Detailed information for compound 104224

Basic information

Technical information
  • TDR Targets ID: 104224
  • Name: 2-[(11E)-11-[3-(dimethylamino)propylidene]-6H -benzo[c][2]benzoxepin-2-yl]ethanol
  • MW: 323.429 | Formula: C21H25NO2
  • H donors: 1 H acceptors: 1 LogP: 3.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCc1ccc2c(c1)/C(=C/CCN(C)C)/c1ccccc1CO2
  • InChi: 1S/C21H25NO2/c1-22(2)12-5-8-19-18-7-4-3-6-17(18)15-24-21-10-9-16(11-13-23)14-20(19)21/h3-4,6-10,14,23H,5,11-13,15H2,1-2H3/b19-8+
  • InChiKey: ZKOHNNRBHUBCOD-UFWORHAWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(11E)-11-(3-dimethylaminopropylidene)-6H-benzo[c][2]benzoxepin-2-yl]ethanol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Histamine H1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus alpha 1A adrenergic receptor Histamine H1 receptor   488 aa 455 aa 19.1 %
Echinococcus multilocularis alpha 1A adrenergic receptor Histamine H1 receptor   488 aa 454 aa 19.4 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H1 receptor   488 aa 455 aa 25.5 %
Echinococcus multilocularis biogenic amine (5HT) receptor Histamine H1 receptor   488 aa 485 aa 26.4 %
Schistosoma mansoni biogenic amine (dopamine) receptor Histamine H1 receptor   488 aa 498 aa 26.1 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H1 receptor   488 aa 484 aa 26.9 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Histamine H1 receptor   488 aa 488 aa 26.6 %
Echinococcus multilocularis serotonin receptor Histamine H1 receptor   488 aa 450 aa 26.0 %
Schistosoma mansoni biogenic amine (dopamine) receptor Histamine H1 receptor   488 aa 471 aa 24.8 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Histamine H1 receptor   488 aa 470 aa 26.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Histamine H1 receptor   488 aa 482 aa 25.1 %
Schistosoma mansoni biogenic amine receptor Histamine H1 receptor   488 aa 487 aa 25.5 %
Loa Loa (eye worm) TYRA-2 protein Histamine H1 receptor   488 aa 489 aa 23.7 %
Schistosoma japonicum Octopamine receptor, putative Histamine H1 receptor   488 aa 472 aa 25.8 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Histamine H1 receptor   488 aa 486 aa 26.5 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Histamine H1 receptor   488 aa 463 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0053 0.0041
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0465 0.1665 0.1655
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0098 0.0529
Echinococcus granulosus Glutaredoxin protein 5 0.0022 0.0051 0.004
Loa Loa (eye worm) hypothetical protein 0.0465 0.1665 0.1655
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0014 0.0002
Echinococcus granulosus acetylcholinesterase 0.2755 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0109
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.012 0.0721
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.012 0.0721
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0058 0.0429
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0078 0.0067
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0078 0.0067
Schistosoma mansoni hypothetical protein 0.0695 0.2499 0.249
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0465 0.1665 0.1655
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0115 0.3922
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2755 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0098 0.0529
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0184
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.012 0.0721
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.008 0.0069
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0519 0.6828
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0195 0.0681 0.4088
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0282 0.1693
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0073
Schistosoma mansoni pyruvate kinase 0.0017 0.0031 0.002
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.0009 0.0056
Mycobacterium ulcerans polyketide synthase Pks9 0.0017 0.0034 0.0203
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.012 0.0109
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.012 0.0109
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0015 0.0003
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0089 0.0077
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0114 0.0683
Brugia malayi glutathione reductase 0.0086 0.0282 0.0282
Mycobacterium ulcerans thioesterase TesA 0.0022 0.005 0.0302
Schistosoma mansoni rotamase 0.0034 0.0093 0.0082
Echinococcus granulosus neuroligin 0.0465 0.1665 0.1655
Onchocerca volvulus 0.0465 0.1665 1
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.0252 0.2079
Schistosoma mansoni pyruvate kinase 0.0032 0.0089 0.0077
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0078 0.2778
Echinococcus granulosus histone acetyltransferase KAT2B 0.0279 0.0986 0.0975
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.008 0.2842
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0089 0.2953
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.0926 0.5559
Echinococcus multilocularis muscleblind protein 0.032 0.1137 0.1127
Trichomonas vaginalis set domain proteins, putative 0.0239 0.0841 0.5018
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0089 0.3145
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.0252 0.2222
Loa Loa (eye worm) hypothetical protein 0.0068 0.0217 0.0205
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0084 0.0278 0.1613
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0078 0.0444
Loa Loa (eye worm) hypothetical protein 0.0465 0.1665 0.1655
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Mycobacterium leprae Probable lipase LipE 0.0041 0.012 0.1572
Mycobacterium tuberculosis Conserved protein 0.0041 0.012 0.0721
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0058 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0084 0.0073
Brugia malayi beta-lactamase family protein 0.0041 0.012 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.012 0.0661
Mycobacterium tuberculosis Probable dehydrogenase 0.0195 0.0681 0.4088
Brugia malayi hypothetical protein 0.0017 0.0033 0.0033
Brugia malayi Hr1 repeat family protein 0.0011 0.0012 0.0012
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0053 0.0383
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0078 0.2576
Echinococcus multilocularis acetylcholinesterase 0.2755 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.012 0.4094
Schistosoma mansoni hypothetical protein 0.0068 0.0217 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0109
Trichomonas vaginalis esterase, putative 0.0041 0.012 0.0661
Brugia malayi hypothetical protein 0.0027 0.0068 0.0068
Trypanosoma brucei rac serine-threonine kinase, putative 0.0035 0.0098 0.3298
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0089 0.0179
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0078 0.2576
Loa Loa (eye worm) hypothetical protein 0.0465 0.1665 0.1655
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.0063 0.0381
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0089 0.0533
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.012 0.0721
Brugia malayi protein kinase C II. 0.0011 0.0012 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.012 0.0721
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0284 0.0272
Echinococcus multilocularis para nitrobenzyl esterase 0.0465 0.1665 0.1655
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0109
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0089 0.0179
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0025 0.015
Trypanosoma brucei trypanothione reductase 0.0086 0.0282 1
Brugia malayi beta-lactamase family protein 0.0041 0.012 0.012
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0078 0.2576
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0019 0.0667
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0013
Loa Loa (eye worm) RNA binding protein 0.0062 0.0195 0.0184
Echinococcus multilocularis rac serine:threonine kinase 0.0024 0.0058 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0073
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0068 0.2177
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.1094 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0195 0.0184
Loa Loa (eye worm) carboxylesterase 0.0465 0.1665 0.1655
Echinococcus multilocularis pyruvate kinase 0.0017 0.0031 0.002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0084 0.0278 0.9849
Brugia malayi Thioredoxin reductase 0.0086 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0465 0.1665 0.1655
Onchocerca volvulus 0.0041 0.012 0.0374
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0014 0.0002
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0022 0.005 0.1776
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0024 0.0058 0.1832
Echinococcus multilocularis GPCR, family 2 0.0031 0.0084 0.0073
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0093 0.0082
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0115 0.4088
Schistosoma mansoni pyruvate kinase 0.0032 0.0089 0.0077
Plasmodium vivax SET domain protein, putative 0.003 0.008 0.2842
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0073
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0195 0.0184
Brugia malayi Protein kinase domain containing protein 0.0011 0.0012 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0078 0.2576
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0282 1
Onchocerca volvulus 0.0041 0.012 0.0374
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0084 0.0084
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.009 0.3011
Brugia malayi Protein kinase domain containing protein 0.0011 0.0012 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0184
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.005 0.0655
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0066 0.0865
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.009 0.0728
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0078 0.1883
Echinococcus multilocularis acetylcholinesterase 0.2755 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0115 0.3922
Plasmodium falciparum glutathione reductase 0.0086 0.0282 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0033 0.009 0.0079
Brugia malayi p70 ribosomal S6 kinase beta 0.0033 0.009 0.009
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0078 0.2576
Mycobacterium ulcerans carboxylesterase, LipT 0.0465 0.1665 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0465 0.1665 0.1655
Leishmania major pyruvate kinase 0.0032 0.0089 0.2953
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.0063 0.0381
Echinococcus granulosus para nitrobenzyl esterase 0.0465 0.1665 0.1655
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0017 0.0034 0.0438
Loa Loa (eye worm) acetylcholinesterase 1 0.2755 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0115 0.0959
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0078 0.0409
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0109
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0073
Echinococcus multilocularis BC026374 protein (S09 family) 0.0465 0.1665 0.1655
Leishmania major hypothetical protein, conserved 0.0041 0.012 0.4094
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0066 0.0865
Echinococcus granulosus expressed protein 0.0034 0.0093 0.0082
Echinococcus multilocularis pyruvate kinase 0.0026 0.0064 0.0052
Onchocerca volvulus 0.0046 0.0137 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0184
Echinococcus granulosus geminin 0.0695 0.2499 0.249
Toxoplasma gondii ABC1 family protein 0.0041 0.012 0.4255
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0519 0.3118
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0008 0.0273
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0058 0.0429
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.012 0.0661
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0115 0.0115
Mycobacterium tuberculosis Probable reductase 0.0195 0.0681 0.4088
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0022 0.005 0.0756
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0089 0.0089
Echinococcus granulosus pyruvate kinase 0.0017 0.0031 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.012 0.0661
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0465 0.1665 1
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0089 0.0472
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0072 0.2559
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0072 0.0943
Brugia malayi hypothetical protein 0.0465 0.1665 0.1665
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0114 0.0683
Schistosoma mansoni ap endonuclease 0.004 0.0115 0.0104
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0001 0.0004
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0089 0.2953
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Onchocerca volvulus 0.0465 0.1665 1
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0282 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0078 0.6567
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.009 0.3011
Onchocerca volvulus 0.0239 0.0841 0.4865
Mycobacterium ulcerans hypothetical protein 0.0041 0.012 0.0721
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.005 0.005
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0022 0.005 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0115 0.0632
Brugia malayi AMP-binding enzyme family protein 0.0025 0.006 0.006
Echinococcus multilocularis muscleblind protein 1 0.032 0.1137 0.1127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Echinococcus granulosus acetylcholinesterase 0.2755 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.012 0.0721
Leishmania major pyruvate kinase 0.0032 0.0089 0.2953
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0217 0.076 0.4564
Onchocerca volvulus 0.0465 0.1665 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0066 0.0398
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.1094 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0195 0.0681 0.4088
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0089 0.0179
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.005 0.005
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0022 0.005 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0093 0.0499
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.008 0.0069
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0066 0.0398
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.0735 0.0724
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0115 0.0693
Loa Loa (eye worm) hypothetical protein 0.2755 1 1
Trypanosoma cruzi Protein kinase B 0.0024 0.0058 0.1832
Trichomonas vaginalis bromodomain-containing protein, putative 0.0084 0.0278 0.1613
Loa Loa (eye worm) hypothetical protein 0.0465 0.1665 0.1655
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0068 0.2177
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0078 0.2778
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0009 0.0003 0.0021
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0078 0.0078
Schistosoma mansoni BC026374 protein (S09 family) 0.0465 0.1665 0.1655
Giardia lamblia Kinase, AGC PKA 0.0022 0.005 0.0178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0084 0.0073
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0031 0.1103
Echinococcus multilocularis pyruvate kinase 0.0032 0.0089 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0109
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0287 0.1015 0.1004
Mycobacterium ulcerans polyketide synthase 0.0026 0.0066 0.0398
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.0152 0.0152
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0089 0.0077
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.012 0.0661
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0089 0.0089
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0066 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0012 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.012 0.4094
Plasmodium falciparum glutathione reductase 0.003 0.0078 0.1883
Echinococcus granulosus muscleblind protein 0.032 0.1137 0.1127
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0066 0.0398
Brugia malayi TAR-binding protein 0.0062 0.0195 0.0195
Schistosoma mansoni acetylcholinesterase 0.0465 0.1665 0.1655
Entamoeba histolytica protein kinase, putative 0.0033 0.009 0.0728
Brugia malayi Carboxylesterase family protein 0.0465 0.1665 0.1665
Echinococcus granulosus nervana 2 0.0022 0.0049 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0098 0.0529
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0195 0.0681 0.8956
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0084 0.0073
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0078 0.2576
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0331 0.0331
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0217 0.076 1
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.012 0.0721
Echinococcus multilocularis Glutaredoxin protein 5 0.0022 0.0051 0.004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0115 0.0104
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0031 0.1103
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0089 0.0077
Loa Loa (eye worm) carboxylesterase 0.0465 0.1665 0.1655
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0115 0.0792
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0017 0.0034 0.0203
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0072 0.0434
Plasmodium vivax glutathione reductase, putative 0.0086 0.0282 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0093 0.0093
Onchocerca volvulus 0.003 0.008 0.0126
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.012 0.0109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0076 0.0065
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0115 0.3922
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0465 0.1665 1
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.009 0.3202
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0072 0.0943
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0217 0.076 0.4564
Echinococcus granulosus nervana 2 0.0022 0.0049 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0089 0.1161
Giardia lamblia Pyruvate kinase 0.0032 0.0089 0.0542
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0089 0.2953
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0001 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.012 0.0661
Mycobacterium tuberculosis Conserved protein 0.0041 0.012 0.0721
Mycobacterium leprae conserved hypothetical protein 0.0041 0.012 0.1572
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0072 0.0943
Brugia malayi Carboxylesterase family protein 0.0465 0.1665 0.1665
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0115 0.0104
Brugia malayi Carboxylesterase family protein 0.2755 1 1
Echinococcus granulosus BC026374 protein S09 family 0.0465 0.1665 0.1655
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0115 1
Onchocerca volvulus 0.0465 0.1665 1
Mycobacterium ulcerans beta-lactamase 0.0041 0.012 0.0721
Loa Loa (eye worm) hypothetical protein 0.2755 1 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.006 0.0361
Echinococcus granulosus pyruvate kinase 0.0017 0.0031 0.002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0115 0.3922
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0078 0.0471
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0078 0.0409
Brugia malayi Muscleblind-like protein 0.032 0.1137 0.1137
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0089 0.0472
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0217 0.0217
Onchocerca volvulus Fatty acid synthase homolog 0.0047 0.0143 0.0518
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0019 0.0053
Schistosoma mansoni neuroligin 3 (S09 family) 0.0465 0.1665 0.1655
Echinococcus multilocularis nervana 2 0.0022 0.0049 0.0038
Echinococcus multilocularis geminin 0.0695 0.2499 0.249
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0089 0.2953
Brugia malayi beta-lactamase 0.0041 0.012 0.012
Echinococcus granulosus pyruvate kinase 0.0032 0.0089 0.0077
Plasmodium falciparum thioredoxin reductase 0.0086 0.0282 1
Leishmania major hypothetical protein, conserved 0.0027 0.0068 0.2177
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0022 0.0049 0.0038
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0465 0.1665 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0109
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.009 0.3011
Echinococcus granulosus GPCR family 2 0.0031 0.0084 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.008 0.0069
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1094 1
Brugia malayi Pre-SET motif family protein 0.021 0.0735 0.0735
Plasmodium falciparum thioredoxin reductase 0.003 0.0078 0.1883
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0084 0.0073
Loa Loa (eye worm) hypothetical protein 0.0099 0.0331 0.0319
Trichomonas vaginalis rotamase, putative 0.0034 0.0093 0.0499
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0078 0.2778
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0072 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.008 0.0069
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0072 0.0434
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0098 0.0529
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0066 0.0398
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0078 0.2576
Loa Loa (eye worm) glutathione reductase 0.0086 0.0282 0.0271
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.012
Mycobacterium tuberculosis Conserved protein 0.0041 0.012 0.0721
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0184
Toxoplasma gondii AGC kinase 0.0033 0.009 0.3202
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0195 0.0184
Echinococcus multilocularis pyruvate kinase 0.0017 0.0031 0.002
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0066 0.0398
Loa Loa (eye worm) hypothetical protein 0.032 0.1137 0.1127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0115 0.0104
Mycobacterium ulcerans lipase LipD 0.0041 0.012 0.0721
Plasmodium vivax hypothetical protein, conserved 0.0041 0.012 0.4255
Mycobacterium tuberculosis Carboxylesterase LipT 0.0465 0.1665 1
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0098 0.0529
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0078 0.0471
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0078 0.2576
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.0077
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0284 0.0272
Schistosoma mansoni gliotactin 0.0465 0.1665 0.1655
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0098 0.0529
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.006 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0282 0.0271
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0078 0.6567
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0049 0.0293
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0078 0.0471
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0084 0.0278 0.9849
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0465 0.1665 0.1655
Brugia malayi Protein kinase domain containing protein 0.0035 0.0098 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0068 0.1447
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0078 0.1883
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0068 0.239
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0048 0.0619
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0033 0.1154
Loa Loa (eye worm) carboxylesterase 0.2755 1 1
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0114 0.1489
Loa Loa (eye worm) hypothetical protein 0.032 0.1137 0.1127
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0195 0.0681 0.4088
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0115 0.0632
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.012 0.0721
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0115 0.0363
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0195 0.0195
Echinococcus granulosus serine threonine protein kinase nrc 0.0022 0.005 0.0039
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0465 0.1665 0.1655
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0066 0.0398
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0068 0.1447
Schistosoma mansoni hypothetical protein 0.0695 0.2499 0.249
Echinococcus multilocularis expressed protein 0.0034 0.0093 0.0082
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0072 0.0434
Loa Loa (eye worm) acetyltransferase 0.0287 0.1015 0.1004
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.008 0.0069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0065 0.0053
Echinococcus granulosus serine/threonine protein kinase 0.0024 0.0058 0.0047
Trichomonas vaginalis spcc417.12 protein, putative 0.0465 0.1665 1
Mycobacterium ulcerans polyketide synthase 0.0028 0.0072 0.0434
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0098 0.0529
Echinococcus multilocularis nervana 2 0.0022 0.0049 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.012 0.0721
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0089 0.0533
Chlamydia trachomatis pyruvate kinase 0.0032 0.0089 1
Entamoeba histolytica protein kinase 2, putative 0.0022 0.005 0.0357
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0078 0.2576
Entamoeba histolytica protein kinase, putative 0.0035 0.0098 0.0801
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0078 0.0471
Schistosoma mansoni ap endonuclease 0.004 0.0115 0.0104
Toxoplasma gondii thioredoxin reductase 0.0086 0.0282 1
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0465 0.1665 0.1655
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0084 0.0278 0.0266
Toxoplasma gondii exonuclease III APE 0.004 0.0115 0.4088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.2847 0.2838
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0184
Mycobacterium ulcerans thioesterase 0.0022 0.005 0.0302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1094 0.6545
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0078 0.0067
Brugia malayi Carboxylesterase family protein 0.0465 0.1665 0.1665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Loa Loa (eye worm) hypothetical protein 0.003 0.008 0.0069
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.005 0.1545
Onchocerca volvulus 0.0465 0.1665 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1094 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0035 0.0098 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0068 0.239
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0068 0.2177
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.0519 0.3118
Brugia malayi acetyltransferase, GNAT family protein 0.0287 0.1015 0.1015
Entamoeba histolytica protein kinase, putative 0.0035 0.0098 0.0801
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.006 0.0048
Trichomonas vaginalis rotamase, putative 0.0033 0.009 0.0481
Echinococcus multilocularis pyruvate kinase 0.0032 0.0089 0.0077
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0022 0.0049 0.0038
Plasmodium falciparum pyruvate kinase 0.0032 0.0089 0.2296
Echinococcus multilocularis carboxylesterase 5A 0.2755 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0465 0.1665 0.1655
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.012 0.0109
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.012 0.4094
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0078 0.2576
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0195 0.0681 0.4088
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.008 0.0069
Echinococcus granulosus carboxylesterase 5A 0.2755 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.008 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0012 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0115 0.3355
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0084 0.0073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.012 0.0109
Brugia malayi Pre-SET motif family protein 0.003 0.008 0.008
Echinococcus multilocularis pyruvate kinase 0.0017 0.0031 0.002
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.005 0.0302
Brugia malayi RNA binding protein 0.0062 0.0195 0.0195
Onchocerca volvulus 0.0041 0.012 0.0374
Echinococcus granulosus pyruvate kinase 0.0032 0.0089 0.0077
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0115 0.0693
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0066 0.0398
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0331 0.0331
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0084 0.0278 0.9849
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0078 0.2778
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0114 0.0683
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0331 0.0319
Echinococcus granulosus tar DNA binding protein 0.0062 0.0195 0.0184
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.009 0.3011
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0039 0.0236
Leishmania major trypanothione reductase 0.0086 0.0282 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0217 0.076 0.4564
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0072 0.0434
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0039 0.1368
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0089 0.3145
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0287 0.1015 0.1004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0084 0.0084
Echinococcus granulosus pyruvate kinase 0.0017 0.0031 0.002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0048 0.0286
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.0252 0.8809
Brugia malayi Carboxylesterase family protein 0.0465 0.1665 0.1665
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0048 0.0286
Loa Loa (eye worm) beta-lactamase 0.0041 0.012 0.0109
Echinococcus multilocularis neuroligin 0.0465 0.1665 0.1655

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.14 mg kg-1 The compound was tested in vivo for inhibitory effect on 48-h homologous passive cutaneous anaphylaxis(PCA) in rats administered peroally ChEMBL. 1350797
ID50 (functional) = 0.0059 mg kg-1 The compound was tested in vivo for the inhibition of IgG1-mediated bronchoconstriction in guinea pig at 0.03 mg/kg administered peroally ChEMBL. 1350797
Inhibition (binding) = 72 % Binding affinity for Muscarinic acetylcholine receptor M1 from rat striatum, using [3H]-quinuclidinyl benzilate as radioligand at 10 uM. ChEMBL. 1350797
Inhibition (binding) = 72 % Binding affinity for Muscarinic acetylcholine receptor M1 from rat striatum, using [3H]-quinuclidinyl benzilate as radioligand at 10 uM. ChEMBL. 1350797
Ki (binding) = 0.48 nM Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]-pyrilamine as radioligand at 0.1 microM. ChEMBL. 1350797
Ki (binding) = 0.48 nM Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]-pyrilamine as radioligand at 0.1 microM. ChEMBL. 1350797

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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