TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 305.455 | Formula: C19H31NO2
H donors: 0 H acceptors: 1 LogP: 4.61 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCOc1cc(C)c(c(c1)C)C(=O)CCN(C)C
InChi: 1S/C19H31NO2/c1-6-7-8-9-12-22-17-13-15(2)19(16(3)14-17)18(21)10-11-20(4)5/h13-14H,6-12H2,1-5H3
InChiKey: WCSRARMLRDKOED-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	References
Homo sapiens	thyroid hormone receptor, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, alpha	451 aa	372 aa	25.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0239	0.3182	1
Brugia malayi	Pre-SET motif family protein	0.0217	0.2867	0.653
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0037	0.0068
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0035	0.0272	0.0272
Echinococcus multilocularis	cpg binding protein	0.0033	0.0251	0.0243
Brugia malayi	Pre-SET motif family protein	0.0032	0.0225	0.0495
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.1543	0.3704
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0307	0.0682
Echinococcus multilocularis	FTZ F1 alpha	0.0035	0.0272	0.0264
Schistosoma mansoni	cpg binding protein	0.003	0.0199	0.0199
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0079	0.0171
Brugia malayi	Blistered cuticle protein 3	0.0075	0.085	0.1923
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0035	0.0272	0.0264
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0035	0.0272	0.0264
Mycobacterium ulcerans	glutaminase	0.0284	0.3824	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0035	0.0272	0.0636
Schistosoma mansoni	nuclear receptor nhr-48	0.0016	0.0008	0.0008
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0307	0.072
Echinococcus multilocularis	survival motor neuron protein 1	0.0245	0.3278	0.3272
Onchocerca volvulus		0.0037	0.0307	0.0909
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.048	0.1139
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.0578	0.0578
Brugia malayi	Nuclear hormone receptor-like 1	0.0306	0.415	0.9463
Brugia malayi	nuclear receptor NHR-88	0.0035	0.0272	0.0602
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.0578	0.057
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0225	0.0225
Schistosoma mansoni	hypothetical protein	0.0152	0.1945	0.1945
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0068	0.0752	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.3278	0.7893
Brugia malayi	Nuclear hormone receptor-like 1	0.0306	0.415	0.9463
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0068	0.0752	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0035	0.0272	0.0602
Brugia malayi	Bromodomain containing protein	0.0079	0.0909	0.2057
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0478	0.0478
Schistosoma mansoni	coup transcription factor	0.0035	0.0272	0.0272
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0272	0.0264
Schistosoma mansoni	cpg binding protein	0.0033	0.0251	0.0251
Brugia malayi	PHD-finger family protein	0.0028	0.0167	0.0362
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0752	1
Schistosoma mansoni	microtubule-associated protein tau	0.0716	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Brugia malayi	glutaminase DH11.1	0.0284	0.3824	0.8718
Brugia malayi	photoreceptor-specific nuclear receptor	0.0035	0.0272	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0046	0.043	0.1017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0272	0.0602
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0035	0.0272	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0037	0.0068
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0035	0.0272	0.0272
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.1543	0.3704
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.0682	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Schistosoma mansoni	hypothetical protein	0.005	0.0488	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.1139
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0035	0.0272	0.0272
Schistosoma mansoni	glutaminase	0.0284	0.3824	0.3824
Schistosoma mansoni	cpg binding protein	0.0033	0.0251	0.0251
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0026	0.0026
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0488	0.1096
Loa Loa (eye worm)	hypothetical protein	0.004	0.0342	0.0805
Brugia malayi	CXXC zinc finger family protein	0.003	0.0199	0.0435
Echinococcus multilocularis	ecdysone induced protein 78C	0.0035	0.0272	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0225	0.0217
Echinococcus granulosus	transcription factor Dp 1	0.004	0.034	0.0331
Brugia malayi	beta-lactamase	0.0037	0.0307	0.0682
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.0035	0.0279	0.3707
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0478	0.1133
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0272	0.0602
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0068	0.0752	0.0744
Schistosoma mansoni	nuclear receptor	0.0016	0.0008	0.0008
Schistosoma mansoni	nuclear hormone receptor	0.0035	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0307	0.072
Echinococcus multilocularis	muscleblind protein 1	0.0155	0.1987	0.198
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0132	0.0132
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.048	0.048
Schistosoma mansoni	survival motor neuron protein	0.005	0.0488	0.0488
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.1945	0.1938
Onchocerca volvulus		0.0035	0.0272	0.0802
Onchocerca volvulus		0.0037	0.0307	0.0909
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0008	0.0008
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0068	0.0752	0.0744
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0035	0.0272	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Schistosoma mansoni	zinc finger protein	0.0016	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0821	0.1963
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.048	0.048
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.034	0.0331
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0035	0.0272	0.0802
Schistosoma mansoni	hypothetical protein	0.0021	0.0079	0.0079
Brugia malayi	hypothetical protein	0.0127	0.1589	0.3611
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0692	0.0692
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.048	0.1436
Brugia malayi	nuclear receptor RXR	0.0018	0.0037	0.0064
Echinococcus granulosus	zinc finger protein	0.0022	0.0088	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1589	0.3816
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.0682	0.0674
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.048	0.0472
Onchocerca volvulus		0.0049	0.048	0.1436
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.0578	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0037	0.0068
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.048	0.0472
Onchocerca volvulus		0.0032	0.0225	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0304	0.4122	0.9932
Onchocerca volvulus	Huntingtin homolog	0.0127	0.1589	0.4812
Echinococcus granulosus	dnaJ subfamily B	0.0424	0.5835	0.5831
Loa Loa (eye worm)	blistered cuticle protein 3	0.0075	0.085	0.2032
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0272	0.0264
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0035	0.0272	0.0264
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0307	0.4083
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0035	0.0272	0.0636
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.2444	0.2444
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.0478	0.047
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0306	0.415	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0035	0.0272	0.0636
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0035	0.0272	0.0264
Brugia malayi	nuclear hormone receptor	0.0035	0.0272	0.0602
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0199	0.046
Onchocerca volvulus		0.005	0.0488	0.146
Onchocerca volvulus		0.003	0.0199	0.058
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0306	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0037	0.0068
Echinococcus granulosus	ecdysone induced protein 78C	0.0035	0.0272	0.0264
Echinococcus multilocularis	dnaJ subfamily B	0.0424	0.5835	0.5831
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.3293	0.8489
Echinococcus granulosus	muscleblind protein	0.0155	0.1987	0.198
Trichomonas vaginalis	glutaminase, putative	0.0284	0.3824	1
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1589	0.3816
Echinococcus multilocularis	muscleblind protein	0.0155	0.1987	0.198
Onchocerca volvulus		0.0037	0.0307	0.0909
Brugia malayi	steroid hormone receptor	0.0035	0.0272	0.0602
Echinococcus granulosus	FTZ F1 alpha	0.0035	0.0272	0.0264
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0306	0.0298
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0307	0.5
Brugia malayi	beta-lactamase family protein	0.0037	0.0307	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.2444	0.2444
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0068	0.0752	0.1698
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0478	0.0478
Brugia malayi	mbt repeat family protein	0.0049	0.048	0.1078
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0752	1
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0307	0.5
Loa Loa (eye worm)	glutaminase 2	0.0284	0.3824	0.9213
Brugia malayi	ecdysteroid receptor	0.0035	0.0272	0.0602
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0035	0.0272	0.0272
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0035	0.0272	0.0272
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0035	0.0272	0.0602
Onchocerca volvulus	Huntingtin homolog	0.0127	0.1589	0.4812
Schistosoma mansoni	retinoic acid receptor RXR	0.0035	0.0272	0.0272
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.0578	0.057
Schistosoma mansoni	hypothetical protein	0.0424	0.5835	0.5835
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0035	0.0272	0.0602
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0307	0.0307
Loa Loa (eye worm)	steroid hormone receptor	0.0035	0.0272	0.0636
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.0035	0.0279	0.3707
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0631	1
Brugia malayi	hypothetical protein	0.0018	0.0037	0.0064
Brugia malayi	Steroid receptor seven-up type 2	0.0035	0.0272	0.0602
Brugia malayi	Bromodomain containing protein	0.004	0.0341	0.0759
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.048	0.0472
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0068	0.0752	0.1794
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0195	0.2559	0.2553
Schistosoma mansoni	hypothetical protein	0.0301	0.4071	0.4071
Loa Loa (eye worm)	hypothetical protein	0.004	0.0345	0.0812
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0272	0.0602
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0018	0.0037	0.0037
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.0578	0.057
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0272	0.0264
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.2867	0.6901
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0035	0.0272	0.0264
Echinococcus multilocularis	zinc finger protein	0.0022	0.0088	0.0079
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0035	0.0272	0.0602
Brugia malayi	hypothetical protein	0.0245	0.3278	0.7469
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0199	0.0191
Onchocerca volvulus	Dual oxidase homolog	0.0075	0.085	0.2562
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0035	0.0272	0.0272
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0068	0.0752	0.0752
Brugia malayi	Nuclear hormone receptor-like 1	0.0323	0.4386	1
Brugia malayi	mbt repeat family protein	0.0049	0.048	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0578	0.1375
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0132	0.0123
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0016	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0035	0.0272	0.0264
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0035	0.0272	0.0264
Loa Loa (eye worm)	glutaminase	0.0284	0.3824	0.9213
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0272	0.0264
Schistosoma mansoni	RAR-like nuclear receptor	0.0035	0.0272	0.0272
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.0478	0.047
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0307	0.072
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.048	0.0472
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0016	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1987	0.4777
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0035	0.0272	0.0636
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0035	0.0272	0.0264
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0035	0.0272	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Echinococcus granulosus	survival motor neuron protein 1	0.0245	0.3278	0.3272
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0035	0.0272	0.0636
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0187	0.2444	0.2437
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0307	1
Trypanosoma brucei	ferric reductase transmembrane protein, putative	0.0035	0.0279	0.3707
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0272	0.0602
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.1945	0.1938
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0307	0.4083
Schistosoma mansoni	zinc finger protein	0.0022	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0307	0.072
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0037	0.0037
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0225	0.0225
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0307	0.0299
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0018	0.0037	0.0028
Onchocerca volvulus	Protein ultraspiracle homolog	0.0035	0.0272	0.0802
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0307	0.0299
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0307	0.072
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0307	0.072
Brugia malayi	MH2 domain containing protein	0.0124	0.1543	0.3505
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0035	0.0064
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0272	0.0602
Brugia malayi	Muscleblind-like protein	0.0155	0.1987	0.452
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0037	0.0068
Onchocerca volvulus		0.0246	0.3293	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0018	0.0037	0.0028
Brugia malayi	beta-lactamase family protein	0.0037	0.0307	0.0682
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0307	0.4083
Echinococcus multilocularis	microtubule associated protein 2	0.0716	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0636
Schistosoma mansoni	nuclear receptor	0.0016	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0035	0.0272	0.0602
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0195	0.2559	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0377	0.089
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0272	0.0602
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0026	0.0018
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0132	0.0123
Loa Loa (eye worm)	MBCTL1	0.0056	0.0578	0.1375
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1987	0.4777
Leishmania major	ferric reductase, putative	0.0035	0.0279	0.3707
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0307	0.072
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0035	0.0272	0.0272
Leishmania major	hypothetical protein, conserved	0.0037	0.0307	0.4083
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0035	0.0272	0.0636
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0035	0.0272	0.0636
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0008	0.0008
Brugia malayi	hypothetical protein	0.0018	0.0037	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0307	0.072
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0752	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.0578	0.057
Echinococcus granulosus	cpg binding protein	0.0033	0.0251	0.0243
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0735	0.0735
Toxoplasma gondii	ABC1 family protein	0.0037	0.0307	0.2017
Onchocerca volvulus	Bile acid receptor homolog	0.0035	0.0272	0.0802
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0026	0.0018
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0307	0.0307

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 15 uM	Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay	ChEMBL.	19469546
IC50 (binding)	= 0.7 uM	Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay	ChEMBL.	19469546
IC50 (binding)	= 1.3 uM	Inhibition of SRC2 binding to TRalpha receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay	ChEMBL.	19469546
Inhibition (binding)		Inhibition of human ERG expressed in HEK293 cells assessed as blockade of KCl-stimulated depolarization relative to terfenadine	ChEMBL.	19469546

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19469546

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL549483

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1042122