Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Putative nuclear protein | Butyrylcholinesterase | 602 aa | 573 aa | 41.4 % |
Brugia malayi | Carboxylesterase family protein | Butyrylcholinesterase | 602 aa | 549 aa | 29.5 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 551 aa | 30.1 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Butyrylcholinesterase | 602 aa | 590 aa | 25.3 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Butyrylcholinesterase | 602 aa | 560 aa | 29.3 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Butyrylcholinesterase | 602 aa | 636 aa | 34.9 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Butyrylcholinesterase | 602 aa | 547 aa | 29.4 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Echinococcus granulosus | BC026374 protein S09 family | Butyrylcholinesterase | 602 aa | 649 aa | 34.2 % |
Loa Loa (eye worm) | hypothetical protein | Butyrylcholinesterase | 602 aa | 574 aa | 26.3 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 587 aa | 27.1 % | |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Butyrylcholinesterase | 602 aa | 554 aa | 35.9 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 578 aa | 25.4 % | |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Loa Loa (eye worm) | hypothetical protein | Butyrylcholinesterase | 602 aa | 573 aa | 26.2 % |
Echinococcus multilocularis | neuroligin | Butyrylcholinesterase | 602 aa | 493 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.2693 | 0.2693 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.1837 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.2693 | 0.2693 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0391 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2693 | 0.2693 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0163 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0343 | 0.0343 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0163 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0088 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.3933 | 0.3933 |
Schistosoma mansoni | Hyaluronidase | 0.0533 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.1837 | 0.1837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0343 | 0.0343 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0163 | 0.0163 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hyaluronidase | 0.0533 | 1 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0533 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0163 | 0.0163 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0343 | 0.0343 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0533 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.4055 | 0.4055 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.4055 | 0.4055 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4055 | 0.4055 |
Brugia malayi | hypothetical protein | 0.0233 | 0.4055 | 0.4055 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0163 | 1 |
Onchocerca volvulus | 0.0047 | 0.0391 | 0.213 | |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0391 | 0.0391 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1837 | 0.1837 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0163 | 0.0163 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0163 | 0.0163 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.2693 | 0.2693 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0163 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0163 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.1837 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0163 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0391 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2693 | 0.2693 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0343 | 0.0343 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0163 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.2693 | 0.2693 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0163 | 0.0163 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0343 | 0.0343 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0163 | 0.0163 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2693 | 0.2693 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1837 | 0.1837 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0343 | 0.0343 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0088 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2693 | 0.2693 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0533 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.86 uM | In vitro inhibitory concentration against purified Acetylcholinesterase of human erythrocytes; value ranges from 0.76-1.05 | ChEMBL. | 12431053 |
IC50 (binding) | = 6.4 uM | In vitro inhibitory concentration against Butyrylcholinesterase of horse serum; value ranges from 4.9-11.2 | ChEMBL. | 12431053 |
IC50 (binding) | = 500 uM | In vitro inhibitory concentration against Monoamine oxidase B of rat brain homogenates; value ranges from 260-1100 | ChEMBL. | 12431053 |
IC50 (binding) | = 700 uM | In vitro inhibitory concentration against Monoamine oxidase A of rat brain homogenates; value ranges from 540-850 | ChEMBL. | 12431053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.