Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0459 | 0.0958 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Loa Loa (eye worm) | carboxylesterase | 0.0459 | 0.0958 | 0.0677 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2719 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0459 | 0.0958 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0459 | 0.0958 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0459 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2719 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2719 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0459 | 0.0958 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0459 | 0.0958 | 0.0958 |
Onchocerca volvulus | 0.0459 | 0.0958 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.2719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Echinococcus multilocularis | acetylcholinesterase | 0.2719 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.0958 | 0.0677 |
Brugia malayi | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Onchocerca volvulus | 0.0459 | 0.0958 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0459 | 0.0958 | 0.0958 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0459 | 0.0958 | 0.0958 |
Onchocerca volvulus | 0.0459 | 0.0958 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0459 | 0.0958 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0459 | 0.0958 | 0.0958 |
Echinococcus multilocularis | acetylcholinesterase | 0.2719 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2719 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.0958 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.0958 | 0.0677 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0459 | 0.0958 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.0958 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0459 | 0.0958 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Onchocerca volvulus | 0.0459 | 0.0958 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0459 | 0.0958 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0958 | 0.0677 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0459 | 0.0958 | 0.0958 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0459 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.2719 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2719 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0459 | 0.0958 | 0.0958 |
Echinococcus granulosus | acetylcholinesterase | 0.2719 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 15 nM | Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells | ChEMBL. | 15080983 |
Ki (binding) | = 15 nM | Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells | ChEMBL. | 15080983 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.