Detailed information for compound 104354

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 378.815 | Formula: C19H15ClN6O
  • H donors: 2 H acceptors: 4 LogP: 4.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nc(Nc2ccc(c(c2)Cl)c2ocnc2)nc(n1)c1ccccc1
  • InChi: 1S/C19H15ClN6O/c1-21-18-24-17(12-5-3-2-4-6-12)25-19(26-18)23-13-7-8-14(15(20)9-13)16-10-22-11-27-16/h2-11H,1H3,(H2,21,23,24,25,26)
  • InChiKey: BYCNLSOWDZXDTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi steroid hormone receptor 0.0018 0.0008 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0008 0.001
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0159 0.2454 0.3053
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0169 0.021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0008 0.001
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0145 0.018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0008 0.0008
Schistosoma mansoni 26S proteasome subunit S9 0.0033 0.0264 0.0328
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0009 0.0011
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0035 0.0307 0.0382
Trypanosoma cruzi GMP reductase 0.0095 0.1338 0.1664
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0145 0.018
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0033 0.0264 0.0328
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0143 0.217 0.2699
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0193 0.3035 0.3776
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0169 0.021
Echinococcus granulosus cathepsin b 0.0141 0.2143 0.2667
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0019 0.0018 0.0023
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0143 0.217 0.2699
Echinococcus granulosus proteasome subunit alpha type 2 0.0152 0.2339 0.291
Giardia lamblia Cathepsin B precursor 0.0047 0.0501 0.0624
Leishmania major proteasome beta 2 subunit, putative 0.0143 0.217 0.2699
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0143 0.217 0.2699
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.0079 0.1067 0.1327
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0145
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0307 0.0382
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0145 0.018
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0028 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.2143 0.2667
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0143 0.217 0.2699
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0035 0.0307 0.0382
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0008 0.0011
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0193 0.3035 0.3776
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0027 0.0034
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.005 0.0556 0.0682
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0119 0.1752 0.218
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0008 0.0011
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0028 0.0035
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0141 0.2143 0.2667
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0008 0.001
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0089 0.124 0.1543
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0149 0.2286 0.2286
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0008 0.001
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0148 0.226 0.2812
Leishmania major hypothetical protein, conserved 0.0045 0.0466 0.0579
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0035 0.0307 0.0382
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0169 0.021
Toxoplasma gondii SAC3/GANP family protein 0.0026 0.0145 0.018
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0008 0.001
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0009 0.0011
Loa Loa (eye worm) IMP dehydrogenase 1 0.0095 0.1338 0.1338
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0143 0.217 0.2699
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0169 0.021
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0145 0.018
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0026 0.0145 0.018
Trypanosoma cruzi GMP reductase 0.0095 0.1338 0.1664
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0027 0.0166 0.0207
Loa Loa (eye worm) hypothetical protein 0.0594 1 1
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0008 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0008 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0008 0.0008
Brugia malayi proteasome subunit alpha type 4 0.0133 0.2005 0.2005
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0147 0.2253 0.2803
Entamoeba histolytica hypothetical protein 0.0037 0.0335 0.0416
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0085 0.1176 0.1464
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0169 0.021
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0168 0.2602 0.3238
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0141 0.2143 0.2667
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0209 0.0261
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0009 0.0011
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0035 0.0298 0.0371
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0039 0.0372 0.0463
Echinococcus granulosus proteasome subunit beta type 6 0.0148 0.2267 0.2821
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0147 0.2253 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0008 0.0008
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0143 0.217 0.2699
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0264 0.0328
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0011
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0141 0.2143 0.2667
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0209 0.0261
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0119 0.1752 0.218
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0147 0.2253 0.2803
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.0211 0.0211
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0149 0.2286 0.2844
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.003 0.0209 0.0261
Giardia lamblia Proteasome subunit beta type 1 0.0168 0.2602 0.3238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0008 0.0008
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0035 0.0298 0.0371
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0033 0.0264 0.0328
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0148 0.2267 0.2821
Giardia lamblia 20S proteasome alpha subunit 3 0.0148 0.226 0.2812
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0079 0.1067 0.1327
Loa Loa (eye worm) hypothetical protein 0.0194 0.3066 0.3066
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0008 0.001
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0148 0.2267 0.2821
Brugia malayi GMP reductase 0.0039 0.0376 0.0376
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.003 0.0209 0.0261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0008 0.0008
Onchocerca volvulus 0.0018 0.0008 0.0036
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0143 0.217 0.2699
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.003 0.0209 0.0261
Brugia malayi cytochrome P450 0.0018 0.0008 0.0008
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0141 0.2143 0.2667
Toxoplasma gondii proteasome beta subunit 0.0143 0.217 0.2699
Echinococcus granulosus subfamily T1A non peptidase ue 0.0158 0.2439 0.3035
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0138 0.2083 0.2592
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0009 0.0011
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0143 0.217 0.2699
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0196 0.0196
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0143 0.2184 0.2717
Brugia malayi proteasome subunit beta type 2 0.0143 0.217 0.217
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0169 0.0169
Loa Loa (eye worm) proteasome subunit beta type 3 0.0143 0.217 0.217
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0152 0.2339 0.291
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0008 0.001
Brugia malayi proteasome subunit beta type 1 0.0168 0.2602 0.2602
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0138 0.2083 0.2083
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0168 0.2602 0.3238
Brugia malayi Proteasome subunit alpha type 7-1 0.0193 0.3035 0.3035
Brugia malayi Cytochrome P450 family protein 0.0018 0.0008 0.0008
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0147 0.2253 0.2803
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0158 0.2439 0.3035
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0008 0.0008
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0119 0.1752 0.218
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0027 0.0153 0.019
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0009 0.0011
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0027 0.0166 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0008 0.0008
Loa Loa (eye worm) cathepsin B 0.0047 0.0501 0.0501
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0039 0.0372 0.0463
Trichomonas vaginalis 26S proteasome subunit, putative 0.0027 0.0166 0.0207
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0148 0.2267 0.2821
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0035 0.0298 0.0371
Plasmodium vivax proteasome subunit beta type-1, putative 0.0168 0.2602 0.3238
Toxoplasma gondii cathepsin B 0.0047 0.0501 0.0624
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0168 0.2602 0.3238
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.003 0.0211 0.0263
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0148 0.2267 0.2821
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0009 0.0011
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.1338 0.1664
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0039 0.0372 0.0463
Toxoplasma gondii proteasome subunit beta type, putative 0.0481 0.8038 1
Giardia lamblia 20S proteasome alpha subunit 4 0.0193 0.3035 0.3776
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0119 0.1752 0.218
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0372 0.0463
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0138 0.2083 0.2592
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0158 0.2439 0.3035
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0193 0.3035 0.3776
Echinococcus granulosus Proteasome subunit alpha beta 0.0149 0.2286 0.2844
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0143 0.217 0.2699
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0028 0.0035
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0027 0.0166 0.0207
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0148 0.226 0.2812
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0481 0.8038 1
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0009 0.0011
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0143 0.217 0.2699
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0009 0.0011
Echinococcus multilocularis 0.0018 0.0008 0.0011
Giardia lamblia Hypothetical protein 0.0033 0.0264 0.0328
Toxoplasma gondii PCI domain-containing protein 0.0027 0.0166 0.0207
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0148 0.2267 0.2821
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0372 0.0463
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0008 0.0008
Brugia malayi Proteasome A-type and B-type family protein 0.0481 0.8038 0.8038
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0119 0.1752 0.218
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0169 0.021
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0027 0.0033
Schistosoma mansoni cytochrome P450 0.0018 0.0008 0.0011
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0159 0.2454 0.3053
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0009 0.0011
Onchocerca volvulus 0.0018 0.0009 0.0039
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0035 0.0307 0.0382
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.003 0.0209 0.0261
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0298 0.0371
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0008 0.001
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0009 0.0011
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0085 0.1176 0.1176
Loa Loa (eye worm) proteasome subunit beta type 2 0.0143 0.217 0.217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0008 0.0008
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.0376 0.0376
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0008 0.0008
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0047 0.0058
Leishmania major proteasome beta 5 subunit, putative 0.0481 0.8038 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0035 0.0307 0.0382
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.3035 0.3776
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0148 0.226 0.2812
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0008 0.001
Echinococcus granulosus adhesion regulating molecule 1 0.0085 0.1176 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0008 0.0008
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0481 0.8038 1
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0009 0.0011
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0466 0.7791 0.9693
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0158 0.2439 0.3035
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0035 0.0298 0.0371
Onchocerca volvulus Putative GMP reductase 0.0039 0.0376 0.1646
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0028 0.0035
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0145 0.018
Leishmania major proteasome alpha 7 subunit, putative 0.0193 0.3035 0.3776
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0145 0.0145
Toxoplasma gondii hypothetical protein 0.0024 0.011 0.0137
Leishmania major cytochrome p450-like protein 0.0018 0.0008 0.0011
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0008 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0335 0.0416
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0009 0.0011
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0009 0.0011
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0481 0.8038 1
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0028 0.0028
Toxoplasma gondii proteasome 26S regulatory subunit 0.0019 0.0018 0.0023
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0149 0.2286 0.2844
Leishmania major proteasome beta 3 subunit, putative 0.0143 0.217 0.2699
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0209 0.0261
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0009 0.0011
Brugia malayi Proteasome A-type and B-type family protein 0.0466 0.7791 0.7791
Brugia malayi nuclear receptor NHR-88 0.0018 0.0008 0.0008
Loa Loa (eye worm) RPN-3 protein 0.0035 0.0307 0.0307
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0033 0.0264 0.0328
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0159 0.2454 0.3053
Brugia malayi hypothetical protein 0.0037 0.0335 0.0335
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0028 0.0035
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0168 0.2602 0.3238
Schistosoma mansoni hypothetical protein 0.0194 0.3066 0.3814
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0008 0.0011
Toxoplasma gondii IMP dehydrogenas 0.0095 0.1338 0.1664
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0147 0.2253 0.2803
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0158 0.2439 0.3035
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.003 0.0209 0.0261
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0209 0.0261
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0027 0.0033
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0158 0.2439 0.3035
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0119 0.1752 0.218
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0168 0.2602 0.3238
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.3035 0.3776
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0035 0.0307 0.0382
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0028 0.0035
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0008 0.0036
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0147 0.2253 0.2803
Plasmodium falciparum proteasome subunit beta type-4 0.0141 0.2143 0.2667
Onchocerca volvulus Notchless protein homolog 0.0149 0.2286 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0008 0.0011
Trypanosoma cruzi 20S proteasome subunit 0.0143 0.217 0.2699
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.1338 0.1664
Echinococcus multilocularis cathepsin b 0.0141 0.2143 0.2667
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0143 0.217 0.2699
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0008 0.0008
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0481 0.8038 1
Schistosoma mansoni coup transcription factor 0.0018 0.0008 0.001
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0169 0.0169
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0039 0.0372 0.0463
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0028 0.0035
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0138 0.2083 0.2592
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.003 0.0211 0.0263
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.2143 0.2667
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0158 0.2439 0.3035
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0085 0.1176 0.1464
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0027 0.0027
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0141 0.2143 0.2667
Loa Loa (eye worm) cytochrome P450 0.0018 0.0008 0.0008
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0372 0.0463
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0028 0.0035
Entamoeba histolytica hypothetical protein 0.0037 0.0335 0.0416
Leishmania major proteasome beta 2 subunit, putative 0.0138 0.2083 0.2592
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.011
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0159 0.2454 0.3053
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0143 0.217 0.2699
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0168 0.2602 0.3238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0008 0.0008
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0481 0.8038 0.8038
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0158 0.2439 0.3035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0008 0.0008
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0193 0.3035 0.3776
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0159 0.2454 0.3053
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.003 0.0211 0.0263
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0009 0.0009
Giardia lamblia Proteasome subunit beta type 3 0.0143 0.217 0.2699
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0008 0.0008
Echinococcus granulosus proteasome subunit beta type 7 0.0466 0.7791 0.9693
Trypanosoma brucei GMP reductase 0.0095 0.1338 0.1664
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0008 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0008 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0008 0.001
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0008 0.001
Leishmania major proteasome alpha 7 subunit, putative 0.0149 0.2286 0.2844
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0019 0.0018 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0008 0.001
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0149 0.2286 0.2844
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0008 0.001
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0152 0.2339 0.291
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0039 0.0372 0.0372
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0028 0.0035
Loa Loa (eye worm) GMP reductase 0.0039 0.0376 0.0376
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0307 0.0382
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0169 0.021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0008 0.0008
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0209 0.0209
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0033 0.0264 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0008 0.0008
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0141 0.2143 0.2143
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0008 0.001
Plasmodium vivax proteasome subunit beta type-4, putative 0.0141 0.2143 0.2667
Plasmodium vivax proteasome subunit beta type-5, putative 0.0481 0.8038 1
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0152 0.2339 0.291
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0008 0.0008
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0145 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.103 0.103
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0169 0.021
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0141 0.2143 0.2667
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0481 0.8038 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.2143 0.2667
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0028 0.0035
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0028 0.0028
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0026 0.0145 0.018
Echinococcus multilocularis proteasome subunit beta type 7 0.0466 0.7791 0.9693
Giardia lamblia 20S proteasome alpha subunit 1 0.0159 0.2454 0.3053
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0372 0.0463
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0193 0.3035 0.3776
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0095 0.1338 0.1338
Mycobacterium ulcerans proteasome PrcA 0.0119 0.1752 0.2172
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0148 0.226 0.2812
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0138 0.2083 0.2592
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0335 0.0416
Echinococcus granulosus proteasome subunit alpha type 6 0.0159 0.2454 0.3053
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0141 0.2143 0.2667
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0027 0.0033
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0145 0.018
Loa Loa (eye worm) hypothetical protein 0.0141 0.2143 0.2143
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0148 0.226 0.2812
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0481 0.8038 1
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0147 0.2253 0.2803
Brugia malayi Proteasome A-type and B-type family protein 0.0141 0.2143 0.2143
Trypanosoma brucei proteasome beta 6 subunit 0.0168 0.2602 0.3238
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0149 0.2286 0.2844
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0264 0.0328
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0481 0.8038 1
Plasmodium vivax proteasome subunit beta type-6, putative 0.0148 0.2267 0.2821
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus granulosus Proteasome subunit alpha type 7 0.0193 0.3035 0.3776
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0008 0.001
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.003 0.0211 0.0263
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0008 0.0008
Echinococcus multilocularis proteasome subunit alpha type 6 0.0159 0.2454 0.3053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0008 0.0008
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.003 0.0211 0.0263
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0009 0.0011
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0033 0.0264 0.0264
Leishmania major proteasome alpha 1 subunit, putative 0.0147 0.2253 0.2803
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0029 0.0196 0.0244
Toxoplasma gondii proteasome subunit 0.0148 0.2267 0.2821
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0143 0.217 0.2699
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0008 0.001
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0045 0.0474 0.058
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0141 0.2143 0.2667
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0169 0.021
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0008 0.001
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0028 0.0035
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0143 0.217 0.2699
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0095 0.1338 0.1664
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0027 0.0033
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0095 0.1338 0.1664
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0168 0.2602 0.3238
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0119 0.1752 0.218
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0152 0.2339 0.291
Giardia lamblia 20S proteasome alpha subunit 6 0.0147 0.2253 0.2803
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.0166 0.0207
Toxoplasma gondii 26s proteasome subunit p55, putative 0.003 0.0211 0.0263
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0045 0.0466 0.0579
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0138 0.2083 0.2592
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0481 0.8038 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0095 0.1338 0.1655
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0009 0.0011
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0143 0.217 0.2699
Brugia malayi proteasome subunit alpha type 1 0.0147 0.2253 0.2253
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0148 0.226 0.2812
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0147 0.2253 0.2253
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0149 0.2286 0.2844
Trichomonas vaginalis proteasome regulatory subunits, putative 0.003 0.0211 0.0263
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.0166 0.0207
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0009 0.0011
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0158 0.2439 0.3035
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.003 0.0209 0.0261
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0145
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0047 0.0501 0.0624
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0008 0.001
Toxoplasma gondii heat shock protein hslv, putative 0.0119 0.1752 0.218
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0193 0.3035 0.3035
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0054 0.0635 0.2777
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0145 0.0145
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0158 0.2439 0.3035
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0372 0.0463
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0159 0.2454 0.3053
Echinococcus multilocularis proteasome subunit alpha type 2 0.0152 0.2339 0.291
Brugia malayi Cytochrome P450 family protein 0.0077 0.103 0.103
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0009 0.0011
Leishmania major proteasome beta-1 subunit, putative 0.0148 0.2267 0.2821
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0168 0.2602 0.3238
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0169 0.021
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0008 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0008 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0008 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0008 0.0036
Loa Loa (eye worm) proteasome regulatory particle 0.0033 0.0264 0.0264
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0169 0.021
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0008 0.0011
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0169 0.0169
Leishmania major proteasome alpha 1 subunit, putative 0.0159 0.2454 0.3053
Leishmania major proteasome beta 7 subunit, putative 0.0141 0.2143 0.2667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0008 0.0008
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0143 0.217 0.2699
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0169 0.021
Brugia malayi proteasome subunit alpha type 6 0.0159 0.2454 0.2454
Echinococcus granulosus proteasome prosome macropain 0.0481 0.8038 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0095 0.1338 0.1664
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0119 0.1752 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0008 0.0008
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0148 0.226 0.2812
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0152 0.2339 0.291
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0145 0.018
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0169 0.0169
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0193 0.3035 0.3776
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0095 0.1338 0.1655
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0009 0.0011
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0027 0.0033
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0095 0.1338 0.1655
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0147 0.2253 0.2803
Echinococcus multilocularis proteasome subunit beta type 6 0.0148 0.2267 0.2821
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0169 0.021
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0148 0.2267 0.2821
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.005 0.0556 0.0682
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0039 0.0372 0.0463
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0009 0.0009
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.003 0.0209 0.0261
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0148 0.2267 0.2821
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0047 0.0058
Leishmania major proteasome alpha 3 subunit, putative 0.0148 0.226 0.2812
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0169 0.0169
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0133 0.2008 0.2498
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0047 0.0501 0.0624
Loa Loa (eye worm) PAS-3 protein 0.0133 0.2005 0.2005
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0152 0.2339 0.291
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0008 0.0008
Giardia lamblia Cathepsin B precursor 0.0047 0.0501 0.0624
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0095 0.1338 0.1664
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0009 0.0011
Giardia lamblia Proteasome subunit beta type 2 0.0143 0.217 0.2699
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0141 0.2143 0.2667
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0009 0.0011
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0158 0.2439 0.3035
Giardia lamblia 20S proteasome alpha subunit 2 0.0152 0.2339 0.291
Leishmania major proteasome alpha 2 subunit, putative 0.0152 0.2339 0.291
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0158 0.2439 0.3035
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0029 0.0196 0.0196
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0148 0.2267 0.2267
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0039 0.0372 0.0463
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0008 0.001
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0089 0.124 0.1534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0027 0.0033
Leishmania major guanosine monophosphate reductase 0.0095 0.1338 0.1664
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0008 0.001
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0141 0.2143 0.2667
Schistosoma mansoni hypothetical protein 0.0027 0.0166 0.0207
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0009 0.0011
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0119 0.1752 0.2172
Giardia lamblia 20S proteasome alpha subunit 5 0.0158 0.2439 0.3035
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0149 0.2286 0.2844
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0039 0.0372 0.0463
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0008 0.0011
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0159 0.2454 0.3053
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0169 0.021
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0158 0.2439 0.2439
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0027 0.0166 0.0207
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0481 0.8038 1
Brugia malayi 20S proteasome alpha5 subunit 0.0158 0.2439 0.2439
Brugia malayi nuclear hormone receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0152 0.2339 0.2339
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0149 0.2286 0.2844
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0148 0.226 0.2812
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0264 0.0328
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.1338 0.1664
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0008 0.001
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0141 0.2143 0.2667
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0119 0.1752 0.218
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0141 0.2143 0.2667
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0264 0.0328
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0168 0.2602 0.3238
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.0376 0.0376
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0158 0.2439 0.3035
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0193 0.3035 0.3776
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0138 0.2083 0.2592
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0027 0.0033
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0169 0.021
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0147 0.2253 0.2803
Entamoeba histolytica hypothetical protein 0.0035 0.0298 0.0371
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0008 0.0011
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0169 0.021
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0028 0.0035
Brugia malayi Proteasome subunit alpha type 1 0.0133 0.1997 0.1997
Giardia lamblia Cathepsin B precursor 0.0047 0.0501 0.0624
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.0037 0.0335 0.0416
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.0501 0.0624
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0169 0.021
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0045 0.0474 0.058
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0138 0.2083 0.2592
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0145 0.018
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.3035 0.3776
Brugia malayi cathepsin B-like cysteine proteinase 0.0141 0.2143 0.2143
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0166 0.0207
Brugia malayi PCI domain containing protein 0.003 0.0211 0.0211
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0009 0.0011
Leishmania major cytochrome p450-like protein 0.0018 0.0008 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0008 0.001
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0008 0.0011
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0152 0.2339 0.291
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0143 0.217 0.2699
Echinococcus granulosus cathepsin b 0.0141 0.2143 0.2667
Echinococcus multilocularis adhesion regulating molecule 1 0.0085 0.1176 0.1464
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0027 0.0033
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0009 0.0011
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0143 0.217 0.2699
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0079 0.1067 0.1327
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0166 0.0207
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0028 0.0035
Trypanosoma brucei proteasome alpha 7 subunit 0.0149 0.2286 0.2844
Entamoeba histolytica hypothetical protein 0.0037 0.0335 0.0416
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0119 0.1752 0.2172
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0095 0.1338 0.1664
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0027 0.0166 0.0207
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.3035 0.3776
Toxoplasma gondii proteasome subunit alpha1, putative 0.0159 0.2454 0.3053
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0168 0.2602 0.3238
Entamoeba histolytica hypothetical protein 0.0037 0.0335 0.0416
Loa Loa (eye worm) proteasome subunit beta type 1 0.0168 0.2602 0.2602
Toxoplasma gondii PCI domain-containing protein 0.0033 0.0264 0.0328
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0159 0.2454 0.2454
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0138 0.2083 0.2592
Brugia malayi ecdysteroid receptor 0.0018 0.0008 0.0008
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0148 0.226 0.2812
Brugia malayi PCI domain containing protein 0.0027 0.0166 0.0166
Toxoplasma gondii PCI domain-containing protein 0.0035 0.0307 0.0382
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0138 0.2083 0.2592
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0194 0.3066 0.3066
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0035 0.0307 0.0307
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0009 0.0011
Brugia malayi proteasome subunit beta type 3 0.0143 0.217 0.217
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0307 0.0382
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0141 0.2143 0.2667
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0159 0.2454 0.3053
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0141 0.2143 0.2667
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0298 0.0371
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0143 0.217 0.2699
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.3035 0.3776
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0009 0.0009
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0147 0.2253 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0008 0.0008
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0143 0.217 0.2699
Mycobacterium ulcerans proteasome PrcB 0.0481 0.8038 1
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0028 0.0035
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0028 0.0035
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0141 0.2143 0.2667
Echinococcus multilocularis proteasome (prosome, macropain) 0.0481 0.8038 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.003 0.0211 0.0263
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0089 0.124 0.1543
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0009 0.0011
Plasmodium vivax proteasome subunit beta type-7, putative 0.0138 0.2083 0.2592
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0008 0.001
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0158 0.2439 0.3035
Loa Loa (eye worm) hypothetical protein 0.0085 0.1176 0.1176
Toxoplasma gondii proteasome subunit alpha type, putative 0.0148 0.226 0.2812
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0211 0.0263
Brugia malayi Proteasome A-type and B-type family protein 0.0148 0.2267 0.2267
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0035 0.0298 0.0371
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0148 0.226 0.2812
Echinococcus multilocularis cathepsin b 0.0141 0.2143 0.2667
Brugia malayi Cytochrome P450 family protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) proteasome Regulatory Particle 0.003 0.0209 0.0209
Trypanosoma brucei proteasome beta 7 subunit 0.0141 0.2143 0.2667
Toxoplasma gondii proteasome subunit alpha type, putative 0.0074 0.0975 0.1213
Plasmodium vivax proteasome subunit beta type-2, putative 0.0143 0.217 0.2699
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0008 0.0008
Echinococcus granulosus proteasome subunit beta t family 0.0143 0.217 0.2699
Plasmodium vivax proteasome subunit beta type-3, putative 0.0143 0.217 0.2699
Onchocerca volvulus 0.0018 0.0009 0.0039
Giardia lamblia 20S proteasome alpha subunit 7 0.0149 0.2286 0.2844
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.003 0.0211 0.0263
Brugia malayi Cytochrome P450 family protein 0.0018 0.0008 0.0008
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0149 0.2286 0.2844
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0149 0.2286 0.2844
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0169 0.021
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0148 0.226 0.2812
Toxoplasma gondii peptidase, T1 family protein 0.0149 0.2286 0.2844
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0145 0.018
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0047 0.0501 0.0624
Brugia malayi proteasome subunit alpha type 3 0.0149 0.2286 0.2286
Brugia malayi proteasome subunit alpha type 2 0.0152 0.2339 0.2339
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.003 0.0209 0.0261
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0196 0.0196
Trypanosoma brucei cysteine peptidase C (CPC) 0.0047 0.0501 0.0624
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0039 0.0372 0.0372
Plasmodium falciparum proteasome subunit beta type-5 0.0481 0.8038 1
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0148 0.2267 0.2821
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0009 0.0011
Leishmania major cytochrome p450-like protein 0.0018 0.0008 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0008 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.2143 0.2667
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0264 0.0328
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0169 0.021
Loa Loa (eye worm) PCI domain-containing protein 0.0027 0.0166 0.0166
Schistosoma mansoni proteasome regulatory subunit-related 0.003 0.0211 0.0263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0335 0.0416

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 0.34 uM Inhibition of inosine-5'-monophosphate dehydrogenase 2. ChEMBL. 12781195
IC50 (binding) > 0.34 uM Inhibition of inosine-5'-monophosphate dehydrogenase 2. ChEMBL. 12781195

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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