Detailed information for compound 104187

Basic information

Technical information
  • TDR Targets ID: 104187
  • Name: (E)-3-[3-(4-methylphenyl)phenyl]-N-[4-[(1-met hylpiperidin-1-ium-1-yl)methyl]phenyl]prop-2- enamide iodide
  • MW: 552.49 | Formula: C29H33IN2O
  • H donors: 1 H acceptors: 1 LogP: 6.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1ccc(cc1)C[N+]1(C)CCCCC1)/C=C/c1cccc(c1)c1ccc(cc1)C.[I-]
  • InChi: 1S/C29H32N2O.HI/c1-23-9-14-26(15-10-23)27-8-6-7-24(21-27)13-18-29(32)30-28-16-11-25(12-17-28)22-31(2)19-4-3-5-20-31;/h6-18,21H,3-5,19-20,22H2,1-2H3;1H/b18-13+;
  • InChiKey: XVHCDLSCKCQZOV-PUBYZPQMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-[4-[(1-methylpiperidin-1-ium-1-yl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]prop-2-enamide iodide
  • (E)-N-[4-[(1-methyl-1-piperidin-1-iumyl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]-2-propenamide iodide
  • (E)-N-[4-[(1-methylpiperidin-1-ium-1-yl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]acrylamide iodide
  • (E)-N-[4-[(1-methyl-1-piperidin-1-iumyl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]prop-2-enamide iodide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis proteasome subunit beta type 6 0.0188 0.2057 0.2057
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.024 0.2698 0.2746
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0039 0.0233 0.0238
Toxoplasma gondii ABC1 family protein 0.0035 0.0187 0.019
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0823 0.9822 1
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.0113 0.0115
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0661 0.7833 0.7974
Echinococcus multilocularis proteasome (prosome, macropain) 0.0823 0.9822 0.9822
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.02 0.2204 0.2243
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0033 0.0164 0.0164
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0262 0.0262
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0237 0.2658 0.2706
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0039 0.0241 0.0245
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Echinococcus granulosus tissue type plasminogen activator 0.002 0.0006 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Leishmania major proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Schistosoma mansoni hypothetical protein 0.0194 0.2128 0.2128
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0189 0.2072 0.2109
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0823 0.9822 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0037 0.0207 0.0211
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0132 0.0135
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0182 0.1981 0.1981
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0165 0.0168
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Toxoplasma gondii proteasome subunit 0.0188 0.2057 0.2094
Brugia malayi Death domain containing protein 0.0036 0.0201 0.0201
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0148 0.0148
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0148 0.0713
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0115
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0155 0.1654 0.1684
Brugia malayi Proteasome A-type and B-type family protein 0.0823 0.9822 0.9822
Trichomonas vaginalis esterase, putative 0.0035 0.0187 0.019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0148 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Echinococcus multilocularis proteasome subunit alpha type 6 0.02 0.2204 0.2204
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0031 0.0132 0.0132
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0241 0.0245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Onchocerca volvulus 0.002 0.0007 0.0034
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.003 0.013 0.0133
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0187 0.2046 0.2083
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0148 0.0148
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0064 0.0536 0.0546
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0031 0.0132 0.0135
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Giardia lamblia 26S protease regulatory subunit 6B 0.002 0.0007 0.0007
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0171 0.1851 0.1851
Giardia lamblia 20S proteasome alpha subunit 1 0.02 0.2204 0.2243
Mycobacterium ulcerans hypothetical protein 0.0038 0.0223 0.0038
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0033 0.0165 0.0165
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0237 0.2658 0.2706
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.024 0.2698 0.2746
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.003 0.013 0.013
Toxoplasma gondii PCI domain-containing protein 0.0039 0.0241 0.0245
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) proteasome Regulatory Particle 0.0033 0.0164 0.0167
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0148 0.015
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.002 0.0007 0.0007
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0023 0.0037 0.0037
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Leishmania major proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Leishmania major proteasome alpha 2 subunit, putative 0.0193 0.2113 0.2151
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0148 0.0148
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.1981 0.2016
Giardia lamblia Proteasome subunit beta type 3 0.0182 0.1981 0.2016
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0155 0.1654 0.1684
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0201 0.0201
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0031 0.0132 0.0132
Echinococcus granulosus proteasome prosome macropain 0.0823 0.9822 0.9822
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0023 0.0037 0.0037
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.003 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0148 0.0148
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0033 0.0164 0.0164
Mycobacterium ulcerans proteasome PrcB 0.0823 0.9822 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0088
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0187 0.2046 0.2046
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.002 0.0007 0.0007
Echinococcus multilocularis geminin 0.0194 0.2128 0.2128
Loa Loa (eye worm) PCI domain-containing protein 0.0033 0.0165 0.0168
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0031 0.0132 0.0135
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.002 0.0007 0.0007
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0132 0.0135
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0823 0.9822 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0038 0.0223 0.0223
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.0006 0.0006
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0039 0.0233 0.0233
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0033 0.0165 0.0168
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0209 0.232 0.232
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0095 0.0921 0.0938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0148 0.015
Schistosoma mansoni 26S protease regulatory subunit 6b 0.002 0.0007 0.0007
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0354 0.4082 0.4082
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0188 0.2057 0.2094
Schistosoma mansoni hypothetical protein 0.0216 0.2401 0.2401
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.002 0.0007 0.0007
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0132 0.0132
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.02 0.2204 0.2243
Toxoplasma gondii proteasome subunit beta type, putative 0.0823 0.9822 1
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.0113 0.0113
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Loa Loa (eye worm) proteasome subunit beta type 1 0.0209 0.232 0.2361
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0237 0.2658 0.2658
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0132 0.0135
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0021 0.0021
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0823 0.9822 0.9822
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0088 0.0836 0.0836
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0029 0.0113 0.0115
Brugia malayi proteasome subunit alpha type 1 0.0187 0.2046 0.2046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0148 0.0148
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.0113 0.0115
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0193 0.2113 0.2151
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0031 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0176 0.1913 0.1947
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0164 0.0167
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0262 0.0262
Plasmodium falciparum proteasome subunit beta type-4 0.018 0.196 0.1995
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Echinococcus granulosus carbonic anhydrase 0.0064 0.0536 0.0536
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0021 0.0022 0.0022
Brugia malayi proteasome subunit beta type 3 0.0182 0.1981 0.1981
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0033 0.0165 0.0168
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.003 0.013 0.013
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0033 0.0164 0.0164
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.018 0.196 0.196
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0209 0.232 0.232
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0187 0.2046 0.2083
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0007 0.0007
Giardia lamblia Proteasome subunit beta type 2 0.0182 0.1981 0.2016
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0823 0.9822 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0036 0.0201 0.0201
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0182 0.1981 0.2016
Brugia malayi beta-lactamase family protein 0.0035 0.0187 0.0187
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0033 0.0164 0.0167
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0033 0.0164 0.0164
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0209 0.232 0.2361
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0021 0.0021 0.0022
Brugia malayi small heat shock protein 0.0661 0.7833 0.7833
Echinococcus multilocularis adhesion regulating molecule 1 0.0095 0.0921 0.0921
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.024 0.2698 0.2746
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0155 0.1654 0.1684
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0021 0.0022 0.0022
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0039 0.0241 0.0245
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0188 0.2052 0.2052
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0171 0.1851 0.1885
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0209 0.232 0.2361
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0033 0.0164 0.0167
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0182 0.1981 0.2016
Giardia lamblia 20S proteasome alpha subunit 2 0.0193 0.2113 0.2151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0187 0.0187
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0033 0.0164 0.0167
Brugia malayi 20S proteasome alpha5 subunit 0.0199 0.2192 0.2192
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0044 0.0292 0.0297
Brugia malayi nuclear hormone receptor 0.0032 0.0148 0.0148
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0132 0.0135
Onchocerca volvulus 0.002 0.0006 0.0027
Brugia malayi hypothetical protein 0.0041 0.0262 0.0262
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Schistosoma mansoni netrin receptor unc5 0.0036 0.0201 0.0201
Toxoplasma gondii SAC3/GANP family protein 0.0029 0.0113 0.0115
Echinococcus granulosus proteasome subunit beta t family 0.0182 0.1981 0.1981
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0038 0.0223 0.0223
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Leishmania major proteasome beta 5 subunit, putative 0.0823 0.9822 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0182 0.1981 0.1981
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0148 0.0148
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0132 0.0135
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0199 0.2192 0.2231
Echinococcus multilocularis carbonic anhydrase 0.0064 0.0536 0.0536
Loa Loa (eye worm) beta-lactamase 0.0035 0.0187 0.019
Schistosoma mansoni coup transcription factor 0.0032 0.0148 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0187 0.019
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0064 0.0536 0.0536
Echinococcus granulosus enteropeptidase 0.0038 0.0223 0.0223
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0033 0.0164 0.0167
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0187 0.2046 0.2046
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.019
Trypanosoma cruzi 20S proteasome subunit 0.0182 0.1981 0.2016
Toxoplasma gondii proteasome 26S regulatory subunit 0.0021 0.0014 0.0014
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0039 0.0241 0.0245
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0021 0.0022 0.0022
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0148 0.0713
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0033 0.0164 0.0167
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0031 0.0132 0.0132
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.003 0.013 0.0133
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0148 0.0148
Brugia malayi beta-lactamase 0.0035 0.0187 0.0187
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0201 0.0205
Giardia lamblia Proteasome subunit beta type 1 0.0209 0.232 0.2361
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0148 0.0713
Onchocerca volvulus 0.0038 0.0223 0.1076
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.0113 0.0115
Echinococcus multilocularis Mastin 0.0038 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0155 0.1654 0.1684
Loa Loa (eye worm) RPN-3 protein 0.0039 0.0241 0.0245
Brugia malayi Proteasome subunit alpha type 7-1 0.0237 0.2658 0.2658
Brugia malayi Protein kinase domain containing protein 0.0036 0.0201 0.0201
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0187 0.2046 0.2083
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.018 0.196 0.1995
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0199 0.2192 0.2192
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Leishmania major proteasome alpha 1 subunit, putative 0.0187 0.2046 0.2083
Schistosoma mansoni multiubiquitin binding protein S5a 0.0021 0.0021 0.0021
Brugia malayi PCI domain containing protein 0.0033 0.0165 0.0165
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0187 0.2046 0.2083
Leishmania major hypothetical protein, conserved 0.005 0.0365 0.0371
Brugia malayi beta-lactamase family protein 0.0035 0.0187 0.0187
Toxoplasma gondii PCI domain-containing protein 0.0037 0.0207 0.0211
Brugia malayi steroid hormone receptor 0.0032 0.0148 0.0148
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0148 0.0148
Toxoplasma gondii heat shock protein hslv, putative 0.0155 0.1654 0.1684
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0183 0.1992 0.1992
Echinococcus granulosus Ankyrin 0.0036 0.0203 0.0203
Onchocerca volvulus 0.0035 0.0187 0.0902
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0838 1 1
Toxoplasma gondii proteasome regulatory subunit 0.0031 0.0132 0.0135
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0037 0.0207 0.0211
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0095 0.0921 0.0921
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0187 0.0187
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0039 0.0241 0.0245
Giardia lamblia 20S proteasome alpha subunit 3 0.0188 0.2052 0.2089
Loa Loa (eye worm) carbonic anhydrase 3 0.0171 0.1851 0.1885
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.013 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0148 0.0148
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Leishmania major proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Schistosoma mansoni hypothetical protein 0.0064 0.0536 0.0536
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0207 0.0211
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0033 0.0164 0.0167
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0148 0.0148
Echinococcus granulosus carbonic anhydrase II 0.0171 0.1851 0.1851
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.0536 0.0536
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.018 0.196 0.1995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0115
Brugia malayi PCI domain containing protein 0.003 0.013 0.013
Loa Loa (eye worm) RPT-2 protein 0.002 0.0007 0.0007
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0132 0.0135
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0132 0.0135
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0193 0.2113 0.2151
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Echinococcus granulosus carbonic anhydrase 0.0064 0.0536 0.0536
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.2072 0.2109
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0021 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0148 0.015
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0029 0.012 0.0122
Entamoeba histolytica hypothetical protein 0.0039 0.0233 0.0238
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Toxoplasma gondii proteasome subunit alpha type, putative 0.0188 0.2052 0.2089
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0041 0.0262 0.0262
Brugia malayi Probable 26S protease regulatory subunit 4 0.002 0.0007 0.0007
Plasmodium vivax proteasome subunit beta type-3, putative 0.0182 0.1981 0.2016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0148 0.015
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.013 0.0133
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.003 0.013 0.0133
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0182 0.1981 0.1981
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0182 0.1981 0.1981
Brugia malayi nuclear receptor NHR-88 0.0032 0.0148 0.0148
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0171 0.1854 0.1887
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0021 0.0021 0.0021
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0187 0.2046 0.2046
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0148 0.0148
Loa Loa (eye worm) trypsin family protein 0.0038 0.0223 0.0227
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0233 0.0233
Brugia malayi Kringle domain containing protein 0.002 0.0006 0.0006
Giardia lamblia 20S proteasome alpha subunit 6 0.0187 0.2046 0.2083
Toxoplasma gondii PCI domain-containing protein 0.003 0.013 0.0133
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0189 0.2072 0.2109
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0044 0.0292 0.0297
Leishmania major hypothetical protein, conserved 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.002 0.0007 0.0007
Brugia malayi proteasome subunit beta type 2 0.0182 0.1981 0.1981
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0188 0.2052 0.2052
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171 0.1851 0.1885
Echinococcus multilocularis transmembrane protease serine 3 0.0038 0.0223 0.0223
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0209 0.232 0.2361
Echinococcus multilocularis proteasome subunit alpha type 2 0.0193 0.2113 0.2113
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0189 0.2072 0.2109
Giardia lamblia 20S proteasome alpha subunit 7 0.0189 0.2072 0.2109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Echinococcus multilocularis glycoprotein Antigen 5 0.0038 0.0223 0.0223
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0132 0.0132
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.024 0.2698 0.2746
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0132 0.0135
Loa Loa (eye worm) hypothetical protein 0.0064 0.0536 0.0546
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0113 0.0115
Echinococcus multilocularis carbonic anhydrase 0.0064 0.0536 0.0536
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0029 0.0113 0.0115
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0036 0.0203 0.0203
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0188 0.2052 0.2089
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0006 0.0006
Onchocerca volvulus 0.0038 0.0223 0.1076
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0237 0.2658 0.2706
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0216 0.2401 0.2401
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.006 0.0497 0.24
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0148 0.015
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0155 0.1654 0.1684
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0189 0.2072 0.2072
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Plasmodium falciparum proteasome subunit beta type-7, putative 0.024 0.2698 0.2746
Leishmania major carbonic anhydrase-like protein 0.0171 0.1851 0.1885
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.002 0.0007 0.0007
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0823 0.9822 1
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0044 0.0292 0.0297
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0237 0.2658 0.2706
Loa Loa (eye worm) proteasome subunit alpha type 6 0.02 0.2204 0.2243
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0176 0.1913 0.1947
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Giardia lamblia 20S proteasome alpha subunit 4 0.0237 0.2658 0.2706
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0148 0.0148
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0182 0.1981 0.1981
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0187 0.019
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0182 0.1981 0.2016
Plasmodium vivax proteasome subunit beta type-1, putative 0.0209 0.232 0.2361
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Leishmania major proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0148 0.0148
Plasmodium vivax proteasome subunit beta type-7, putative 0.024 0.2698 0.2746
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0029 0.0113 0.0115
Schistosoma mansoni ankyrin 23/unc44 0.0036 0.0201 0.0201
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0171 0.1851 0.1851
Schistosoma mansoni hypothetical protein 0.0036 0.0201 0.0201
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0148 0.0148
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.1981 0.2016
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0148 0.0148
Echinococcus granulosus Mastin 0.0038 0.0223 0.0223
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171 0.1851 0.1885
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0033 0.0164 0.0167
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Loa Loa (eye worm) hypothetical protein 0.0216 0.2401 0.2445
Giardia lamblia Proteasome subunit beta type 7 precursor 0.024 0.2698 0.2746
Echinococcus granulosus proteasome subunit alpha type 6 0.02 0.2204 0.2204
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0044 0.0292 0.0297
Echinococcus multilocularis netrin receptor unc 5 0.0036 0.0201 0.0201
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Brugia malayi Proteasome subunit alpha type 1 0.0171 0.1845 0.1845
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0033 0.0165 0.0168
Giardia lamblia Hypothetical protein 0.0037 0.0207 0.0211
Echinococcus multilocularis enteropeptidase 0.0038 0.0223 0.0223
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0148 0.0148
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0044 0.0292 0.0292
Toxoplasma gondii hypothetical protein 0.0064 0.0536 0.0546
Echinococcus multilocularis Ankyrin 0.0036 0.0203 0.0203
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0233 0.0233
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0031 0.0132 0.0135
Toxoplasma gondii hypothetical protein 0.0027 0.0086 0.0088
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171 0.1851 0.1851
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0193 0.2113 0.2151
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0148 0.0148
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.002 0.0007 0.0007
Entamoeba histolytica proteasome regulatory subunit, putative 0.0037 0.0207 0.0211
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0209 0.232 0.232
Toxoplasma gondii proteasome subunit alpha1, putative 0.02 0.2204 0.2243
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0132 0.0135
Giardia lamblia 20S proteasome alpha subunit 5 0.0199 0.2192 0.2231
Echinococcus granulosus death domain containing protein 0.0036 0.0201 0.0201
Echinococcus multilocularis proteasome subunit beta type 7 0.0838 1 1
Brugia malayi Proteasome A-type and B-type family protein 0.0188 0.2057 0.2057
Brugia malayi proteasome subunit alpha type 2 0.0193 0.2113 0.2113
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0095 0.0921 0.0921
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0223 0.0223
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0021 0.0022 0.0022
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0033 0.0165 0.0168
Echinococcus granulosus carbonic anhydrase 0.0064 0.0536 0.0536
Loa Loa (eye worm) proteasome subunit beta type 3 0.0182 0.1981 0.2016
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0148 0.015
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0193 0.2113 0.2151
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0207
Trypanosoma brucei proteasome beta 2 subunit, putative 0.024 0.2698 0.2746
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0187 0.019
Echinococcus granulosus adhesion regulating molecule 1 0.0095 0.0921 0.0921
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0155 0.1654 0.1684
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.0006 0.0006
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0233 0.0238
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.002 0.0007 0.0007
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0039 0.0233 0.0238
Trypanosoma brucei proteasome beta 6 subunit 0.0209 0.232 0.2361
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0038 0.0223 0.0223
Plasmodium vivax proteasome subunit alpha type-6, putative 0.02 0.2204 0.2243
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0237 0.2658 0.2706
Toxoplasma gondii peptidase, T1 family protein 0.0189 0.2072 0.2109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.018 0.196 0.1995
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.002 0.0007 0.0007
Leishmania major proteasome beta 2 subunit, putative 0.024 0.2698 0.2746
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0187 0.019
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Leishmania major hypothetical protein, conserved 0.0035 0.0187 0.019
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0182 0.1981 0.1981
Toxoplasma gondii kringle domain-containing protein 0.002 0.0006 0.0006
Brugia malayi hypothetical protein 0.0038 0.0223 0.0223
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0148 0.0148
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0148 0.0148
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0199 0.2192 0.2231
Schistosoma mansoni 26S protease regulatory subunit 0.002 0.0007 0.0007
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0022 0.0022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0148 0.0148
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.0536 0.0536
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.1981 0.2016
Trypanosoma brucei proteasome beta 7 subunit 0.018 0.196 0.1995
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0033 0.0164 0.0167
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0033 0.0165 0.0165
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0823 0.9822 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.0536 0.0536
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.018 0.196 0.1995
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0823 0.9822 1
Loa Loa (eye worm) PAS-3 protein 0.0171 0.1852 0.1885
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0064 0.0536 0.0546
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0199 0.2192 0.2231
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0188 0.2052 0.2089
Brugia malayi 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Brugia malayi ecdysteroid receptor 0.0032 0.0148 0.0148
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Echinococcus granulosus Proteasome subunit alpha beta 0.0189 0.2072 0.2072
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0233 0.0238
Trypanosoma brucei proteasome alpha 7 subunit 0.0189 0.2072 0.2109
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0037 0.0207 0.0207
Brugia malayi Proteasome A-type and B-type family protein 0.018 0.196 0.196
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus nuclear factor of activated T cells 5 0.0354 0.4082 0.4082
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0148 0.0148
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0188 0.2052 0.2052
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0187 0.2046 0.2083
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0209 0.232 0.2361
Echinococcus granulosus glycoprotein Antigen 5 0.0038 0.0223 0.0223
Leishmania major proteasome beta 7 subunit, putative 0.018 0.196 0.1995
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.013 0.0133
Echinococcus granulosus Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0182 0.1981 0.2016
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0031 0.0132 0.0135
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0188 0.2052 0.2089
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0059 0.0482 0.0482
Echinococcus granulosus proteasome subunit alpha type 2 0.0193 0.2113 0.2113
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0037 0.0207 0.0207
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0199 0.2192 0.2192
Plasmodium falciparum carbonic anhydrase 0.0064 0.0536 0.0546
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0154
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0189 0.2072 0.2109
Plasmodium falciparum proteasome subunit beta type-5 0.0823 0.9822 1
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0292 0.0297
Loa Loa (eye worm) proteasome subunit beta type 2 0.0182 0.1981 0.2016
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0113 0.0115
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0148 0.0148
Echinococcus granulosus netrin receptor unc 5 0.0036 0.0201 0.0201
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0036 0.0201 0.0201
Onchocerca volvulus 0.0038 0.0223 0.1076
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0039 0.0241 0.0241
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.0113 0.0113
Onchocerca volvulus 0.0038 0.0223 0.1076
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0031 0.0132 0.0132
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.018 0.196 0.196
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0021 0.0022 0.0022
Plasmodium vivax proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0064 0.0536 0.0536
Onchocerca volvulus 0.0038 0.0223 0.1076
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Brugia malayi 26S proteasome subunit P45 family protein 0.002 0.0007 0.0007
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0187 0.2046 0.2083
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.0113 0.0113
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0182 0.1981 0.1981
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.003 0.013 0.0133
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0193 0.2113 0.2113
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0193 0.2113 0.2151
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0187 0.019
Schistosoma mansoni hypothetical protein 0.0194 0.2128 0.2128
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0188 0.2057 0.2057
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0207 0.0211
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0193 0.2113 0.2151
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0187 0.2046 0.2083
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0188 0.2057 0.2094
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0292 0.0297
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0148 0.0148
Leishmania major proteasome beta 2 subunit, putative 0.0182 0.1981 0.2016
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0029 0.0113 0.0113
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0187 0.019
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0188 0.2057 0.2094
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0033 0.0165 0.0168
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0155 0.1654 0.1522
Schistosoma mansoni proteasome regulatory subunit-related 0.0033 0.0165 0.0165
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0155 0.1654 0.1522
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0199 0.2192 0.2231
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Mycobacterium ulcerans proteasome PrcA 0.0155 0.1654 0.1522
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0187 0.019
Giardia lamblia Proteasome subunit beta type 4 precursor 0.018 0.196 0.1995
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.002 0.0007 0.0007
Echinococcus granulosus proteasome subunit beta type 6 0.0188 0.2057 0.2057
Echinococcus granulosus geminin 0.0194 0.2128 0.2128
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.249 0.2391
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.018 0.196 0.1995
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0188 0.2052 0.2089
Echinococcus granulosus proteasome subunit beta type 7 0.0838 1 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0823 0.9822 1
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0006
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Onchocerca volvulus 0.002 0.0007 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0189 0.2072 0.2109
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0132 0.0135
Brugia malayi Ubiquitin interaction motif family protein 0.0021 0.0021 0.0021
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0029 0.0113 0.0115
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0209 0.232 0.2361
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0038 0.0223 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0032 0.0154 0.0157
Echinococcus granulosus transmembrane protease serine 3 0.0038 0.0223 0.0223
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Onchocerca volvulus 0.0038 0.0223 0.1076
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.02 0.2204 0.2204
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0148 0.0148
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.0223
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0044 0.0292 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0148 0.0148
Onchocerca volvulus 0.0035 0.0187 0.0902
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.019
Loa Loa (eye worm) hypothetical protein 0.0064 0.0536 0.0546
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.024 0.2698 0.2746
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0021 0.0014 0.0014
Brugia malayi proteasome subunit alpha type 4 0.0171 0.1852 0.1852
Entamoeba histolytica proteasome regulatory subunit, putative 0.0021 0.0021 0.0021
Brugia malayi proteasome subunit beta type 1 0.0209 0.232 0.232
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Brugia malayi proteasome subunit alpha type 6 0.02 0.2204 0.2204
Echinococcus granulosus subfamily T1A non peptidase ue 0.0199 0.2192 0.2192
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0006 0.0006
Leishmania major proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Brugia malayi Uncoordinated protein 44 0.0036 0.0201 0.0201
Echinococcus multilocularis carbonic anhydrase II 0.0171 0.1851 0.1851
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0044 0.0292 0.0297
Toxoplasma gondii proteasome subunit alpha type, putative 0.0082 0.0764 0.0778
Plasmodium vivax proteasome subunit beta type-5, putative 0.0823 0.9822 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0188 0.2057 0.2094
Onchocerca volvulus Notchless protein homolog 0.0189 0.2072 1
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0193 0.2113 0.2151
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0189 0.2072 0.2072
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0029 0.0113 0.0113
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0155 0.1654 0.5
Schistosoma mansoni hypothetical protein 0.0088 0.0836 0.0836
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Onchocerca volvulus 0.0035 0.0187 0.0902
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0187 0.0187
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0155 0.1654 0.1684
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0088 0.0836 0.0836
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0033 0.0165 0.0168
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0148 0.0148
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0188 0.2057 0.2094
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0189 0.2072 0.2109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0148 0.0148
Echinococcus multilocularis carbonic anhydrase 0.0064 0.0536 0.0536
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0037 0.0207 0.0207
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0237 0.2658 0.2706
Onchocerca volvulus 0.0032 0.0148 0.0713
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0148 0.015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0205
Brugia malayi Trypsin-like protease protein 5 0.0038 0.0223 0.0223
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0209 0.232 0.2361
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.018 0.196 0.196
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0037 0.0207 0.0211
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0148 0.0148
Brugia malayi Protein kinase domain containing protein 0.002 0.0006 0.0006
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0823 0.9822 1
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0209 0.232 0.2361
Schistosoma mansoni 26S proteasome subunit S9 0.0037 0.0207 0.0207
Toxoplasma gondii proteasome beta subunit 0.0182 0.1981 0.2016
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0021 0.0014 0.0014
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.002 0.0007 0.0007
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0187 0.2046 0.2083
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.02 0.2204 0.2243
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0132 0.0132
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Leishmania major proteasome alpha 7 subunit, putative 0.0189 0.2072 0.2109
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0199 0.2192 0.2231
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.0223
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0199 0.2192 0.2231
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0031 0.0132 0.0135
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0262 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0148 0.015
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0033 0.0165 0.0168
Schistosoma mansoni carbonic anhydrase 0.0064 0.0536 0.0536
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0155 0.1654 0.1654
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.0006 0.0006
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0037 0.0207 0.0211
Plasmodium vivax proteasome subunit beta type-4, putative 0.018 0.196 0.1995
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0157
Loa Loa (eye worm) proteasome regulatory particle 0.0037 0.0207 0.0211
Brugia malayi proteasome subunit alpha type 3 0.0189 0.2072 0.2072
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0188 0.2052 0.2089
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.003 0.013 0.013
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Onchocerca volvulus Netrin receptor homolog 0.0036 0.0201 0.0972
Plasmodium vivax proteasome subunit beta type-6, putative 0.0188 0.2057 0.2094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0187 0.0187
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.2072 0.2109
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0021 0.0021
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0199 0.2192 0.2192
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171 0.1851 0.1851
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.005 0.0365 0.0371
Trypanosoma brucei carbonic anhydrase-like protein 0.0171 0.1851 0.1885
Trichomonas vaginalis 26S proteasome subunit, putative 0.003 0.013 0.0133
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0095 0.0921 0.0938
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.0536 0.0536
Giardia lamblia 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0148 0.0148

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.57 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717
IC50 (binding) = 0.57 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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