Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | urotensin 2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.3096 | 0.2799 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.6174 | 0.6133 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.6174 | 0.6009 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.3096 | 0.3022 |
Echinococcus multilocularis | lamin | 0.0031 | 0.3096 | 0.3022 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.6174 | 0.4458 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.3096 | 0.3022 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.3096 | 0.3096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.6174 | 0.6133 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0.3096 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.3096 | 0.3022 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.6174 | 0.6133 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.299 | 0.299 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.6174 | 0.6133 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.6174 | 0.4458 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0106 | 0.0106 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.3096 | 0.3022 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.6174 | 0.6174 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0413 | 0.0413 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.3096 | 0.3022 |
Onchocerca volvulus | 0.0031 | 0.3096 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.6174 | 0.4458 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3096 | 0.3096 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.3096 | 0.2799 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 47 nM | Displacement of [I125]hU2 from human recombinant urotensin 2 receptor expressed in HEK293 cells | ChEMBL. | 18573659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.