TDR Targets

Basic information

Technical information

TDR Targets ID: 1043337
Name: 5,7-dihydroxy-8-methoxy-2-(2-methoxyphenyl)ch romen-4-one
MW: 314.289 | Formula: C17H14O6
H donors: 2 H acceptors: 3 LogP: 2.96 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1c1cc(=O)c2c(o1)c(OC)c(cc2O)O
InChi: 1S/C17H14O6/c1-21-13-6-4-3-5-9(13)14-8-11(19)15-10(18)7-12(20)16(22-2)17(15)23-14/h3-8,18,20H,1-2H3
InChiKey: YHZJRFKTTMDPDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5,7-dihydroxy-8-methoxy-2-(2-methoxyphenyl)-4-chromenone
5,7-dihydroxy-8-methoxy-2-(2-methoxyphenyl)chromone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine proteinase, putative	0.0452	0.2683	0.2046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	Papain family cysteine protease containing protein	0.0452	0.2683	0.2683
Onchocerca volvulus		0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0667	0.4927	0.4927
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0848	0.6806	0.6806
Echinococcus granulosus	cathepsin l1	0.0848	0.6806	0.6806
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0848	0.6806	0.6806
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1156	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0667	0.4927	0.4927
Plasmodium vivax	vivapain-2	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Brugia malayi	Papain family cysteine protease containing protein	0.0452	0.2683	0.2683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0452	0.2683	0.2683
Toxoplasma gondii	cathepsin CPL	0.0848	0.6806	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0452	0.2683	0.2683
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0848	0.6806	1
Echinococcus granulosus	cathepsin l1	0.0578	0.3995	0.3995
Echinococcus multilocularis	cathepsin b	0.1156	1	1
Giardia lamblia	Cathepsin B precursor	0.0482	0.3005	0.5
Echinococcus granulosus	cathepsin L	0.0452	0.2683	0.2683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0578	0.3995	0.3182
Echinococcus granulosus	cathepsin b	0.1156	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Echinococcus multilocularis	cysteine protease	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1156	1	1
Giardia lamblia	Cathepsin B precursor	0.0482	0.3005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0848	0.6806	0.6806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0482	0.3005	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0452	0.2683	0.2683
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0667	0.4927	0.4927
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Echinococcus granulosus	cathepsin b	0.1156	1	1
Loa Loa (eye worm)	hypothetical protein	0.0578	0.3995	0.3995
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	cathepsin L-like precursor	0.0578	0.3995	0.3995
Onchocerca volvulus	Cathepsin L homolog	0.0848	0.6806	1
Loa Loa (eye worm)	hypothetical protein	0.0578	0.3995	0.3995
Brugia malayi	Cathepsin L-like precursor	0.027	0.0801	0.0801
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0452	0.2683	0.2046
Trypanosoma cruzi	cruzipain precursor, putative	0.0848	0.6806	0.6528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Loa Loa (eye worm)	cysteine protease	0.0848	0.6806	0.6806
Entamoeba histolytica	cysteine protease, putative	0.0848	0.6806	1
Loa Loa (eye worm)	hypothetical protein	0.027	0.0801	0.0801
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0848	0.6806	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.027	0.0801	0.0801
Plasmodium vivax	unspecified product	0.0452	0.2683	0.3135
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0848	0.6806	0.6806
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0667	0.4927	0.4927
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Loa Loa (eye worm)	hypothetical protein	0.0578	0.3995	0.3995
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Loa Loa (eye worm)	hypothetical protein	0.0579	0.4011	0.4011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Giardia lamblia	Cathepsin B precursor	0.0482	0.3005	0.5
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Onchocerca volvulus		0.0848	0.6806	1
Echinococcus multilocularis	cathepsin b	0.1156	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0848	0.6806	1
Leishmania major	cysteine peptidase A (CPA)	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Plasmodium vivax	vivapain-1	0.0452	0.2683	0.3135
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Echinococcus granulosus	cysteine protease	0.0452	0.2683	0.2683
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0578	0.3995	0.3472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0578	0.3995	0.3995
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Entamoeba histolytica	cysteine proteinase, putative	0.0848	0.6806	1
Loa Loa (eye worm)	ctsf protein	0.0848	0.6806	0.6806
Echinococcus multilocularis	cathepsin L cysteine protease	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0482	0.3005	0.0779
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1156	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Onchocerca volvulus		0.0848	0.6806	1
Onchocerca volvulus		0.0848	0.6806	1
Schistosoma mansoni	voltage-gated potassium channel	0.0729	0.5565	0.5565
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1156	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0452	0.2683	0.2683
Brugia malayi	Papain family cysteine protease containing protein	0.0848	0.6806	0.6806
Loa Loa (eye worm)	hypothetical protein	0.027	0.0801	0.0801
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0624	0.4471	0.4336
Onchocerca volvulus		0.0848	0.6806	1
Plasmodium vivax	vivapain-3	0.0452	0.2683	0.3135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0624	0.4471	0.4336
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0482	0.3005	0.2396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0578	0.3995	0.3182
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0848	0.6806	0.6806
Onchocerca volvulus	Cathepsin L homolog	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Loa Loa (eye worm)	cathepsin B	0.0482	0.3005	0.3005
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Onchocerca volvulus	Cathepsin F homolog	0.0848	0.6806	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0578	0.3995	0.3995
Onchocerca volvulus		0.0848	0.6806	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0848	0.6806	0.6806
Schistosoma mansoni	voltage-gated potassium channel	0.0729	0.5565	0.5565
Brugia malayi	Cathepsin L-like precursor	0.0578	0.3995	0.3995
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.027	0.0801	0.0801
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0848	0.6806	0.6806
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Loa Loa (eye worm)	fibroinase	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0452	0.2683	0.2046
Entamoeba histolytica	cysteine proteinase, putative	0.0578	0.3995	0.3182
Echinococcus multilocularis	cathepsin L cysteine protease	0.0848	0.6806	0.6806
Trypanosoma cruzi	cysteine peptidase, putative	0.0452	0.2683	0.2046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Loa Loa (eye worm)	hypothetical protein	0.027	0.0801	0.0801
Loa Loa (eye worm)	hypothetical protein	0.1156	1	1
Schistosoma mansoni	cathepsin s	0.027	0.0801	0.0801
Brugia malayi	cathepsin F-like cysteine proteinase	0.027	0.0801	0.0801
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1156	1	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Echinococcus multilocularis	cysteine protease	0.0848	0.6806	0.6806
Schistosoma mansoni	cathepsin F (C01 family)	0.0848	0.6806	0.6806
Brugia malayi	Cathepsin L-like precursor	0.0578	0.3995	0.3995
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Entamoeba histolytica	cysteine proteinase, putative	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma cruzi	cysteine protease, putative	0.0452	0.2683	0.2046
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0482	0.3005	0.3005
Plasmodium vivax	vivapain-2	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Echinococcus multilocularis	cathepsin L	0.0452	0.2683	0.2683
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0848	0.6806	0.6806
Onchocerca volvulus		0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL549356

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1043337