TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.173 | Formula: C16H10BrN3O3
H donors: 0 H acceptors: 4 LogP: 3.74 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccccc1c1nccn1C(=O)c1ccccc1Br
InChi: 1S/C16H10BrN3O3/c17-13-7-3-1-5-11(13)16(21)19-10-9-18-15(19)12-6-2-4-8-14(12)20(22)23/h1-10H
InChiKey: DUMBBRRGIOSKKY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	thioredoxin reductase	0.0082	0.2573	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0783	0.0872
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0155	0.046
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0155	0.046
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0155	0.0173
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0155	0.0173
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0155	0.046
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.0824	0.0425
Toxoplasma gondii	thioredoxin reductase	0.0082	0.2573	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0783	0.0872
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0155	0.046
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0576	0.1706
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0783	0.0431
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.1569	0.1746
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0186	0.6798	0.8775
Leishmania major	hypothetical protein, conserved	0.0037	0.0783	0.1699
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0783	0.0431
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1925	0.6997
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0155	0.0158
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0234	0.8698	0.9683
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0155	0.046
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0783	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0207	0.7638	0.8496
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0038	0.0824	0.244
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0155	0.0158
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0155	0.0173
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0186	0.6798	0.7508
Plasmodium falciparum	glutathione reductase	0.0082	0.2573	1
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0783	0.1699
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0038	0.0824	0.0838
Trichomonas vaginalis	esterase, putative	0.0037	0.0783	0.0382
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1925	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0038	0.0824	1
Brugia malayi	ecdysteroid receptor	0.0022	0.0155	0.0173
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0155	0.046
Plasmodium vivax	SET domain protein, putative	0.0034	0.0626	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0824	0.0917
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0783	0.0796
Brugia malayi	beta-lactamase family protein	0.0037	0.0783	0.0872
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0783	0.2428
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0155	0.046
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0102	0.3377	0.3759
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0155	0.0158
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0824	0.1889
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0038	0.0824	0.244
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0626	0.0636
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0155	0.0173
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0155	0.0173
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0783	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Treponema pallidum	NADH oxidase	0.0028	0.0417	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0155	0.0173
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.3377	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0626	0.1853
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0155	0.0173
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0155	0.0158
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0783	0.0431
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0155	0.0173
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0783	0.0382
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0783	0.1699
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0241	0.8983	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0038	0.0824	0.1889
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0155	0.0158
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.3377	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0028	0.0417	0.5
Onchocerca volvulus		0.0037	0.0783	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0186	0.6798	0.7508
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0783	0.1699
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0155	0.0173
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0155	0.0158
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1925	0.5701
Brugia malayi	nuclear hormone receptor	0.0022	0.0155	0.0173
Brugia malayi	glutathione reductase	0.0082	0.2573	0.2864
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.3377	0.3433
Schistosoma mansoni	hypothetical protein	0.0039	0.0843	0.0857
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0155	0.0173
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0155	0.0173
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0155	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0021	0.0114	0.0126
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0028	0.0417	0.0464
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0843	0.0938
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0155	0.0173
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0155	0.0158
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0626	0.0968
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.3377	1
Brugia malayi	beta-lactamase family protein	0.0037	0.0783	0.0872
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0207	0.7638	1
Mycobacterium tuberculosis	Probable reductase	0.0186	0.6798	0.7508
Onchocerca volvulus		0.0037	0.0783	0.0638
Plasmodium vivax	thioredoxin reductase, putative	0.0082	0.2573	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0783	0.2428
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.0824	0.244
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0155	0.0173
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0626	0.1853
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0155	0.0173
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0028	0.0417	0.5
Brugia malayi	Pre-SET motif family protein	0.0034	0.0626	0.0696
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0155	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0783	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1569	0.1746
Brugia malayi	follicle stimulating hormone receptor	0.0241	0.8983	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0783	0.0431
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0783	0.1699
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0783	0.0872
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0155	0.0158
Trichomonas vaginalis	set domain proteins, putative	0.0266	1	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0186	0.6798	0.7508
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1925	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0783	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0028	0.0417	0.1235
Brugia malayi	steroid hormone receptor	0.0022	0.0155	0.0173
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0783	0.0382
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0155	0.0158
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0102	0.3377	0.3759
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0783	0.0382
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0155	0.0158
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.1569	0.1746
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0824	0.0425
Trypanosoma brucei	trypanothione reductase	0.0082	0.2573	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0783	0.2428
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1925	0.6997
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0783	0.0431
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0626	0.0636
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0783	0.0872
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0783	0.0872
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0155	0.0173
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.0824	0.0425
Onchocerca volvulus		0.0037	0.0783	0.0638
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0626	0.0636
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0083	0.2617	0.7749
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1925	0.5701
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0038	0.0824	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0155	0.046
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1925	0.1957
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0155	0.046
Onchocerca volvulus		0.0034	0.0626	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0783	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Mycobacterium tuberculosis	Probable dehydrogenase	0.0186	0.6798	0.7508
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0155	0.0173
Trypanosoma cruzi	trypanothione reductase, putative	0.0082	0.2573	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0155	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0843	0.0938
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0824	0.1889
Plasmodium vivax	glutathione reductase, putative	0.0082	0.2573	1
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0155	0.046
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0824	0.1889
Brugia malayi	Thioredoxin reductase	0.0082	0.2573	0.2864
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0155	0.0158
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0038	0.0824	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0626	0.0696
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.3377	0.3433
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0239	0.8916	1
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0155	0.046
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.0824	0.244
Echinococcus multilocularis	ubiquitin specific protease 41	0.0038	0.0824	0.244
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0207	0.7638	0.8496
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0155	0.046
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0155	0.046
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0155	0.046
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0155	0.0173
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0155	0.0173
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.3377	0.3433
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0783	0.0431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0038	0.0824	0.0838
Loa Loa (eye worm)	glutathione reductase	0.0082	0.2573	0.2864
Echinococcus granulosus	thioredoxin glutathione reductase	0.0083	0.2617	0.7749
Echinococcus granulosus	ubiquitin specific protease 41	0.0038	0.0824	0.244
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0783	0.0431
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0155	0.0173
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0021	0.0114	0.0126
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0626	0.0636
Leishmania major	trypanothione reductase	0.0082	0.2573	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0783	0.2319
Mycobacterium tuberculosis	Probable oxidoreductase	0.0207	0.7638	0.8496
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1925	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0173
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0783	0.0872
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0186	0.6798	0.7508
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0155	0.0173
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0155	0.046
Loa Loa (eye worm)	thioredoxin reductase	0.0082	0.2573	0.2864
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0783	0.0431
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.3377	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0783	0.0431
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0028	0.0417	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0155	0.046
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0783	0.2428
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.1569	0.1746
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0155	0.0158
Schistosoma mansoni	coup transcription factor	0.0022	0.0155	0.0158
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1925	0.1957
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0082	0.2573	0.2536
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0783	0.0431
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0155	0.046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0155	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0783	0.0872
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0028	0.0417	0.1235
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0783	0.2319
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1925	1
Brugia malayi	beta-lactamase	0.0037	0.0783	0.0872
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0626	0.1853
Toxoplasma gondii	ABC1 family protein	0.0037	0.0783	0.1699
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0155	0.046
Mycobacterium ulcerans	lipase LipD	0.0037	0.0783	0.2428
Brugia malayi	Pre-SET motif family protein	0.0234	0.8698	0.9683
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0155	0.0173
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0028	0.0417	0.0424

Activities

Activity type	Activity value	Assay description	Source	Reference
MBC (functional)	= 268 10'-3micromol/ml	Antimicrobial activity against Escherichia coli after 24 hrs by tube dilution method	ChEMBL.	18851889
MCC (ADMET)	> 100 ug ml-1	Cytotoxicity against human HEL cells assessed as alteration in cell morphology	ChEMBL.	18851889
MCC (ADMET)	> 100 ug ml-1	Cytotoxicity against human HeLa cells assessed as alteration in cell morphology	ChEMBL.	18851889
MFC (functional)	= 268 10'-3micromol/ml	Antimicrobial activity against Candida albicans after 48 hrs by tube dilution method	ChEMBL.	18851889
MIC (functional)	= 33 10'-3micromol/ml	Antimicrobial activity against Escherichia coli after 24 hrs by tube dilution method	ChEMBL.	18851889
MIC (functional)	= 33 10'-3micromol/ml	Antimicrobial activity against Candida albicans after 48 hrs by tube dilution method	ChEMBL.	18851889

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL549604

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1042231