Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0173 | 0.6902 | 0.8897 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.104 | 0.203 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0098 | 0.3564 | 0.7528 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0319 | 0.059 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.2072 | 0.529 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0077 | 0.2639 | 0.3394 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.223 | 0.1908 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1518 | 0.3161 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0077 | 0.2639 | 0.3394 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.223 | 0.5787 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.2594 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.2072 | 0.1744 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 0.4629 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0026 | 0.0397 | 0.0181 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3564 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0098 | 0.3564 | 0.4794 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0122 | 0.4629 | 0.5967 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.223 | 0.2774 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0026 | 0.0397 | 0.1383 |
Plasmodium falciparum | glutathione reductase | 0.0026 | 0.0397 | 0.1383 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0173 | 0.6902 | 0.8897 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0173 | 0.6902 | 0.8897 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.4707 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0026 | 0.0397 | 0.1383 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.223 | 0.2774 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.2594 | 0.5192 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3564 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1518 | 0.3096 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0122 | 0.4629 | 0.6407 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1518 | 0.3096 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0193 | 0.7758 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0173 | 0.6902 | 0.8897 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.3564 | 1 |
Leishmania major | trypanothione reductase | 0.0076 | 0.2594 | 0.5279 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.0397 | 0.0769 |
Echinococcus multilocularis | geminin | 0.0176 | 0.7003 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.2594 | 0.6938 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 0.2594 | 0.5469 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0098 | 0.3564 | 0.3298 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0122 | 0.4629 | 0.6407 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0319 | 0.06 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3564 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.223 | 0.2774 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.0397 | 0.0769 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.2072 | 0.529 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.0397 | 0.0181 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.223 | 0.4687 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0319 | 0.06 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 0.4629 | 0.4407 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.0397 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3564 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 0.4629 | 0.4407 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0026 | 0.0397 | 0.1383 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.2072 | 0.2536 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.104 | 0.2221 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.2594 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0173 | 0.6902 | 0.8897 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.223 | 0.5787 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.2072 | 0.2536 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0795 | 0.153 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0397 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 0.4629 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0319 | 0.0411 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0319 | 0.0501 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.2072 | 0.4296 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.0397 | 0.0769 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0912 | 0.1828 |
Mycobacterium tuberculosis | Probable reductase | 0.0173 | 0.6902 | 0.8897 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7003 | 0.6879 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7003 | 0.6879 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0193 | 0.7758 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3564 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0319 | 0.06 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3564 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.2594 | 0.6938 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0122 | 0.4629 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.0397 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0912 | 0.1785 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0026 | 0.0397 | 0.1383 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 0.4629 | 1 |
Giardia lamblia | Kinase, PLK | 0.0098 | 0.3564 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 0.2594 | 0.5469 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.2594 | 1 |
Brugia malayi | glutathione reductase | 0.0076 | 0.2594 | 0.5426 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0319 | 0.06 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0048 | 0.1376 | 0.3092 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0319 | 0.0501 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.0397 | 0.067 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0319 | 0.06 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0173 | 0.6902 | 0.8849 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0319 | 0.06 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0064 | 0.2072 | 0.5403 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0122 | 0.4629 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.2072 | 0.4067 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0098 | 0.3564 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0795 | 0.1609 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0098 | 0.3564 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0795 | 0.0414 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0422 | 0.0078 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.223 | 0.4637 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1518 | 0.3161 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0319 | 0.0411 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0422 | 0.0078 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.3564 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.2594 | 0.5426 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0193 | 0.7758 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0912 | 0.1627 |
Onchocerca volvulus | 0.003 | 0.0549 | 0.0709 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0048 | 0.1376 | 0.3092 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0912 | 0.1862 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0912 | 0.1627 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0026 | 0.0397 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0549 | 0.1083 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.0876 | 0.0725 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.4707 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.223 | 0.2774 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.4707 | 1 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.223 | 0.1908 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0098 | 0.3564 | 0.7548 |
Trypanosoma brucei | polo-like protein kinase | 0.0098 | 0.3564 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0319 | 0.06 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0193 | 0.7758 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.2072 | 0.4349 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0319 | 0.059 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.2072 | 0.529 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0319 | 0.06 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.0397 | 0.0181 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.104 | 0.203 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.3564 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0026 | 0.0397 | 0.1383 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0319 | 0.0501 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0044 | 0.0057 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.2594 | 0.3344 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0098 | 0.3564 | 0.7525 |
Schistosoma mansoni | kinase | 0.005 | 0.1434 | 0.1079 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.0876 | 0.0725 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0098 | 0.3564 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.2594 | 1 |
Echinococcus granulosus | geminin | 0.0176 | 0.7003 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0026 | 0.0397 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0319 | 0.059 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -4 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.