Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0103 | 0.4678 | 0.538 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2036 | 0.3366 |
Brugia malayi | beta-lactamase family protein | 0.0031 | 0.0812 | 0.1706 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0031 | 0.0812 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0001 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1036 | 0.1191 |
Echinococcus multilocularis | serotonin receptor | 0.0128 | 0.6048 | 0.6955 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0147 | 0.7069 | 0.8129 |
Echinococcus multilocularis | serotonin receptor | 0.0128 | 0.6048 | 0.6955 |
Echinococcus granulosus | geminin | 0.0177 | 0.8696 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0128 | 0.6048 | 0.6955 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0812 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | beta-lactamase | 0.0031 | 0.0812 | 0.1343 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2692 | 0.5654 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0031 | 0.0812 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.6048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1498 | 0.2477 |
Onchocerca volvulus | 0.0031 | 0.0812 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1412 | 0.1624 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0031 | 0.0812 | 0.0811 |
Brugia malayi | beta-lactamase | 0.0031 | 0.0812 | 0.1706 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0812 | 0.1343 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0031 | 0.0812 | 0.0811 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0031 | 0.0812 | 0.1343 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0103 | 0.4678 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0031 | 0.0812 | 0.0811 |
Mycobacterium ulcerans | beta-lactamase | 0.0031 | 0.0812 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.4678 | 0.7735 |
Echinococcus granulosus | expressed conserved protein | 0.0097 | 0.4341 | 0.4992 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1928 | 0.3188 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0103 | 0.4678 | 0.538 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0044 | 0.1498 | 0.1723 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2692 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0812 | 0.1343 |
Mycobacterium tuberculosis | Conserved protein | 0.0031 | 0.0812 | 0.0811 |
Echinococcus multilocularis | geminin | 0.0177 | 0.8696 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2692 | 0.3096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2692 | 0.3096 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Onchocerca volvulus | 0.0031 | 0.0812 | 0.5 | |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0003 |
Mycobacterium leprae | Probable lipase LipE | 0.0031 | 0.0812 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0031 | 0.0812 | 0.0934 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0812 | 0.1343 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0812 | 0.1343 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0031 | 0.0812 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0001 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1412 | 0.1624 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1928 | 0.405 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0031 | 0.0812 | 0.0811 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0147 | 0.7069 | 0.8129 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0031 | 0.0812 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.8696 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0812 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1412 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0812 | 0.1343 |
Brugia malayi | CHE-14 protein | 0.0044 | 0.1498 | 0.3147 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1928 | 0.405 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1412 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.6048 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0031 | 0.0812 | 0.1706 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0104 | 0.4765 | 0.5479 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2692 | 0.3096 |
Mycobacterium ulcerans | hypothetical protein | 0.0031 | 0.0812 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.0812 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0104 | 0.4761 | 0.7871 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0031 | 0.0812 | 0.0811 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0044 | 0.1498 | 0.2477 |
Mycobacterium tuberculosis | Conserved protein | 0.0031 | 0.0812 | 0.0811 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.1498 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2692 | 0.5654 |
Toxoplasma gondii | ABC1 family protein | 0.0031 | 0.0812 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0128 | 0.6048 | 0.6955 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0031 | 0.0812 | 0.0811 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2692 | 0.4451 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.8696 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0044 | 0.1498 | 0.1723 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0031 | 0.0812 | 0.0934 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0031 | 0.0812 | 0.0934 |
Mycobacterium ulcerans | lipase LipD | 0.0031 | 0.0812 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2692 | 0.3096 |
Mycobacterium tuberculosis | Conserved protein | 0.0031 | 0.0812 | 0.0811 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2692 | 0.4451 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1036 | 0.1713 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.0812 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0103 | 0.4678 | 0.9827 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1036 | 0.2176 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2692 | 0.5654 |
Echinococcus multilocularis | protein patched | 0.0044 | 0.1498 | 0.1723 |
Mycobacterium leprae | conserved hypothetical protein | 0.0031 | 0.0812 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.0812 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1928 | 0.3188 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2692 | 0.3096 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0104 | 0.4761 | 0.7871 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0031 | 0.0812 | 0.0811 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2692 | 0.3096 |
Brugia malayi | MH2 domain containing protein | 0.0104 | 0.4761 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2692 | 0.4451 |
Brugia malayi | beta-lactamase family protein | 0.0031 | 0.0812 | 0.1706 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0812 | 0.1343 |
Schistosoma mansoni | patched 1 | 0.0044 | 0.1498 | 0.1723 |
Echinococcus multilocularis | protein dispatched 1 | 0.005 | 0.1836 | 0.2111 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0044 | 0.1498 | 0.1723 |
Echinococcus multilocularis | expressed conserved protein | 0.0097 | 0.4341 | 0.4992 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.