Detailed information for compound 1042436

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.893 | Formula: C23H22ClN3O
  • H donors: 1 H acceptors: 2 LogP: 4.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)ccc(n2)CN1CCCC1)/C=C/c1cccc(c1)Cl
  • InChi: 1S/C23H22ClN3O/c24-19-5-3-4-17(14-19)6-11-23(28)26-20-9-10-22-18(15-20)7-8-21(25-22)16-27-12-1-2-13-27/h3-11,14-15H,1-2,12-13,16H2,(H,26,28)/b11-6+
  • InChiKey: VIBPEIOGGSJOLN-IZZDOVSWSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0577 0.4867 0.5461
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0034 0.0147 0.0167
Mycobacterium tuberculosis Probable methyltransferase 0.0121 0.0902 0.1006
Schistosoma mansoni bromodomain containing protein 0.0066 0.0428 0.0428
Echinococcus multilocularis inhibitor of apoptosis protein 0.0024 0.0058 0.0058
Brugia malayi hypothetical protein 0.0018 0.0009 0.001
Leishmania major oxidoreductase-like protein 0.0034 0.0147 0.1107
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0137 0.1041 0.1041
Echinococcus granulosus lamin dm0 0.0034 0.0144 0.0144
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0118 0.0879 0.0879
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0283 0.2073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.005 0.0283 0.0311
Echinococcus multilocularis disintegrin and metalloproteinase 0.0017 0.0002 0.0002
Loa Loa (eye worm) O-methyltransferase 0.0121 0.0902 0.1157
Mycobacterium ulcerans polyketide synthase 0.0544 0.4574 0.459
Brugia malayi Phosphopantetheine attachment site family protein 0.0055 0.0331 0.0376
Echinococcus multilocularis GPCR, family 2 0.0026 0.0077 0.0077
Onchocerca volvulus 0.0034 0.0147 0.0175
Trichomonas vaginalis chromobox protein, putative 0.003 0.0115 0.0462
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0577 0.4867 0.5461
Schistosoma mansoni hypothetical protein 0.0024 0.0058 0.0058
Onchocerca volvulus 0.0121 0.0902 0.1076
Brugia malayi O-methyltransferase 0.0121 0.0902 0.1024
Echinococcus multilocularis AMP dependent ligase 0.0056 0.0335 0.0335
Mycobacterium tuberculosis Probable oxidoreductase 0.0057 0.0348 0.0384
Leishmania major zinc-binding dehydrogenase-like protein 0.0034 0.0147 0.1107
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0353 0.2923 0.5959
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0396 0.0396
Brugia malayi O-methyltransferase family protein 0.0121 0.0902 0.1024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.0287
Mycobacterium leprae conserved hypothetical protein 0.0055 0.0331 0.0272
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0017 0.0002 0.0002
Leishmania major d-xylulose reductase, putative 0.0034 0.0147 0.1107
Mycobacterium leprae Probable polyketide synthase Pks1 0.0577 0.4867 0.6976
Schistosoma mansoni zinc binding dehydrogenase 0.0034 0.0147 0.0147
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0059 0.0362 0.0318
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0057 0.0348 0.0297
Onchocerca volvulus Putative alcohol dehydrogenase 0.0034 0.0147 0.0175
Brugia malayi RNA recognition motif domain containing protein 0.0034 0.0147 0.0167
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0029 0.0103 0.0132
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0121 0.0902 0.8445
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0577 0.4867 0.4885
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0137 0.1041 0.2058
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0137 0.1041 1
Loa Loa (eye worm) beta-lactamase 0.005 0.0283 0.0363
Echinococcus granulosus chromobox protein 1 0.005 0.0288 0.0288
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0059 0.0362 0.0358
Echinococcus granulosus beta LACTamase domain containing family member 0.005 0.0283 0.0283
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.005 0.0283 0.0278
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Trypanosoma cruzi acyl transferase-like protein 0.0034 0.0152 0.1239
Loa Loa (eye worm) matrixin family protein 0.009 0.0636 0.0816
Loa Loa (eye worm) plexin A 0.0048 0.0269 0.0345
Trichomonas vaginalis chromobox protein, putative 0.003 0.0115 0.0462
Schistosoma mansoni inhibitor of apoptosis protein 0.0024 0.0058 0.0058
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0034 0.0147 0.0158
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0137 0.1041 0.104
Trichomonas vaginalis chromobox protein, putative 0.005 0.0288 0.119
Loa Loa (eye worm) reprolysin 0.0017 0.0002 0.0003
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.1043 0.8908 1
Echinococcus multilocularis caspase 2 0.0018 0.0009 0.0009
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0577 0.4867 0.6976
Mycobacterium leprae Polyketide synthase Pks13 0.0813 0.6914 1
Schistosoma mansoni dihydroceramide desaturase 0.0017 0.0002 0.0002
Loa Loa (eye worm) matrix metalloproteinase 0.0041 0.0206 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0055 0.0331 0.2764
Plasmodium vivax SET domain protein, putative 0.0037 0.0171 0.1239
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0171 0.0171
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0034 0.0147 0.1199
Brugia malayi Pre-SET motif family protein 0.0255 0.207 0.235
Mycobacterium ulcerans oxidoreductase 0.0034 0.0147 0.0142
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0362 0.0358
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0528 0.444 0.498
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0383
Schistosoma mansoni hypothetical protein 0.0055 0.0331 0.0331
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0034 0.0147 0.0205
Brugia malayi Hemopexin family protein 0.0058 0.0353 0.0401
Mycobacterium leprae conserved hypothetical protein 0.005 0.0283 0.0201
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0034 0.0147 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0026 0.0083
Mycobacterium tuberculosis Probable lipase LipD 0.005 0.0283 0.0311
Mycobacterium ulcerans hypothetical protein 0.0055 0.0331 0.0327
Echinococcus multilocularis musashi 0.0034 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0362 0.2994 0.384
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0024 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Schistosoma mansoni hypothetical protein 0.0056 0.0337 0.0337
Brugia malayi Bromodomain containing protein 0.004 0.0201 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0391 0.3252 0.3646
Brugia malayi latrophilin 2 splice variant baaae 0.0056 0.0337 0.0383
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0437 0.3649 0.3661
Mycobacterium tuberculosis Probable hydrolase 0.005 0.0283 0.0311
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0396 0.0396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0103 0.0103
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0028 0.0097 0.0116
Leishmania major zinc binding dehydrogenase-like protein 0.0034 0.0147 0.1107
Mycobacterium tuberculosis Possible dehydrogenase 0.0034 0.0147 0.0158
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0034 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0178
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0137 0.1041 0.8801
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.022 0.1766 0.1977
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0059 0.0362 0.0411
Toxoplasma gondii acyl transferase domain-containing protein 0.0034 0.0152 0.0215
Loa Loa (eye worm) hypothetical protein 0.0074 0.0496 0.0636
Brugia malayi AMP-binding enzyme family protein 0.0513 0.4305 0.4886
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0148 0.1136 0.1136
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0137 0.1041 0.1181
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Toxoplasma gondii acyl carrier protein ACP 0.0055 0.0331 0.0586
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0034 0.0152 0.1044
Echinococcus granulosus citrate lyase subunit beta protein 0.0018 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0024 0.0058 0.0058
Mycobacterium ulcerans thioesterase 0.0454 0.3796 0.3809
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0513 0.4305 0.4829
Mycobacterium tuberculosis Conserved protein 0.005 0.0283 0.0311
Plasmodium vivax hypothetical protein, conserved 0.005 0.0283 0.2368
Onchocerca volvulus Matrix metalloproteinase homolog 0.009 0.0636 0.0758
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0283 0.1169
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0055 0.0331 0.0376
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0022 0.0048 0.0047
Echinococcus granulosus tar DNA binding protein 0.0034 0.0147 0.0147
Brugia malayi Bromodomain containing protein 0.0079 0.0535 0.0607
Brugia malayi beta-lactamase family protein 0.005 0.0283 0.0321
Mycobacterium ulcerans hypothetical protein 0.005 0.0283 0.0278
Echinococcus multilocularis citrate lyase subunit beta protein 0.0018 0.0006 0.0006
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0813 0.6914 0.7759
Leishmania major quinone oxidoreductase, putative 0.0034 0.0147 0.1107
Schistosoma mansoni methyltransferase-related 0.0164 0.1278 0.1278
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.0077 0.0077
Echinococcus multilocularis lamin dm0 0.0034 0.0144 0.0144
Echinococcus multilocularis apoptotic protease activating factor 1 0.0018 0.0009 0.0009
Brugia malayi Methyltransferase-like protein 4 0.0164 0.1278 0.1451
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.0077 0.0077
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0034 0.0147 0.0594
Brugia malayi Hint module family protein 0.0048 0.0269 0.0306
Toxoplasma gondii type I fatty acid synthase 0.0084 0.0579 0.11
Schistosoma mansoni hypothetical protein 0.0022 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0021 0.0034 0.0034
Toxoplasma gondii ABC1 family protein 0.005 0.0283 0.0487
Onchocerca volvulus 0.0034 0.0144 0.0172
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0029 0.0103 0.0116
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0118 0.0879 0.0997
Brugia malayi Matrixin family protein 0.0098 0.0706 0.0802
Onchocerca volvulus 0.0022 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0121 0.0902 0.1157
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0034 0.0147 0.0872
Trypanosoma cruzi acyl transferase-like protein, putative 0.0034 0.0152 0.1239
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0148 0.1136 0.1136
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.005 0.0283 0.0321
Onchocerca volvulus 0.0064 0.0411 0.0491
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.005 0.0283 0.0311
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0055 0.0331 0.2495
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.018 0.018
Mycobacterium tuberculosis Probable oxidoreductase 0.0411 0.3422 0.3837
Loa Loa (eye worm) MH2 domain-containing protein 0.0064 0.0408 0.0523
Brugia malayi PHD-finger family protein 0.0026 0.008 0.009
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0059 0.0362 0.0358
Trypanosoma cruzi oxidoreductase, putative 0.0034 0.0147 0.1199
Onchocerca volvulus 0.0291 0.2377 0.2835
Echinococcus granulosus intermediate filament protein 0.0034 0.0144 0.0144
Echinococcus granulosus plexin a4 0.0048 0.0269 0.0269
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0034 0.0152 0.1044
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0577 0.4867 0.4885
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0074
Mycobacterium ulcerans acyl carrier protein 0.0055 0.0331 0.0327
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0017 0.0002 0.0002
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0034 0.0147 0.0142
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0437 0.3649 0.5175
Schistosoma mansoni lamin 0.0034 0.0144 0.0144
Loa Loa (eye worm) RNA binding protein 0.0034 0.0147 0.0189
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.005 0.0283 0.0363
Toxoplasma gondii type I fatty acid synthase, putative 0.0578 0.4872 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0021 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.005 0.0283 0.2178
Loa Loa (eye worm) hypothetical protein 0.0304 0.2493 0.3198
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0137 0.1041 1
Brugia malayi AMP-binding enzyme family protein 0.0168 0.1312 0.1489
Leishmania major hypothetical protein, conserved 0.0153 0.1182 0.9239
Trypanosoma cruzi oxidoreductase, putative 0.0034 0.0147 0.1199
Loa Loa (eye worm) hypothetical protein 0.0041 0.0206 0.0264
Leishmania major hypothetical protein, conserved 0.0164 0.1278 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0847 0.1086
Onchocerca volvulus 0.0058 0.0353 0.0422
Chlamydia trachomatis acyl carrier protein 0.0055 0.0331 0.2016
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0059 0.0362 0.0358
Trypanosoma brucei oxidoreductase, putative 0.0034 0.0147 0.0872
Toxoplasma gondii quinone oxidoreductase, putative 0.0034 0.0147 0.0205
Onchocerca volvulus 0.004 0.0205 0.0244
Mycobacterium tuberculosis Probable dehydrogenase 0.0051 0.0298 0.0328
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0081 0.0559 0.0634
Loa Loa (eye worm) matrixin family protein 0.0098 0.0706 0.0906
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0084 0.0579 0.0643
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0034 0.0147 0.0142
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0283 0.2357
Trypanosoma cruzi oxidoreductase, putative 0.0034 0.0147 0.1199
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0276 0.2249 0.4562
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0255 0.207 0.2656
Mycobacterium ulcerans quinone oxidoreductase 0.0034 0.0147 0.0142
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0259
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0034 0.0147 0.281
Onchocerca volvulus Deterin homolog 0.0024 0.0058 0.0069
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0544 0.4574 0.6542
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0056 0.0335 0.0331
Mycobacterium ulcerans fatty acid synthase Fas 0.0171 0.1339 0.134
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0034 0.0147 0.0158
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0055 0.0331 0.0365
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0124
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Brugia malayi Cell death protein 3 precursor 0.0018 0.0009 0.001
Trypanosoma brucei oxidoreductase, putative 0.0034 0.0147 0.0872
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0168 0.1308 0.1462
Echinococcus granulosus adam 0.003 0.0113 0.0113
Echinococcus multilocularis thioredoxin glutathione reductase 0.0023 0.0051 0.0051
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0034 0.0147 0.0142
Echinococcus multilocularis adam 0.003 0.0113 0.0113
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0051 0.0298 0.0328
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0009 0.001
Mycobacterium tuberculosis Conserved protein 0.0164 0.1278 0.1429
Onchocerca volvulus 0.0024 0.0058 0.0069
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0057 0.0348 0.0384
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0082 0.0561 0.072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0144 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0099
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.018 0.018
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0034 0.0147 0.0158
Mycobacterium tuberculosis Probable thioesterase TesA 0.0454 0.3796 0.4257
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0059 0.0362 0.04
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0326 0.0326
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0137 0.1041 0.8131
Loa Loa (eye worm) heterochromatin protein 1 0.005 0.0288 0.037
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0034 0.0152 0.0146
Echinococcus multilocularis microtubule associated protein 2 0.1169 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.1278 0.5367
Loa Loa (eye worm) hypothetical protein 0.0105 0.0763 0.0979
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0057
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Mycobacterium ulcerans polyketide synthase Pks9 0.0359 0.2971 0.2979
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0012
Brugia malayi Plexin repeat family protein 0.004 0.0205 0.0232
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0051 0.0298 0.0328
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0335 0.037
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0058 0.0058
Echinococcus multilocularis zinc finger protein 0.002 0.0031 0.0031
Brugia malayi Heterochromatin protein 1 0.005 0.0288 0.0327
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0195
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0359 0.2971 0.4173
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0059 0.0362 0.04
Schistosoma mansoni lamin 0.0034 0.0144 0.0144
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0059 0.0362 0.04
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0137 0.1041 0.8801
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0137 0.1041 0.1041
Onchocerca volvulus 0.0018 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0206 0.0264
Loa Loa (eye worm) hypothetical protein 0.0048 0.0269 0.0345
Echinococcus granulosus zinc finger protein 0.002 0.0031 0.0031
Mycobacterium leprae Probable lipase LipE 0.005 0.0283 0.0201
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0034 0.0147 0.0158
Entamoeba histolytica acyl-CoA synthetase, putative 0.0056 0.0335 0.7488
Plasmodium vivax hypothetical protein, conserved 0.0084 0.058 0.5364
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0034 0.0147 0.0158
Mycobacterium ulcerans polyketide synthase MbtD 0.0168 0.1308 0.1308
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0034 0.0147 0.0142
Schistosoma mansoni [ACP] S-malonyltransferase 0.0034 0.0152 0.0152
Echinococcus granulosus disintegrin and metalloproteinase 0.0017 0.0002 0.0002
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0034 0.0147 0.0142
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0056 0.0335 0.0331
Trichomonas vaginalis chromobox protein, putative 0.005 0.0288 0.119
Treponema pallidum acyl carrier protein 0.0055 0.0331 0.5
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0034 0.0147 0.1199
Onchocerca volvulus Cell death protein 3 homolog 0.0018 0.0009 0.0011
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0009 0.0009
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.003 0.0113 0.0113
Mycobacterium tuberculosis Possible dehydrogenase 0.0034 0.0147 0.0158
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0055 0.0331 0.0365
Loa Loa (eye worm) hypothetical protein 0.0041 0.0206 0.0264
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0159 0.0159
Brugia malayi beta-lactamase family protein 0.005 0.0283 0.0321
Loa Loa (eye worm) fatty acid synthase 0.0538 0.4522 0.5801
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1032 0.881 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0544 0.4574 0.459
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0008 0.0008
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0034 0.0152 0.0172
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0055 0.0331 0.0365
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0074
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0034 0.0147 0.0594
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0081 0.0559 0.0559
Echinococcus granulosus lamin 0.0034 0.0144 0.0144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.005 0.0283 0.0283
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0103 0.0103
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0034 0.0147 0.0189
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0137 0.1041 0.104
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0048 0.0358
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0051 0.0298 0.0328
Loa Loa (eye worm) acyl carrier protein 0.0055 0.0331 0.0425
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0055 0.0331 0.2059
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0137 0.1041 0.1041
Loa Loa (eye worm) intermediate filament protein 0.0034 0.0144 0.0185
Brugia malayi O-methyltransferase family protein 0.0121 0.0902 0.1024
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0084 0.0579 0.0643
Brugia malayi RNA binding protein 0.0034 0.0147 0.0167
Onchocerca volvulus Matrilysin homolog 0.009 0.0636 0.0758
Mycobacterium ulcerans hydrolase 0.0049 0.0283 0.0278
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0103 0.0103
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.005 0.0283 0.0311
Leishmania major acyl carrier protein, putative 0.0055 0.0331 0.2554
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0074
Mycobacterium ulcerans short-chain dehydrogenase 0.004 0.0196 0.0191
Mycobacterium tuberculosis Probable lipase LipE 0.005 0.0283 0.0311
Brugia malayi Disintegrin family protein 0.0017 0.0002 0.0002
Toxoplasma gondii type I fatty acid synthase, putative 0.0388 0.3221 0.6578
Loa Loa (eye worm) glutathione reductase 0.0022 0.0048 0.0062
Mycobacterium ulcerans polyketide synthase 0.0577 0.4867 0.4885
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0034 0.0152 0.0152
Onchocerca volvulus 0.005 0.0283 0.0338
Mycobacterium ulcerans oxidoreductase 0.0034 0.0147 0.0142
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0024 0.0058 0.0058
Loa Loa (eye worm) acyl carrier protein 0.0251 0.2029 0.2603
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0055 0.0331 0.0395
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0326 0.0326
Schistosoma mansoni alcohol dehydrogenase 0.0034 0.0147 0.0147
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0034 0.0147 0.0158
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.058 0.5364
Loa Loa (eye worm) hypothetical protein 0.0084 0.0579 0.0743
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0137 0.1041 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0544 0.4574 0.5191
Echinococcus multilocularis geminin 0.0204 0.162 0.162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0171 0.0255
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0171 0.1339 0.1498
Echinococcus multilocularis plexin a4 0.0048 0.0269 0.0269
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0082 0.0561 0.0637
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0034 0.0147 0.281
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0137 0.1041 1
Leishmania major nuclear receptor binding factor-like protein 0.0034 0.0147 0.1107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0029 0.0103 0.0103
Echinococcus multilocularis lamin 0.0034 0.0144 0.0144
Brugia malayi Hint module family protein 0.0048 0.0269 0.0306
Echinococcus granulosus acyl carrier protein mitochondrial 0.0055 0.0331 0.0331
Mycobacterium ulcerans polyketide synthase MbtC 0.0137 0.1041 0.104
Schistosoma mansoni chromobox protein 0.005 0.0288 0.0288
Schistosoma mansoni intermediate filament proteins 0.0034 0.0144 0.0144
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0118 0.0879 0.0879
Mycobacterium tuberculosis Conserved protein 0.005 0.0283 0.0311
Mycobacterium ulcerans short chain dehydrogenase 0.0411 0.3422 0.3433
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0437 0.3649 0.3661
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1182 1
Brugia malayi Alcohol dehydrogenase class III 0.0034 0.0147 0.0167
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.0077 0.0077
Echinococcus multilocularis beta LACTamase domain containing family member 0.005 0.0283 0.0283
Mycobacterium ulcerans O-methyltransferase 0.1164 0.9957 1
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0108 0.0791 0.0791
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.005 0.0283 0.0283
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0055 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.0058 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0082 0.0561 0.072
Brugia malayi Thioredoxin reductase 0.0022 0.0048 0.0055
Schistosoma mansoni [ACP] S-malonyltransferase 0.0034 0.0152 0.0152
Schistosoma mansoni plexin 0.0024 0.0058 0.0058
Leishmania major trypanothione reductase 0.0022 0.0048 0.0331
Loa Loa (eye worm) hypothetical protein 0.0048 0.0269 0.0345
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0049 0.0283 0.0321
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0051 0.0298 0.0223
Schistosoma mansoni transcription factor LCR-F1 0.0021 0.0034 0.0034
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0444 0.3711 0.4162
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0108 0.0791 0.0791
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0034 0.0147 0.0594
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0544 0.4574 0.5131
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0283 0.1169
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0171 0.0171
Mycobacterium ulcerans oxidoreductase FadB5 0.0034 0.0147 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0103 0.0103
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0024 0.0058 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0242 0.0242
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Schistosoma mansoni acyl carrier protein 0.0055 0.0331 0.0331
Mycobacterium leprae PROBABLE HYDROLASE 0.0049 0.0283 0.0201
Echinococcus granulosus thioredoxin glutathione reductase 0.0023 0.0051 0.0051
Echinococcus granulosus apoptotic protease activating factor 1 0.0018 0.0009 0.0009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0544 0.4574 0.459
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1182 1
Echinococcus granulosus Desert hedgehog protein 0.0176 0.1386 0.1386
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0024 0.0058 0.0058
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.0077 0.0099
Giardia lamblia Methyltransferase like 2 0.0164 0.1278 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0026 0.0083
Mycobacterium ulcerans acyl carrier protein 0.0055 0.0331 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0029 0.0103 0.0103
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0081 0.0559 0.0559
Brugia malayi Pre-SET motif family protein 0.0037 0.0171 0.0194
Loa Loa (eye worm) hypothetical protein 0.0915 0.7795 1
Mycobacterium ulcerans thioesterase TesA 0.0454 0.3796 0.3809
Leishmania major oxidoreductase, putative 0.0034 0.0147 0.1107
Brugia malayi O-methyltransferase family protein 0.0121 0.0902 0.1024
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Onchocerca volvulus 0.005 0.0283 0.0338
Loa Loa (eye worm) TAR-binding protein 0.0034 0.0147 0.0189
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0335 0.0278
Mycobacterium ulcerans methyltransferase 0.0121 0.0902 0.09
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0059 0.0362 0.04
Echinococcus multilocularis chromobox protein 1 0.005 0.0288 0.0288
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0034 0.0147 0.0142
Echinococcus multilocularis hedgehog 0.0176 0.1386 0.1386
Onchocerca volvulus 0.0513 0.4305 0.5135
Trypanosoma brucei acyl transferase-like protein 0.0034 0.0152 0.0914
Brugia malayi chromobox protein homolog 3 0.0028 0.0097 0.011
Trichomonas vaginalis penicillin-binding protein, putative 0.005 0.0283 0.1169
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0055 0.0331 0.0425
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0034 0.0147 0.281
Onchocerca volvulus Fatty acid synthase homolog 0.0982 0.8382 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0029 0.0103 0.0103
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0528 0.444 0.498
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0189
Echinococcus granulosus geminin 0.0204 0.162 0.162
Mycobacterium tuberculosis Hypothetical protein 0.0164 0.1278 0.1429
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0034 0.0147 0.0142
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0513 0.4305 0.5523
Onchocerca volvulus 0.0041 0.0206 0.0246
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0544 0.4574 0.6542
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0034 0.0147 0.0158
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0034 0.0147 0.0142
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0057 0.0348 0.0384
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0008 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0082 0.0561 0.0637
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0326 0.0326
Brugia malayi MH2 domain containing protein 0.0064 0.0408 0.0463
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0034 0.0147 0.0167
Echinococcus multilocularis chromobox protein 1 0.005 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.0204 0.162 0.162
Brugia malayi TAR-binding protein 0.0034 0.0147 0.0167
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0034 0.0147 0.0167
Mycobacterium tuberculosis Conserved protein 0.005 0.0283 0.0311
Schistosoma mansoni [ACP] S-malonyltransferase 0.0034 0.0152 0.0152
Mycobacterium ulcerans beta-lactamase 0.005 0.0283 0.0278
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.031 0.2543 0.285
Loa Loa (eye worm) transcription factor SMAD2 0.0064 0.0408 0.0523
Mycobacterium tuberculosis Probable reductase 0.0051 0.0298 0.0328
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.016
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0172 0.1348 0.1348
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0283 0.2357
Onchocerca volvulus 0.0045 0.0242 0.0289
Brugia malayi plexin A 0.0048 0.0269 0.0305
Mycobacterium tuberculosis Probable esterase LipL 0.005 0.0283 0.0311
Loa Loa (eye worm) hypothetical protein 0.0054 0.0326 0.0418
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0024 0.0058 0.0066
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0331 0.0365
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0316 0.2601 0.2915
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0137 0.1041 0.8757
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0544 0.4574 0.5131
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0034 0.0152 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0034 0.0147 0.0147
Echinococcus granulosus NADH dehydrogenase 0.0055 0.0331 0.0331
Schistosoma mansoni microtubule-associated protein tau 0.1169 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0359 0.2971 0.2979
Mycobacterium ulcerans dehydrogenase 0.0034 0.0147 0.0142
Mycobacterium ulcerans quinone oxidoreductase 0.0034 0.0147 0.0142
Leishmania major hypothetical protein, conserved 0.0034 0.0152 0.1145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0283 0.0363
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0034 0.0147 0.1199
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0058 0.0058
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0034 0.0147 0.1107
Loa Loa (eye worm) thioredoxin reductase 0.0022 0.0048 0.0062
Mycobacterium ulcerans lipase LipD 0.005 0.0283 0.0278
Mycobacterium ulcerans esterase/lipase LipP 0.005 0.0283 0.0278
Onchocerca volvulus 0.0952 0.812 0.9686
Plasmodium vivax acyl carrier protein, putative 0.0055 0.0331 0.285
Mycobacterium ulcerans Type I modular polyketide synthase 0.0544 0.4574 0.459
Trichomonas vaginalis penicillin-binding protein, putative 0.005 0.0283 0.1169
Echinococcus multilocularis adam 17 protease 0.0172 0.1348 0.1348
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0186 0.1468 0.1643
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0059 0.0362 0.0358
Onchocerca volvulus 0.0034 0.0144 0.0172
Mycobacterium ulcerans quinone reductase Qor 0.0034 0.0147 0.0142
Brugia malayi Latrophilin receptor protein 2 0.0026 0.0077 0.0088
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0363
Echinococcus granulosus AMP dependent ligase 0.0056 0.0335 0.0335
Echinococcus granulosus caspase 2 0.0018 0.0009 0.0009
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0577 0.4867 0.5461
Schistosoma mansoni hypothetical protein 0.0129 0.0969 0.0969
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0121 0.0902 0.1115
Mycobacterium ulcerans Type I modular polyketide synthase 0.0544 0.4574 0.459
Brugia malayi hypothetical protein 0.0021 0.0034 0.0038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0868 0.7388 0.7388
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.0077 0.0088
Onchocerca volvulus 0.0031 0.0125 0.0149
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0051 0.0298 0.0328
Schistosoma mansoni plexin 0.004 0.0205 0.0205
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0034 0.0144 0.0185
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0049 0.0283 0.0311
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0041 0.0206 0.0206
Mycobacterium ulcerans polyketide synthase Pks13 0.0813 0.6914 0.6942
Echinococcus granulosus chromobox protein 1 0.005 0.0288 0.0288
Mycobacterium tuberculosis Probable oxidoreductase 0.0034 0.0147 0.0158
Schistosoma mansoni zinc finger protein 0.002 0.0031 0.0031
Plasmodium falciparum acyl carrier protein 0.0055 0.0331 0.285
Echinococcus granulosus inhibitor of apoptosis protein 0.0024 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0383
Onchocerca volvulus Heterochromatin protein 1 homolog 0.003 0.0115 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.1182 1
Onchocerca volvulus 0.0034 0.0147 0.0175
Onchocerca volvulus 0.0121 0.0902 0.1076
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.0263
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0058 0.0058
Echinococcus granulosus adam 17 protease 0.0189 0.1497 0.1497
Schistosoma mansoni chromobox protein 0.005 0.0288 0.0288
Brugia malayi beta-lactamase 0.005 0.0283 0.0321
Echinococcus granulosus GPCR family 2 0.0026 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0056 0.0337 0.0433
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0813 0.6914 0.7759
Schistosoma mansoni o-methyltransferase 0.0121 0.0902 0.0902
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0326 0.0326
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0034 0.0147 0.0147
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0034 0.0147 0.0158
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0137 0.1041 0.1335
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0084 0.0579 0.0643
Brugia malayi glutathione reductase 0.0022 0.0048 0.0055
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0077
Brugia malayi hypothetical protein 0.003 0.0113 0.0128
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0081 0.0559 0.0559
Onchocerca volvulus 0.005 0.0283 0.0338
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0017 0.0002 0.0002
Brugia malayi intermediate filament protein 0.0034 0.0144 0.0164
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0084 0.0579 0.0638
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0012
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0454 0.3796 0.5392
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0034 0.0152 0.0053
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0577 0.4867 0.6976
Echinococcus multilocularis tumor protein p63 0.0214 0.1711 0.1711
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0034 0.0147 0.0158
Brugia malayi Intermediate filament tail domain containing protein 0.0034 0.0144 0.0164
Echinococcus granulosus tumor protein p63 0.0214 0.1711 0.1711
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0084 0.0579 0.0643
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0021 0.0034 0.0034
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0041 0.0052
Trichomonas vaginalis esterase, putative 0.005 0.0283 0.1169
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0034 0.0147 0.0142
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0133 0.1009 0.1127
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0544 0.4574 0.5131
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0436 1
Echinococcus multilocularis NADH dehydrogenase 0.0055 0.0331 0.0331
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.0204 0.162 0.162
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0034 0.0147 0.0142
Brugia malayi Matrixin family protein 0.0041 0.0206 0.0234
Echinococcus multilocularis tar DNA binding protein 0.0034 0.0147 0.0147
Schistosoma mansoni cellular tumor antigen P53 0.0031 0.0125 0.0125
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0171 0.1339 0.1762
Loa Loa (eye worm) hypothetical protein 0.0084 0.0579 0.0743
Trichomonas vaginalis set domain proteins, putative 0.0291 0.2377 1
Onchocerca volvulus Matrilysin homolog 0.0041 0.0206 0.0246
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0283 0.1169

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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