TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.416 | Formula: C20H24N2O4
H donors: 3 H acceptors: 3 LogP: 3.45 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cccc(c1)NC(=O)c1ccc(cc1O)OCCCN1CCCC1
InChi: 1S/C20H24N2O4/c23-16-6-3-5-15(13-16)21-20(25)18-8-7-17(14-19(18)24)26-12-4-11-22-9-1-2-10-22/h3,5-8,13-14,23-24H,1-2,4,9-12H2,(H,21,25)
InChiKey: KQQZSUCDRHHIEY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0138	0.0763	0.1341
Schistosoma mansoni	intermediate filament proteins	0.0025	0.0071	0.0113
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0216	0.1233	1
Schistosoma mansoni	thyroid hormone receptor	0.0938	0.564	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0046	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0027
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0065	0.0317	0.0646
Loa Loa (eye worm)	plexin A	0.0025	0.0069	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0138	0.0763	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0065	0.0317	0.0646
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0138	0.0763	0.0763
Schistosoma mansoni	nuclear receptor	0.0065	0.0317	0.0549
Echinococcus granulosus	geminin	0.0327	0.191	0.3974
Schistosoma mansoni	sex comb on midleg homolog	0.0044	0.0188	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Echinococcus multilocularis	FTZ F1 alpha	0.0138	0.0763	0.1341
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0025	0.0071	0.0074
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0065	0.0317	0.0549
Echinococcus multilocularis	lamin dm0	0.0025	0.0071	0.0113
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0194	0.1101	0.8872
Loa Loa (eye worm)	mbt repeat family protein	0.0044	0.0188	0.0196
Brugia malayi	Steroid receptor seven-up type 2	0.0138	0.0763	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0046	0.02	0.0209
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0029	0.0098	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0138	0.0763	0.0795
Brugia malayi	hypothetical protein	0.0073	0.0364	0.0364
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0008	0.0008
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0138	0.0763	0.1341
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Brugia malayi	mbt repeat family protein	0.0044	0.0188	0.0188
Echinococcus granulosus	ecdysone induced protein 78C	0.0138	0.0763	0.1578
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0138	0.0763	0.0763
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.08	0.4795	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0065	0.0317	0.0317
Trichomonas vaginalis	glutathione reductase, putative	0.0029	0.0098	0.5
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0138	0.0763	0.1578
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0138	0.0763	0.1578
Onchocerca volvulus	Bile acid receptor homolog	0.0138	0.0763	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0029	0.0098	0.1748
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Echinococcus multilocularis	ecdysone induced protein 78C	0.0138	0.0763	0.1341
Brugia malayi	hypothetical protein	0.0023	0.0061	0.0061
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0044	0.0188	0.0321
Loa Loa (eye worm)	hypothetical protein	0.158	0.9554	0.995
Brugia malayi	nuclear receptor RXR	0.0073	0.0364	0.0364
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0194	0.1101	0.8912
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0022	0.005	0.005
Schistosoma mansoni	lamin	0.0025	0.0071	0.0113
Trichomonas vaginalis	mercuric reductase, putative	0.0029	0.0098	0.5
Schistosoma mansoni	nuclear receptor nhr-48	0.0065	0.0317	0.0549
Brugia malayi	nuclear receptor NHR-88	0.0138	0.0763	0.0763
Onchocerca volvulus		0.0065	0.0317	0.378
Plasmodium falciparum	thioredoxin reductase	0.0029	0.0098	0.1748
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0065	0.0317	0.0549
Echinococcus granulosus	lamin dm0	0.0025	0.0071	0.0132
Schistosoma mansoni	nuclear receptor	0.0065	0.0317	0.0549
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0055	0.0057
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0138	0.0763	0.1341
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0029	0.0098	1
Echinococcus granulosus	FTZ F1 alpha	0.0138	0.0763	0.1578
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0065	0.0317	0.378
Loa Loa (eye worm)	steroid hormone receptor	0.0138	0.0763	0.0795
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0127	0.0127
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0063	0.0063
Onchocerca volvulus		0.0138	0.0763	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0026	0.0049
Echinococcus granulosus	thioredoxin glutathione reductase	0.0086	0.044	0.0903
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0138	0.0763	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Schistosoma mansoni	myelin transcription factor 1 myt1	0.005	0.0226	0.0387
Treponema pallidum	NADH oxidase	0.0029	0.0098	0.5
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0216	0.1233	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0065	0.0317	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0111	0.0116
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0194	0.1101	0.8912
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.08	0.4795	0.85
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0065	0.0317	0.0549
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0138	0.0763	0.0795
Echinococcus multilocularis	histone acetyltransferase MYST2	0.005	0.0226	0.0387
Brugia malayi	nuclear receptor NHR-67	0.0065	0.0317	0.0317
Leishmania major	hypothetical protein, conserved	0.0023	0.0061	0.0166
Schistosoma mansoni	hypothetical protein	0.0327	0.191	0.3378
Plasmodium vivax	ataxin-2 like protein, putative	0.0023	0.0061	0.0846
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0138	0.0763	0.0763
Onchocerca volvulus		0.0048	0.0212	0.2323
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0938	0.564	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0138	0.0763	0.1578
Schistosoma mansoni	hypothetical protein	0.0032	0.0111	0.0184
Loa Loa (eye worm)	MBCTL1	0.005	0.0226	0.0235
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0065	0.0317	0.0646
Loa Loa (eye worm)	CYP4Cod1	0.0022	0.0055	0.0057
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0138	0.0763	0.1341
Loa Loa (eye worm)	thioredoxin reductase	0.0085	0.0437	0.0455
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0138	0.0763	0.1341
Loa Loa (eye worm)	intermediate filament protein	0.0025	0.0071	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0029	0.0098	0.0161
Trypanosoma brucei	trypanothione reductase	0.0085	0.0437	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0188	0.0196
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0029	0.0098	0.1748
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0138	0.0763	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0364	0.038
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0174	0.0982	0.2036
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0071	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0138	0.0763	0.0763
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0138	0.0763	0.1578
Echinococcus multilocularis	musashi	0.0025	0.0071	0.0113
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0138	0.0763	0.0763
Brugia malayi	ecdysteroid receptor	0.0138	0.0763	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0364	0.038
Echinococcus granulosus	plexin a4	0.0025	0.0069	0.0128
Schistosoma mansoni	transcription factor LCR-F1	0.0069	0.0341	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0364	0.038
Mycobacterium tuberculosis	Probable reductase	0.0194	0.1101	0.8912
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0063	0.0065
Brugia malayi	ecdysone receptor	0.0065	0.0317	0.0317
Brugia malayi	orphan nuclear receptor NR2E1	0.0065	0.0317	0.0317
Echinococcus granulosus	intermediate filament protein	0.0025	0.0071	0.0132
Brugia malayi	tailless protein	0.0065	0.0317	0.0317
Echinococcus multilocularis	nuclear receptor nhr 48	0.0065	0.0317	0.0549
Onchocerca volvulus	Protein ultraspiracle homolog	0.0138	0.0763	1
Brugia malayi	Plexin repeat family protein	0.0021	0.0045	0.0045
Brugia malayi	conserved hypotetical protein	0.0065	0.0317	0.0317
Schistosoma mansoni	hypothetical protein	0.0069	0.0341	0.0592
Brugia malayi	Nuclear hormone receptor-like 1	0.1587	0.9602	0.9602
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0138	0.0763	0.0795
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0065	0.0317	0.0317
Schistosoma mansoni	nuclear hormone receptor	0.0065	0.0317	0.0549
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.0127	0.0132
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0029	0.0098	0.0985
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0061	0.0846
Schistosoma mansoni	zinc finger protein	0.0065	0.0317	0.0549
Toxoplasma gondii	NADPH-glutathione reductase	0.0029	0.0098	0.0985
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0194	0.1101	0.8912
Brugia malayi	hypothetical protein	0.0065	0.0317	0.0317
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0085	0.0437	0.3434
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0138	0.0763	0.0795
Brugia malayi	nuclear receptor RXR	0.0065	0.0317	0.0317
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0029	0.0098	0.5
Plasmodium falciparum	thioredoxin reductase	0.0085	0.0437	1
Brugia malayi	Nuclear hormone receptor E75	0.0065	0.0317	0.0317
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0063	0.5088
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0069	0.0341	0.0592
Schistosoma mansoni	nuclear hormone receptor	0.0138	0.0763	0.1341
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0063	0.0212
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0138	0.0763	0.1578
Entamoeba histolytica	hypothetical protein	0.0069	0.0341	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0194	0.1101	0.8912
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0073	0.0364	0.0634
Brugia malayi	glutathione reductase	0.0085	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.005	0.0226	0.0235
Brugia malayi	hypothetical protein	0.0236	0.1359	0.1359
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0063	0.0212
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0044	0.0188	0.1991
Schistosoma mansoni	lamin	0.0025	0.0071	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0008
Entamoeba histolytica	hypothetical protein	0.0069	0.0341	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0063	0.035
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0061	0.0846
Leishmania major	trypanothione reductase	0.0085	0.0437	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0065	0.0317	0.0549
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0063	0.035
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0029	0.0098	0.1135
Onchocerca volvulus		0.0065	0.0317	0.378
Schistosoma mansoni	plexin	0.0021	0.0045	0.0067
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0029	0.0098	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0212	0.0363
Brugia malayi	hypothetical protein	0.0073	0.0364	0.0364
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.1587	0.9602	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0022	0.005	0.005
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0029	0.0098	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0236	0.1359	0.1416
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0044	0.0188	0.0321
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0138	0.0763	0.1341
Brugia malayi	Nuclear hormone receptor-like 1	0.1587	0.9602	0.9602
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0138	0.0763	0.0763
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0046	0.02	0.0209
Brugia malayi	nuclear hormone receptor	0.0065	0.0317	0.0317
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0065	0.0317	0.0549
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0212	0.0363
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0138	0.0763	0.0763
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0138	0.0763	0.0795
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.1359	0.2823
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0029	0.0098	0.1135
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0138	0.0763	0.1578
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0063	0.5088
Brugia malayi	hypothetical protein	0.0015	0.001	0.001
Mycobacterium tuberculosis	Probable oxidoreductase	0.0216	0.1233	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0098	0.1135
Echinococcus multilocularis	lamin	0.0025	0.0071	0.0113
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0029	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0029	0.0098	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0063	0.0065
Onchocerca volvulus		0.0044	0.0188	0.1991
Plasmodium vivax	thioredoxin reductase, putative	0.0085	0.0437	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0216	0.1233	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0063	0.0212
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0073	0.0364	0.0634
Echinococcus multilocularis	geminin	0.0327	0.191	0.3378
Echinococcus granulosus	histone acetyltransferase MYST2	0.005	0.0226	0.0456
Entamoeba histolytica	hypothetical protein	0.0069	0.0341	1
Schistosoma mansoni	coup transcription factor	0.0138	0.0763	0.1341
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0055	0.0055
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0138	0.0763	0.0763
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0063	0.5088
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0063	0.5088
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Brugia malayi	latrophilin 2 splice variant baaae	0.0032	0.0111	0.0111
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0138	0.0763	0.0795
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0138	0.0763	0.1341
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0138	0.0763	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0029	0.0098	0.1135
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0029	0.0098	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0025	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0068	0.0071
Schistosoma mansoni	hypothetical protein	0.08	0.4795	0.85
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Loa Loa (eye worm)	nuclear hormone receptor	0.0065	0.0317	0.033
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0138	0.0763	0.1341
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.081	0.486	0.8615
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0061	0.0063
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0212	0.0212
Onchocerca volvulus		0.0024	0.0063	0.024
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0063	0.0065
Brugia malayi	nuclear hormone receptor family member odr-7	0.0065	0.0317	0.0317
Echinococcus granulosus	nuclear receptor nhr 48	0.0065	0.0317	0.0646
Brugia malayi	intermediate filament protein	0.0025	0.0071	0.0071
Brugia malayi	hypothetical protein	0.0065	0.0317	0.0317
Echinococcus granulosus	SAM and MBT domain containing protein	0.0044	0.0188	0.0378
Toxoplasma gondii	thioredoxin reductase	0.0085	0.0437	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0364	0.038
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0055	0.0055
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0086	0.044	0.0768
Brugia malayi	mbt repeat family protein	0.0044	0.0188	0.0188
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0065	0.0317	0.378
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0029	0.0098	0.1135
Brugia malayi	Thioredoxin reductase	0.0085	0.0437	0.0437
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0138	0.0763	0.0763
Onchocerca volvulus		0.0025	0.0071	0.0355
Brugia malayi	nuclear hormone receptor	0.0138	0.0763	0.0763
Brugia malayi	plexin A	0.0025	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0364	0.038
Schistosoma mansoni	RAR-like nuclear receptor	0.0138	0.0763	0.1341
Brugia malayi	Nuclear hormone receptor E75	0.0065	0.0317	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.005	0.0226	0.0226
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0194	0.1101	0.8912
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Plasmodium vivax	glutathione reductase, putative	0.0085	0.0437	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0022	0.0055	0.3957
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Echinococcus multilocularis	polycomb protein SCMH1	0.0044	0.0188	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0029	0.0098	0.5
Plasmodium falciparum	glutathione reductase	0.0029	0.0098	0.1748
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0029	0.0098	0.0189
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0029	0.0098	0.1748
Loa Loa (eye worm)	DR-78	0.0065	0.0317	0.033
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0065	0.0317	0.0549
Brugia malayi	nuclear receptor NHR-88	0.0065	0.0317	0.0317
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0174	0.0982	0.1731
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0046	0.02	0.02
Schistosoma mansoni	thyroid hormone receptor	0.0938	0.564	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.1359	0.24
Echinococcus granulosus	thyroid hormone receptor alpha	0.0065	0.0317	0.0646
Schistosoma mansoni	hypothetical protein	0.0327	0.191	0.3378
Brugia malayi	steroid hormone receptor	0.0138	0.0763	0.0763
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.005	0.0226	0.0387
Schistosoma mansoni	sex comb on midleg homolog	0.0044	0.0188	0.0321
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0063	0.5088
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0138	0.0763	0.1341
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0029	0.0098	0.1748
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0069	0.0341	0.0697
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0065	0.0317	0.0549
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0138	0.0763	0.0763
Schistosoma mansoni	hypothetical protein	0.0269	0.156	0.2756
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Echinococcus multilocularis	plexin a4	0.0025	0.0069	0.0109
Onchocerca volvulus		0.0025	0.0071	0.0355
Trypanosoma cruzi	trypanothione reductase, putative	0.0085	0.0437	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0138	0.0763	0.1341
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0138	0.0763	0.1341
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0317	0.033
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0029	0.0098	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0063	0.5088
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0138	0.0763	0.1341
Trypanosoma brucei	PAB1-binding protein , putative	0.0023	0.0061	0.0166
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0138	0.0763	0.1341
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0008	0.0008
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0063	0.5088
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0763	0.0795
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0008	0.0008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0063	0.5088
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0098	0.1135
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0061	0.0166
Loa Loa (eye worm)	glutathione reductase	0.0085	0.0437	0.0455
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0065	0.0317	0.033
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.005	0.0226	0.0456
Brugia malayi	hypothetical protein	0.0069	0.0341	0.0341
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0029	0.0098	0.1135
Entamoeba histolytica	hypothetical protein	0.0069	0.0341	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0138	0.0763	0.1341
Echinococcus granulosus	polycomb protein SCMH1	0.0044	0.0188	0.0378
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0065	0.0317	0.033
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0138	0.0763	0.0763
Schistosoma mansoni	nuclear hormone receptor	0.0065	0.0317	0.0549
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0029	0.0098	0.0161
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0055	0.0057
Echinococcus granulosus	lamin	0.0025	0.0071	0.0132
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0061	0.0166
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0073	0.0364	0.0634
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0138	0.0763	0.1578
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0098	0.1135
Plasmodium falciparum	glutathione reductase	0.0085	0.0437	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0063	0.0063
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0073	0.0364	0.0745
Brugia malayi	photoreceptor-specific nuclear receptor	0.0138	0.0763	0.0763
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0029	0.0098	0.064

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.86	Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP after 60 mins by microplate reader analysis	ChEMBL.	21835616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1824604

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1043751