Detailed information for compound 104152

Basic information

Technical information
  • TDR Targets ID: 104152
  • Name: carboxymethyl-dimethyl-[(4-nitrophenyl)methyl ]azanium bromide
  • MW: 319.152 | Formula: C11H15BrN2O4
  • H donors: 1 H acceptors: 4 LogP: 2.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C[N+](Cc1ccc(cc1)[N+](=O)[O-])(C)C.[Br-]
  • InChi: 1S/C11H14N2O4.BrH/c1-13(2,8-11(14)15)7-9-3-5-10(6-4-9)12(16)17;/h3-6H,7-8H2,1-2H3;1H
  • InChiKey: WPENPZQNBGSSJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • carboxymethyl-dimethyl-[(4-nitrophenyl)methyl]ammonium bromide
  • carboxymethyl-dimethyl-(4-nitrobenzyl)ammonium bromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) proprotein convertase 2 0.027 0.0979 0.1464
Loa Loa (eye worm) histone deacetylase 1 0.0159 0.0496 0.0742
Brugia malayi G protein-coupled receptor F59B2.13 0.0305 0.1131 0.1691
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0305 0.1131 0.1131
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0305 0.1131 0.1131
Echinococcus multilocularis nervana 2 0.0081 0.016 0.016
Schistosoma mansoni tyrosine kinase 0.0078 0.0143 0.0162
Schistosoma mansoni neuropeptide receptor 0.0761 0.3114 0.3528
Echinococcus multilocularis histone deacetylase 3 0.0159 0.0496 0.0496
Plasmodium falciparum cyclin 1 0.0045 0 0.0005
Trypanosoma brucei cdc2-related kinase 3 0.0134 0.0391 0.2406
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0045 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0305 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi Serotonin receptor 0.0305 0.1131 0.1691
Echinococcus multilocularis nervana 2 0.0081 0.016 0.016
Loa Loa (eye worm) TK/EGFR protein kinase 0.0268 0.0973 0.1456
Loa Loa (eye worm) hypothetical protein 0.0083 0.0168 0.0252
Schistosoma mansoni neuropeptide F-like receptor 0.0305 0.1131 0.1281
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0585 0.3601
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Loa Loa (eye worm) hypothetical protein 0.0242 0.0859 0.1285
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0084 0.017 0.017
Loa Loa (eye worm) melatonin receptor type 1A 0.0305 0.1131 0.1691
Onchocerca volvulus 0.0305 0.1131 0.3439
Schistosoma mansoni amine GPCR 0.0305 0.1131 0.1281
Trypanosoma cruzi histone deacetylase, putative 0.0067 0.0098 0.0601
Plasmodium vivax cyclin 4, putative 0.0045 0 0.0005
Echinococcus granulosus allatostatin A receptor 0.0305 0.1131 0.1131
Onchocerca volvulus 0.0179 0.0585 0.1779
Echinococcus granulosus epidermal growth factor receptor 0.0268 0.0973 0.0973
Trichomonas vaginalis histone deacetylase, putative 0.0159 0.0496 0.2522
Schistosoma mansoni tyrosine kinase 0.0078 0.0143 0.0162
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Entamoeba histolytica histone deacetylase, putative 0.0159 0.0496 0.3051
Trypanosoma brucei histone deacetylase, putative 0.0095 0.0221 0.1359
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0305 0.1131 0.1131
Brugia malayi Trypsin family protein 0.0078 0.0144 0.0216
Echinococcus granulosus sex peptide receptor 0.0305 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0801 0.3288 0.4918
Onchocerca volvulus Cyclin L homolog 0.0045 0 0.0001
Echinococcus multilocularis cyclins 0.0185 0.0611 0.0611
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0078 0.0144 0.0144
Onchocerca volvulus 0.0305 0.1131 0.3439
Echinococcus granulosus cyclins 0.0185 0.0611 0.0611
Echinococcus granulosus cyclin b3 0.0185 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0216
Schistosoma mansoni hypothetical protein 0.0202 0.0683 0.0774
Echinococcus multilocularis fibrillin 1 0.0053 0.0037 0.0037
Echinococcus multilocularis 0.0045 0.0002 0.0002
Trichomonas vaginalis histone deacetylase, putative 0.0159 0.0496 0.2522
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0045 0 0.0005
Echinococcus multilocularis cyclins 0.0185 0.0611 0.0611
Loa Loa (eye worm) TK/ROR protein kinase 0.018 0.0589 0.088
Echinococcus multilocularis dro:myosuppressin receptor 0.0305 0.1131 0.1131
Giardia lamblia Kinase, CMGC CDK 0.0134 0.0391 0.2405
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0305 0.1131 0.1281
Echinococcus multilocularis g-protein coupled receptor 0.0305 0.1131 0.1131
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0305 0.1131 0.1281
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi RE15519p 0.0305 0.1131 0.1691
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0084 0.0173 0.5
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0134 0.0391 0.0585
Trichomonas vaginalis cyclins, putative 0.0278 0.1014 0.5157
Trichomonas vaginalis cyclin A, putative 0.0418 0.1624 0.8262
Echinococcus multilocularis integrin alpha ps 0.0065 0.0089 0.0089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0305 0.1131 0.1281
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0009 0.0009
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0147 0.0147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0391 0.1988
Echinococcus multilocularis 0.0704 0.2868 0.2868
Onchocerca volvulus 0.0418 0.1624 0.494
Loa Loa (eye worm) TYRA-2 protein 0.0305 0.1131 0.1691
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0185 0.0611 0.0611
Echinococcus granulosus biogenic amine 5HT receptor 0.0305 0.1131 0.1131
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0084 0.0173 1
Echinococcus multilocularis neuroendocrine convertase 2 0.0679 0.2758 0.2758
Schistosoma mansoni biogenic amine (5HT) receptor 0.0305 0.1131 0.1281
Onchocerca volvulus 0.0305 0.1131 0.3439
Schistosoma mansoni neuropeptide receptor 0.0305 0.1131 0.1281
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0305 0.1131 0.1691
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0159 0.0496 0.2522
Leishmania major histone deacetylase, putative 0.0159 0.0496 0.3052
Echinococcus multilocularis neuropeptide s receptor 0.0305 0.1131 0.1131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.027 0.0979 0.4979
Echinococcus granulosus neuropeptide s receptor 0.0305 0.1131 0.1131
Echinococcus granulosus g protein coupled receptor 0.0305 0.1131 0.1131
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0391 0.0443
Echinococcus granulosus integrin alpha 3 0.0232 0.0816 0.0816
Trypanosoma cruzi histone deacetylase 1, putative 0.0159 0.0496 0.3052
Onchocerca volvulus 0.0305 0.1131 0.3439
Onchocerca volvulus 0.0078 0.0144 0.0439
Echinococcus granulosus histone deacetylase 3 0.0159 0.0496 0.0496
Brugia malayi Cyclin, N-terminal domain containing protein 0.0185 0.0611 0.0913
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0391 0.1988
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0125 0.035 0.0523
Entamoeba histolytica cyclin, putative 0.0185 0.0611 0.3759
Loa Loa (eye worm) hypothetical protein 0.0083 0.0168 0.0252
Schistosoma mansoni tyrosine kinase 0.0047 0.0009 0.001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0305 0.1131 0.1131
Trichomonas vaginalis cyclin B3, putative 0.0045 0 0.0002
Echinococcus multilocularis serotonin receptor 0.0305 0.1131 0.1131
Onchocerca volvulus 0.0305 0.1131 0.3439
Onchocerca volvulus 0.0801 0.3288 1
Echinococcus multilocularis integrin alpha ps 0.0136 0.0397 0.0397
Echinococcus granulosus cyclin B 0.0418 0.1624 0.1624
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0305 0.1131 0.1131
Echinococcus granulosus histone deacetylase 1 0.0159 0.0496 0.0496
Giardia lamblia Kinase, AGC PKA 0.0084 0.017 0.1043
Echinococcus granulosus enteropeptidase 0.0078 0.0144 0.0144
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0045 0 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0305 0.1131 0.1281
Brugia malayi putative neuropeptide receptor 0.0305 0.1131 0.1691
Echinococcus granulosus neuropeptide receptor 0.0305 0.1131 0.1131
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0133 0.0385 0.0385
Brugia malayi AKH receptor 0.0305 0.1131 0.1691
Trypanosoma brucei histone deacetylase 2 0.0067 0.0098 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Trichomonas vaginalis cyclin B, putative 0.0418 0.1624 0.8262
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0216
Schistosoma mansoni opsin-like receptor 0.0305 0.1131 0.1281
Echinococcus multilocularis sex peptide receptor 0.0305 0.1131 0.1131
Trypanosoma brucei cyclin 3 0.0045 0 0.0002
Echinococcus multilocularis glycoprotein Antigen 5 0.0078 0.0144 0.0144
Echinococcus granulosus neuropeptide receptor A26 0.0305 0.1131 0.1131
Trichomonas vaginalis histone deacetylase, putative 0.0159 0.0496 0.2522
Schistosoma mansoni furin-1 (S08 family) 0.0454 0.1779 0.2015
Echinococcus multilocularis fmrfamide receptor 0.0305 0.1131 0.1131
Trypanosoma cruzi cdc2-related kinase 1 0.0134 0.0391 0.2406
Loa Loa (eye worm) histone deacetylase 0.0095 0.0221 0.033
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni growth hormone secretagogue receptor 0.0305 0.1131 0.1281
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Leishmania major cyclin 0.0418 0.1624 1
Echinococcus multilocularis cyclin dependent kinase 0.0134 0.0391 0.0391
Schistosoma mansoni histone deacetylase 1 2 3 0.0067 0.0098 0.0111
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0185 0.0611 0.0611
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0084 0.0173 0.5
Echinococcus granulosus integrin alpha ps 0.0136 0.0397 0.0397
Echinococcus granulosus g protein coupled receptor 0.0305 0.1131 0.1131
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0305 0.1131 0.1131
Echinococcus multilocularis transmembrane protease serine 3 0.0078 0.0144 0.0144
Onchocerca volvulus 0.0045 0 0.0001
Trypanosoma cruzi histone deacetylase, putative 0.0095 0.0221 0.1359
Echinococcus multilocularis tissue type plasminogen activator 0.0179 0.0585 0.0585
Brugia malayi histone deacetylase 3 (HD3) 0.0159 0.0496 0.0742
Echinococcus multilocularis Mastin 0.0078 0.0144 0.0144
Trypanosoma cruzi mitotic cyclin, putative 0.0045 0 0.0002
Brugia malayi Tachykinin-like peptides receptor 99D 0.1477 0.6231 0.932
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi Furin-like cysteine rich region family protein 0.0268 0.0973 0.1456
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0225 0.0785 0.3993
Loa Loa (eye worm) hypothetical protein 0.0083 0.0168 0.0252
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0305 0.1131 0.1131
Trichomonas vaginalis cyclin D, putative 0.0185 0.0611 0.3106
Echinococcus multilocularis neuropeptide Y receptor 0.0305 0.1131 0.1131
Giardia lamblia Furin precursor putative serine protease 0.0225 0.0785 0.4832
Trichomonas vaginalis cyclin B, putative 0.0045 0 0.0002
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0116 0.0312 0.0312
Plasmodium vivax histone deacetylase 1, putative 0.0159 0.0496 0.8477
Echinococcus granulosus neuropeptides capa receptor 0.0305 0.1131 0.1131
Echinococcus granulosus tm gpcr rhodopsin 0.0305 0.1131 0.1131
Echinococcus multilocularis g protein coupled receptor 0.0305 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0238 0.084 0.1257
Echinococcus granulosus transmembrane protease serine 3 0.0078 0.0144 0.0144
Echinococcus granulosus cyclins 0.0185 0.0611 0.0611
Brugia malayi Serotonin receptor 0.0305 0.1131 0.1691
Brugia malayi proprotein convertase 2 0.0679 0.2758 0.4125
Echinococcus multilocularis integrin alpha 3 0.0232 0.0816 0.0816
Trichomonas vaginalis conserved hypothetical protein 0.0045 0 0.0002
Brugia malayi Trypsin family protein 0.0078 0.0144 0.0216
Leishmania major histone deacetylase, putative 0.0095 0.0221 0.1359
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Onchocerca volvulus 0.0305 0.1131 0.3439
Loa Loa (eye worm) hypothetical protein 0.0065 0.0089 0.0133
Echinococcus granulosus furin 0.0906 0.3745 0.3745
Onchocerca volvulus 0.0078 0.0144 0.0439
Trypanosoma brucei RNA helicase, putative 0.0107 0.0271 0.1666
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0084 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0305 0.1131 0.1691
Echinococcus multilocularis cyclin dependent kinase 1 0.0134 0.0391 0.0391
Onchocerca volvulus 0.0305 0.1131 0.3439
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Echinococcus multilocularis enteropeptidase 0.0078 0.0144 0.0144
Brugia malayi follicle stimulating hormone receptor 0.0305 0.1131 0.1691
Echinococcus multilocularis g protein coupled receptor 0.0305 0.1131 0.1131
Onchocerca volvulus Neuropeptide F receptor homolog 0.0305 0.1131 0.3439
Brugia malayi Cyclin, N-terminal domain containing protein 0.0418 0.1624 0.243
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi celfurPC protein 0.0704 0.2868 0.4289
Giardia lamblia G2/mitotic-specific cyclin B 0.0418 0.1624 1
Schistosoma mansoni amine GPCR 0.0305 0.1131 0.1281
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Echinococcus multilocularis neuropeptide receptor 0.0761 0.3114 0.3114
Onchocerca volvulus 0.0305 0.1131 0.3439
Schistosoma mansoni hypothetical protein 0.2075 0.8828 1
Plasmodium falciparum histone deacetylase, putative 0.0095 0.0221 0.3616
Trypanosoma cruzi cdc2-related kinase 1 0.0134 0.0391 0.2406
Loa Loa (eye worm) AGC/AKT protein kinase 0.0133 0.0385 0.0576
Plasmodium vivax protein kinase Crk2 0.0134 0.0391 0.6682
Schistosoma mansoni serine/threonine-protein kinase 0.0092 0.0205 0.0232
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi Histone deacetylase 1 0.0159 0.0496 0.0742
Schistosoma mansoni histone deacetylase 4 5 0.0095 0.0221 0.025
Plasmodium falciparum cysteine repeat modular protein 1 0.0179 0.0585 0.9577
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0305 0.1131 0.1281
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Brugia malayi Dopamine receptor 0.0305 0.1131 0.1691
Onchocerca volvulus 0.0305 0.1131 0.3439
Onchocerca volvulus 0.0305 0.1131 0.3439
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Onchocerca volvulus Protein CNPPD1 homolog 0.0045 0 0.0001
Entamoeba histolytica cell division protein kinase 2, putative 0.0134 0.0391 0.2405
Schistosoma mansoni cyclin B3 0.0185 0.0611 0.0692
Echinococcus granulosus cyclin dependent kinase 1 0.0134 0.0391 0.0391
Echinococcus granulosus Furin 1 0.027 0.0979 0.0979
Plasmodium falciparum protein kinase 5 0.0134 0.0391 0.6399
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0134 0.0391 0.2406
Leishmania major hypothetical protein, conserved 0.0179 0.0585 0.3601
Toxoplasma gondii AGC kinase 0.0125 0.035 0.5983
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0385 0.196
Loa Loa (eye worm) hypothetical protein 0.1477 0.6231 0.932
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.027 0.0979 0.4979
Echinococcus multilocularis histone deacetylase 1 0.0159 0.0496 0.0496
Trypanosoma cruzi cyclin 6, putative 0.0418 0.1624 1
Echinococcus granulosus histone deacetylase 6 0.0095 0.0221 0.0221
Trypanosoma brucei histone deacetylase 3 0.0095 0.0221 0.1359
Brugia malayi G-protein coupled receptor 0.0305 0.1131 0.1691
Schistosoma mansoni hypothetical protein 0.0305 0.1131 0.1281
Echinococcus granulosus tissue type plasminogen activator 0.0179 0.0585 0.0585
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0032 0.0163
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0229 0.0803 0.12
Loa Loa (eye worm) integrin beta-2 0.1582 0.6686 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.027 0.0979 0.4979
Brugia malayi Histone deacetylase family protein 0.0095 0.0221 0.033
Schistosoma mansoni alpha-1 adrenergic receptor 0.0305 0.1131 0.1281
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0045 0 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0078 0.0144 0.0164
Loa Loa (eye worm) trypsin family protein 0.0078 0.0144 0.0216
Echinococcus multilocularis histone deacetylase 6 0.0095 0.0221 0.0221
Trypanosoma cruzi cyclin, putative 0.0418 0.1624 1
Schistosoma mansoni amine GPCR 0.0305 0.1131 0.1281
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0133 0.0385 0.0385
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Brugia malayi Protein kinase domain containing protein 0.0047 0.0009 0.0013
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0023 0.0023
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0305 0.1131 0.1131
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Brugia malayi histone deacetylase 1 (HD1) 0.0159 0.0496 0.0742
Plasmodium vivax histone deacetylase 2, putative 0.0095 0.0221 0.3775
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Trichomonas vaginalis cyclins, putative 0.0045 0 0.0002
Trypanosoma brucei rac serine-threonine kinase, putative 0.0133 0.0385 0.2372
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0084 0.017 0.2901
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0023 0.0023
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Onchocerca volvulus Cyclin L homolog 0.0045 0 0.0001
Trichomonas vaginalis cyclins, putative 0.0418 0.1624 0.8262
Giardia lamblia Hypothetical protein 0.0185 0.0611 0.3759
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0305 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0418 0.1624 0.243
Trypanosoma brucei mitotic cyclin 6 0.0418 0.1624 1
Echinococcus multilocularis insulin receptor 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0045 0 0.0002
Schistosoma mansoni biogenic amine receptor 0.0305 0.1131 0.1281
Trypanosoma cruzi mitotic cyclin, putative 0.0045 0 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0385 0.196
Echinococcus multilocularis g protein coupled receptor 0.0305 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Echinococcus multilocularis cyclin dependent kinase 5 0.0134 0.0391 0.0391
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0305 0.1131 0.1691
Trypanosoma cruzi cyclin, putative 0.0418 0.1624 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0078 0.0144 0.0164
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0023 0.0023
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis epidermal growth factor receptor 0.0268 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Giardia lamblia Kinase, CMGC CDK 0.0134 0.0391 0.2405
Schistosoma mansoni serine-type protease inhibitor 0.0866 0.3573 0.4047
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Echinococcus granulosus fmrfamide receptor 0.0305 0.1131 0.1131
Plasmodium falciparum histone deacetylase 1 0.0159 0.0496 0.8118
Schistosoma mansoni histone deacetylase hda2 0.0102 0.0248 0.0281
Trypanosoma cruzi histone deacetylase, putative 0.0095 0.0221 0.1359
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Plasmodium vivax hypothetical protein, conserved 0.0045 0 0.0005
Onchocerca volvulus 0.0078 0.0144 0.0439
Loa Loa (eye worm) hypothetical protein 0.0179 0.0585 0.0875
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0305 0.1131 0.1131
Echinococcus granulosus cyclin dependent kinase 0.0134 0.0391 0.0391
Echinococcus granulosus cyclin dependent kinase 5 0.0134 0.0391 0.0391
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0134 0.0391 0.0585
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Onchocerca volvulus 0.0078 0.0144 0.0439
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.027 0.0979 0.4979
Plasmodium vivax histone deacetylase, putative 0.0067 0.0098 0.1668
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0906 0.3745 0.4242
Brugia malayi p70 ribosomal S6 kinase beta 0.0125 0.035 0.0523
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0134 0.0391 0.2406
Trichomonas vaginalis cyclin B, putative 0.0185 0.0611 0.3106
Trichomonas vaginalis cyclins, putative 0.0185 0.0611 0.3106
Toxoplasma gondii kringle domain-containing protein 0.0179 0.0585 1
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0385 0.196
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0305 0.1131 0.1691
Toxoplasma gondii histone deacetylase HDAC3 0.0159 0.0496 0.8477
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Echinococcus granulosus histone deacetylase 0.0095 0.0221 0.0221
Onchocerca volvulus Histone deacetylase 10 homolog 0.0067 0.0098 0.0297
Echinococcus granulosus insulin receptor 0.0047 0.0009 0.0009
Echinococcus granulosus cyclin B3 1 0.0185 0.0611 0.0611
Echinococcus granulosus cyclins 0.0185 0.0611 0.0611
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0068 0.0102 0.0115
Schistosoma mansoni hypothetical protein 0.0305 0.1131 0.1281
Echinococcus multilocularis nmda type glutamate receptor 0.0117 0.0317 0.0317
Echinococcus granulosus biogenic amine 5HT receptor 0.0305 0.1131 0.1131
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0305 0.1131 0.1131
Echinococcus multilocularis orexin receptor type 2 0.0305 0.1131 0.1131
Trypanosoma cruzi cyclin 9, putative 0.0045 0 0.0002
Echinococcus granulosus peptide allatostatin:somatostatin 0.0305 0.1131 0.1131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0102 0.0517
Entamoeba histolytica protein kinase, putative 0.0133 0.0385 0.2371
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0078 0.0144 0.0216
Echinococcus multilocularis G-protein coupled receptor, putative 0.0305 0.1131 0.1131
Brugia malayi Cyclin, N-terminal domain containing protein 0.0418 0.1624 0.243
Echinococcus granulosus serotonin receptor 0.0305 0.1131 0.1131
Brugia malayi Dopamine receptor protein 1 0.0305 0.1131 0.1691
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0081 0.016 0.016
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0305 0.1131 0.1691
Schistosoma mansoni biogenic amine receptor 0.0305 0.1131 0.1281
Entamoeba histolytica cyclin family protein 0.0185 0.0611 0.3759
Echinococcus granulosus histone deacetylase 6 0.0095 0.0221 0.0221
Echinococcus granulosus dro:myosuppressin receptor 0.0305 0.1131 0.1131
Schistosoma mansoni tyrosine kinase 0.0078 0.0147 0.0166
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0179 0.0585 1
Brugia malayi Melatonin receptor type 1A 0.0305 0.1131 0.1691
Schistosoma mansoni serine/threonine-protein kinase 0.0092 0.0205 0.0232
Brugia malayi Trypsin-like protease protein 5 0.0078 0.0144 0.0216
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0497 0.1966 0.1966
Leishmania major cyclin 9, putative 0.0045 0 0.0002
Giardia lamblia High cysteine membrane protein Group 2 0.025 0.0895 0.5509
Loa Loa (eye worm) hypothetical protein 0.0071 0.0114 0.017
Leishmania major histone deacetylase, putative 0.0095 0.0221 0.1359
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0159 0.0496 0.2522
Toxoplasma gondii histone deacetylase HDAC5 0.0067 0.0098 0.1668
Schistosoma mansoni neuropeptide F-like receptor 0.0305 0.1131 0.1281
Onchocerca volvulus 0.0305 0.1131 0.3439
Echinococcus granulosus tm gpcr rhodopsin 0.0305 0.1131 0.1131
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0385 0.196
Brugia malayi Trypsin family protein 0.0078 0.0144 0.0216
Echinococcus granulosus nmda type glutamate receptor 0.0117 0.0317 0.0317
Entamoeba histolytica cell division protein kinase 2, putative 0.0134 0.0391 0.2405
Loa Loa (eye worm) hypothetical protein 0.0229 0.0803 0.12
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0216
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0305 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0216
Schistosoma mansoni neuropeptide f receptor 76f 0.0305 0.1131 0.1281
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0305 0.1131 0.1281
Echinococcus granulosus histone deacetylase 7 0.0095 0.0221 0.0221
Mycobacterium leprae Possible secreted protease 0.0045 0 0.5
Schistosoma mansoni tyrosine kinase 0.0047 0.0009 0.001
Echinococcus granulosus glutamate receptor 2 0.01 0.0242 0.0242
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Echinococcus granulosus somatostatin receptor 0.0305 0.1131 0.1131
Echinococcus granulosus integrin beta 2 0.1169 0.4889 0.4889
Entamoeba histolytica protein kinase, putative 0.0125 0.035 0.2153
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0611 0.3106
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0081 0.016 0.016
Schistosoma mansoni histone deacetylase 0.0159 0.0496 0.0562
Loa Loa (eye worm) histone deacetylase 11 0.0067 0.0098 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Echinococcus multilocularis cyclins 0.0185 0.0611 0.0611
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0391 0.1988
Schistosoma mansoni hypothetical protein 0.0107 0.0271 0.0307
Trypanosoma brucei mitotic cyclin 0.0045 0 0.0002
Schistosoma mansoni amine GPCR 0.0305 0.1131 0.1281
Trichomonas vaginalis histone deacetylase, putative 0.0159 0.0496 0.2522
Echinococcus granulosus neuropeptides capa receptor 0.1886 0.8007 0.8007
Echinococcus multilocularis neuropeptide receptor A26 0.0305 0.1131 0.1131
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0305 0.1131 0.1131
Brugia malayi Glutamate receptor 2 precursor 0.0116 0.0312 0.0466
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis histone deacetylase 6 0.0095 0.0221 0.0221
Echinococcus multilocularis cyclin B3 1 0.0185 0.0611 0.0611
Echinococcus multilocularis glutamate receptor 2 0.0116 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0202 0.0683 0.3476
Brugia malayi Kringle domain containing protein 0.0179 0.0585 0.0875
Schistosoma mansoni hypothetical protein 0.0065 0.0089 0.0101
Schistosoma mansoni histone deacetylase 0.0159 0.0496 0.0562
Schistosoma mansoni histone deacetylase 4 5 0.0095 0.0221 0.025
Echinococcus granulosus 7tm_1 domain containing protein 0.0305 0.1131 0.1131
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0084 0.017 0.2779
Trichomonas vaginalis cyclins, putative 0.0418 0.1624 0.8262
Echinococcus granulosus G protein coupled receptor 139 0.0305 0.1131 0.1131
Trichomonas vaginalis cyclin B, putative 0.0418 0.1624 0.8262
Schistosoma mansoni hypothetical protein 0.0305 0.1131 0.1281
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0305 0.1131 0.3439
Schistosoma mansoni integrin alpha 0.0303 0.1123 0.1273
Schistosoma mansoni histamine h1 receptor 0.0305 0.1131 0.1281
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0497 0.1966 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0023 0.0023
Schistosoma mansoni amine GPCR 0.0305 0.1131 0.1281
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0305 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Toxoplasma gondii histone deacetylase HDAC2 0.0159 0.0496 0.8477
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis neuropeptide receptor 0.0305 0.1131 0.1131
Onchocerca volvulus 0.0305 0.1131 0.3439
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0225 0.0785 0.3993
Schistosoma mansoni biogenic amine (5HT) receptor 0.0305 0.1131 0.1281
Brugia malayi Kelch motif family protein 0.0242 0.0859 0.1285
Echinococcus granulosus neuropeptide FF receptor 2 0.1477 0.6231 0.6231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Loa Loa (eye worm) G-protein coupled receptor 0.0305 0.1131 0.1691
Brugia malayi neuroendocrine convertase 1 precursor 0.0826 0.34 0.5086
Echinococcus multilocularis expressed protein 0.0368 0.1405 0.1405
Echinococcus multilocularis neuropeptides capa receptor 0.0305 0.1131 0.1131
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0305 0.1131 0.1281
Brugia malayi Integrin alpha pat-2 precursor 0.0303 0.1123 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0045 0 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0305 0.1131 0.1131
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Onchocerca volvulus 0.0305 0.1131 0.3439
Plasmodium vivax cyclin homologue, putative 0.0045 0 0.0005
Echinococcus multilocularis histone deacetylase 7 0.0095 0.0221 0.0221
Echinococcus granulosus nervana 2 0.0081 0.016 0.016
Schistosoma mansoni neuropeptide receptor 0.0305 0.1131 0.1281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0078 0.0144 0.0164
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni adenoreceptor 0.0305 0.1131 0.1281
Trichomonas vaginalis cyclin A, putative 0.0045 0 0.0002
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0092 0.0205 0.1263
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Echinococcus multilocularis somatostatin receptor 0.0305 0.1131 0.1131
Echinococcus granulosus tachykinin peptides receptor 99D 0.0305 0.1131 0.1131
Brugia malayi G-protein coupled receptor 0.0305 0.1131 0.1691
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0305 0.1131 0.1691
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0078 0.0144 0.0144
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0418 0.1624 1
Toxoplasma gondii hypothetical protein 0.0045 0 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0801 0.3288 0.3725
Schistosoma mansoni tyrosine kinase 0.0078 0.0143 0.0162
Loa Loa (eye worm) G-protein coupled receptor 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni hypothetical protein 0.0078 0.0144 0.0164
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Echinococcus granulosus hypothetical protein 0.0305 0.1131 0.1131
Loa Loa (eye worm) histone deacetylase 7A 0.0095 0.0221 0.033
Brugia malayi Protein kinase domain containing protein 0.018 0.0589 0.088
Loa Loa (eye worm) hypothetical protein 0.0132 0.0381 0.0569
Loa Loa (eye worm) hypothetical protein 0.0067 0.0098 0.0146
Toxoplasma gondii cyclin dependent kinase binding protein 0.0045 0 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0385 0.196
Brugia malayi Glutamate receptor 1 precursor 0.0116 0.0312 0.0466
Brugia malayi larval opioid receptor 0.0305 0.1131 0.1691
Trypanosoma cruzi histone deacetylase, putative 0.0095 0.0221 0.1359
Trichomonas vaginalis cyclin B3, putative 0.0045 0 0.0002
Brugia malayi endoprotease bli-4 precursor 0.0906 0.3745 0.5601
Brugia malayi cell division control protein 2 homolog 0.0134 0.0391 0.0585
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.027 0.0979 0.4979
Echinococcus granulosus alpha 1A adrenergic receptor 0.0305 0.1131 0.1131
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0078 0.0144 0.0144
Toxoplasma gondii cyclin 4, putative 0.0045 0 0.0005
Onchocerca volvulus 0.0305 0.1131 0.3439
Loa Loa (eye worm) hypothetical protein 0.0167 0.0533 0.0797
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0134 0.0391 0.0585
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0305 0.1131 0.1281
Brugia malayi neuropeptide F receptor 0.0305 0.1131 0.1691
Echinococcus granulosus 7TM GPCR rhodopsin 0.0305 0.1131 0.1131
Echinococcus multilocularis cyclins 0.0185 0.0611 0.0611
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0084 0.017 0.1045
Echinococcus granulosus neuropeptide receptor 0.0761 0.3114 0.3114
Trypanosoma cruzi CYC2-like cyclin, putative 0.0418 0.1624 1
Entamoeba histolytica cyclin family protein 0.0185 0.0611 0.3759
Mycobacterium ulcerans hypothetical protein 0.0078 0.0144 0.833
Trypanosoma brucei cdc2-related kinase 1 0.0134 0.0391 0.2406
Trichomonas vaginalis cyclin D, putative 0.0045 0 0.0002
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0084 0.0173 1
Giardia lamblia Histone deacetylase 0.0159 0.0496 0.3051
Trypanosoma cruzi histone deacetylase, putative 0.0067 0.0098 0.0601
Trypanosoma cruzi histone deacetylase 1, putative 0.0159 0.0496 0.3052
Onchocerca volvulus 0.0723 0.295 0.8971
Trypanosoma brucei cyclin 9 0.0045 0 0.0002
Echinococcus multilocularis glutamate receptor 2 0.0133 0.0385 0.0385
Echinococcus granulosus integrin alpha ps 0.0065 0.0089 0.0089
Trichomonas vaginalis histone deacetylase, putative 0.0159 0.0496 0.2522
Schistosoma mansoni cyclin B 0.0418 0.1624 0.184
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.027 0.0979 0.4979
Schistosoma mansoni opsin-like receptor 0.0305 0.1131 0.1281
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0159 0.0496 0.2522
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0078 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0078 0.0144 0.0164
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0045 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis neuropeptides capa receptor 0.1886 0.8007 0.8007
Chlamydia trachomatis glutamine binding protein 0.0084 0.0173 0.5
Echinococcus multilocularis dnaJ subfamily B 0.2075 0.8828 0.8828
Brugia malayi Dopamine receptor protein 2 0.0305 0.1131 0.1691
Trypanosoma brucei histone deacetylase 1 0.0159 0.0496 0.3052
Echinococcus multilocularis cyclin dependent kinase 1 0.0134 0.0391 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0078 0.0144 0.0164
Loa Loa (eye worm) hypothetical protein 0.0233 0.082 0.1226
Echinococcus multilocularis glutamate receptor 2 0.01 0.0242 0.0242
Leishmania major histone deacetylase, putative 0.0159 0.0496 0.3052
Onchocerca volvulus 0.0305 0.1131 0.3439
Echinococcus granulosus glutamate receptor 4 0.0083 0.0168 0.0168
Echinococcus multilocularis cyclin b3 0.0185 0.0611 0.0611
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0385 0.196
Trichomonas vaginalis cyclin B, putative 0.0418 0.1624 0.8262
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Toxoplasma gondii hypothetical protein 0.014 0.0417 0.7122
Trichomonas vaginalis cyclins, putative 0.0418 0.1624 0.8262
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni serine-type protease inhibitor 0.0866 0.3573 0.4047
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0023 0.0023
Echinococcus multilocularis Glutaredoxin protein 5 0.0081 0.016 0.016
Echinococcus granulosus g-protein coupled receptor 0.0305 0.1131 0.1131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0801 0.3288 0.3725
Echinococcus granulosus glutamate receptor 1 0.0083 0.0168 0.0168
Echinococcus multilocularis cyclins 0.0185 0.0611 0.0611
Echinococcus multilocularis cyclins 0.0185 0.0611 0.0611
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Schistosoma mansoni myosin xvIII 0.0305 0.1131 0.1281
Trichomonas vaginalis cyclin D, putative 0.0185 0.0611 0.3106
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Brugia malayi histone deacetylase 11 0.0067 0.0098 0.0146
Brugia malayi hypothetical protein 0.0242 0.0859 0.1285
Toxoplasma gondii histone deacetylase HDAC1 0.0095 0.0221 0.3775
Echinococcus multilocularis histone deacetylase 8 0.0067 0.0098 0.0098
Entamoeba histolytica PH domain containing protein kinase, putative 0.0092 0.0205 0.1261
Plasmodium falciparum histone deacetylase 2 0.0095 0.0221 0.3616
Leishmania major mitotic cyclin, putative 0.0045 0 0.0002
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0045 0 0.5
Loa Loa (eye worm) glutamate receptor 1 0.0116 0.0312 0.0466
Echinococcus multilocularis rac serine:threonine kinase 0.0092 0.0205 0.0205
Echinococcus multilocularis histone deacetylase 6 0.0102 0.0248 0.0248
Echinococcus multilocularis histone deacetylase 0.0095 0.0221 0.0221
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi sulfakinin receptor protein 0.0305 0.1131 0.1691
Echinococcus granulosus Glutaredoxin protein 5 0.0081 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0045 0 0.0002
Schistosoma mansoni cyclins 0.0185 0.0611 0.0692
Loa Loa (eye worm) cyclin domain-containing protein 0.0185 0.0611 0.0913
Schistosoma mansoni tyrosine kinase 0.0078 0.0147 0.0166
Echinococcus multilocularis cyclin B 0.0418 0.1624 0.1624
Echinococcus granulosus cyclins 0.0185 0.0611 0.0611
Brugia malayi hypothetical protein 0.0078 0.0144 0.0216
Onchocerca volvulus 0.0078 0.0144 0.0439
Echinococcus granulosus histone deacetylase 6 0.0102 0.0248 0.0248
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0305 0.1131 0.1281
Echinococcus multilocularis G protein coupled receptor 139 0.0761 0.3114 0.3114
Loa Loa (eye worm) hypothetical protein 0.0159 0.0496 0.0742
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.027 0.0979 0.1109
Loa Loa (eye worm) integrin alpha pat-2 0.0467 0.1837 0.2747
Trypanosoma cruzi Protein kinase B 0.0092 0.0205 0.1263
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Brugia malayi G protein-coupled receptor 0.0305 0.1131 0.1691
Brugia malayi Protein kinase domain containing protein 0.0133 0.0385 0.0576
Echinococcus granulosus glutamate receptor 2 0.0133 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0171 0.055 0.0823
Echinococcus granulosus histone deacetylase 8 0.0067 0.0098 0.0098
Schistosoma mansoni histone deacetylase hda2 0.0067 0.0098 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Echinococcus multilocularis integrin beta 2 0.1169 0.4889 0.4889
Brugia malayi ORL1-like opioid receptor 0.0305 0.1131 0.1691
Trichomonas vaginalis histone deacetylase, putative 0.0159 0.0496 0.2522
Echinococcus multilocularis allatostatin A receptor 0.0305 0.1131 0.1131
Plasmodium vivax histone deacetylase, putative 0.0095 0.0221 0.3775
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0023 0.0026
Loa Loa (eye worm) neuropeptide F receptor 0.0305 0.1131 0.1691
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Entamoeba histolytica cyclin, putative 0.0418 0.1624 1
Giardia lamblia Cyclin A 0.0185 0.0611 0.3759
Echinococcus granulosus Mastin 0.0078 0.0144 0.0144
Echinococcus granulosus dnaJ subfamily B 0.2075 0.8828 0.8828
Echinococcus granulosus expressed protein 0.0368 0.1405 0.1405
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0078 0.0144 0.0164
Trypanosoma cruzi cdc2-related kinase 3 0.0134 0.0391 0.2406
Loa Loa (eye worm) histone deacetylase 3 0.0159 0.0496 0.0742
Echinococcus granulosus serine/threonine protein kinase 0.0092 0.0205 0.0205
Schistosoma mansoni neuropeptide receptor 0.0305 0.1131 0.1281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0242 0.0859 0.1285
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Echinococcus multilocularis Furin 1 0.027 0.0979 0.0979
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0078 0.0144 0.0164
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0305 0.1131 0.1281
Leishmania major mitotic cyclin, putative 0.0045 0 0.0002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0305 0.1131 0.1691
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0134 0.0391 0.6682
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0906 0.3745 0.5601
Loa Loa (eye worm) hypothetical protein 0.0432 0.1687 0.2523
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0305 0.1131 0.1691
Schistosoma mansoni integrin alpha-ps 0.0136 0.0397 0.0449
Echinococcus granulosus glutamate receptor subunit protein glur 0.0116 0.0312 0.0312
Schistosoma mansoni integrin beta subunit 0.0927 0.3836 0.4345
Trichomonas vaginalis cyclins, putative 0.0045 0 0.0002
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0497 0.1966 0.1966
Trichomonas vaginalis cyclin B, putative 0.0418 0.1624 0.8262
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0305 0.1131 0.1131
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.1131 0.1131
Trichomonas vaginalis cyclins, putative 0.0418 0.1624 0.8262
Onchocerca volvulus 0.0305 0.1131 0.3439
Trichomonas vaginalis cyclin B, putative 0.0045 0 0.0002
Brugia malayi putative neuropeptide receptor NPR1 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0305 0.1131 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0683 0.3476
Trypanosoma cruzi cdc2-related kinase 3 0.0134 0.0391 0.2406
Loa Loa (eye worm) neuropeptide F receptor 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi Histone deacetylase family protein 0.0095 0.0221 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.1131 0.1281
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0009 0.0013
Entamoeba histolytica protein kinase 2, putative 0.0084 0.017 0.1043
Onchocerca volvulus 0.0305 0.1131 0.3439
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0305 0.1131 0.1281
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0497 0.1966 1
Echinococcus multilocularis neuropeptide Y receptor 0.0305 0.1131 0.1131
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0305 0.1131 0.1691
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0305 0.1131 0.1131
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0385 0.196
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0305 0.1131 0.1281
Echinococcus granulosus neuroendocrine convertase 2 0.0679 0.2758 0.2758
Echinococcus granulosus orexin receptor type 2 0.0305 0.1131 0.1131
Trichomonas vaginalis cyclin B3, putative 0.0185 0.0611 0.3106
Schistosoma mansoni tyrosine kinase 0.0268 0.0973 0.1103
Echinococcus multilocularis integrin alpha ps 0.0136 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni integrin alpha-ps 0.0071 0.0114 0.0129
Echinococcus multilocularis neuropeptide FF receptor 2 0.1477 0.6231 0.6231
Loa Loa (eye worm) endoprotease bli-4 0.0906 0.3745 0.5601
Schistosoma mansoni opsin-like receptor 0.0305 0.1131 0.1281
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis glutamate receptor 4 0.0083 0.0168 0.0168
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0305 0.1131 0.1131
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0305 0.1131 0.1281
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Brugia malayi neuropeptide F receptor 0.0305 0.1131 0.1691
Echinococcus granulosus nervana 2 0.0081 0.016 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0391 0.0443
Loa Loa (eye worm) hypothetical protein 0.0801 0.3288 0.4918
Echinococcus multilocularis cyclins 0.0185 0.0611 0.0611
Echinococcus granulosus neuropeptide Y receptor 0.0305 0.1131 0.1131
Plasmodium falciparum cyclin 0.0185 0.0611 1
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0305 0.1131 0.1131
Echinococcus granulosus cyclins 0.0185 0.0611 0.0611
Echinococcus granulosus serine threonine protein kinase nrc 0.0084 0.017 0.017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2344 1 1
Schistosoma mansoni biogenic amine receptor 0.0305 0.1131 0.1281
Brugia malayi Protein kinase domain containing protein 0.0134 0.0391 0.0585
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Schistosoma mansoni hypothetical protein 0.0179 0.0585 0.0663
Toxoplasma gondii histone deacetylase HDAC4 0.0067 0.0098 0.1668
Loa Loa (eye worm) hypothetical protein 0.0418 0.1624 0.243
Trichomonas vaginalis hypothetical protein 0.0202 0.0683 0.3476
Entamoeba histolytica PH domain containing protein kinase, putative 0.0092 0.0205 0.1261
Schistosoma mansoni cercarial elastase (S01 family) 0.0078 0.0144 0.0164
Brugia malayi Integrin beta pat-3 precursor 0.1582 0.6686 1
Brugia malayi GnHR receptor homolog 0.0305 0.1131 0.1691
Loa Loa (eye worm) hypothetical protein 0.0305 0.1131 0.1691
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0045 0 0.0005
Trypanosoma brucei histone deacetylase 4 0.0095 0.0221 0.1359
Brugia malayi Trypsin family protein 0.0801 0.3288 0.4918
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0147 0.0147
Echinococcus granulosus glycoprotein Antigen 5 0.0078 0.0144 0.0144
Echinococcus multilocularis serotonin receptor 0.0305 0.1131 0.1131
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0117 0.0317 0.0317
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0134 0.0391 0.0391
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0305 0.1131 0.1691
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0023 0.0023
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0084 0.0173 0.5
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691
Echinococcus multilocularis fmrfamide receptor 0.0305 0.1131 0.1131
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0045 0 0.0005
Schistosoma mansoni hypothetical protein 0.0305 0.1131 0.1281
Entamoeba histolytica protein kinase, putative 0.0133 0.0385 0.2371
Brugia malayi hypothetical protein 0.0305 0.1131 0.1691

Activities

Activity type Activity value Assay description Source Reference
Absorbance (functional) = 0.03 nm Effect of the compound (1 mM) on Citrobacter freundii growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.09 nm ChEMBL. 15080979
Absorbance (functional) = 0.06 nm Effect of the compound (1 mM) on Aeromonas hydrophila growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.65 nm ChEMBL. 15080979
Absorbance (functional) = 0.06 nm Effect of the compound (1 mM) on Erwinia chrysanthemi growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.97 nm ChEMBL. 15080979
Absorbance (functional) = 0.07 nm Effect of the compound (1 mM) on Salmonella enterica growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.23 nm ChEMBL. 15080979
Absorbance (functional) = 0.07 nm Effect of the compound (1 mM) on Serratia marcescens growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.03 nm ChEMBL. 15080979
Absorbance (functional) = 0.09 nm Effect of the compound (1 mM) on Escherichia coli growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.24 nm ChEMBL. 15080979
Absorbance (functional) = 0.09 nm Effect of the compound (1 mM) on Escherichia coli growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.24 nm ChEMBL. 15080979
Absorbance (functional) = 0.16 nm Effect of the compound (1 mM) on Pseudomonas aeruginosa growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.24 nm ChEMBL. 15080979
Absorbance (functional) = 0.18 nm Effect of the compound (1 mM) on Bacillus subtilis growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 3.20 nm ChEMBL. 15080979
Absorbance (functional) = 0.19 nm Effect of the compound (1 mM) on Acinetobacter baumannii growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.14 nm ChEMBL. 15080979
Absorbance (functional) = 0.23 nm Effect of the compound (1 mM) on Klebsiella pneumoniae growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.80 nm ChEMBL. 15080979
Absorbance (functional) = 0.24 nm Effect of the compound (1 mM) on Enterobacter cloacae growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.25 nm ChEMBL. 15080979
Absorbance (functional) = 0.33 nm Effect of the compound (1 mM) on Corynebacterium glutamicum growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 0.87 nm ChEMBL. 15080979
Absorbance (functional) = 1.23 nm Effect of the compound (1 mM) on Enterobacter faecalis growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.16 nm ChEMBL. 15080979
Absorbance (functional) = 1.74 nm Effect of the compound (1 mM) on Brevibacterium linens growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.76 nm ChEMBL. 15080979
Absorbance (functional) = 1.85 nm Effect of the compound (1 mM) on Sinorhizobium meliloti growth under stressing conditions; Expressed as absorbance (OD) at 570 nm; Control 1.46 nm ChEMBL. 15080979

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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