Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0111 | 0.4039 | 0.3758 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0125 | 0.4684 | 0.3986 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.4684 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.4684 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.2446 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.2446 | 0.209 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1255 | 0.0842 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.4684 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1255 | 0.0842 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.1161 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0111 | 0.4039 | 0.8477 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0125 | 0.4684 | 0.3986 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2446 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2446 | 0.209 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.4039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5787 | 0.5588 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1255 | 0.0842 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 1 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.5787 | 0.5588 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.5787 | 0.5234 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2446 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.5787 | 0.5234 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.5787 | 0.5234 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5787 | 0.5588 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2446 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0111 | 0.4039 | 0.3257 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0125 | 0.4684 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.2446 | 0.5223 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.2446 | 0.5223 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2446 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1016 | 0.1335 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.4039 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.1016 | 0.0592 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0111 | 0.4039 | 0.3257 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.4684 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.1016 | 0.1335 |
Onchocerca volvulus | 0.0048 | 0.1016 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.4039 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0125 | 0.4684 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.4684 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.2446 | 0.1455 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.2446 | 0.1455 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.2446 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.4039 | 0.8477 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2446 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.4039 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.2446 | 0.4715 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1255 | 0.0842 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0125 | 0.4684 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.