Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 1 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0049 | 0.6187 | 0.5 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0049 | 0.6187 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.4283 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.6187 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.3122 | 0.5047 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.3802 | 0.6145 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0037 | 0.3802 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1897 | 0.3066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1905 | 0.3078 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0021 | 0.0745 | 0.1204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.4283 | 0.6922 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 1 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0049 | 0.6187 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.6187 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.2385 | 0.3855 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0039 | 0.429 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.3802 | 0.6145 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.2385 | 0.3855 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.3802 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1905 | 0.3078 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0023 | 0.1281 | 0.207 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 1 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0039 | 0.429 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1905 | 0.3078 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.4826 | 0.78 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.4283 | 0.6922 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0049 | 0.6187 | 0.6187 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.4283 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.6187 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.2441 | 0.3945 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.3802 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.2441 | 0.3945 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0049 | 0.6187 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.2921 | 0.4722 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0049 | 0.6187 | 0.6187 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0049 | 0.6187 | 0.6187 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0049 | 0.6187 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1897 | 0.3066 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0049 | 0.6187 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0049 | 0.6187 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1905 | 0.3078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.4283 | 0.6922 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0049 | 0.6187 | 0.6187 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.2441 | 0.3945 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0049 | 0.6187 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.3802 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.3802 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1897 | 0.3066 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0039 | 0.429 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.3802 | 0.6145 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0049 | 0.6187 | 0.6187 |
Giardia lamblia | GTOR | 0.0049 | 0.6187 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay | ChEMBL. | 19523822 | |
IC50 (binding) | Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay | ChEMBL. | 19523822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.