TDR Targets

Basic information

Technical information

TDR Targets ID: 104158
Name: ethyl 3-[[benzyl(methyl)amino]methyl]-8-[(2,6 -difluorophenyl)methyl]-2-[4-(2-methylpropano ylamino)phenyl]-5-oxoimidazo[1,2-a]pyrimidine -6-carboxylate
MW: 627.68 | Formula: C35H35F2N5O4
H donors: 1 H acceptors: 4 LogP: 5.6 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)c1cn(Cc2c(F)cccc2F)c2n(c1=O)c(CN(Cc1ccccc1)C)c(n2)c1ccc(cc1)NC(=O)C(C)C
InChi: 1S/C35H35F2N5O4/c1-5-46-34(45)27-20-41(19-26-28(36)12-9-13-29(26)37)35-39-31(24-14-16-25(17-15-24)38-32(43)22(2)3)30(42(35)33(27)44)21-40(4)18-23-10-7-6-8-11-23/h6-17,20,22H,5,18-19,21H2,1-4H3,(H,38,43)
InChiKey: GLRQKOKFWIXNOJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-(2-methylpropanoylamino)phenyl]-5-oxo-imidazo[1,2-a]pyrimidine-6-carboxylate
3-[[benzyl(methyl)amino]methyl]-8-[(2,6-difluorophenyl)methyl]-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-5-oxo-6-imidazo[1,2-a]pyrimidinecarboxylic acid ethyl ester
ethyl 8-[(2,6-difluorophenyl)methyl]-3-[[methyl(phenylmethyl)amino]methyl]-2-[4-(2-methylpropanoylamino)phenyl]-5-oxo-imidazo[1,2-a]pyrimidine-6-carboxylate
3-[[benzyl(methyl)amino]methyl]-8-(2,6-difluorobenzyl)-2-[4-(isobutyrylamino)phenyl]-5-keto-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester
ethyl 8-[(2,6-difluorophenyl)methyl]-3-[(methyl-(phenylmethyl)amino)methyl]-2-[4-(2-methylpropanoylamino)phenyl]-5-oxoimidazo[2,1-b]pyrimidine-6-carboxylate
ethyl 8-[(2,6-difluorophenyl)methyl]-3-[(methyl-(phenylmethyl)amino)methyl]-2-[4-(2-methylpropanoylamino)phenyl]-5-oxo-imidazo[2,1-b]pyrimidine-6-carboxylate
8-[(2,6-difluorophenyl)methyl]-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[(methyl-(phenylmethyl)amino)methyl]-5-oxo-6-imidazo[2,1-b]pyrimidinecarboxylic acid ethyl ester
3-[(benzyl-methyl-amino)methyl]-8-(2,6-difluorobenzyl)-2-[4-(isobutyrylamino)phenyl]-5-keto-imidazo[2,1-b]pyrimidine-6-carboxylic acid ethyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gonadotropin-releasing hormone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GnHR receptor homolog	Get druggable targets OG5_131719	All targets in OG5_131719

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0376	0.4394	0.9913
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0038	0.0148	0.0148
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0086	0.0748	0.1698
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0038	0.0148	0.0334
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0748	0.1109
Brugia malayi	intermediate filament protein	0.0027	0.0017	0.0026
Schistosoma mansoni	lamin	0.0027	0.0017	0.0039
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0086	0.0748	0.1698
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0207	0.2272	0.5157
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0017	0.004
Schistosoma mansoni	glutaminase	0.0267	0.3031	0.6838
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0078	0.0659	0.1495
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0152	0.1586	1
Schistosoma mansoni	hypothetical protein	0.0076	0.0629	0.142
Echinococcus multilocularis	lamin dm0	0.0027	0.0017	0.0017
Entamoeba histolytica	protein kinase, putative	0.009	0.0803	0.455
Brugia malayi	RhoGAP domain containing protein	0.0076	0.0629	0.0933
Brugia malayi	diacylglycerol kinase	0.0076	0.0629	0.0933
Loa Loa (eye worm)	raf kinase	0.0076	0.0629	0.1429
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0748	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0629	0.1429
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0086	0.0748	0.0748
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0748	0.1688
Onchocerca volvulus		0.0027	0.0017	0.0053
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0452	0.1029
Schistosoma mansoni	protein kinase C mu	0.0207	0.2272	0.5126
Echinococcus granulosus	intermediate filament protein	0.0027	0.0017	0.004
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0629	0.1429
Entamoeba histolytica	protein kinase, putative	0.0086	0.0748	0.4172
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0148	0.3212
Onchocerca volvulus		0.0209	0.2297	0.6895
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0287	0.0425
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0076	0.0629	0.1429
Echinococcus granulosus	protein kinase c iota type	0.0162	0.1703	0.3877
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.0629	0.142
Trypanosoma brucei	unspecified product	0.0026	0.0001	0.0007
Onchocerca volvulus		0.0128	0.1287	0.3864
Loa Loa (eye worm)	hypothetical protein	0.0367	0.4287	0.973
Brugia malayi	Protein kinase c protein 2	0.0293	0.3349	0.4964
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0148	0.1081
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.0629	0.0933
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0086	0.0748	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0629	0.1429
Trypanosoma brucei	unspecified product	0.0038	0.0148	0.1081
Echinococcus granulosus	dna polymerase eta	0.0063	0.0461	0.1049
Toxoplasma gondii	AGC kinase	0.0086	0.0748	1
Echinococcus granulosus	protein kinase c epsilon type	0.0316	0.3647	0.8302
Echinococcus multilocularis	N chimaerin	0.0076	0.0629	0.0629
Schistosoma mansoni	hypothetical protein	0.0135	0.1369	0.3088
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0148	0.3212
Onchocerca volvulus		0.0204	0.2243	0.6731
Loa Loa (eye worm)	hypothetical protein	0.008	0.0684	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0017	0.004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Schistosoma mansoni	diacylglycerol kinase theta	0.0076	0.0629	0.142
Loa Loa (eye worm)	hypothetical protein	0.0281	0.3204	0.7273
Trypanosoma brucei	DNA polymerase kappa, putative	0.0026	0.0001	0.0007
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.1194	0.2711
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0148	0.1081
Brugia malayi	ImpB/MucB/SamB family protein	0.0063	0.0461	0.0683
Echinococcus granulosus	tumor protein p63	0.0343	0.3977	0.9051
Brugia malayi	Hr1 repeat family protein	0.0086	0.0748	0.1109
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0086	0.0748	0.1703
Echinococcus granulosus	lamin	0.0027	0.0017	0.004
Brugia malayi	RhoGAP domain containing protein	0.0076	0.0629	0.0933
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0083	0.0719	0.2372
Echinococcus granulosus	Rac GTPase activating protein 1	0.0076	0.0629	0.1433
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0216	0.2393	0.5432
Plasmodium falciparum	metacaspase-like protein	0.0026	0	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Leishmania major	DNA polymerase eta, putative	0.0063	0.0461	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0017	0.0039
Echinococcus multilocularis	dna polymerase eta	0.0063	0.0461	0.0461
Trichomonas vaginalis	glutaminase, putative	0.0267	0.3031	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0641	0.0641
Entamoeba histolytica	protein kinase, putative	0.009	0.0803	0.455
Trypanosoma brucei	rac serine-threonine kinase, putative	0.009	0.0803	0.5863
Schistosoma mansoni	unc-13 (munc13)	0.0085	0.0745	0.168
Echinococcus multilocularis	lamin	0.0027	0.0017	0.0017
Schistosoma mansoni	diacylglycerol kinase theta	0.0076	0.0629	0.142
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Giardia lamblia	DINP protein human, muc B family	0.0038	0.0148	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0085	0.0745	0.0745
Echinococcus multilocularis	myotubularin protein 13	0.008	0.0684	0.0684
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0641	0.1445
Loa Loa (eye worm)	glutaminase 2	0.0267	0.3031	0.6879
Echinococcus granulosus	protein kinase C gamma type	0.03	0.3438	0.7826
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0452	0.1026
Echinococcus granulosus	myotubularin protein 13	0.008	0.0684	0.1556
Onchocerca volvulus		0.005	0.0304	0.0912
Brugia malayi	GnHR receptor homolog	0.0563	0.6746	1
Echinococcus granulosus	lamin dm0	0.0027	0.0017	0.004
Leishmania major	DNA polymerase eta, putative	0.0037	0.0134	0.2907
Echinococcus multilocularis	serine threonine protein kinase	0.03	0.3438	0.3438
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0093	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0461	0.1046
Echinococcus multilocularis	unc 13 (munc13)	0.0085	0.0745	0.0745
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0641	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0629	0.1429
Schistosoma mansoni	hypothetical protein	0.0033	0.0093	0.021
Schistosoma mansoni	serine/threonine protein kinase	0.0316	0.3647	0.823
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0452	0.102
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.0629	0.1429
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0452	0.1026
Echinococcus multilocularis	dna polymerase kappa	0.0038	0.0148	0.0148
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0376	0.4394	0.4394
Brugia malayi	Protein kinase domain containing protein	0.009	0.0803	0.119
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0304	0.0686
Echinococcus granulosus	serine:threonine protein kinase N2	0.0148	0.1532	0.3487
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0291	0.3332	0.7562
Brugia malayi	RhoGEF domain containing protein	0.0076	0.0629	0.0933
Brugia malayi	RNA binding protein	0.0062	0.0452	0.067
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0748	0.2469
Schistosoma mansoni	serine/threonine protein kinase	0.0076	0.0629	0.142
Echinococcus granulosus	geminin	0.0338	0.3914	0.8909
Loa Loa (eye worm)	glutaminase	0.0267	0.3031	0.6879
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0017	0.0026
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0076	0.0629	0.0629
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.0629	0.142
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0086	0.0748	0.1698
Schistosoma mansoni	protein kinase C	0.0085	0.0745	0.168
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0086	0.0748	0.0748
Entamoeba histolytica	hypothetical protein	0.0077	0.0641	0.3424
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0086	0.0748	0.1703
Echinococcus granulosus	serine:threonine protein kinase N2	0.0086	0.0748	0.1703
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Trypanosoma brucei	DNA polymerase kappa, putative	0.0026	0.0001	0.0007
Mycobacterium ulcerans	glutaminase	0.0267	0.3031	1
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0078	0.0659	0.1499
Entamoeba histolytica	hypothetical protein	0.0077	0.0641	0.3424
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0231	0.2577	0.2577
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.0659	0.1486
Loa Loa (eye worm)	hypothetical protein	0.0209	0.2297	0.5214
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0038	0.0148	0.0488
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0038	0.0148	0.3212
Onchocerca volvulus		0.0085	0.0745	0.2235
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0748	0.1688
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0748	0.1688
Entamoeba histolytica	diacylglycerol kinase, putative	0.0076	0.0629	0.3347
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Entamoeba histolytica	diacylglycerol kinase, putative	0.0076	0.0629	0.3347
Brugia malayi	hypothetical protein	0.0077	0.0641	0.095
Entamoeba histolytica	hypothetical protein	0.0076	0.0629	0.3347
Loa Loa (eye worm)	hypothetical protein	0.0377	0.4406	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0452	0.067
Schistosoma mansoni	rac gtpase activating protein	0.0076	0.0629	0.142
Trypanosoma cruzi	DNA polymerase eta, putative	0.0063	0.0461	1
Echinococcus granulosus	Diacylglycerol kinase theta	0.0076	0.0629	0.1433
Plasmodium vivax	hypothetical protein, conserved	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.2243	0.509
Schistosoma mansoni	hypothetical protein	0.0338	0.3914	0.8832
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0086	0.0748	0.1698
Echinococcus granulosus	NDR protein kinase	0.0086	0.0748	0.1703
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2249	0.5105
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0093	0.0211
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0148	0.1081
Trypanosoma brucei	DNA polymerase eta, putative	0.0063	0.0461	0.3367
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0452	0.102
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0076	0.0629	0.1429
Echinococcus multilocularis	tumor protein p63	0.0343	0.3977	0.3977
Schistosoma mansoni	serine/threonine kinase	0.0086	0.0748	0.1688
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0076	0.0629	0.0629
Toxoplasma gondii	diacylglycerol kinase, putative	0.0076	0.0629	0.8413
Loa Loa (eye worm)	hypothetical protein	0.005	0.0304	0.069
Schistosoma mansoni	unc-13 (munc13)	0.0085	0.0745	0.168
Echinococcus multilocularis	musashi	0.0027	0.0017	0.0017
Brugia malayi	p70 ribosomal S6 kinase beta	0.0086	0.0748	0.1109
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.0659	0.1486
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0748	0.2469
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0148	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0076	0.0629	0.1429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0086	0.0748	0.1698
Trypanosoma brucei	RNA helicase, putative	0.0135	0.1369	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0076	0.0629	0.1433
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1287	0.2922
Brugia malayi	Protein kinase domain containing protein	0.0078	0.0659	0.0976
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0086	0.0748	0.0748
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.1194	0.2711
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0148	0.3212
Schistosoma mansoni	serine/threonine protein kinase	0.0379	0.4432	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0086	0.0748	0.1703
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0287	0.0425
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0148	0.0219
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0316	0.3647	0.8279
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0748	0.2469
Loa Loa (eye worm)	AGC/AKT protein kinase	0.009	0.0803	0.1822
Schistosoma mansoni	atypical protein kinase C	0.0162	0.1703	0.3844
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0076	0.0629	0.0629
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0287	0.0651
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0452	0.102
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0038	0.0148	0.0334
Schistosoma mansoni	lamin	0.0027	0.0017	0.0039
Echinococcus granulosus	protein kinase c eta type	0.0076	0.0629	0.1433
Trypanosoma brucei	DNA polymerase kappa, putative	0.0026	0.0001	0.0007
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0038	0.0148	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0291	0.3332	0.7562
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0208	0.2287	0.2287
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Brugia malayi	protein kinase C3,putative	0.0078	0.0659	0.0976
Onchocerca volvulus		0.0291	0.3332	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0085	0.0745	0.1695
Schistosoma mansoni	hypothetical protein	0.0077	0.0641	0.1445
Echinococcus multilocularis	geminin	0.0338	0.3914	0.3914
Schistosoma mansoni	hypothetical protein	0.0052	0.0333	0.0751
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0086	0.0748	0.0748
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0148	0.3212
Entamoeba histolytica	protein kinase, putative	0.0086	0.0748	0.4172
Entamoeba histolytica	hypothetical protein	0.0077	0.0641	0.3424
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0037	0.0134	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0629	0.1429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0038	0.0148	0.0336
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0452	0.0452
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0076	0.0629	0.0629
Schistosoma mansoni	vav2	0.008	0.0684	0.1543
Plasmodium falciparum	metacaspase 1	0.0026	0	0.5
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0038	0.0148	0.5
Echinococcus multilocularis	RNA directed DNA polymerase	0.0208	0.2287	0.2287
Schistosoma mansoni	DNA polymerase eta	0.0063	0.0461	0.104
Brugia malayi	diacylglycerol kinase	0.0076	0.0629	0.0933
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0078	0.0659	0.0659
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Echinococcus granulosus	RNA directed DNA polymerase	0.0208	0.2287	0.5206
Trichomonas vaginalis	DNA polymerase eta, putative	0.0038	0.0148	0.0488
Echinococcus multilocularis	protein kinase c iota type	0.0162	0.1703	0.1703
Brugia malayi	Pleckstrin Homology Domain	0.008	0.0684	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0745	0.169
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0629	0.1429
Onchocerca volvulus		0.0027	0.0017	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0748	0.1688
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0131	0.1316	0.2988
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0148	0.1081
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0452	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0291	0.3332	0.7562
Echinococcus granulosus	dna polymerase kappa	0.0038	0.0148	0.0337
Echinococcus granulosus	unc 13 munc13	0.0085	0.0745	0.1695
Brugia malayi	TAR-binding protein	0.0062	0.0452	0.067
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0452	0.102
Brugia malayi	glutaminase DH11.1	0.0267	0.3031	0.4493
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0017	0.004
Schistosoma mansoni	protein kinase C mu	0.0076	0.0629	0.142
Plasmodium vivax	metacaspase 1, putative	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0011	0.0025
Brugia malayi	MH2 domain containing protein	0.0121	0.1194	0.177
Trypanosoma brucei	unspecified product	0.0026	0.0001	0.0007
Entamoeba histolytica	hypothetical protein	0.0077	0.0641	0.3424
Echinococcus multilocularis	protein kinase c eta type	0.0076	0.0629	0.0629
Brugia malayi	C1-like domain containing protein	0.0207	0.2272	0.3368
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0452	0.102
Echinococcus granulosus	N chimaerin	0.0076	0.0629	0.1433
Schistosoma mansoni	hypothetical protein	0.0338	0.3914	0.8832
Echinococcus granulosus	Protein kinase C brain isozyme	0.0376	0.4394	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0316	0.3647	0.3647
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0287	0.0651
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0148	0.3212
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1287	0.2922
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0086	0.0748	0.1698
Trypanosoma cruzi	DNA polymerase eta, putative	0.0037	0.0134	0.2907
Brugia malayi	Ras association domain family 1 isoform A	0.0076	0.0629	0.0933
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0803	0.2648
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0207	0.2272	0.3368
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0076	0.0629	0.1433
Brugia malayi	protein kinase C II.	0.0316	0.3647	0.5407

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 30 nM	In vitro inhibition of specific [125I]-leuprorelin binding to the cloned human LHRH receptor expressed in chinese hamster ovary cells	ChEMBL.	12127507
IC50 (binding)	= 30 nM	In vitro inhibition of specific [125I]-leuprorelin binding to the cloned human LHRH receptor expressed in chinese hamster ovary cells	ChEMBL.	12127507

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 9917213

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 104158