Detailed information for compound 1042494

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.087 | Formula: C28H38ClN5O2
  • H donors: 2 H acceptors: 3 LogP: 4.43 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCN1CCC(CC1)CN(CC(c1[nH]c(c(n1)c1ccc(c(c1)O)Cl)c1ccncc1)(C)C)C
  • InChi: 1S/C28H38ClN5O2/c1-28(2,19-33(3)18-20-9-13-34(14-10-20)15-16-36-4)27-31-25(21-7-11-30-12-8-21)26(32-27)22-5-6-23(29)24(35)17-22/h5-8,11-12,17,20,35H,9-10,13-16,18-19H2,1-4H3,(H,31,32)
  • InChiKey: ZDHRAIMNASEUNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0282 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0033 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.1233 0.1405
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0033 0.0061
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0559 0.2075
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0065
Brugia malayi TAR-binding protein 0.0333 0.3026 0.7079
Onchocerca volvulus 0.0145 0.1233 0.2876
Brugia malayi MH2 domain containing protein 0.0129 0.1073 0.2501
Schistosoma mansoni thyroid hormone receptor 0.002 0.0033 0.0033
Mycobacterium ulcerans bacterioferritin BfrB 0.0025 0.0078 0.0114
Loa Loa (eye worm) hypothetical protein 0.0109 0.0889 0.2071
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0215 0.1902 0.2172
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0239 0.0871
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0809 0.0809
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0065
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0668 0.6237 0.7139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0282 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0017 0.0082
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0758 0.1761
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0027
Brugia malayi hypothetical protein 0.015 0.1275 0.2972
Schistosoma mansoni ferritin light chain 0.0025 0.0078 0.0078
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0017 0.0007 0.0003
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0559 0.2045
Echinococcus granulosus expressed conserved protein 0.0104 0.0842 0.0842
Mycobacterium ulcerans epoxide hydrolase EphF 0.0018 0.0017 0.0016
Onchocerca volvulus 0.0149 0.1265 0.2951
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0155 0.2
Echinococcus granulosus p2X purinoceptor 4 0.0218 0.1928 0.1928
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1233 0.592
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0293 0.0673
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0033 0.0033
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0559 0.2075
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0018 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0068 0.0489 0.1134
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3026 0.3026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0124 0.0124
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0018 0.0017 0.0038
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0018 0.0017 0.0016
Echinococcus granulosus GPCR family 2 0.0047 0.0293 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0033 0.0064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0033 0.0033
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0155 0.0346
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0519
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0098 0.0213
Mycobacterium ulcerans hypothetical protein 0.0145 0.1233 0.1969
Brugia malayi Bromodomain containing protein 0.0073 0.0538 0.1246
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0155 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.1233 0.1405
Loa Loa (eye worm) runx1 0.0058 0.0397 0.0918
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0033 0.0033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0047 0.0293 0.0293
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.1233 0.1405
Schistosoma mansoni hypothetical protein 0.015 0.1275 0.1275
Echinococcus granulosus p2X purinoceptor 4 0.0218 0.1928 0.1928
Mycobacterium ulcerans bacterioferritin BfrA 0.0025 0.0078 0.0114
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1267 0.2958
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0293 0.067
Toxoplasma gondii thioredoxin reductase 0.0094 0.0745 0.5984
Schistosoma mansoni myelin transcription factor 1 myt1 0.0109 0.0889 0.0889
Loa Loa (eye worm) voltage-gated potassium channel 0.0148 0.1257 0.2933
Mycobacterium ulcerans beta-lactamase 0.0145 0.1233 0.1969
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0155 0.0712
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0018 0.0017 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0487 0.1127
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0018 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.0155 0.1329 0.2123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0555
Echinococcus multilocularis abhydrolase domain containing protein 0.0018 0.0017 0.0017
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0257 0.0257
Echinococcus granulosus abhydrolase domain containing protein 11 0.0018 0.0017 0.0017
Echinococcus granulosus ferritin 0.0025 0.0078 0.0078
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.015 0.1281 0.1281
Brugia malayi ecdysteroid receptor 0.002 0.0033 0.0061
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0809 0.0809
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0033 0.0061
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.1233 0.1969
Brugia malayi Thioredoxin reductase 0.0094 0.0745 0.173
Mycobacterium ulcerans epoxide hydrolase EphA 0.0668 0.6237 1
Entamoeba histolytica hypothetical protein 0.015 0.1275 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0215 0.1902 0.2172
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0379 0.3467 0.3467
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0758 0.1764
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.015 0.1281 0.2988
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0809 0.0809
Loa Loa (eye worm) hypothetical protein 0.0463 0.4271 1
Schistosoma mansoni hypothetical protein 0.002 0.0033 0.0033
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0018 0.0017 0.0012
Schistosoma mansoni hypothetical protein 0.0102 0.0816 0.0816
Loa Loa (eye worm) TAR-binding protein 0.0333 0.3026 0.708
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0033 0.0061
Schistosoma mansoni zinc finger protein 0.0019 0.0023 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Schistosoma mansoni hypothetical protein 0.1061 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0762 0.0762
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0023 0.0018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0519
Loa Loa (eye worm) glutamate receptor 0.0021 0.0047 0.0097
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.1233 0.1969
Mycobacterium leprae Probable exported protease 0.0018 0.0017 0.0047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0039 0.0212 0.048
Loa Loa (eye worm) hypothetical protein 0.0096 0.0762 0.1772
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.1233 0.4612
Loa Loa (eye worm) hypothetical protein 0.0149 0.1265 0.2953
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.1364 0.1364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1267 0.2956
Echinococcus granulosus metabotropic glutamate receptor 2 0.0046 0.0279 0.0279
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0017 0.0007 0.0003
Plasmodium falciparum alpha/beta hydrolase, putative 0.0018 0.0017 0.0137
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0033 0.0033
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0068 0.0489 0.1134
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0098 0.0718
Entamoeba histolytica hypothetical protein 0.015 0.1275 1
Schistosoma mansoni ferritin 0.0025 0.0078 0.0078
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1178 0.4405
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0033 0.0064
Mycobacterium tuberculosis Conserved protein 0.0145 0.1233 0.1405
Mycobacterium ulcerans lipase/esterase 0.0018 0.0017 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0758 0.0758
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0033 0.0033
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0239 0.2132 0.2435
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.1233 0.1233
Echinococcus granulosus abhydrolase domain containing protein 0.0018 0.0017 0.0017
Brugia malayi mbt repeat family protein 0.0096 0.0762 0.177
Brugia malayi RNA recognition motif domain containing protein 0.0333 0.3026 0.7079
Loa Loa (eye worm) hypothetical protein 0.0047 0.0293 0.0673
Schistosoma mansoni ferritin 0.0025 0.0078 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0033 0.0033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0047 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0067 0.0485 0.1123
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0018 0.0017 0.0017
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0155 0.2
Schistosoma mansoni patched 1 0.0048 0.0299 0.0299
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0745 0.6017
Schistosoma mansoni hypothetical protein 0.1061 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.1233 0.4612
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0326 0.1198
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0155 0.0555
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0018 0.0017 0.008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0033 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1073 0.2503
Echinococcus multilocularis protein patched 0.0048 0.0299 0.0299
Brugia malayi Bromodomain containing protein 0.0037 0.0197 0.0446
Onchocerca volvulus 0.0096 0.0762 0.177
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0155 0.0519
Schistosoma mansoni survival motor neuron protein 0.0039 0.0212 0.0212
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0124 0.0874
Loa Loa (eye worm) glutamate receptor 0.0055 0.0364 0.084
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0175 0.0175
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.1233 0.1405
Leishmania major hypothetical protein, conserved 0.0145 0.1233 0.4591
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0033 0.0061
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.2666 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.1267 0.2958
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0098 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3026 0.3026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0217
Mycobacterium ulcerans peroxidase BpoB 0.0018 0.0017 0.0016
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.015 0.1281 0.1281
Echinococcus multilocularis expressed protein 0.0025 0.0078 0.0078
Echinococcus granulosus p2X purinoceptor 4 0.0218 0.1928 0.1928
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0033 0.0033
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0559 0.0559
Mycobacterium ulcerans lipase LipD 0.0145 0.1233 0.1969
Echinococcus multilocularis geminin 0.1061 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0033 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0033 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0017 0.0082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0098 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0051 0.0051
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0018 0.0017 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0003
Plasmodium falciparum glutathione reductase 0.0033 0.0155 0.2
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0033 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.015 0.1275 0.1275
Leishmania major trypanothione reductase 0.0094 0.0745 0.2747
Trichomonas vaginalis esterase, putative 0.0145 0.1233 0.592
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3026 0.3026
Echinococcus granulosus abhydrolase domain containing protein 3 0.0018 0.0017 0.0017
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0018 0.0017 0.008
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0155 0.0237
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0487 0.0487
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0033 0.0065
Brugia malayi nuclear receptor NHR-88 0.002 0.0033 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0017 0.0082
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0098 0.0146
Mycobacterium tuberculosis Conserved protein 0.0018 0.0017 0.0012
Mycobacterium ulcerans lipase/esterase 0.0018 0.0017 0.0016
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0072 0.0151
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0018 0.0017 0.0017
Brugia malayi glutathione reductase 0.0094 0.0745 0.173
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0239 0.0871
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0033 0.0033
Onchocerca volvulus 0.0039 0.0212 0.048
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0745 0.1733
Schistosoma mansoni nuclear hormone receptor 0.002 0.0033 0.0033
Brugia malayi hypothetical protein 0.0463 0.4271 1
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0018 0.0017 0.0017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0033 0.0033
Schistosoma mansoni ferritin light chain 0.0025 0.0078 0.0078
Mycobacterium ulcerans hypothetical protein 0.0018 0.0017 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0098 0.0428
Entamoeba histolytica hypothetical protein 0.015 0.1275 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0215 0.1902 0.2172
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0762 0.0762
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0018 0.0017 0.0012
Brugia malayi beta-lactamase 0.0145 0.1233 0.2876
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0033 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.0502
Brugia malayi hypothetical protein 0.0149 0.1265 0.2951
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0046 0.0282 0.0648
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0145 0.1233 0.2878
Loa Loa (eye worm) beta-lactamase 0.0145 0.1233 0.2878
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0018 0.0017 0.0027
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0068 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0145 0.1233 0.2878
Mycobacterium ulcerans lignin peroxidase LipJ 0.0018 0.0017 0.0016
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.1233 0.1405
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0559 0.1294
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0098 0.0104
Mycobacterium ulcerans haloalkane dehalogenase 0.0018 0.0017 0.0016
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0018 0.0017 0.0049
Schistosoma mansoni hydrolase 0.0018 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0047 0.0293 0.0293
Schistosoma mansoni hypothetical protein 0.0047 0.0293 0.0293
Brugia malayi nuclear hormone receptor 0.002 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0145 0.1233 0.2878
Toxoplasma gondii hypothetical protein 0.0048 0.0297 0.2302
Brugia malayi metabotropic glutamate receptor type 2 0.0027 0.0096 0.0209
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0155 0.0237
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0155 0.1203
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0396 0.0396
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0299 0.0299
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0816 0.1898
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.015 0.1281 0.1281
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0018 0.0017 0.0137
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0017 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0033 0.0033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.1233 0.2878
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0096 0.0762 0.0762
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3026 0.3026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0033 0.0042
Mycobacterium ulcerans hydrolase 0.0018 0.0017 0.0016
Echinococcus multilocularis p2X purinoceptor 4 0.0218 0.1928 0.1928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0033 0.0064
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.0907 0.0907
Schistosoma mansoni metabotropic glutamate receptor 0.0027 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Onchocerca volvulus 0.0463 0.4271 1
Trichomonas vaginalis hydrolase, putative 0.0018 0.0017 0.0049
Echinococcus granulosus tar DNA binding protein 0.0333 0.3026 0.3026
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0559 0.1297
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0559 0.2075
Mycobacterium ulcerans hypothetical protein 0.0018 0.0017 0.0016
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0017 0.0049
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.1364 0.1364
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0049 0.0315 0.0722
Treponema pallidum bacterioferrin (TpF1) 0.0025 0.0078 0.4813
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0033 0.0213
Trypanosoma brucei trypanothione reductase 0.0094 0.0745 0.2775
Loa Loa (eye worm) MBCTL1 0.0109 0.0889 0.2071
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.1233 0.592
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0018 0.0017 0.0017
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0155 0.0155
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0098 0.0146
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0033 0.0061
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0018 0.0017 0.0017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0124 0.0124
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.1233 0.1405
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.1275 0.1275
Mycobacterium tuberculosis Probable exported protease 0.0018 0.0017 0.0012
Mycobacterium ulcerans hypothetical protein 0.0027 0.0098 0.0146
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0018 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0217
Onchocerca volvulus 0.0234 0.2079 0.4858
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0155 0.0237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0555
Trichomonas vaginalis ferritin, putative 0.0025 0.0078 0.0343
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0017 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.1233 0.592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0033 0.0064
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0018 0.0017 0.0012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0155 1
Mycobacterium ulcerans hypothetical protein 0.0018 0.0017 0.0016
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0487 0.0487
Echinococcus multilocularis p2X purinoceptor 4 0.0218 0.1928 0.1928
Brugia malayi mbt repeat family protein 0.0096 0.0762 0.177
Trypanosoma cruzi hydrolase-like protein 0.0018 0.0017 0.0038
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0018 0.0017 0.0047
Mycobacterium ulcerans proline iminopeptidase PIP 0.0018 0.0017 0.0016
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0809 0.0809
Schistosoma mansoni ferritin 0.0025 0.0078 0.0078
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0017 0.0007 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0758 0.0758
Echinococcus granulosus histone acetyltransferase MYST2 0.0109 0.0889 0.0889
Echinococcus multilocularis protein dispatched 1 0.0054 0.0363 0.0363
Schistosoma mansoni ferritin 0.0025 0.0078 0.0078
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0155 0.113
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0065
Loa Loa (eye worm) RNA binding protein 0.0333 0.3026 0.708
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0018 0.0017 0.0016
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0025 0.0078 0.0081
Onchocerca volvulus 0.002 0.0033 0.0061
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0018 0.0017 0.0038
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0017 0.0049
Brugia malayi Pre-SET motif family protein 0.0205 0.1807 0.4221
Echinococcus multilocularis zinc finger protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0463 0.4271 1
Echinococcus multilocularis survival motor neuron protein 1 0.0189 0.1656 0.1656
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0033 0.0061
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0028 0.0033
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0299 0.0299
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0113 0.0113
Brugia malayi Alpha/beta hydrolase 0.0018 0.0017 0.0024
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0215 0.1902 0.2172
Mycobacterium ulcerans haloalkane dehalogenase 0.0018 0.0017 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0098 0.0305
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0098 0.0146
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0046 0.0279 0.0279
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0809 0.0809
Trypanosoma cruzi hydrolase-like protein, putative 0.0018 0.0017 0.0038
Mycobacterium tuberculosis Probable oxidoreductase 0.0018 0.0017 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0017 0.0038
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0239 0.0871
Mycobacterium tuberculosis Probable dehydrogenase 0.0215 0.1902 0.2172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0033 0.0033
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.2666 1
Echinococcus granulosus expressed protein 0.0025 0.0078 0.0078
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0929 0.8734 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0025 0.0078 0.0334
Plasmodium vivax alpha/beta hydrolase, putative 0.0018 0.0017 0.0082
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0018 0.0017 0.0038
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0017 0.0007 0.0003
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0299 0.0687
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0023 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0033 0.0064
Onchocerca volvulus 0.0145 0.1233 0.2876
Onchocerca volvulus Lipase homolog 0.0018 0.0017 0.0024
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0155 0.1203
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0239 0.2132 0.2435
Loa Loa (eye worm) hypothetical protein 0.0048 0.0299 0.0687
Schistosoma mansoni P2X receptor subunit 0.0218 0.1928 0.1928
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.0907 0.2109
Onchocerca volvulus 0.0027 0.0098 0.0213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0033 0.0061
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0033 0.0033
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0809 0.6509
Echinococcus multilocularis ferritin 0.0025 0.0078 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0293 0.0293
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.0907 0.0907
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0018 0.0017 0.0024
Echinococcus multilocularis SAM and MBT domain containing protein 0.0096 0.0762 0.0762
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0293 0.0293
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0109 0.0889 0.0889
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0238 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0033 0.0061
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.1233 0.1405
Mycobacterium leprae Probable lipase LipE 0.0145 0.1233 0.5771
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0155 0.0155
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.0923 0.0923
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0067 0.0485 0.0485
Plasmodium vivax glutathione reductase, putative 0.0094 0.0745 0.6017
Brugia malayi UPF0017 protein CG3488 0.0018 0.0017 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0155 0.0555
Brugia malayi PHD-finger family protein 0.0024 0.0073 0.0155
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0155 0.0169
Plasmodium falciparum glutathione reductase 0.0094 0.0745 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0027
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.2666 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0033 0.0061
Brugia malayi Melibiase family protein 0.0067 0.0487 0.1125
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0051 0.0051
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0098 0.0305
Echinococcus granulosus SAM and MBT domain containing protein 0.0096 0.0762 0.0762
Entamoeba histolytica hypothetical protein 0.015 0.1275 1
Toxoplasma gondii ABC1 family protein 0.0145 0.1233 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0065
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0809 0.0809
Loa Loa (eye worm) mbt repeat family protein 0.0096 0.0762 0.1772
Echinococcus multilocularis polycomb protein SCMH1 0.0096 0.0762 0.0762
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.2666 1
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0155 0.0712
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0124 0.0124
Mycobacterium ulcerans exported protease 0.0018 0.0017 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.1233 0.1233
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.1233 0.1233
Schistosoma mansoni hypothetical protein 0.0046 0.0282 0.0282
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0155 0.0519
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1267 0.2956
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0098 0.0146
Schistosoma mansoni hypothetical protein 0.0046 0.0282 0.0282
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0239 0.2132 1
Brugia malayi beta-lactamase family protein 0.0145 0.1233 0.2876
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2079 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0396 0.0396
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.1233 0.1233
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1329 0.1515
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0175 0.0175
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0018 0.0017 0.0047
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0018 0.0017 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0033 0.0061
Plasmodium falciparum thioredoxin reductase 0.0033 0.0155 0.2
Onchocerca volvulus Lipase homolog 0.0018 0.0017 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0758 0.0758
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0293 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0758 0.0758
Plasmodium falciparum epoxide hydrolase 1 0.0018 0.0017 0.0137
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0155 0.113
Brugia malayi RNA binding protein 0.0333 0.3026 0.7079
Trypanosoma cruzi hydrolase-like protein, putative 0.0018 0.0017 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0299 0.1407
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0098 0.0213
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Brugia malayi beta-lactamase family protein 0.0145 0.1233 0.2876
Brugia malayi steroid hormone receptor 0.002 0.0033 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.1233 0.4612
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0239 0.0871
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0559 0.0559
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0033 0.0033
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0017 0.0007 0.0007
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0072 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0033 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0033 0.0064
Plasmodium falciparum thioredoxin reductase 0.0094 0.0745 1
Echinococcus multilocularis tar DNA binding protein 0.0333 0.3026 0.3026
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0018 0.0017 0.0012
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0017 0.0049
Brugia malayi alpha/beta hydrolase 0.0018 0.0017 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1233 0.592
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0155 0.0155
Brugia malayi Metabotropic glutamate receptor precursor. 0.0055 0.0364 0.0837
Schistosoma mansoni thyroid hormone receptor 0.002 0.0033 0.0033
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.0907 0.7097
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0745 0.0846
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0023 0.0018
Echinococcus granulosus polycomb protein SCMH1 0.0096 0.0762 0.0762
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0017 0.0049
Echinococcus multilocularis abhydrolase domain containing 3 0.0018 0.0017 0.0017
Echinococcus granulosus survival motor neuron protein 1 0.0189 0.1656 0.1656
Loa Loa (eye worm) hypothetical protein 0.0068 0.0489 0.1134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0033 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0098 0.0213
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0155 1
Mycobacterium ulcerans exported protease 0.0018 0.0017 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0033 0.0033
Schistosoma mansoni P2X receptor subunit 0.0218 0.1928 0.1928
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0555
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0033 0.0033
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1178 0.4384
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0379 0.3467 0.3467
Mycobacterium ulcerans oxidoreductase 0.0018 0.0017 0.0016
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0017 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0451
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0033 0.1772
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0064
Mycobacterium tuberculosis Conserved protein 0.0145 0.1233 0.1405
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0559 0.4353
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0155 0.0555
Echinococcus multilocularis histone acetyltransferase MYST2 0.0109 0.0889 0.0889
Echinococcus multilocularis GPCR, family 2 0.0047 0.0293 0.0293
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0282 0.0282
Schistosoma mansoni lozenge 0.0058 0.0397 0.0397
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0018 0.0017 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0333 0.3026 0.3026
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0025 0.0078 0.4813
Onchocerca volvulus 0.0029 0.0124 0.0273
Loa Loa (eye worm) hypothetical protein 0.0111 0.0907 0.2112
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0033 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0555
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0096 0.0762 0.177
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0017 0.0038
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0033 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0155 0.0555
Schistosoma mansoni hypothetical protein 0.0584 0.5435 0.5435
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0098 0.0305
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0018 0.0017 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0145 0.1233 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0555
Echinococcus multilocularis expressed conserved protein 0.0104 0.0842 0.0842
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0109 0.0889 0.2068
Schistosoma mansoni P2X receptor subunit 0.0218 0.1928 0.1928
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0282 0.0282
Schistosoma mansoni metabotropic glutamate receptor 0.0046 0.0279 0.0279
Brugia malayi CHE-14 protein 0.0048 0.0299 0.0684
Echinococcus granulosus metabotropic glutamate receptor 5 0.0067 0.0485 0.0485
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.1275 0.1275
Mycobacterium leprae conserved hypothetical protein 0.0145 0.1233 0.5771
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0217
Echinococcus multilocularis p2X purinoceptor 4 0.0218 0.1928 0.1928
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0487 0.2315
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0033 0.0061
Brugia malayi hypothetical protein 0.0189 0.1656 0.3867
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0018 0.0017 0.0027
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0018 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0065
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0033 0.0354
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0017 0.0007 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0098 0.0428
Schistosoma mansoni coup transcription factor 0.002 0.0033 0.0033
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0299 0.0299
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1073 0.2503
Loa Loa (eye worm) hypothetical protein 0.0145 0.1233 0.2878
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0155 0.0555
Schistosoma mansoni apoferritin-2 0.0025 0.0078 0.0078
Mycobacterium ulcerans bromoperoxidase BpoC 0.0018 0.0017 0.0016
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0239 0.2132 0.2435
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0745 0.0745
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0745 0.2775
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0033 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0758 0.0758
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0293 0.067
Brugia malayi Pre-SET motif family protein 0.0029 0.0124 0.0273
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0098 0.0146
Mycobacterium tuberculosis Probable reductase 0.0215 0.1902 0.2172
Brugia malayi hydrolase, alpha/beta fold family protein 0.0018 0.0017 0.0024
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0017 0.0049
Loa Loa (eye worm) hypothetical protein 0.0069 0.0499 0.1155
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0109 0.0889 0.0889
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.1233 0.2876
Entamoeba histolytica hypothetical protein 0.0018 0.0017 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0098 0.0146
Echinococcus granulosus FTZ F1 alpha 0.002 0.0033 0.0033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0333 0.3026 0.708
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0745 0.0745
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0155 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1807 0.4223
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0098 0.0718
Mycobacterium leprae Probable exported protease 0.0018 0.0017 0.0047
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0257 0.0257
Mycobacterium ulcerans hydrolase 0.0018 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0046 0.0282 0.0282
Schistosoma mansoni choline dehydrogenase 0.0017 0.0007 0.0007
Loa Loa (eye worm) hydrolase 0.0018 0.0017 0.0027
Mycobacterium ulcerans epoxide hydrolase EphE 0.0018 0.0017 0.0016
Echinococcus granulosus zinc finger protein 0.0019 0.0023 0.0023
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0018 0.0017 0.0016
Mycobacterium tuberculosis Conserved protein 0.0145 0.1233 0.1405
Loa Loa (eye worm) hypothetical protein 0.0189 0.1656 0.3869
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0293 0.0293
Giardia lamblia ENC6 protein 0.0018 0.0017 0.0684
Treponema pallidum NADH oxidase 0.0033 0.0155 1
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0068 0.0489 0.0489
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0025 0.0078 0.0081
Schistosoma mansoni P2X receptor subunit 0.0218 0.1928 0.1928
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0809 0.0809
Loa Loa (eye worm) glutathione reductase 0.0094 0.0745 0.1733
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0916 0.8614 0.8614
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0017 0.0038
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0145 0.1233 0.2878
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1178 0.4405
Mycobacterium ulcerans hypothetical protein 0.0018 0.0017 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0155 0.0555
Schistosoma mansoni apoferritin-2 0.0025 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0058 0.0401 0.0928
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0098 0.0104
Plasmodium vivax SET domain protein, putative 0.0029 0.0124 0.0949
Echinococcus multilocularis Protein lozenge 0.0058 0.0397 0.0397
Onchocerca volvulus 0.0145 0.1233 0.2876
Schistosoma mansoni hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0155 0.0555
Schistosoma mansoni bromodomain containing protein 0.0061 0.0429 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1233 0.592
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0145 0.1233 0.2878
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0062 0.0435 0.0435
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0215 0.1902 0.8918
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0017 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0046 0.0282 0.0282
Brugia malayi hydrolase, alpha/beta fold family protein 0.0018 0.0017 0.0024
Mycobacterium ulcerans short chain dehydrogenase 0.0018 0.0017 0.0016
Mycobacterium ulcerans epoxide hydrolase EphB 0.0018 0.0017 0.0016
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0155 0.0555
Loa Loa (eye worm) hypothetical protein 0.0102 0.0816 0.19
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0017 0.0007 0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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