TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 396.405 | Formula: C23H19F3N2O
H donors: 1 H acceptors: 1 LogP: 5.43 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1cccc2c1cccc2)NCc1coc(n1)c1ccc(cc1)C(F)(F)F
InChi: 1S/C23H19F3N2O/c1-15(20-8-4-6-16-5-2-3-7-21(16)20)27-13-19-14-29-22(28-19)17-9-11-18(12-10-17)23(24,25)26/h2-12,14-15,27H,13H2,1H3
InChiKey: KVTMXTPGMVJIAY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein, conserved	0.0046	0.0266	0.0076
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0052	0.0333	0.0484
Loa Loa (eye worm)	hypothetical protein	0.027	0.2826	0.3043
Brugia malayi	Protein kinase domain containing protein	0.027	0.2826	0.3043
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0202	0.0232
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.2826	0.3286
Leishmania major	hypothetical protein, conserved	0.0046	0.0266	0.0584
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0266	0.0286
Trypanosoma brucei	protein kinase, putative	0.0052	0.0333	0.0297
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0046	0.0266	0.7511
Onchocerca volvulus		0.0054	0.0354	1
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0046	0.0266	0.0309
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.027	0.2826	0.3286
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0202	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Loa Loa (eye worm)	transcription factor SMAD2	0.0134	0.1268	0.1366
Brugia malayi	Oxysterol binding protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0161	0.1571	0.2438
Entamoeba histolytica	PH domain containing protein	0.0046	0.0266	0.0076
Entamoeba histolytica	protein kinase, putative	0.0052	0.0333	0.015
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0046	0.0266	0.0266
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0202	0.0156
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Schistosoma mansoni	rho gtpase activating protein	0.0046	0.0266	0.0309
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0266	0.007
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0046	0.0266	0.0266
Loa Loa (eye worm)	PH domain-containing protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Echinococcus granulosus	Pleckstrin y	0.0046	0.0266	0.0309
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0052	0.0333	0.0297
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0052	0.0333	0.0442
Entamoeba histolytica	protein kinase, putative	0.0835	0.9288	1
Schistosoma mansoni	syntrophin	0.0046	0.0266	0.0309
Echinococcus multilocularis	survival motor neuron protein 1	0.0266	0.2772	0.2772
Brugia malayi	hypothetical protein	0.0028	0.0058	0.0063
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0046	0.0266	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Loa Loa (eye worm)	uncoordinated protein 104	0.0046	0.0266	0.0286
Leishmania major	hypothetical protein, conserved	0.0046	0.0266	0.0584
Brugia malayi	Syntrophin-1	0.0046	0.0266	0.0286
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0339	0.3614	0.5732
Trichomonas vaginalis	AGC family protein kinase	0.0835	0.9288	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0256	0.0297
Schistosoma mansoni	hypothetical protein	0.0046	0.0266	0.0309
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.027	0.2826	0.2826
Leishmania major	mitochondrial DNA polymerase beta	0.0339	0.3614	1
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0266	0.0335
Echinococcus granulosus	protein kinase c epsilon type	0.027	0.2826	0.3286
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0179	0.1778	1
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Trypanosoma cruzi	hypothetical protein	0.0046	0.0266	0.0335
Echinococcus multilocularis	Oxysterol binding protein 11	0.0046	0.0266	0.0266
Toxoplasma gondii	hypothetical protein	0.0046	0.0266	0.0239
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.027	0.2826	0.3043
Echinococcus multilocularis	nervana 2	0.0519	0.5665	0.5665
Plasmodium vivax	PH domain containing protein	0.0046	0.0266	0.0366
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0266	0.0286
Echinococcus granulosus	Rho GTPase activating protein 24	0.0046	0.0266	0.0309
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0375	0.0404
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0046	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0058	0.0063
Trypanosoma cruzi	Protein kinase B	0.0571	0.6263	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0266	0.0076
Entamoeba histolytica	protein kinase, putative	0.0052	0.0333	0.015
Entamoeba histolytica	protein kinase, putative	0.0789	0.8756	0.9415
Trichomonas vaginalis	centaurin gamma, putative	0.0046	0.0266	0.007
Brugia malayi	Dynamin	0.0046	0.0266	0.0286
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0256	0.0297
Trypanosoma cruzi	hypothetical protein	0.0046	0.0266	0.0335
Onchocerca volvulus		0.0046	0.0266	0.7511
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0256	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0052	0.0333	0.0297
Echinococcus granulosus	oxysterol binding protein 1	0.0046	0.0266	0.0309
Trichomonas vaginalis	centaurin alpha, putative	0.0046	0.0266	0.007
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0266	0.0076
Schistosoma mansoni	hypothetical protein	0.0046	0.0266	0.0309
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Schistosoma mansoni	serine/threonine-protein kinase	0.0571	0.6263	0.7283
Onchocerca volvulus		0.0046	0.0266	0.7511
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0046	0.0266	0.0309
Entamoeba histolytica	hypothetical protein	0.0046	0.0266	0.0076
Echinococcus granulosus	microtubule associated protein 2	0.0775	0.86	1
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0046	0.0266	0.0266
Loa Loa (eye worm)	AGC/NDR protein kinase	0.027	0.2826	0.3043
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0046	0.0266	0.0309
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0046	0.0266	0.0366
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Loa Loa (eye worm)	cytohesin 3	0.0046	0.0266	0.0286
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.2826	0.3286
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0046	0.0266	0.0286
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0266	0.0286
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0339	0.3614	0.5732
Trichomonas vaginalis	AGC family protein kinase	0.0835	0.9288	1
Trypanosoma cruzi	hypothetical protein	0.0046	0.0266	0.0335
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.027	0.2826	0.3286
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.2826	0.3286
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0046	0.0266	0.0335
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0266	0.007
Brugia malayi	probable spectrin beta chain	0.0046	0.0266	0.0286
Schistosoma mansoni	hypothetical protein	0.0046	0.0266	0.0309
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0202	0.0235
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0266	0.0309
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0519	0.5665	0.6587
Echinococcus granulosus	cytohesin 1	0.0046	0.0266	0.0309
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0266	0.0309
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Trichomonas vaginalis	AGC family protein kinase	0.0317	0.3358	0.3473
Schistosoma mansoni	hypothetical protein	0.0054	0.0354	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Schistosoma mansoni	zinc finger protein	0.0046	0.0266	0.0309
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0266	0.0076
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.0266	0.0286
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Echinococcus multilocularis	nervana 2	0.0519	0.5665	0.5665
Loa Loa (eye worm)	rho-GTPase-activating	0.0046	0.0266	0.0286
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0333	0.0297
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Trichomonas vaginalis	kinesin light chain, putative	0.0046	0.0266	0.007
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.0202	0.0235
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0266	0.007
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0333	0.015
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0046	0.0266	0.0266
Entamoeba histolytica	protein kinase, putative	0.0052	0.0333	0.015
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.027	0.2826	0.2826
Trichomonas vaginalis	hypothetical protein	0.0046	0.0266	0.007
Brugia malayi	Cytohesin 3	0.0046	0.0266	0.0286
Echinococcus multilocularis	dynamin 1	0.0046	0.0266	0.0266
Echinococcus granulosus	myotubularin protein 13	0.0046	0.0266	0.0309
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0046	0.0266	0.0366
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0333	0.015
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0256	0.0297
Schistosoma mansoni	centaurin alpha	0.0046	0.0266	0.0309
Echinococcus granulosus	pdz domain containing protein	0.0046	0.0266	0.0309
Trichomonas vaginalis	AGC family protein kinase	0.027	0.2826	0.2888
Brugia malayi	Protein kinase domain containing protein	0.027	0.2826	0.3043
Echinococcus granulosus	pleckstrin y domain containing family A	0.0046	0.0266	0.0309
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0256	0.0297
Loa Loa (eye worm)	syntrophin-1	0.0046	0.0266	0.0286
Echinococcus multilocularis	beta 1 syntrophin	0.0046	0.0266	0.0266
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0161	0.1571	0.1639
Entamoeba histolytica	hypothetical protein	0.0046	0.0266	0.0076
Echinococcus granulosus	NDR protein kinase	0.027	0.2826	0.3286
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0046	0.0266	0.0309
Loa Loa (eye worm)	MH2 domain-containing protein	0.0134	0.1268	0.1366
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.027	0.2826	0.3043
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0046	0.0266	0.0266
Entamoeba histolytica	hypothetical protein	0.0046	0.0266	0.0076
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0052	0.0333	0.0297
Echinococcus multilocularis	Glutaredoxin protein 5	0.0519	0.5665	0.5665
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0266	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0052	0.0333	0.0484
Toxoplasma gondii	AGC kinase	0.0789	0.8756	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.027	0.2826	0.2888
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0046	0.0266	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Schistosoma mansoni	hypothetical protein	0.004	0.0197	0.0229
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0266	0.0335
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0052	0.0333	0.0442
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0519	0.5665	0.5665
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0835	0.9288	1
Trichomonas vaginalis	AGC family protein kinase	0.0835	0.9288	1
Schistosoma mansoni	microtubule-associated protein tau	0.0775	0.86	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0041	0.0202	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Brugia malayi	Cadps2 protein	0.0046	0.0266	0.0286
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0046	0.0266	0.0309
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0046	0.0266	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Echinococcus granulosus	oxysterol binding protein 3	0.0046	0.0266	0.0309
Entamoeba histolytica	protein kinase 2, putative	0.0524	0.5731	0.6088
Onchocerca volvulus		0.0046	0.0266	0.7511
Schistosoma mansoni	hypothetical protein	0.0046	0.0266	0.0309
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0256	0.0256
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0266	0.0286
Leishmania major	serine/threonine-protein kinase a, putative	0.0052	0.0333	0.0771
Echinococcus granulosus	beta 1 syntrophin	0.0046	0.0266	0.0309
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0052	0.0333	0.0442
Echinococcus granulosus	calcium dependent secretion activator 1	0.0046	0.0266	0.0309
Echinococcus multilocularis	serine:threonine protein kinase N2	0.027	0.2826	0.2826
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0046	0.0266	0.007
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.2826	0.3286
Entamoeba histolytica	PH domain containing protein	0.0046	0.0266	0.0076
Echinococcus granulosus	Pleckstrin y	0.0046	0.0266	0.0309
Onchocerca volvulus		0.0046	0.0266	0.7511
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0041	0.0202	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Schistosoma mansoni	serine/threonine-protein kinase	0.0571	0.6263	0.7283
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0046	0.0266	0.0309
Echinococcus granulosus	oxysterol binding protein 9	0.0046	0.0266	0.0309
Plasmodium falciparum	oxysterol-binding protein, putative	0.0046	0.0266	0.0366
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0058	0.0399	0.055
Brugia malayi	MH2 domain containing protein	0.0134	0.1268	0.1366
Echinococcus granulosus	serine:threonine protein kinase N2	0.027	0.2826	0.3286
Schistosoma mansoni	growth factor receptor-bound protein	0.0046	0.0266	0.0309
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0052	0.0333	0.0442
Entamoeba histolytica	PH domain containing protein	0.0046	0.0266	0.0076
Onchocerca volvulus		0.0046	0.0266	0.7511
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0202	0.0235
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0266	0.0286
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0046	0.0266	0.0266
Echinococcus granulosus	nervana 2	0.0519	0.5665	0.6587
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0266	0.0076
Giardia lamblia	Kinase, AGC PKA	0.0524	0.5731	0.5
Loa Loa (eye worm)	hypothetical protein	0.0266	0.2772	0.2985
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0266	0.007
Onchocerca volvulus		0.0046	0.0266	0.7511
Toxoplasma gondii	protein kinase domain-containing protein	0.0052	0.0333	0.0315
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0046	0.0266	0.0266
Brugia malayi	Dynamin	0.0046	0.0266	0.0286
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0052	0.0333	0.0771
Echinococcus multilocularis	protein kinase c iota type	0.027	0.2826	0.2826
Toxoplasma gondii	hypothetical protein	0.0046	0.0266	0.0239
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0048	0.028	0.024
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.2826	0.3286
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Onchocerca volvulus	Putative zinc finger protein	0.0046	0.0266	0.7511
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0041	0.0202	0.0165
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0524	0.5731	0.5731
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0266	0.007
Echinococcus granulosus	Pleckstrin y	0.0046	0.0266	0.0309
Schistosoma mansoni	dynamin	0.0046	0.0266	0.0309
Echinococcus granulosus	protein kinase c iota type	0.027	0.2826	0.3286
Toxoplasma gondii	AtPH1 family protein	0.0046	0.0266	0.0239
Entamoeba histolytica	hypothetical protein	0.0046	0.0266	0.0076
Trypanosoma brucei	PH domain containing protein, putative	0.0046	0.0266	0.0225
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0046	0.0266	0.0076
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.027	0.2826	0.3043
Echinococcus granulosus	Oxysterol binding protein 11	0.0046	0.0266	0.0309
Echinococcus multilocularis	actin binding protein anillin	0.0046	0.0266	0.0266
Brugia malayi	Protein kinase domain containing protein	0.0835	0.9288	1
Trypanosoma cruzi	hypothetical protein	0.0046	0.0266	0.0335
Trichomonas vaginalis	AGC family protein kinase	0.027	0.2826	0.2888
Onchocerca volvulus	Protein melted homolog	0.0046	0.0266	0.7511
Brugia malayi	protein kinase C II.	0.027	0.2826	0.3043
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0266	0.0366
Echinococcus granulosus	nervana 2	0.0519	0.5665	0.6587
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0046	0.0266	0.0266
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0265	0.2759	0.2815
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0046	0.0266	0.007
Brugia malayi	Pleckstrin Homology Domain	0.0046	0.0266	0.0286
Echinococcus multilocularis	serine threonine protein kinase	0.027	0.2826	0.2826
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0835	0.9288	1
Schistosoma mansoni	atypical protein kinase C	0.027	0.2826	0.3286
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0266	0.0366
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0266	0.0309
Loa Loa (eye worm)	AGC/PKN protein kinase	0.027	0.2826	0.3043
Trypanosoma cruzi	NIMA-related kinase, putative	0.0052	0.0333	0.0442
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0256	0.0297
Echinococcus multilocularis	protein kinase c epsilon type	0.027	0.2826	0.2826
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Trypanosoma cruzi	hypothetical protein	0.0046	0.0266	0.0335
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0339	0.3614	0.3853
Schistosoma mansoni	dynamin	0.0046	0.0266	0.0309
Echinococcus multilocularis	pdz domain containing protein	0.0046	0.0266	0.0266
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0052	0.0333	0.0442
Schistosoma mansoni	hypothetical protein	0.0046	0.0266	0.0309
Echinococcus granulosus	dynamin 1	0.0046	0.0266	0.0309
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0046	0.0266	0.0286
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0571	0.6263	0.6673
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0046	0.0266	0.0335
Leishmania major	folate/biopterin transporter, putative	0.0052	0.0333	0.0771
Brugia malayi	Uncoordinated protein 104	0.0046	0.0266	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0197	0.0229
Brugia malayi	MAX-1A	0.0046	0.0266	0.0286
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.027	0.2826	0.3286
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0266	0.0266
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0046	0.0266	0.0366
Brugia malayi	TBC domain containing protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Entamoeba histolytica	hypothetical protein	0.0052	0.0333	0.015
Brugia malayi	p70 ribosomal S6 kinase beta	0.0789	0.8756	0.9428
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0161	0.1571	0.4253
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0266	0.0335
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0046	0.0266	0.0335
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0266	0.0309
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0046	0.0266	0.0266
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0333	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.027	0.2826	0.2826
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.027	0.2826	0.2826
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0256	0.0275
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Entamoeba histolytica	protein kinase, putative	0.0835	0.9288	1
Brugia malayi	Inositol-1	0.0041	0.0202	0.0218
Echinococcus granulosus	serine/threonine protein kinase	0.0571	0.6263	0.7283
Brugia malayi	Oxysterol-binding protein	0.0046	0.0266	0.0286
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Echinococcus multilocularis	oxysterol binding protein 3	0.0046	0.0266	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0046	0.0266	0.7511
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0835	0.9288	1
Toxoplasma gondii	Oxysterol-binding protein	0.0046	0.0266	0.0239
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0266	0.0266
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0046	0.0266	0.0239
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0266	0.0266
Echinococcus multilocularis	microtubule associated protein 2	0.0775	0.86	0.86
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0052	0.0333	0.0144
Echinococcus multilocularis	oxysterol binding protein 9	0.0046	0.0266	0.0266
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0046	0.0266	0.007
Schistosoma mansoni	myotubularin-related protein	0.0046	0.0266	0.0309
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0375	0.0404
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0266	0.0266
Echinococcus multilocularis	cytohesin 1	0.0046	0.0266	0.0266
Entamoeba histolytica	protein kinase, putative	0.0052	0.0333	0.015
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0046	0.0266	0.0366
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0046	0.0266	0.0309
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0046	0.0266	0.0266
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.0202	0.0202
Entamoeba histolytica	protein kinase, putative	0.0052	0.0333	0.015
Echinococcus granulosus	serine threonine protein kinase nrc	0.0524	0.5731	0.6665
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0375	0.0404
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Echinococcus multilocularis	rac serine:threonine kinase	0.0571	0.6263	0.6263
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Schistosoma mansoni	hypothetical protein	0.0038	0.0172	0.02
Entamoeba histolytica	p21-activated kinase	0.0052	0.0333	0.015
Schistosoma mansoni	serine/threonine kinase	0.027	0.2826	0.3286
Brugia malayi	hypothetical protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Entamoeba histolytica	protein kinase, putative	0.027	0.2826	0.2892
Echinococcus multilocularis	myotubularin protein 13	0.0046	0.0266	0.0266
Brugia malayi	hypothetical protein	0.004	0.0197	0.0212
Onchocerca volvulus	outspread protein homolog	0.0046	0.0266	0.7511
Toxoplasma gondii	hypothetical protein	0.0055	0.036	0.0347
Echinococcus granulosus	DCC interacting protein 13 beta	0.0046	0.0266	0.0309
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0052	0.0333	0.0442
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0197	0.0229
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0172	0.0186
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0354	0.0412
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.028	0.0357
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0524	0.5731	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0046	0.0266	0.0309
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0571	0.6263	1
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Loa Loa (eye worm)	oxysterol binding protein	0.0046	0.0266	0.0286
Onchocerca volvulus		0.0046	0.0266	0.7511
Loa Loa (eye worm)	Plekhf2 protein	0.0046	0.0266	0.0286
Brugia malayi	hypothetical protein	0.0266	0.2772	0.2985
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0197	0.0197
Trichomonas vaginalis	centaurin beta, putative	0.0046	0.0266	0.007
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0052	0.0333	0.0315
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0333	0.015
Trichomonas vaginalis	AGC family protein kinase	0.0835	0.9288	1
Plasmodium vivax	hypothetical protein, conserved	0.0046	0.0266	0.0366
Trypanosoma cruzi	NIMA-related kinase, putative	0.0052	0.0333	0.0442
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0266	0.007
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0048	0.028	0.0357
Echinococcus multilocularis	serine:threonine protein kinase 38	0.027	0.2826	0.2826
Trypanosoma cruzi	hypothetical protein	0.0046	0.0266	0.0335
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0046	0.0266	0.007
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.028	0.0357
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0052	0.0333	0.0771
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0256	0.0256
Brugia malayi	Plekhf2 protein	0.0046	0.0266	0.0286
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.2826	0.3286
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0266	0.0286
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.027	0.2826	0.3043
Echinococcus multilocularis	serine:threonine protein kinase N2	0.027	0.2826	0.2826
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0266	0.0335
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0052	0.0333	0.0144
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0524	0.5731	0.9143
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0266	0.0309
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0046	0.0266	0.0309
Entamoeba histolytica	hypothetical protein	0.0046	0.0266	0.0076
Plasmodium falciparum	PH domain-containing protein, putative	0.0046	0.0266	0.0366
Trichomonas vaginalis	alpha chimerin, putative	0.0046	0.0266	0.007
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0375	0.0404
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0524	0.5731	1
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0333	0.0144
Echinococcus granulosus	Glutaredoxin protein 5	0.0519	0.5665	0.6587
Schistosoma mansoni	vav2	0.0046	0.0266	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Schistosoma mansoni	zinc finger protein	0.0046	0.0266	0.0309
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.2826	0.3286
Echinococcus multilocularis	oxysterol binding protein 1	0.0046	0.0266	0.0266
Leishmania major	protein kinase, putative	0.0052	0.0333	0.0771
Entamoeba histolytica	hypothetical protein	0.0052	0.0333	0.015
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0172	0.0186
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0046	0.0266	0.0076
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0354	0.0381
Echinococcus granulosus	survival motor neuron protein 1	0.0266	0.2772	0.3224
Mycobacterium ulcerans	hypothetical protein	0.0179	0.1778	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0202	0.0404
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0046	0.0266	0.0266
Loa Loa (eye worm)	inositol-1	0.0041	0.0202	0.0218
Echinococcus granulosus	GRB2 associated binding protein 3	0.0046	0.0266	0.0309
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Trypanosoma cruzi	hypothetical protein	0.0046	0.0266	0.0335
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0789	0.8756	0.9428
Brugia malayi	PH domain containing protein	0.0046	0.0266	0.0286
Brugia malayi	Hr1 repeat family protein	0.027	0.2826	0.3043
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0333	0.015
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0266	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0835	0.9288	1
Echinococcus granulosus	protein kinase C gamma type	0.027	0.2826	0.3286
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0266	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0571	0.6263	0.6673
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0333	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0835	0.9288	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0037	0.0153	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0524	0.5731	0.6665
Echinococcus granulosus	Protein kinase C brain isozyme	0.027	0.2826	0.3286
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0266	0.007
Leishmania major	protein kinase, putative	0.0052	0.0333	0.0771

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 1 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference
Inhibition (functional)	= 2 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1862210

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1041962