Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.0968 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.9198 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.9198 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.9198 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.0968 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.9198 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.0968 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0968 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.0968 | 0.5 |
Brugia malayi | glutathione reductase | 0.0076 | 0.9198 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.9198 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.9198 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.9198 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.0968 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.9198 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.0968 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.9198 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0968 | 0.5 |
Leishmania major | trypanothione reductase | 0.0076 | 0.9198 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.0968 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.0968 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.0968 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.9198 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.9198 | 1 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | uM | Inhibitory activity against Selectin E using cell-cell assay; Not active | ChEMBL. | 11405647 |
IC50 (binding) | 0 uM | Inhibitory activity against P-selectin using ELISA-based assay; Not tested | ChEMBL. | 11405647 |
IC50 (functional) | 0 uM | Inhibitory activity against P-selectin using cell-cell assay; Not active | ChEMBL. | 11405647 |
IC50 (functional) | 0 uM | Inhibitory activity against Selectin E using cell-cell assay; Not active | ChEMBL. | 11405647 |
IC50 (binding) | = 21 uM | Inhibitory activity against P-selectin using cell-selectin protein assay | ChEMBL. | 11405647 |
IC50 (binding) | = 21 uM | Inhibitory activity against P-selectin using cell-selectin protein assay | ChEMBL. | 11405647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.