ulcerans lipoprotein LppH 0.0059 0.0273 0.0398
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0811 0.4726
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0014 0.0079
Toxoplasma gondii AGC kinase 0.0286 0.1702 1
Brugia malayi RhoGEF domain containing protein 0.0132 0.0737 0.2109
Onchocerca volvulus 0.0032 0.0106 0.0205
Echinococcus granulosus unc 13 munc13 0.0145 0.0815 0.1605
Leishmania major protein kinase, putative 0.0017 0.0013 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0196 0.0385
Entamoeba histolytica hypothetical protein 0.0037 0.0137 0.0714
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0255 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.0563
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0137 0.0271
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0151 0.0852 0.1679
Trypanosoma cruzi NIMA-related kinase, putative 0.0017 0.0013 0.0033
Brugia malayi Death domain containing protein 0.0028 0.0079 0.0226
Leishmania major cytochrome p450-like protein 0.0018 0.0014 0.0079
Treponema pallidum penicillin-binding protein (pbp-3) 0.0414 0.2505 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.1702 0.3352
Loa Loa (eye worm) hypothetical protein 0.055 0.3361 0.7798
Echinococcus multilocularis axis inhibition protein axin 0.0037 0.0137 0.0137
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0286 0.1702 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.023
Mycobacterium leprae conserved hypothetical protein 0.0059 0.0273 0.0398
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0186
Loa Loa (eye worm) hypothetical protein 0.0243 0.1429 0.3314
Giardia lamblia Kinase, NEK 0.0171 0.0977 0.5244
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1354 0.7943
Entamoeba histolytica protein kinase, putative 0.0151 0.0852 0.4823
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0151 0.0852 0.1679
Loa Loa (eye worm) hypothetical protein 0.0141 0.0788 0.1827
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0037 0.0137 0.0271
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0151 0.0852 0.1679
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0641 0.3934 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0086 0.0506
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0142 0.0795 0.1565
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0037 0.0137 0.027
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0 0.0001
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0286 0.1702 0.3352
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.0137 0.0137
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0151 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0701 0.431 1
Schistosoma mansoni serine/threonine protein kinase 0.0571 0.3493 0.688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0082 0.0409
Echinococcus multilocularis Regulator of G protein signaling 20 0.0037 0.0137 0.0137
Mycobacterium tuberculosis Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E) 0.0171 0.0977 0.1495
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0017 0.0013 0.0076
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0286 0.1702 0.4325
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0123 0.0719
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0064 0.0298
Onchocerca volvulus 0.0231 0.1356 0.3966
Brugia malayi cytochrome P450 0.0018 0.0014 0.0039
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0236 0.1386 0.1385
Brugia malayi PXA domain containing protein 0.0037 0.0137 0.0393
Schistosoma mansoni diacylglycerol kinase theta 0.0132 0.0737 0.1451
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0017 0.0013 0.0033
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0151 0.0852 0.1977
Brugia malayi Protein kinase domain containing protein 0.0142 0.0795 0.2275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0086 0.017
Leishmania major serine/threonine-protein kinase a, putative 0.0017 0.0013 0.0076
Echinococcus granulosus RNA directed DNA polymerase 0.0236 0.1386 0.2729
Echinococcus multilocularis serine:threonine protein kinase N2 0.0426 0.2581 0.2581
Entamoeba histolytica protein kinase , putative 0.0144 0.0811 0.4587
Schistosoma mansoni vav2 0.0141 0.0788 0.1552
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0014 0.002
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0811 0.4726
Echinococcus granulosus microtubule associated protein 2 0.0823 0.5077 1
Onchocerca volvulus 0.0375 0.2262 0.6691
Brugia malayi isocitrate dehydrogenase 0.0015 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0182
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0286 0.1702 0.4325
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0179 0.1049
Brugia malayi Ras association domain family 1 isoform A 0.0132 0.0737 0.2109
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) 0.0162 0.0919 0.1406
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0124 0.0124
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0571 0.3493 0.8104
Loa Loa (eye worm) hypothetical protein 0.0683 0.4194 0.9731
Loa Loa (eye worm) RasGEF domain-containing protein 0.0132 0.0737 0.1708
Brugia malayi RhoGAP domain containing protein 0.0132 0.0737 0.2109
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.0647
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0014 0.002
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0014 0.002
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0384 0.232 0.6642
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0151 0.0852 0.0852
Entamoeba histolytica PH domain containing protein kinase, putative 0.0294 0.1753 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0144 0.0811 0.1597
Echinococcus granulosus Protein kinase C brain isozyme 0.0532 0.3246 0.6394
Trichomonas vaginalis AGC family protein kinase 0.0151 0.0852 0.497
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0014 0.0079
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0286 0.1702 1
Echinococcus multilocularis 0.0018 0.0014 0.0013
Echinococcus granulosus protein kinase c epsilon type 0.0571 0.3493 0.688
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Loa Loa (eye worm) PXA domain-containing protein 0.0037 0.0137 0.0318
Mycobacterium ulcerans lipoprotein LpqQ 0.0059 0.0273 0.0398
Schistosoma mansoni protein kinase C 0.0145 0.0815 0.1606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.0563
Trypanosoma brucei protein kinase, putative 0.0017 0.0013 0.0076
Schistosoma mansoni hypothetical protein 0.0171 0.0976 0.1922
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0137 0.0736
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0014 0.002
Schistosoma mansoni hypothetical protein 0.0171 0.0976 0.1922
Echinococcus multilocularis RNA directed DNA polymerase 0.0236 0.1386 0.1385
Loa Loa (eye worm) hypothetical protein 0.0132 0.0737 0.1708
Loa Loa (eye worm) hypothetical protein 0.0132 0.0737 0.1708
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0017 0.0013 0.0033
Onchocerca volvulus 0.0383 0.2313 0.6846
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0737 0.1451
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0017 0.0013 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0014 0.002
Echinococcus granulosus nuclear factor of activated T cells 5 0.0143 0.0802 0.1579
Loa Loa (eye worm) AGC/PKN protein kinase 0.0151 0.0852 0.1977
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0137 0.0736
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0037 0.0137 0.0271
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0255 0.073
Onchocerca volvulus 0.0032 0.0106 0.0205
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0106 0.0245
Entamoeba histolytica protein kinase, putative 0.0159 0.0904 0.5119
Echinococcus multilocularis geminin 0.0171 0.0976 0.0975
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0286 0.1702 0.1702
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0384 0.232 0.5382
Loa Loa (eye worm) hypothetical protein 0.0368 0.2218 0.5146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.0318
Schistosoma mansoni serine/threonine-protein kinase 0.0017 0.0013 0.0026
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0037 0.0137 0.0318
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0017 0.0013 0.0076
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0017 0.0013 0.0033
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0641 0.3934 1
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0852 0.1679
Echinococcus multilocularis aurora kinase A 0.0144 0.0811 0.0811
Loa Loa (eye worm) AGC/PKA protein kinase 0.0286 0.1702 0.3948
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0255 0.0255
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0145 0.0815 0.1605
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0795 0.1565
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0318 0.1903 0.4415
Loa Loa (eye worm) hypothetical protein 0.0132 0.0737 0.1708
Trypanosoma cruzi aurora B kinase, putative 0.0144 0.0811 0.2062
Echinococcus multilocularis microtubule associated protein 2 0.0823 0.5077 0.5077
Onchocerca volvulus 0.0145 0.0815 0.2339
Leishmania major protein kinase A catalytic subunit isoform 1 0.0286 0.1702 1
Loa Loa (eye worm) RecQ helicase 0.0025 0.0064 0.0147
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0179 0.0352
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0177 0.0448
Schistosoma mansoni hypothetical protein 0.0028 0.0079 0.0156
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.001 0.0059
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0255 0.039
Echinococcus granulosus serine:threonine protein kinase N2 0.0284 0.1691 0.333
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0151 0.0852 0.0852
Trypanosoma brucei aurora B kinase 0.0144 0.0811 0.4766
Loa Loa (eye worm) hypothetical protein 0.0145 0.0815 0.189
Loa Loa (eye worm) hypothetical protein 0.055 0.3361 0.7798
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0014 0.0026
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0132 0.0737 0.145
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0811 0.4726
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0179 0.0414
Brugia malayi Regulator of G protein signaling domain containing protein 0.0037 0.0137 0.0393
Echinococcus granulosus geminin 0.0171 0.0976 0.1921
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0177 0.1036
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0142 0.0795 0.0794
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0144 0.0811 0.4766
Brugia malayi Hr1 repeat family protein 0.0151 0.0852 0.2441
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0277 0.1644 0.3237
Echinococcus multilocularis unc 13 (munc13) 0.0145 0.0815 0.0815
Leishmania major protein kinase, putative 0.0144 0.0811 0.4766
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0012 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0137 0.0271
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0196 0.0385
Brugia malayi Protein kinase domain containing protein 0.0021 0.0038 0.0108
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.003 0.0059
Brugia malayi A-kinase anchor protein 10, precursor 0.0037 0.0137 0.0393
Onchocerca volvulus 0.055 0.3361 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0017 0.0013 0.0076
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0179 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0852 0.1679
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0177 0.025
Entamoeba histolytica protein kinase, putative 0.0151 0.0852 0.4823
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0143 0.0802 0.0802
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.1055 0.6535 1
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0079 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0088 0.0444
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0136 0.0314
Brugia malayi regulator of G-protein signaling rgs-7 0.0037 0.0137 0.0393
Brugia malayi diacylglycerol kinase 0.0132 0.0737 0.2109
Echinococcus granulosus Ankyrin 0.0028 0.008 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.0231
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0179 0.1049
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0179 0.0454
Loa Loa (eye worm) hypothetical protein 0.0132 0.0737 0.1708
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0079 0.0079
Giardia lamblia Aurora kinase 0.0144 0.0811 0.4153
Brugia malayi RhoGAP domain containing protein 0.0132 0.0737 0.2109
Loa Loa (eye worm) RGS-3 protein 0.0037 0.0137 0.0318
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0079 0.0156
Echinococcus multilocularis rac serine:threonine kinase 0.0017 0.0013 0.0013
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0137 0.0271
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0014 0.002
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0641 0.3934 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.2262 0.5247
Loa Loa (eye worm) hypothetical protein 0.0286 0.1702 0.3948
Entamoeba histolytica hypothetical protein 0.0037 0.0137 0.0714
Treponema pallidum hypothetical protein 0.0414 0.2505 0.5
Plasmodium falciparum calcium-dependent protein kinase 7 0.0017 0.0013 0.0076
Loa Loa (eye worm) hypothetical protein 0.0236 0.1386 0.3214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0179 0.0981
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0034 0.0096
Schistosoma mansoni axis inhibition protein axin 0.0037 0.0137 0.0271
Mycobacterium ulcerans lipoprotein LpqA 0.0059 0.0273 0.0398
Schistosoma mansoni cytochrome P450 0.0018 0.0014 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0179 0.0981
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0144 0.0811 0.4587
Schistosoma mansoni hypothetical protein 0.0018 0.0014 0.0027
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0151 0.0852 0.1977
Echinococcus multilocularis regulator of G protein signaling 0.0037 0.0137 0.0137
Brugia malayi hypothetical protein 0.0035 0.0124 0.0355
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.1702 0.3352
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0001 0.0002
Mycobacterium tuberculosis Probable lipoprotein LpqA 0.0059 0.0273 0.0418
Trypanosoma cruzi NIMA-related kinase, putative 0.0017 0.0013 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0086 0.017
Loa Loa (eye worm) hypothetical protein 0.0132 0.0737 0.1708
Echinococcus granulosus protein kinase c iota type 0.0448 0.2718 0.5354
Leishmania major protein kinase, putative 0.0017 0.0013 0.0076
Mycobacterium ulcerans Ser/Thr protein kinase 0.0171 0.0977 0.1478
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0286 0.1702 1
Schistosoma mansoni axis inhibition protein axin 0.0037 0.0137 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0137 0.0736
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0179 0.1049
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.0737 0.1451
Trypanosoma cruzi Protein kinase B 0.0017 0.0013 0.0033
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0255 0.0502
Entamoeba histolytica protein kinase domain containing protein 0.0144 0.0811 0.4587
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0132 0.0737 0.1708
Brugia malayi protein kinase C II. 0.0571 0.3493 1
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0414 0.2505 0.382
Echinococcus granulosus lamin dm0 0.0032 0.0106 0.0208
Brugia malayi C1-like domain containing protein 0.0384 0.232 0.6642
Echinococcus granulosus myotubularin protein 13 0.0141 0.0788 0.1551
Brugia malayi Protein kinase domain containing protein 0.0159 0.0904 0.2588
Echinococcus granulosus N chimaerin 0.0132 0.0737 0.145
Schistosoma mansoni serine/threonine kinase 0.0151 0.0852 0.1679
Brugia malayi Cytochrome P450 family protein 0.0037 0.0136 0.0389
Entamoeba histolytica protein kinase, putative 0.0022 0.004 0.0157
Schistosoma mansoni microtubule-associated protein tau 0.0823 0.5077 1
Schistosoma mansoni unc-13 (munc13) 0.0147 0.0827 0.1629
Echinococcus multilocularis beta adrenergic receptor kinase 0.0046 0.0196 0.0195
Schistosoma mansoni diacylglycerol kinase theta 0.0132 0.0737 0.1451
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0106 0.0303
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.0737 0.1451
Brugia malayi Cytochrome P450 family protein 0.0043 0.0177 0.0506
Mycobacterium tuberculosis Probable conserved lipoprotein LppR 0.0059 0.0273 0.0418
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0017 0.0013 0.0033
Brugia malayi protein kinase C3,putative 0.0306 0.1828 0.5232
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0014 0.002
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0123 0.0719
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0017 0.0013 0.0076
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0079 0.0155
Brugia malayi Isocitrate dehydrogenase 0.0015 0 0.0001
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0641 0.3934 1
Entamoeba histolytica hypothetical protein 0.0037 0.0137 0.0714
Echinococcus granulosus death domain containing protein 0.0028 0.0079 0.0155
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0064 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0852 0.1679
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0017 0.0013 0.0033
Echinococcus multilocularis serine:threonine protein kinase N2 0.0151 0.0852 0.0852
Toxoplasma gondii AGC kinase 0.0286 0.1702 1
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0106 0.0245
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0255 0.0502
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0236
Brugia malayi Pre-SET motif family protein 0.0203 0.1178 0.3373
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0179 0.0952
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0017 0.0013 0.0033
Schistosoma mansoni hypothetical protein 0.0132 0.0737 0.1451
Loa Loa (eye worm) hypothetical protein 0.0383 0.2313 0.5366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0068 0.0325
Schistosoma mansoni serine/threonine-protein kinase 0.0017 0.0013 0.0026
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.0137 0.027
Echinococcus multilocularis expressed protein 0.0724 0.4457 0.4456
Schistosoma mansoni protein kinase 0.0144 0.0811 0.1598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.0231
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0286 0.1702 0.4325
Echinococcus granulosus aurora kinase A 0.0144 0.0811 0.1597
Schistosoma mansoni lamin 0.0032 0.0106 0.0208
Brugia malayi Regulator of G protein signaling domain containing protein 0.0037 0.0137 0.0393
Echinococcus granulosus bloom syndrome protein 0.0025 0.0064 0.0124
Brugia malayi serine/threonine protein kinase 6 0.0144 0.0811 0.2323
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.0318
Plasmodium falciparum serine/threonine protein kinase, putative 0.0144 0.0811 0.4766
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0018 0.0103
Loa Loa (eye worm) hypothetical protein 0.055 0.3361 0.7798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.0231
Echinococcus granulosus Regulator of G protein signaling 20 0.0037 0.0137 0.027
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0014 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.0231
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.1055 0.6535 1
Echinococcus multilocularis Ankyrin 0.0028 0.008 0.008
Echinococcus granulosus Diacylglycerol kinase theta 0.0132 0.0737 0.145
Echinococcus granulosus Rac GTPase activating protein 1 0.0132 0.0737 0.145
Echinococcus granulosus raf serine:threonine protein kinase 0.0132 0.0737 0.145
Leishmania major folate/biopterin transporter, putative 0.0017 0.0013 0.0076
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0142 0.0794 0.4625
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0132 0.0737 0.1708
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0017 0.0013 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0014 0.002
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0532 0.3246 0.3246
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0012 0.0067
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.008 0.0158
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.0318
Mycobacterium ulcerans hypothetical protein 0.0059 0.0273 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.0563
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0258 0.1522 0.3531
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0086 0.0506
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0179 0.0454
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0144 0.0811 0.4587
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0795 0.1565
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.1055 0.6535 1
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.0647
Echinococcus multilocularis serine:threonine protein kinase 38 0.0151 0.0852 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.0647
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0177 0.0409
Mycobacterium ulcerans lipoprotein LppR 0.0059 0.0273 0.0398
Schistosoma mansoni intermediate filament proteins 0.0032 0.0106 0.0208
Toxoplasma gondii aurora kinase 0.0144 0.0811 0.4766
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0196 0.0385
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0636
Brugia malayi diacylglycerol kinase 0.0132 0.0737 0.2109
Echinococcus multilocularis lamin 0.0032 0.0106 0.0105
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0151 0.0852 0.1977
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0014 0.002
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0904 0.5274
Leishmania major cytochrome p450-like protein 0.0018 0.0014 0.0079
Entamoeba histolytica protein kinase, putative 0.0022 0.004 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0079 0.0226
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0255 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0137 0.0736
Entamoeba histolytica hypothetical protein 0.0132 0.0737 0.4157
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0137 0.0736
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0145 0.0815 0.0815
Loa Loa (eye worm) AUR protein kinase 0.0144 0.0811 0.1882
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0151 0.0852 0.1977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.023
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0014 0.0079
Echinococcus multilocularis myotubularin protein 13 0.0141 0.0788 0.0788
Brugia malayi serine/threonine kinase 12 0.0144 0.0811 0.2323
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0286 0.1702 0.4872
Brugia malayi PXA domain containing protein 0.0037 0.0137 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0139 0.0743
Leishmania major cytochrome p450-like protein 0.0043 0.0177 0.1036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0086 0.017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0086 0.0086
Onchocerca volvulus Huntingtin homolog 0.0119 0.0654 0.1854
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0037 0.0137 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.0563
Brugia malayi Variant SH3 domain containing protein 0.0132 0.0737 0.2109
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0017 0.0013 0.0076
Schistosoma mansoni unc-13 (munc13) 0.0145 0.0815 0.1606
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0286 0.1702 1
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0177 0.0448
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0046 0.0196 0.0453
Loa Loa (eye worm) AGC/NDR protein kinase 0.0151 0.0852 0.1977
Echinococcus granulosus regulator of G protein signaling 3 0.0037 0.0137 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.0563
Brugia malayi Pre-SET motif family protein 0.0029 0.0086 0.0247
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0017 0.0013 0.0033
Mycobacterium tuberculosis Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro 0.0171 0.0977 0.1495
Schistosoma mansoni serine/threonine protein kinase 0.0532 0.3246 0.6394
Trypanosoma brucei rac serine-threonine kinase, putative 0.0159 0.0904 0.531
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0286 0.1702 0.1702
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.1516
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0014 0.002
Onchocerca volvulus Huntingtin homolog 0.0119 0.0654 0.1854
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0014 0.002
Mycobacterium ulcerans Ser/Thr protein kinase 0.0171 0.0977 0.1478
Brugia malayi Protein kinase domain containing protein 0.0151 0.0852 0.2441
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0144 0.0811 0.0811
Trichomonas vaginalis AGC family protein kinase 0.0151 0.0852 0.497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.023
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0017 0.0013 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0014 0.002
Brugia malayi Cytochrome P450 family protein 0.0018 0.0014 0.0039
Echinococcus multilocularis lamin dm0 0.0032 0.0106 0.0105
Loa Loa (eye worm) AUR protein kinase 0.0144 0.0811 0.1882
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0811 0.1598
Echinococcus multilocularis N chimaerin 0.0132 0.0737 0.0736
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.0318
Echinococcus granulosus protein kinase c eta type 0.0132 0.0737 0.145
Schistosoma mansoni hypothetical protein 0.0035 0.0124 0.0244
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0021 0.0038 0.0086
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0277 0.1644 0.1643
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0255 0.1496
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0079 0.0182
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0108 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0179 0.0981
Echinococcus multilocularis regulator of G protein signaling 3 0.0037 0.0137 0.0137
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0132 0.0737 0.1708
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0034 0.0196
Mycobacterium tuberculosis Possible lipoprotein LpqQ 0.0059 0.0273 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.0647
Schistosoma mansoni lamin 0.0032 0.0106 0.0208
Loa Loa (eye worm) AGC/AKT protein kinase 0.0159 0.0904 0.2096
Brugia malayi regulator of G-protein signaling egl-10 0.0037 0.0137 0.0393
Entamoeba histolytica PH domain containing protein kinase, putative 0.0292 0.1742 0.9936
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0012 0.0034
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0044 0.0257
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0014 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0532 0.3246 0.6394
Loa Loa (eye worm) hypothetical protein 0.0032 0.0106 0.0245
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0137 0.0271
Brugia malayi Protein kinase domain containing protein 0.0151 0.0852 0.2441
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.1702 0.3352
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0177 0.0409
Toxoplasma gondii AGC kinase 0.0151 0.0852 0.5008
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0414 0.2505 0.3832
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0124 0.0243
Brugia malayi serine/threonine-protein kinase 6 0.0144 0.0811 0.2323
Brugia malayi p70 ribosomal S6 kinase beta 0.0151 0.0852 0.2441
Schistosoma mansoni netrin receptor unc5 0.0028 0.0079 0.0156
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0124 0.0244
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0017 0.0013 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0014 0.002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0086 0.0086
Entamoeba histolytica protein kinase, putative 0.0159 0.0904 0.5119
Echinococcus granulosus protein kinase C gamma type 0.0399 0.2413 0.4753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.0563

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.05 uM Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake assay ChEMBL. 19447622
Ki (binding) = 86 nM Inhibition of Aurora-A by coupled assay ChEMBL. 19447622
Ki (binding) = 207 nM Inhibition of Aurora-B ChEMBL. 19447622

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19447622

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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