Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2741 | 1 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0197 | 0.0197 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0623 | 0.226 |
Giardia lamblia | Kinase, PLK | 0.0093 | 0.2741 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0.0197 | 0.0536 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0383 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0053 | 0.0138 |
Brugia malayi | hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Echinococcus multilocularis | nibrin | 0.001 | 0.0197 | 0.0704 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0.0197 | 0.5 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.001 | 0.0197 | 0.5009 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.2741 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0199 | 0.0551 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0623 | 0.226 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2741 | 1 |
Echinococcus granulosus | replication factor c subunit 1 | 0.001 | 0.0197 | 0.0704 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.2741 | 0.7753 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.001 | 0.0197 | 0.363 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0287 | 0.1031 |
Brugia malayi | topoisomerase | 0.001 | 0.0197 | 0.0704 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0.0197 | 0.5 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0.0197 | 0.5 |
Plasmodium vivax | ATP-dependent DNA helicase Q1, putative | 0.0005 | 0.0047 | 0.1111 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0.0197 | 0.5085 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3534 | 1 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0.0197 | 0.0193 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2741 | 1 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0197 | 0.0197 |
Entamoeba histolytica | recQ family helicase, putative | 0.0005 | 0.0047 | 0.0156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0.0197 | 0.0536 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.1307 | 0.476 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0.0197 | 0.0704 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0.0197 | 0.0536 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0199 | 0.5136 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0389 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2741 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0197 | 0.0546 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0093 | 0.2741 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0623 | 0.1752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.001 | 0.0197 | 0.0704 |
Brugia malayi | hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0287 | 0.0869 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.2741 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.0199 | 0.3667 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.001 | 0.0197 | 0.0704 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0199 | 0.0199 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0623 | 0.226 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0199 | 0.0711 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0199 | 0.5136 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0197 | 0.0704 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0623 | 0.226 |
Brugia malayi | DKFZp564C0469 protein | 0.001 | 0.0197 | 0.0704 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0197 | 0.0704 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0.0197 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0199 | 0.0711 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.001 | 0.0197 | 0.0197 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0199 | 0.0711 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0005 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0197 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0197 | 0.0546 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0197 | 0.0704 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.2741 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0197 | 0.0704 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0471 | 0.0471 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.001 | 0.0197 | 0.0704 |
Entamoeba histolytica | recQ family DNA helicase | 0.0005 | 0.0053 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0197 | 0.0546 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2741 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2741 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2741 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.2741 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.2741 | 0.2741 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0199 | 0.0711 |
Echinococcus granulosus | nibrin | 0.001 | 0.0197 | 0.0704 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.0199 | 0.0711 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0287 | 0.0282 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.2741 | 1 |
Schistosoma mansoni | ribosomal RNA methyltransferase | 0.0003 | 0.0004 | 0.0004 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0005 | 0.0053 | 0.1281 |
Schistosoma mansoni | DNA ligase IV | 0.001 | 0.0197 | 0.0197 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.001 | 0.0197 | 0.0704 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0.0197 | 0.5 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0.0197 | 0.0704 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0199 | 0.0711 |
Schistosoma mansoni | cell division protein ftsj | 0.0003 | 0.0004 | 0.0004 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0.0197 | 0.0536 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0.0053 | 0.2519 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.1307 | 0.476 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0623 | 0.226 |
Trypanosoma brucei | RNA helicase, putative | 0.033 | 1 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0197 | 0.0704 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0.0197 | 0.5085 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0287 | 0.1031 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0199 | 0.0711 |
Onchocerca volvulus | 0.001 | 0.0197 | 0.0704 | |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.2741 | 1 |
Schistosoma mansoni | kinase | 0.0047 | 0.1344 | 0.1344 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.2741 | 0.2738 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0199 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0197 | 0.0546 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.2741 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0197 | 0.0546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.