Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutathione reductase | 0.0091 | 0.2535 | 0.8081 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2909 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0962 | 0.067 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0208 | 0.6892 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0231 | 0.7757 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0208 | 0.6892 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0208 | 0.6892 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0208 | 0.6892 | 0.8837 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.2909 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0962 | 0.1161 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0572 | 0.0463 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.5905 | 0.5773 |
Leishmania major | trypanothione reductase | 0.0091 | 0.2535 | 0.8561 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0313 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0572 | 0.0463 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2909 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0032 | 0.0313 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0101 | 0.2909 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2909 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0032 | 0.0313 | 0.1075 |
Plasmodium falciparum | glutathione reductase | 0.0091 | 0.2535 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2909 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0091 | 0.2535 | 1 |
Brugia malayi | glutathione reductase | 0.0091 | 0.2535 | 0.8716 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0231 | 0.7757 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2909 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0101 | 0.2909 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0313 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0091 | 0.2535 | 0.8561 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0962 | 0.1161 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0208 | 0.6892 | 0.8837 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0032 | 0.0313 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0091 | 0.2535 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0572 | 0.0267 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0962 | 0.1161 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0231 | 0.7757 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0962 | 0.067 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0091 | 0.2535 | 0.8081 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0101 | 0.2909 | 1 |
Echinococcus granulosus | geminin | 0.0181 | 0.5905 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.5905 | 0.5773 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0101 | 0.2909 | 0.4642 |
Treponema pallidum | NADH oxidase | 0.0032 | 0.0313 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0101 | 0.2909 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0572 | 0.0267 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0091 | 0.2535 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0091 | 0.2535 | 0.2985 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0231 | 0.7757 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.2909 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0208 | 0.6892 | 0.8837 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2909 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0032 | 0.0313 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0032 | 0.0313 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0091 | 0.2535 | 0.8716 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1003 | 0.2658 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0962 | 0.1161 |
Giardia lamblia | Kinase, PLK | 0.0101 | 0.2909 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0092 | 0.2555 | 0.401 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0101 | 0.2909 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0962 | 0.3307 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.2909 | 0.268 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0091 | 0.2535 | 0.8561 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0962 | 0.067 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0572 | 0.1966 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0101 | 0.2909 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0092 | 0.2555 | 0.401 |
Echinococcus multilocularis | geminin | 0.0181 | 0.5905 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0101 | 0.2909 | 0.4642 |
Plasmodium falciparum | thioredoxin reductase | 0.0091 | 0.2535 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1003 | 0.2658 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.2909 | 1 |
Schistosoma mansoni | kinase | 0.0051 | 0.1053 | 0.0764 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.