Detailed information for compound 104187

Basic information

Technical information
  • TDR Targets ID: 104187
  • Name: (E)-3-[3-(4-methylphenyl)phenyl]-N-[4-[(1-met hylpiperidin-1-ium-1-yl)methyl]phenyl]prop-2- enamide iodide
  • MW: 552.49 | Formula: C29H33IN2O
  • H donors: 1 H acceptors: 1 LogP: 6.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1ccc(cc1)C[N+]1(C)CCCCC1)/C=C/c1cccc(c1)c1ccc(cc1)C.[I-]
  • InChi: 1S/C29H32N2O.HI/c1-23-9-14-26(15-10-23)27-8-6-7-24(21-27)13-18-29(32)30-28-16-11-25(12-17-28)22-31(2)19-4-3-5-20-31;/h6-18,21H,3-5,19-20,22H2,1-2H3;1H/b18-13+;
  • InChiKey: XVHCDLSCKCQZOV-PUBYZPQMSA-N  

Network

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Synonyms

  • (E)-N-[4-[(1-methylpiperidin-1-ium-1-yl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]prop-2-enamide iodide
  • (E)-N-[4-[(1-methyl-1-piperidin-1-iumyl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]-2-propenamide iodide
  • (E)-N-[4-[(1-methylpiperidin-1-ium-1-yl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]acrylamide iodide
  • (E)-N-[4-[(1-methyl-1-piperidin-1-iumyl)methyl]phenyl]-3-[3-(p-tolyl)phenyl]prop-2-enamide iodide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis glycoprotein Antigen 5 0.0038 0.0223 0.0223
Onchocerca volvulus 0.002 0.0006 0.0027
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0031 0.0132 0.0135
Echinococcus granulosus carbonic anhydrase 0.0064 0.0536 0.0536
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0188 0.2057 0.2094
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0237 0.2658 0.2706
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0155 0.1654 0.5
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0262 0.0262
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0038 0.0223 0.0223
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0132 0.0135
Brugia malayi proteasome subunit alpha type 1 0.0187 0.2046 0.2046
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Brugia malayi beta-lactamase 0.0035 0.0187 0.0187
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0171 0.1851 0.1851
Echinococcus multilocularis proteasome subunit alpha type 6 0.02 0.2204 0.2204
Loa Loa (eye worm) carbonic anhydrase 3 0.0171 0.1851 0.1885
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0201 0.0205
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0037 0.0207 0.0211
Echinococcus multilocularis proteasome subunit beta type 6 0.0188 0.2057 0.2057
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0033 0.0164 0.0167
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0292 0.0297
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Brugia malayi steroid hormone receptor 0.0032 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0148 0.0148
Echinococcus multilocularis transmembrane protease serine 3 0.0038 0.0223 0.0223
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0033 0.0165 0.0168
Schistosoma mansoni netrin receptor unc5 0.0036 0.0201 0.0201
Onchocerca volvulus 0.0038 0.0223 0.1076
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0132 0.0135
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0193 0.2113 0.2151
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171 0.1851 0.1851
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0155 0.1654 0.1684
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0188 0.2052 0.2089
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0132 0.0135
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.0223
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.0536 0.0536
Leishmania major proteasome alpha 2 subunit, putative 0.0193 0.2113 0.2151
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0033 0.0164 0.0167
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0187 0.2046 0.2083
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.018 0.196 0.196
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Giardia lamblia 20S proteasome alpha subunit 2 0.0193 0.2113 0.2151
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0148 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0187 0.019
Echinococcus granulosus adhesion regulating molecule 1 0.0095 0.0921 0.0921
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0148 0.015
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Onchocerca volvulus Notchless protein homolog 0.0189 0.2072 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0148 0.0713
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0132 0.0132
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0032 0.0154 0.0157
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0088 0.0836 0.0836
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.003 0.013 0.0133
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.018 0.196 0.1995
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.002 0.0007 0.0007
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Giardia lamblia 20S proteasome alpha subunit 5 0.0199 0.2192 0.2231
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0201 0.0201
Echinococcus multilocularis proteasome subunit beta type 7 0.0838 1 1
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0205
Brugia malayi Kringle domain containing protein 0.002 0.0006 0.0006
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0237 0.2658 0.2706
Onchocerca volvulus 0.0035 0.0187 0.0902
Schistosoma mansoni multiubiquitin binding protein S5a 0.0021 0.0021 0.0021
Echinococcus granulosus carbonic anhydrase 0.0064 0.0536 0.0536
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0033 0.0165 0.0165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0187 0.0187
Brugia malayi nuclear receptor NHR-88 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0823 0.9822 1
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0199 0.2192 0.2231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0189 0.2072 0.2109
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0194 0.2128 0.2128
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0148 0.0148
Schistosoma mansoni coup transcription factor 0.0032 0.0148 0.0148
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.0113 0.0115
Brugia malayi Trypsin-like protease protein 5 0.0038 0.0223 0.0223
Toxoplasma gondii proteasome 26S regulatory subunit 0.0021 0.0014 0.0014
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0823 0.9822 1
Brugia malayi proteasome subunit beta type 2 0.0182 0.1981 0.1981
Brugia malayi 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0199 0.2192 0.2192
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0182 0.1981 0.1981
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0209 0.232 0.232
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0154
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Brugia malayi Proteasome A-type and B-type family protein 0.0188 0.2057 0.2057
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0148 0.0148
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0155 0.1654 0.1684
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0132 0.0135
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0292 0.0297
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.002 0.0007 0.0007
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0023 0.0037 0.0037
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.018 0.196 0.196
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0007 0.0007
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0209 0.232 0.2361
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0176 0.1913 0.1947
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.0536 0.0536
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Brugia malayi Ubiquitin interaction motif family protein 0.0021 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0216 0.2401 0.2401
Loa Loa (eye worm) hypothetical protein 0.0064 0.0536 0.0546
Echinococcus granulosus carbonic anhydrase 0.0064 0.0536 0.0536
Echinococcus multilocularis carbonic anhydrase 0.0064 0.0536 0.0536
Toxoplasma gondii hypothetical protein 0.0064 0.0536 0.0546
Loa Loa (eye worm) proteasome regulatory particle 0.0037 0.0207 0.0211
Brugia malayi Proteasome subunit alpha type 7-1 0.0237 0.2658 0.2658
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0199 0.2192 0.2192
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0033 0.0165 0.0168
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0155 0.1654 0.1684
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0148 0.0148
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Echinococcus granulosus proteasome prosome macropain 0.0823 0.9822 0.9822
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0165 0.0168
Echinococcus multilocularis geminin 0.0194 0.2128 0.2128
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.002 0.0007 0.0007
Echinococcus multilocularis carbonic anhydrase 0.0064 0.0536 0.0536
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.003 0.013 0.013
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0031 0.0132 0.0132
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0233 0.0233
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0033 0.0164 0.0167
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0188 0.2052 0.2089
Plasmodium falciparum carbonic anhydrase 0.0064 0.0536 0.0546
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.024 0.2698 0.2746
Trypanosoma brucei proteasome beta 6 subunit 0.0209 0.232 0.2361
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Onchocerca volvulus 0.0032 0.0148 0.0713
Schistosoma mansoni hypothetical protein 0.0059 0.0482 0.0482
Brugia malayi PCI domain containing protein 0.003 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0661 0.7833 0.7974
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0148 0.0148
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.018 0.196 0.1995
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0187 0.0187
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.003 0.013 0.0133
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0262 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.024 0.2698 0.2746
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0148 0.0148
Giardia lamblia 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0132 0.0135
Brugia malayi nuclear hormone receptor 0.0032 0.0148 0.0148
Leishmania major proteasome beta 7 subunit, putative 0.018 0.196 0.1995
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Brugia malayi Protein kinase domain containing protein 0.002 0.0006 0.0006
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.02 0.2204 0.2204
Schistosoma mansoni 26S protease regulatory subunit 6b 0.002 0.0007 0.0007
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0041 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0088
Echinococcus granulosus death domain containing protein 0.0036 0.0201 0.0201
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0823 0.9822 1
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0148 0.0148
Echinococcus granulosus proteasome subunit beta type 6 0.0188 0.2057 0.2057
Schistosoma mansoni hypothetical protein 0.0041 0.0262 0.0262
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0193 0.2113 0.2151
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0148 0.0148
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0148 0.0148
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0193 0.2113 0.2151
Loa Loa (eye worm) proteasome subunit beta type 2 0.0182 0.1981 0.2016
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.003 0.013 0.013
Giardia lamblia 20S proteasome alpha subunit 1 0.02 0.2204 0.2243
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0187 0.2046 0.2046
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0155 0.1654 0.1522
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.002 0.0007 0.0007
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0155 0.1654 0.1684
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0132 0.0135
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Echinococcus granulosus Ankyrin 0.0036 0.0203 0.0203
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0157
Brugia malayi proteasome subunit alpha type 4 0.0171 0.1852 0.1852
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0223 0.0223
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0022 0.0022
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0029 0.0113 0.0113
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0187 0.019
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0037 0.0207 0.0207
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0187 0.2046 0.2083
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0021 0.0014 0.0014
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0148 0.0148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0187 0.0187
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0031 0.0132 0.0132
Leishmania major proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Onchocerca volvulus 0.0038 0.0223 0.1076
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0132 0.0135
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0187 0.2046 0.2046
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0193 0.2113 0.2151
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.006 0.0497 0.24
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.003 0.013 0.013
Toxoplasma gondii proteasome subunit alpha type, putative 0.0188 0.2052 0.2089
Giardia lamblia Proteasome subunit beta type 1 0.0209 0.232 0.2361
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0199 0.2192 0.2192
Loa Loa (eye worm) beta-lactamase 0.0035 0.0187 0.019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0187 0.0187
Plasmodium falciparum proteasome subunit beta type-5 0.0823 0.9822 1
Toxoplasma gondii proteasome beta subunit 0.0182 0.1981 0.2016
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0188 0.2057 0.2094
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0187 0.019
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0044 0.0292 0.0297
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0189 0.2072 0.2109
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0033 0.0164 0.0164
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0132 0.0135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0148 0.0148
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0237 0.2658 0.2706
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Trichomonas vaginalis 26S proteasome subunit, putative 0.003 0.013 0.0133
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0095 0.0921 0.0938
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.018 0.196 0.1995
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0044 0.0292 0.0297
Leishmania major hypothetical protein, conserved 0.002 0.0006 0.0006
Plasmodium vivax proteasome subunit beta type-4, putative 0.018 0.196 0.1995
Loa Loa (eye worm) proteasome subunit beta type 1 0.0209 0.232 0.2361
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0155 0.1654 0.1684
Loa Loa (eye worm) hypothetical protein 0.0095 0.0921 0.0938
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0036 0.0201 0.0201
Echinococcus granulosus proteasome subunit beta type 7 0.0838 1 1
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.0113 0.0115
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0021 0.0021
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0031 0.0132 0.0135
Trichomonas vaginalis esterase, putative 0.0035 0.0187 0.019
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0354 0.4082 0.4082
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0182 0.1981 0.1981
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0039 0.0241 0.0245
Brugia malayi small heat shock protein 0.0661 0.7833 0.7833
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0237 0.2658 0.2706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0148 0.015
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0021 0.0022 0.0022
Brugia malayi proteasome subunit alpha type 6 0.02 0.2204 0.2204
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0188 0.2052 0.2052
Loa Loa (eye worm) RPN-3 protein 0.0039 0.0241 0.0245
Echinococcus granulosus glycoprotein Antigen 5 0.0038 0.0223 0.0223
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0064 0.0536 0.0536
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.0536 0.0536
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.018 0.196 0.1995
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.005 0.0365 0.0371
Loa Loa (eye worm) PAS-3 protein 0.0171 0.1852 0.1885
Leishmania major hypothetical protein, conserved 0.005 0.0365 0.0371
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0044 0.0292 0.0297
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.02 0.2204 0.2243
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0148 0.0148
Schistosoma mansoni 26S proteasome subunit S9 0.0037 0.0207 0.0207
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0033 0.0165 0.0168
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0171 0.1851 0.1885
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Brugia malayi beta-lactamase family protein 0.0035 0.0187 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0064 0.0536 0.0536
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Echinococcus granulosus proteasome subunit alpha type 6 0.02 0.2204 0.2204
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0188 0.2057 0.2094
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0039 0.0241 0.0245
Onchocerca volvulus 0.0035 0.0187 0.0902
Brugia malayi PCI domain containing protein 0.0033 0.0165 0.0165
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0023 0.0037 0.0037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.249 0.2391
Echinococcus granulosus Proteasome subunit alpha beta 0.0189 0.2072 0.2072
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.1981 0.2016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0148 0.0148
Toxoplasma gondii PCI domain-containing protein 0.0037 0.0207 0.0211
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0033 0.0164 0.0167
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0189 0.2072 0.2072
Giardia lamblia 20S proteasome alpha subunit 7 0.0189 0.2072 0.2109
Brugia malayi Uncoordinated protein 44 0.0036 0.0201 0.0201
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0188 0.2052 0.2089
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0039 0.0233 0.0238
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.1981 0.2016
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0188 0.2057 0.2094
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0237 0.2658 0.2658
Onchocerca volvulus 0.0038 0.0223 0.1076
Echinococcus multilocularis Ankyrin 0.0036 0.0203 0.0203
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0029 0.0113 0.0115
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.0536 0.0536
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.018 0.196 0.1995
Leishmania major proteasome alpha 1 subunit, putative 0.0187 0.2046 0.2083
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Schistosoma mansoni ankyrin 23/unc44 0.0036 0.0201 0.0201
Giardia lamblia Proteasome subunit beta type 3 0.0182 0.1981 0.2016
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0189 0.2072 0.2109
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0182 0.1981 0.2016
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0823 0.9822 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0182 0.1981 0.1981
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.0006 0.0006
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0021 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.0006 0.0006
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0182 0.1981 0.1981
Onchocerca volvulus 0.002 0.0007 0.0034
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.0113 0.0113
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0233 0.0238
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0209 0.232 0.232
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0199 0.2192 0.2231
Echinococcus granulosus nuclear factor of activated T cells 5 0.0354 0.4082 0.4082
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0044 0.0292 0.0297
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0182 0.1981 0.1981
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0039 0.0233 0.0238
Leishmania major proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0823 0.9822 1
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0113 0.0115
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0029 0.012 0.0122
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0038 0.0223 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0148 0.015
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Echinococcus granulosus transmembrane protease serine 3 0.0038 0.0223 0.0223
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.013 0.0133
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.002 0.0007 0.0007
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0233 0.0238
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0037 0.0207 0.0211
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0021 0.0014 0.0014
Trypanosoma brucei proteasome beta 7 subunit 0.018 0.196 0.1995
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0154
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0207 0.0211
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.0241 0.0241
Echinococcus multilocularis proteasome subunit alpha type 2 0.0193 0.2113 0.2113
Onchocerca volvulus 0.0038 0.0223 0.1076
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0044 0.0292 0.0297
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0033 0.0164 0.0167
Echinococcus granulosus Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0209 0.232 0.2361
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0148 0.0148
Brugia malayi proteasome subunit alpha type 3 0.0189 0.2072 0.2072
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0188 0.2057 0.2094
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0033 0.0164 0.0164
Brugia malayi 26S proteasome subunit P45 family protein 0.002 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0148 0.0148
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Toxoplasma gondii proteasome subunit beta type, putative 0.0823 0.9822 1
Echinococcus multilocularis netrin receptor unc 5 0.0036 0.0201 0.0201
Trypanosoma cruzi 20S proteasome subunit 0.0182 0.1981 0.2016
Leishmania major proteasome beta 2 subunit, putative 0.024 0.2698 0.2746
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0031 0.0132 0.0132
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0148 0.0148
Schistosoma mansoni proteasome regulatory subunit-related 0.0033 0.0165 0.0165
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0216 0.2401 0.2401
Leishmania major proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Entamoeba histolytica proteasome regulatory subunit, putative 0.0037 0.0207 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0148 0.0148
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0033 0.0165 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0187 0.019
Echinococcus multilocularis enteropeptidase 0.0038 0.0223 0.0223
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.024 0.2698 0.2746
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0189 0.2072 0.2109
Echinococcus granulosus netrin receptor unc 5 0.0036 0.0201 0.0201
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0044 0.0292 0.0292
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0033 0.0165 0.0168
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Schistosoma mansoni 26S protease regulatory subunit 0.002 0.0007 0.0007
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0095 0.0921 0.0921
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0148 0.0148
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.002 0.0007 0.0007
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0029 0.0113 0.0115
Loa Loa (eye worm) hypothetical protein 0.0064 0.0536 0.0546
Echinococcus granulosus proteasome subunit alpha type 2 0.0193 0.2113 0.2113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Brugia malayi Probable 26S protease regulatory subunit 4 0.002 0.0007 0.0007
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0199 0.2192 0.2231
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.019
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0037 0.0207 0.0207
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0183 0.1992 0.1992
Toxoplasma gondii proteasome subunit 0.0188 0.2057 0.2094
Leishmania major proteasome beta 5 subunit, putative 0.0823 0.9822 1
Echinococcus granulosus proteasome subunit beta t family 0.0182 0.1981 0.1981
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0033 0.0164 0.0167
Echinococcus granulosus geminin 0.0194 0.2128 0.2128
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0021 0.0021 0.0022
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0021 0.0021
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Onchocerca volvulus Netrin receptor homolog 0.0036 0.0201 0.0972
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Giardia lamblia Hypothetical protein 0.0037 0.0207 0.0211
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0209 0.232 0.2361
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.0113 0.0113
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0029 0.0113 0.0115
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0187 0.2046 0.2083
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0031 0.0132 0.0135
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Echinococcus granulosus tissue type plasminogen activator 0.002 0.0006 0.0006
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0189 0.2072 0.2109
Toxoplasma gondii PCI domain-containing protein 0.003 0.013 0.0133
Onchocerca volvulus 0.0038 0.0223 0.1076
Plasmodium falciparum proteasome subunit beta type-7, putative 0.024 0.2698 0.2746
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0188 0.2052 0.2089
Loa Loa (eye worm) hypothetical protein 0.0216 0.2401 0.2445
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0148 0.015
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.003 0.013 0.0133
Plasmodium vivax proteasome subunit beta type-6, putative 0.0188 0.2057 0.2094
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0021 0.0022 0.0022
Plasmodium falciparum proteasome subunit beta type-4 0.018 0.196 0.1995
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0006
Plasmodium vivax proteasome subunit beta type-7, putative 0.024 0.2698 0.2746
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171 0.1851 0.1885
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0155 0.1654 0.1684
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0207
Brugia malayi Proteasome A-type and B-type family protein 0.0823 0.9822 0.9822
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0188 0.2052 0.2052
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.0113 0.0113
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.002 0.0007 0.0007
Leishmania major proteasome beta 2 subunit, putative 0.0182 0.1981 0.2016
Echinococcus multilocularis adhesion regulating molecule 1 0.0095 0.0921 0.0921
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0209 0.232 0.2361
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0187 0.0187
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0207 0.0211
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0182 0.1981 0.2016
Mycobacterium ulcerans proteasome PrcB 0.0823 0.9822 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.024 0.2698 0.2746
Toxoplasma gondii PCI domain-containing protein 0.0039 0.0241 0.0245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0155 0.1654 0.1522
Schistosoma mansoni hypothetical protein 0.0088 0.0836 0.0836
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0148 0.015
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0823 0.9822 1
Leishmania major proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0148 0.0148
Plasmodium vivax proteasome subunit beta type-5, putative 0.0823 0.9822 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0241 0.0245
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0237 0.2658 0.2658
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0006 0.0006
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0037 0.0207 0.0207
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0188 0.2052 0.2089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0148 0.0148
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0088 0.0836 0.0836
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0187 0.019
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0171 0.1854 0.1887
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0033 0.0164 0.0164
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0113 0.0115
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0823 0.9822 0.9822
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0006 0.0006
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0132 0.0135
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Schistosoma mansoni hypothetical protein 0.0036 0.0201 0.0201
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0132 0.0132
Trypanosoma brucei carbonic anhydrase-like protein 0.0171 0.1851 0.1885
Toxoplasma gondii SAC3/GANP family protein 0.0029 0.0113 0.0115
Brugia malayi Trypsin family protein 0.0038 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Onchocerca volvulus 0.0038 0.0223 0.1076
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0031 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0148 0.0148
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.02 0.2204 0.2243
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0155 0.1654 0.1654
Plasmodium vivax proteasome subunit beta type-3, putative 0.0182 0.1981 0.2016
Giardia lamblia Proteasome subunit beta type 2 0.0182 0.1981 0.2016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0148 0.0148
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0182 0.1981 0.1981
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0064 0.0536 0.0546
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0187 0.2046 0.2083
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0188 0.2052 0.2089
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.002 0.0007 0.0007
Entamoeba histolytica proteasome regulatory subunit, putative 0.0021 0.0021 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0148 0.0148
Loa Loa (eye worm) proteasome subunit alpha type 6 0.02 0.2204 0.2243
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0838 1 1
Toxoplasma gondii heat shock protein hslv, putative 0.0155 0.1654 0.1684
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0187 0.019
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0176 0.1913 0.1947
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0021 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0148 0.0148
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0187 0.019
Toxoplasma gondii hypothetical protein 0.0027 0.0086 0.0088
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0029 0.0113 0.0115
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0037 0.0207 0.0211
Giardia lamblia 26S protease regulatory subunit 6B 0.002 0.0007 0.0007
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0233 0.0233
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0189 0.2072 0.2109
Giardia lamblia Proteasome subunit beta type 4 precursor 0.018 0.196 0.1995
Onchocerca volvulus 0.002 0.0007 0.0034
Giardia lamblia 20S proteasome alpha subunit 6 0.0187 0.2046 0.2083
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.0113 0.0115
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0155 0.1654 0.1684
Toxoplasma gondii proteasome subunit alpha type, putative 0.0082 0.0764 0.0778
Brugia malayi ecdysteroid receptor 0.0032 0.0148 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.019
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0209 0.232 0.2361
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Brugia malayi 20S proteasome alpha5 subunit 0.0199 0.2192 0.2192
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.024 0.2698 0.2746
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0188 0.2057 0.2094
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Brugia malayi proteasome subunit alpha type 2 0.0193 0.2113 0.2113
Loa Loa (eye worm) hypothetical protein 0.0064 0.0536 0.0546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0115
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0022 0.0022
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.02 0.2204 0.2243
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.003 0.013 0.0133
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0021 0.0022 0.0022
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0237 0.2658 0.2706
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0031 0.0132 0.0135
Leishmania major carbonic anhydrase-like protein 0.0171 0.1851 0.1885
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0148 0.0713
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0193 0.2113 0.2113
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0292 0.0292
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0193 0.2113 0.2151
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.003 0.013 0.0133
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0187 0.2046 0.2083
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0209 0.232 0.2361
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.018 0.196 0.1995
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Entamoeba histolytica hypothetical protein 0.0039 0.0233 0.0238
Toxoplasma gondii peptidase, T1 family protein 0.0189 0.2072 0.2109
Brugia malayi Protein kinase domain containing protein 0.0036 0.0201 0.0201
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0148 0.015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0262 0.0262
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0148 0.0148
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0148 0.0713
Brugia malayi proteasome subunit beta type 1 0.0209 0.232 0.232
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0148 0.0148
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0039 0.0241 0.0241
Brugia malayi Proteasome subunit alpha type 1 0.0171 0.1845 0.1845
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0209 0.232 0.2361
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0031 0.0132 0.0132
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0193 0.2113 0.2151
Leishmania major hypothetical protein, conserved 0.0035 0.0187 0.019
Mycobacterium ulcerans proteasome PrcA 0.0155 0.1654 0.1522
Plasmodium vivax proteasome subunit beta type-2, putative 0.0182 0.1981 0.2016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0115
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0193 0.2113 0.2151
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0199 0.2192 0.2231
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0031 0.0132 0.0135
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0187 0.2046 0.2083
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0182 0.1981 0.2016
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0044 0.0292 0.0297
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.013 0.0133
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.1981 0.2016
Brugia malayi Proteasome A-type and B-type family protein 0.018 0.196 0.196
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0021 0.0021 0.0021
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0037 0.0207 0.0211
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0029 0.0113 0.0113
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.002 0.0007 0.0007
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0033 0.0165 0.0168
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0036 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0194 0.2128 0.2128
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0148 0.0148
Brugia malayi Death domain containing protein 0.0036 0.0201 0.0201
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0036 0.0203 0.0203
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0148 0.015
Plasmodium vivax proteasome subunit alpha type-6, putative 0.02 0.2204 0.2243
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0148 0.0148
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0199 0.2192 0.2231
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0171 0.1851 0.1851
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0148 0.0148
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.0536 0.0536
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.2072 0.2109
Echinococcus multilocularis Mastin 0.0038 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0033 0.0165 0.0168
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0038 0.0223 0.0223
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.018 0.196 0.196
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0039 0.0233 0.0233
Trypanosoma brucei proteasome alpha 7 subunit 0.0189 0.2072 0.2109
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Brugia malayi beta-lactamase family protein 0.0035 0.0187 0.0187
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0823 0.9822 1
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0187 0.2046 0.2046
Echinococcus multilocularis carbonic anhydrase II 0.0171 0.1851 0.1851
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.002 0.0007 0.0007
Echinococcus granulosus carbonic anhydrase II 0.0171 0.1851 0.1851
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0064 0.0536 0.0536
Loa Loa (eye worm) trypsin family protein 0.0038 0.0223 0.0227
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0267
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.0536 0.0536
Echinococcus granulosus subfamily T1A non peptidase ue 0.0199 0.2192 0.2192
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0095 0.0921 0.0921
Giardia lamblia 20S proteasome alpha subunit 4 0.0237 0.2658 0.2706
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0039 0.0241 0.0245
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0132 0.0135
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.02 0.2204 0.2243
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0033 0.0164 0.0167
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0007 0.0007
Onchocerca volvulus 0.0035 0.0187 0.0902
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0182 0.1981 0.1981
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0209 0.232 0.232
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.002 0.0007 0.0007
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0187 0.2046 0.2083
Schistosoma mansoni carbonic anhydrase 0.0064 0.0536 0.0536
Plasmodium vivax proteasome subunit beta type-1, putative 0.0209 0.232 0.2361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0148 0.015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0227
Echinococcus granulosus enteropeptidase 0.0038 0.0223 0.0223
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0188 0.2057 0.2057
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0033 0.0164 0.0164
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171 0.1851 0.1851
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0182 0.1981 0.2016
Loa Loa (eye worm) RPT-2 protein 0.002 0.0007 0.0007
Loa Loa (eye worm) proteasome subunit beta type 3 0.0182 0.1981 0.2016
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0199 0.2192 0.2231
Loa Loa (eye worm) PCI domain-containing protein 0.0033 0.0165 0.0168
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.2072 0.2109
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0823 0.9822 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0823 0.9822 1
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.0006 0.0006
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.013 0.0133
Echinococcus granulosus Mastin 0.0038 0.0223 0.0223
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0038 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.019
Brugia malayi proteasome subunit beta type 3 0.0182 0.1981 0.1981
Mycobacterium ulcerans hypothetical protein 0.0038 0.0223 0.0038
Toxoplasma gondii proteasome subunit alpha1, putative 0.02 0.2204 0.2243
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0033 0.0164 0.0167
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0187 0.2046 0.2083
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0148 0.0148
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0223 0.0223
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0182 0.1981 0.2016
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0199 0.2192 0.2231
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0033 0.0165 0.0165
Loa Loa (eye worm) proteasome Regulatory Particle 0.0033 0.0164 0.0167
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0188 0.2052 0.2052
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0164 0.0167
Leishmania major proteasome alpha 7 subunit, putative 0.0189 0.2072 0.2109
Toxoplasma gondii proteasome regulatory subunit 0.0031 0.0132 0.0135
Echinococcus multilocularis proteasome (prosome, macropain) 0.0823 0.9822 0.9822
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0237 0.2658 0.2706
Brugia malayi hypothetical protein 0.0038 0.0223 0.0223
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0021 0.0022 0.0022
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171 0.1851 0.1885
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Trypanosoma brucei proteasome beta 2 subunit, putative 0.024 0.2698 0.2746
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0148 0.0148
Toxoplasma gondii kringle domain-containing protein 0.002 0.0006 0.0006
Toxoplasma gondii ABC1 family protein 0.0035 0.0187 0.019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0148 0.0148
Giardia lamblia Proteasome subunit beta type 7 precursor 0.024 0.2698 0.2746
Leishmania major proteasome alpha 7 subunit, putative 0.0237 0.2658 0.2706
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0189 0.2072 0.2072
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0039 0.0241 0.0245
Echinococcus multilocularis carbonic anhydrase 0.0064 0.0536 0.0536
Giardia lamblia 20S proteasome alpha subunit 3 0.0188 0.2052 0.2089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.57 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717
IC50 (binding) = 0.57 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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