Detailed information for compound 1042436

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.893 | Formula: C23H22ClN3O
  • H donors: 1 H acceptors: 2 LogP: 4.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)ccc(n2)CN1CCCC1)/C=C/c1cccc(c1)Cl
  • InChi: 1S/C23H22ClN3O/c24-19-5-3-4-17(14-19)6-11-23(28)26-20-9-10-22-18(15-20)7-8-21(25-22)16-27-12-1-2-13-27/h3-11,14-15H,1-2,12-13,16H2,(H,26,28)/b11-6+
  • InChiKey: VIBPEIOGGSJOLN-IZZDOVSWSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni [ACP] S-malonyltransferase 0.0034 0.0152 0.0152
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0034 0.0147 0.0189
Trypanosoma brucei oxidoreductase, putative 0.0034 0.0147 0.0872
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.022 0.1766 0.1977
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0059 0.0362 0.0358
Brugia malayi O-methyltransferase family protein 0.0121 0.0902 0.1024
Onchocerca volvulus 0.0058 0.0353 0.0422
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0081 0.0559 0.0559
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0059 0.0362 0.0358
Brugia malayi beta-lactamase family protein 0.005 0.0283 0.0321
Mycobacterium tuberculosis Probable esterase LipL 0.005 0.0283 0.0311
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0544 0.4574 0.5131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0171 0.0171
Echinococcus granulosus disintegrin and metalloproteinase 0.0017 0.0002 0.0002
Brugia malayi O-methyltransferase family protein 0.0121 0.0902 0.1024
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0544 0.4574 0.5191
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0528 0.444 0.498
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0051 0.0298 0.0328
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0137 0.1041 0.104
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.0263
Echinococcus multilocularis adam 17 protease 0.0172 0.1348 0.1348
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0159 0.0159
Brugia malayi beta-lactamase 0.005 0.0283 0.0321
Trichomonas vaginalis chromobox protein, putative 0.005 0.0288 0.119
Loa Loa (eye worm) hypothetical protein 0.0084 0.0579 0.0743
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0137 0.1041 0.8801
Mycobacterium tuberculosis Conserved protein 0.0164 0.1278 0.1429
Onchocerca volvulus 0.0041 0.0206 0.0246
Schistosoma mansoni alcohol dehydrogenase 0.0034 0.0147 0.0147
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0034 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Brugia malayi plexin A 0.0048 0.0269 0.0305
Loa Loa (eye worm) hypothetical protein 0.0048 0.0269 0.0345
Leishmania major zinc binding dehydrogenase-like protein 0.0034 0.0147 0.1107
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0108 0.0791 0.0791
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0055 0.0331 0.0425
Schistosoma mansoni hypothetical protein 0.0056 0.0337 0.0337
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0034 0.0152 0.0152
Brugia malayi Phosphopantetheine attachment site family protein 0.0055 0.0331 0.0376
Leishmania major oxidoreductase-like protein 0.0034 0.0147 0.1107
Echinococcus granulosus AMP dependent ligase 0.0056 0.0335 0.0335
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0544 0.4574 0.6542
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Possible dehydrogenase 0.0034 0.0147 0.0158
Mycobacterium ulcerans polyketide synthase 0.0577 0.4867 0.4885
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0137 0.1041 0.1181
Brugia malayi O-methyltransferase 0.0121 0.0902 0.1024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0034 0.0147 0.0189
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0029 0.0103 0.0116
Loa Loa (eye worm) intermediate filament protein 0.0034 0.0144 0.0185
Loa Loa (eye worm) acyl carrier protein 0.0055 0.0331 0.0425
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.005 0.0283 0.0321
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0021 0.0034 0.0034
Brugia malayi O-methyltransferase family protein 0.0121 0.0902 0.1024
Echinococcus granulosus caspase 2 0.0018 0.0009 0.0009
Schistosoma mansoni [ACP] S-malonyltransferase 0.0034 0.0152 0.0152
Schistosoma mansoni cellular tumor antigen P53 0.0031 0.0125 0.0125
Leishmania major hypothetical protein, conserved 0.0034 0.0152 0.1145
Onchocerca volvulus 0.0034 0.0144 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0335 0.037
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0577 0.4867 0.6976
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0041 0.0052
Echinococcus multilocularis GPCR, family 2 0.0026 0.0077 0.0077
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0276 0.2249 0.4562
Loa Loa (eye worm) beta-lactamase 0.005 0.0283 0.0363
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0283 0.1169
Onchocerca volvulus 0.0034 0.0144 0.0172
Brugia malayi intermediate filament protein 0.0034 0.0144 0.0164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.005 0.0283 0.0283
Brugia malayi MH2 domain containing protein 0.0064 0.0408 0.0463
Schistosoma mansoni hypothetical protein 0.0024 0.0058 0.0058
Echinococcus multilocularis plexin a4 0.0048 0.0269 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.0077 0.0099
Onchocerca volvulus Putative alcohol dehydrogenase 0.0034 0.0147 0.0175
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0059 0.0362 0.04
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.031 0.2543 0.285
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0034 0.0147 0.0158
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0868 0.7388 0.7388
Mycobacterium tuberculosis Probable lipase LipE 0.005 0.0283 0.0311
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0034 0.0147 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0383
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0391 0.3252 0.3646
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0034 0.0147 0.0167
Echinococcus multilocularis disintegrin and metalloproteinase 0.0017 0.0002 0.0002
Plasmodium vivax SET domain protein, putative 0.0037 0.0171 0.1239
Brugia malayi Bromodomain containing protein 0.0079 0.0535 0.0607
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0024 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0074
Trypanosoma cruzi oxidoreductase, putative 0.0034 0.0147 0.1199
Mycobacterium leprae conserved hypothetical protein 0.005 0.0283 0.0201
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0074 0.0496 0.0636
Leishmania major d-xylulose reductase, putative 0.0034 0.0147 0.1107
Onchocerca volvulus 0.0024 0.0058 0.0069
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0057
Onchocerca volvulus Matrix metalloproteinase homolog 0.009 0.0636 0.0758
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0034 0.0147 0.0158
Mycobacterium tuberculosis Probable reductase 0.0051 0.0298 0.0328
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0059 0.0362 0.0318
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0259
Onchocerca volvulus Heterochromatin protein 1 homolog 0.003 0.0115 0.0138
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.0077 0.0077
Brugia malayi hypothetical protein 0.0018 0.0009 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0103 0.0103
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0359 0.2971 0.2979
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0103 0.0103
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0577 0.4867 0.4885
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0034 0.0147 0.0142
Schistosoma mansoni hypothetical protein 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0137 0.1041 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.0077 0.0077
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0283 0.1169
Echinococcus multilocularis musashi 0.0034 0.0144 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0103 0.0103
Onchocerca volvulus 0.0513 0.4305 0.5135
Loa Loa (eye worm) hypothetical protein 0.0105 0.0763 0.0979
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.005 0.0283 0.0311
Mycobacterium tuberculosis Possible dehydrogenase 0.0034 0.0147 0.0158
Loa Loa (eye worm) fatty acid synthase 0.0538 0.4522 0.5801
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0081 0.0559 0.0634
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0034 0.0147 0.0158
Echinococcus granulosus adam 0.003 0.0113 0.0113
Echinococcus granulosus beta LACTamase domain containing family member 0.005 0.0283 0.0283
Loa Loa (eye worm) MH2 domain-containing protein 0.0064 0.0408 0.0523
Echinococcus multilocularis lamin dm0 0.0034 0.0144 0.0144
Onchocerca volvulus 0.0031 0.0125 0.0149
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0059 0.0362 0.04
Onchocerca volvulus Matrilysin homolog 0.009 0.0636 0.0758
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0058 0.0058
Mycobacterium ulcerans polyketide synthase 0.0544 0.4574 0.459
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Mycobacterium tuberculosis Probable hydrolase 0.005 0.0283 0.0311
Mycobacterium tuberculosis Probable oxidoreductase 0.0411 0.3422 0.3837
Toxoplasma gondii quinone oxidoreductase, putative 0.0034 0.0147 0.0205
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.1043 0.8908 1
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0034 0.0147 0.0142
Echinococcus multilocularis thioredoxin glutathione reductase 0.0023 0.0051 0.0051
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0024 0.0058 0.0066
Mycobacterium ulcerans polyketide synthase Pks9 0.0359 0.2971 0.2979
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0034 0.0152 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0283 0.2357
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Brugia malayi Thioredoxin reductase 0.0022 0.0048 0.0055
Brugia malayi Disintegrin family protein 0.0017 0.0002 0.0002
Onchocerca volvulus 0.005 0.0283 0.0338
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0009 0.001
Mycobacterium leprae Probable lipase LipE 0.005 0.0283 0.0201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0316 0.2601 0.2915
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0124
Onchocerca volvulus 0.0121 0.0902 0.1076
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0056 0.0335 0.0331
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0454 0.3796 0.5392
Brugia malayi Calcitonin receptor-like protein seb-1 0.0082 0.0561 0.0637
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1032 0.881 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.0077 0.0088
Onchocerca volvulus Cell death protein 3 homolog 0.0018 0.0009 0.0011
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0049 0.0283 0.0321
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0055 0.0331 0.0331
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0034 0.0147 0.0872
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0057 0.0348 0.0384
Mycobacterium tuberculosis Probable oxidoreductase 0.0057 0.0348 0.0384
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0544 0.4574 0.5131
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0171 0.0255
Brugia malayi Intermediate filament tail domain containing protein 0.0034 0.0144 0.0164
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0436 1
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0283 0.2357
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0084 0.0579 0.0643
Leishmania major quinone oxidoreductase, putative 0.0034 0.0147 0.1107
Loa Loa (eye worm) hypothetical protein 0.0362 0.2994 0.384
Echinococcus multilocularis caspase 2 0.0018 0.0009 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0048 0.0358
Echinococcus granulosus acyl carrier protein mitochondrial 0.0055 0.0331 0.0331
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0034 0.0147 0.0594
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0056 0.0335 0.0331
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0544 0.4574 0.459
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0137 0.1041 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0026 0.0083
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0034 0.0147 0.0167
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0055 0.0331 0.2764
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0055 0.0331 0.0376
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0437 0.3649 0.5175
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0137 0.1041 0.8757
Onchocerca volvulus 0.0022 0.0044 0.0053
Toxoplasma gondii ABC1 family protein 0.005 0.0283 0.0487
Onchocerca volvulus 0.0045 0.0242 0.0289
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0082 0.0561 0.072
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0017 0.0002 0.0002
Loa Loa (eye worm) reprolysin 0.0017 0.0002 0.0003
Onchocerca volvulus 0.0121 0.0902 0.1076
Echinococcus multilocularis lamin 0.0034 0.0144 0.0144
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0118 0.0879 0.0879
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0309
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0017 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0326 0.0326
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0034 0.0147 0.0158
Mycobacterium ulcerans quinone oxidoreductase 0.0034 0.0147 0.0142
Brugia malayi Plexin repeat family protein 0.004 0.0205 0.0232
Brugia malayi Hint module family protein 0.0048 0.0269 0.0306
Loa Loa (eye worm) hypothetical protein 0.0054 0.0326 0.0418
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0137 0.1041 0.2058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.005 0.0283 0.0278
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Brugia malayi AMP-binding enzyme family protein 0.0513 0.4305 0.4886
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0041 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.005 0.0283 0.0311
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0034 0.0147 0.0167
Trichomonas vaginalis chromobox protein, putative 0.003 0.0115 0.0462
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0137 0.1041 0.1041
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0118 0.0879 0.0879
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0813 0.6914 0.7759
Onchocerca volvulus 0.004 0.0205 0.0244
Echinococcus multilocularis chromobox protein 1 0.005 0.0288 0.0288
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.058 0.5364
Echinococcus granulosus chromobox protein 1 0.005 0.0288 0.0288
Leishmania major acyl carrier protein, putative 0.0055 0.0331 0.2554
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0034 0.0147 0.0158
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.018 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0544 0.4574 0.6542
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0051 0.0298 0.0223
Mycobacterium ulcerans hydrolase 0.0049 0.0283 0.0278
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0034 0.0147 0.281
Loa Loa (eye worm) matrixin family protein 0.0098 0.0706 0.0906
Echinococcus granulosus NADH dehydrogenase 0.0055 0.0331 0.0331
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0028 0.0097 0.0116
Onchocerca volvulus 0.0018 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.0058 0.0353 0.0353
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0055 0.0331 0.0395
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0353 0.2923 0.5959
Schistosoma mansoni dihydroceramide desaturase 0.0017 0.0002 0.0002
Toxoplasma gondii acyl transferase domain-containing protein 0.0034 0.0152 0.0215
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0034 0.0147 0.1199
Loa Loa (eye worm) thioredoxin reductase 0.0022 0.0048 0.0062
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.003 0.0113 0.0113
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0024 0.0058 0.0066
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0034 0.0147 0.281
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0359 0.2971 0.4173
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0034 0.0147 0.0147
Echinococcus granulosus intermediate filament protein 0.0034 0.0144 0.0144
Trichomonas vaginalis penicillin-binding protein, putative 0.005 0.0283 0.1169
Mycobacterium ulcerans quinone reductase Qor 0.0034 0.0147 0.0142
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0034 0.0147 0.0142
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0114 0.0847 0.1086
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0137 0.1041 1
Loa Loa (eye worm) matrix metalloproteinase 0.0041 0.0206 0.0264
Schistosoma mansoni [ACP] S-malonyltransferase 0.0034 0.0152 0.0152
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0059 0.0362 0.04
Loa Loa (eye worm) hypothetical protein 0.0048 0.0269 0.0345
Brugia malayi Matrixin family protein 0.0098 0.0706 0.0802
Leishmania major trypanothione reductase 0.0022 0.0048 0.0331
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0915 0.7795 1
Schistosoma mansoni methyltransferase-related 0.0164 0.1278 0.1278
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0084 0.0579 0.0638
Plasmodium vivax hypothetical protein, conserved 0.0084 0.058 0.5364
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0024 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.016
Brugia malayi Hint module family protein 0.0048 0.0269 0.0306
Loa Loa (eye worm) heterochromatin protein 1 0.005 0.0288 0.037
Brugia malayi beta-lactamase family protein 0.005 0.0283 0.0321
Mycobacterium ulcerans thioesterase TesA 0.0454 0.3796 0.3809
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0186 0.1468 0.1643
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0148 0.1136 0.1136
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0034 0.0147 0.0142
Mycobacterium ulcerans thioesterase 0.0454 0.3796 0.3809
Plasmodium falciparum acyl carrier protein 0.0055 0.0331 0.285
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0283 0.1169
Schistosoma mansoni hypothetical protein 0.0055 0.0331 0.0331
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0034 0.0147 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1182 1
Loa Loa (eye worm) transcription factor SMAD2 0.0064 0.0408 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0103 0.0103
Onchocerca volvulus 0.0064 0.0411 0.0491
Mycobacterium ulcerans O-methyltransferase 0.1164 0.9957 1
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Brugia malayi chromobox protein homolog 3 0.0028 0.0097 0.011
Brugia malayi glutathione reductase 0.0022 0.0048 0.0055
Mycobacterium tuberculosis Conserved protein 0.005 0.0283 0.0311
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0059 0.0362 0.0411
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0034 0.0152 0.0146
Mycobacterium ulcerans methyltransferase 0.0121 0.0902 0.09
Mycobacterium ulcerans fatty acid synthase Fas 0.0171 0.1339 0.134
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0171 0.1339 0.1762
Onchocerca volvulus 0.0291 0.2377 0.2835
Plasmodium vivax hypothetical protein, conserved 0.005 0.0283 0.2368
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0026 0.0083
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Echinococcus multilocularis NADH dehydrogenase 0.0055 0.0331 0.0331
Brugia malayi RNA recognition motif domain containing protein 0.0034 0.0147 0.0167
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0081 0.0559 0.0559
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.1182 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0034 0.0147 0.0594
Toxoplasma gondii type I fatty acid synthase, putative 0.0578 0.4872 1
Brugia malayi Hemopexin family protein 0.0058 0.0353 0.0401
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0057 0.0348 0.0384
Onchocerca volvulus Fatty acid synthase homolog 0.0982 0.8382 1
Schistosoma mansoni hypothetical protein 0.0204 0.162 0.162
Mycobacterium ulcerans short chain dehydrogenase 0.0411 0.3422 0.3433
Echinococcus granulosus GPCR family 2 0.0026 0.0077 0.0077
Mycobacterium leprae Probable polyketide synthase Pks1 0.0577 0.4867 0.6976
Loa Loa (eye worm) hypothetical protein 0.0082 0.0561 0.072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0103 0.0103
Echinococcus granulosus adam 17 protease 0.0189 0.1497 0.1497
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0082 0.0561 0.0637
Onchocerca volvulus 0.0034 0.0147 0.0175
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0813 0.6914 0.7759
Echinococcus multilocularis microtubule associated protein 2 0.1169 1 1
Echinococcus multilocularis AMP dependent ligase 0.0056 0.0335 0.0335
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0137 0.1041 0.8801
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0051 0.0298 0.0328
Loa Loa (eye worm) hypothetical protein 0.0041 0.0206 0.0264
Echinococcus multilocularis zinc finger protein 0.002 0.0031 0.0031
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0034 0.0147 0.0142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.0287
Trichomonas vaginalis penicillin-binding protein, putative 0.005 0.0283 0.1169
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0362 0.0358
Echinococcus granulosus plexin a4 0.0048 0.0269 0.0269
Mycobacterium tuberculosis Probable conserved lipoprotein 0.005 0.0283 0.0311
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0108 0.0791 0.0791
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.005 0.0283 0.0311
Mycobacterium tuberculosis Conserved protein 0.005 0.0283 0.0311
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0051 0.0298 0.0328
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.018 0.018
Mycobacterium ulcerans polyketide synthase MbtC 0.0137 0.1041 0.104
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Echinococcus multilocularis adam 0.003 0.0113 0.0113
Echinococcus granulosus tar DNA binding protein 0.0034 0.0147 0.0147
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0544 0.4574 0.5131
Mycobacterium ulcerans beta-lactamase 0.005 0.0283 0.0278
Mycobacterium tuberculosis Probable methyltransferase 0.0121 0.0902 0.1006
Trypanosoma brucei acyl transferase-like protein 0.0034 0.0152 0.0914
Echinococcus granulosus geminin 0.0204 0.162 0.162
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0137 0.1041 1
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0034 0.0152 0.1044
Schistosoma mansoni hypothetical protein 0.0021 0.0034 0.0034
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0137 0.1041 0.8131
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0396 0.0396
Mycobacterium ulcerans Type I modular polyketide synthase 0.0544 0.4574 0.459
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0178
Mycobacterium ulcerans esterase/lipase LipP 0.005 0.0283 0.0278
Plasmodium vivax acyl carrier protein, putative 0.0055 0.0331 0.285
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0059 0.0362 0.04
Mycobacterium ulcerans hypothetical protein 0.005 0.0283 0.0278
Mycobacterium ulcerans Type I modular polyketide synthase 0.0544 0.4574 0.459
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0034 0.0147 0.0142
Brugia malayi hypothetical protein 0.003 0.0113 0.0128
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0029 0.0103 0.0132
Mycobacterium ulcerans oxidoreductase FadB5 0.0034 0.0147 0.0142
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0055 0.0331 0.0365
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0021 0.0034 0.0034
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0059 0.0362 0.0358
Echinococcus granulosus thioredoxin glutathione reductase 0.0023 0.0051 0.0051
Echinococcus multilocularis geminin 0.0204 0.162 0.162
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0171 0.1339 0.1498
Brugia malayi Bromodomain containing protein 0.004 0.0201 0.0228
Toxoplasma gondii type I fatty acid synthase 0.0084 0.0579 0.11
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0008 0.0008
Mycobacterium ulcerans hypothetical protein 0.0055 0.0331 0.0327
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0133 0.1009 0.1127
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0444 0.3711 0.4162
Trichomonas vaginalis chromobox protein, putative 0.005 0.0288 0.119
Brugia malayi Alcohol dehydrogenase class III 0.0034 0.0147 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0331 0.0365
Brugia malayi Pre-SET motif family protein 0.0037 0.0171 0.0194
Mycobacterium ulcerans Type I modular polyketide synthase 0.0544 0.4574 0.459
Schistosoma mansoni acyl carrier protein 0.0055 0.0331 0.0331
Brugia malayi TAR-binding protein 0.0034 0.0147 0.0167
Brugia malayi Heterochromatin protein 1 0.005 0.0288 0.0327
Echinococcus multilocularis tar DNA binding protein 0.0034 0.0147 0.0147
Leishmania major hypothetical protein, conserved 0.0164 0.1278 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0103 0.0103
Mycobacterium ulcerans oxidoreductase 0.0034 0.0147 0.0142
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0034 0.0144 0.0185
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0148 0.1136 0.1136
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0577 0.4867 0.5461
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0118 0.0879 0.0997
Mycobacterium ulcerans acyl carrier protein 0.0055 0.0331 0.0327
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0084 0.0579 0.0643
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0437 0.3649 0.3661
Mycobacterium tuberculosis Conserved protein 0.005 0.0283 0.0311
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0081 0.0559 0.0559
Leishmania major hypothetical protein, conserved 0.005 0.0283 0.2178
Echinococcus granulosus lamin 0.0034 0.0144 0.0144
Onchocerca volvulus 0.0952 0.812 0.9686
Loa Loa (eye worm) hypothetical protein 0.0084 0.0579 0.0743
Mycobacterium ulcerans polyketide synthase MbtD 0.0168 0.1308 0.1308
Loa Loa (eye worm) hypothetical protein 0.0056 0.0337 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0026 0.0077 0.0088
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Leishmania major hypothetical protein, conserved 0.0153 0.1182 0.9239
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Treponema pallidum acyl carrier protein 0.0055 0.0331 0.5
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Onchocerca volvulus 0.005 0.0283 0.0338
Trichomonas vaginalis set domain proteins, putative 0.0291 0.2377 1
Onchocerca volvulus Matrilysin homolog 0.0041 0.0206 0.0246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0099
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0034 0.0147 0.0158
Brugia malayi hypothetical protein 0.0021 0.0034 0.0038
Echinococcus multilocularis hedgehog 0.0176 0.1386 0.1386
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0024 0.0058 0.0058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.005 0.0283 0.0283
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0017 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Trypanosoma cruzi oxidoreductase, putative 0.0034 0.0147 0.1199
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0121 0.0902 0.1115
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0034 0.0147 0.0142
Loa Loa (eye worm) hypothetical protein 0.0041 0.0206 0.0264
Schistosoma mansoni lamin 0.0034 0.0144 0.0144
Loa Loa (eye worm) TAR-binding protein 0.0034 0.0147 0.0189
Toxoplasma gondii acyl carrier protein ACP 0.0055 0.0331 0.0586
Giardia lamblia Methyltransferase like 2 0.0164 0.1278 0.5
Loa Loa (eye worm) plexin A 0.0048 0.0269 0.0345
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0326 0.0326
Brugia malayi AMP-binding enzyme family protein 0.0168 0.1312 0.1489
Echinococcus granulosus chromobox protein 1 0.005 0.0288 0.0288
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.005 0.0283 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1182 1
Brugia malayi Pre-SET motif family protein 0.0255 0.207 0.235
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0034 0.0147 0.0158
Mycobacterium tuberculosis Probable thioesterase TesA 0.0454 0.3796 0.4257
Brugia malayi PHD-finger family protein 0.0026 0.008 0.009
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0137 0.1041 0.1335
Mycobacterium tuberculosis Probable dehydrogenase 0.0051 0.0298 0.0328
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0084 0.0579 0.0643
Echinococcus granulosus tumor protein p63 0.0214 0.1711 0.1711
Leishmania major zinc-binding dehydrogenase-like protein 0.0034 0.0147 0.1107
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0513 0.4305 0.4829
Schistosoma mansoni bromodomain containing protein 0.0066 0.0428 0.0428
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0577 0.4867 0.5461
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0034 0.0152 0.0172
Loa Loa (eye worm) matrixin family protein 0.009 0.0636 0.0816
Mycobacterium ulcerans polyketide synthase Pks13 0.0813 0.6914 0.6942
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0577 0.4867 0.4885
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0022 0.0048 0.0047
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0055 0.0331 0.0365
Mycobacterium ulcerans dehydrogenase 0.0034 0.0147 0.0142
Mycobacterium tuberculosis Probable oxidoreductase 0.0034 0.0147 0.0158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0144 0.0185
Echinococcus multilocularis apoptotic protease activating factor 1 0.0018 0.0009 0.0009
Echinococcus multilocularis inhibitor of apoptosis protein 0.0024 0.0058 0.0058
Echinococcus multilocularis beta LACTamase domain containing family member 0.005 0.0283 0.0283
Brugia malayi Cell death protein 3 precursor 0.0018 0.0009 0.001
Trichomonas vaginalis esterase, putative 0.005 0.0283 0.1169
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0034 0.0147 0.1199
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0049 0.0283 0.0311
Trypanosoma brucei oxidoreductase, putative 0.0034 0.0147 0.0872
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0168 0.1308 0.1462
Echinococcus multilocularis chromobox protein 1 0.005 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0206 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0049 0.0283 0.0363
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.0077 0.0077
Trypanosoma cruzi acyl transferase-like protein, putative 0.0034 0.0152 0.1239
Trypanosoma cruzi acyl transferase-like protein 0.0034 0.0152 0.1239
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0528 0.444 0.498
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.0129 0.0969 0.0969
Schistosoma mansoni plexin 0.004 0.0205 0.0205
Mycobacterium ulcerans oxidoreductase 0.0034 0.0147 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0242 0.0242
Trichomonas vaginalis chromobox protein, putative 0.003 0.0115 0.0462
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.0077 0.0077
Mycobacterium ulcerans acyl carrier protein 0.0055 0.0331 0.0327
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0059 0.0362 0.0358
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0513 0.4305 0.5523
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0034 0.0147 0.0158
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0051 0.0298 0.0328
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0034 0.0152 0.1044
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0009 0.0012
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0055 0.0331 0.2495
Loa Loa (eye worm) hypothetical protein 0.0304 0.2493 0.3198
Schistosoma mansoni transcription factor LCR-F1 0.0021 0.0034 0.0034
Schistosoma mansoni plexin 0.0024 0.0058 0.0058
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0335 0.0278
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0084 0.0579 0.0643
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0137 0.1041 1
Schistosoma mansoni chromobox protein 0.005 0.0288 0.0288
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0034 0.0147 0.0205
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Mycobacterium ulcerans short-chain dehydrogenase 0.004 0.0196 0.0191
Mycobacterium tuberculosis Hypothetical protein 0.0164 0.1278 0.1429
Schistosoma mansoni hypothetical protein 0.0024 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0204 0.162 0.162
Onchocerca volvulus Deterin homolog 0.0024 0.0058 0.0069
Echinococcus multilocularis tumor protein p63 0.0214 0.1711 0.1711
Mycobacterium ulcerans lipase LipD 0.005 0.0283 0.0278
Schistosoma mansoni lamin 0.0034 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0121 0.0902 0.1157
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0577 0.4867 0.6976
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0074
Brugia malayi latrophilin 2 splice variant baaae 0.0056 0.0337 0.0383
Mycobacterium leprae conserved hypothetical protein 0.0055 0.0331 0.0272
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Leishmania major nuclear receptor binding factor-like protein 0.0034 0.0147 0.1107
Schistosoma mansoni inhibitor of apoptosis protein 0.0024 0.0058 0.0058
Mycobacterium leprae PROBABLE HYDROLASE 0.0049 0.0283 0.0201
Echinococcus granulosus zinc finger protein 0.002 0.0031 0.0031
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Echinococcus granulosus inhibitor of apoptosis protein 0.0024 0.0058 0.0058
Echinococcus granulosus citrate lyase subunit beta protein 0.0018 0.0006 0.0006
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0034 0.0147 0.1107
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0577 0.4867 0.5461
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0195
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0172 0.1348 0.1348
Trypanosoma cruzi oxidoreductase, putative 0.0034 0.0147 0.1199
Onchocerca volvulus 0.0034 0.0147 0.0175
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0255 0.207 0.2656
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0437 0.3649 0.3661
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.1169 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0103 0.0103
Chlamydia trachomatis acyl carrier protein 0.0055 0.0331 0.2016
Brugia malayi Methyltransferase-like protein 4 0.0164 0.1278 0.1451
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0074
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0034 0.0147 0.0142
Schistosoma mansoni intermediate filament proteins 0.0034 0.0144 0.0144
Leishmania major oxidoreductase, putative 0.0034 0.0147 0.1107
Loa Loa (eye worm) glutathione reductase 0.0022 0.0048 0.0062
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0034 0.0147 0.0594
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0034 0.0147 0.281
Toxoplasma gondii type I fatty acid synthase, putative 0.0388 0.3221 0.6578
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0396 0.0396
Loa Loa (eye worm) O-methyltransferase 0.0121 0.0902 0.1157
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0058 0.0058
Loa Loa (eye worm) RNA binding protein 0.0034 0.0147 0.0189
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0058 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0283 0.2073
Echinococcus granulosus Desert hedgehog protein 0.0176 0.1386 0.1386
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0137 0.1041 0.104
Echinococcus granulosus lamin dm0 0.0034 0.0144 0.0144
Onchocerca volvulus 0.005 0.0283 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.1278 0.5367
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0121 0.0902 0.8445
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0137 0.1041 0.1041
Echinococcus multilocularis citrate lyase subunit beta protein 0.0018 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0055 0.0331 0.2059
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0055 0.0331 0.0365
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0034 0.0152 0.0152
Schistosoma mansoni chromobox protein 0.005 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0057 0.0348 0.0297
Entamoeba histolytica acyl-CoA synthetase, putative 0.0056 0.0335 0.7488
Brugia malayi RNA binding protein 0.0034 0.0147 0.0167
Schistosoma mansoni zinc binding dehydrogenase 0.0034 0.0147 0.0147
Mycobacterium leprae Polyketide synthase Pks13 0.0813 0.6914 1
Schistosoma mansoni zinc finger protein 0.002 0.0031 0.0031
Echinococcus granulosus apoptotic protease activating factor 1 0.0018 0.0009 0.0009
Mycobacterium ulcerans quinone oxidoreductase 0.0034 0.0147 0.0142
Loa Loa (eye worm) acyl carrier protein 0.0251 0.2029 0.2603
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0034 0.0147 0.0158

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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