Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.3616 | 0.4349 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.1175 | 0.1413 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0018 | 0.1427 | 0.183 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.2026 | 0.2597 |
Brugia malayi | hypothetical protein | 0.0054 | 0.6609 | 0.6426 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.5555 | 0.6681 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.3106 | 0.3735 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.1517 | 0.1825 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.6609 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.7143 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.6609 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.6609 | 0.7145 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.7738 | 0.9308 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.5555 | 0.7123 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.4143 | 0.5313 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.5555 | 0.7123 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1175 | 0.1413 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.5555 | 0.6681 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.5555 | 0.7123 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0252 | 0.0323 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.3106 | 0.3207 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.3106 | 0.2735 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.5555 | 0.596 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.2398 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.9149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4835 | 0.5151 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.6609 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.6609 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.5555 | 0.7123 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.1517 | 0.1825 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.2398 | 0.2884 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.3616 | 0.4637 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.2453 | 0.3145 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.4484 | 0.4187 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.7799 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.6609 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.2453 | 0.295 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0018 | 0.1427 | 0.183 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.7799 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.1517 | 0.1946 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.1427 | 0.1717 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.2398 | 0.3075 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.8314 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.1517 | 0.1946 |
Onchocerca volvulus | 0.0029 | 0.3106 | 0.5 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.6609 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.3616 | 0.4637 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3903 | 0.3575 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.1942 | 0.2336 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.2453 | 0.3145 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.2026 | 0.2597 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.5555 | 0.5316 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.5345 | 0.5725 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.2026 | 0.2437 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.3616 | 0.4349 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.5555 | 0.6681 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1517 | 0.1422 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.1942 | 0.19 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.1515 | 0.142 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.4143 | 0.5313 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.1427 | 0.1717 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4494 | 0.4768 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.2793 | 0.2406 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.6609 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0252 | 0.0323 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at S1P1 receptor upto 25 uM | ChEMBL. | 21783362 | |
IC50 (functional) | = 59 nM | Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay | ChEMBL. | 21783362 |
IC50 (functional) | = 1100 nM | Antagonist activity at S1P2 receptor | ChEMBL. | 21783362 |
Inhibition (binding) | = 30 % | Inhibition of S1P5 receptor at 25 uM | ChEMBL. | 21783362 |
Inhibition (binding) | = 35 % | Inhibition of S1P3 receptor at 25 uM | ChEMBL. | 21783362 |
Inhibition (binding) | = 40 % | Inhibition of S1P2 receptor | ChEMBL. | 21783362 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.