Detailed information for compound 1043799

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.289 | Formula: C15H14FN3O2
  • H donors: 2 H acceptors: 2 LogP: 2.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1cccnc1Oc1ccccc1F)\NC1CC1
  • InChi: 1S/C15H14FN3O2/c16-12-5-1-2-6-13(12)21-15-11(4-3-9-17-15)14(19-20)18-10-7-8-10/h1-6,9-10,20H,7-8H2,(H,18,19)
  • InChiKey: ONXTWKYITQJSNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transient receptor potential channel 0.0065 0.0583 0.0565
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0894 0.2288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0766 0.0766
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0207 0.0207
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0028 0.0028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.2743 0.9421
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0207 0.0189
Loa Loa (eye worm) RNA binding protein 0.027 0.2911 1
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.1828 0.6257
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0081 0.0766 0.0748
Onchocerca volvulus 0.0031 0.0207 0.3462
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0039 0.0078
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.016 0.0496
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0039 0.0039
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0071 0.0373
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1247 0.4283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0207 0.0207
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0207 0.0189
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0321 0.0321
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.017 0.1778 0.1762
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0766 0.0766
Mycobacterium ulcerans hypothetical protein 0.0041 0.0321 0.1523
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1411 0.1395
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0321 0.0303
Toxoplasma gondii exonuclease III APE 0.0019 0.0071 0.0275
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0039 0.0039
Echinococcus granulosus lamin 0.0027 0.016 0.016
Echinococcus multilocularis lamin 0.0027 0.016 0.016
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0079 0.0079
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0019 0.0065
Onchocerca volvulus 0.0027 0.016 0.2594
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0207 0.0189
Onchocerca volvulus 0.0041 0.0321 0.5555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Treponema pallidum fructose-bisphosphate aldolase 0.0337 0.3671 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0019 0.0019
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0039 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0207 0.066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1411 0.4847
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0556 0.0538
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0071 0.0373
Brugia malayi beta-lactamase 0.0041 0.0321 0.1053
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0596 0.2048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.092 0.092
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0052
Brugia malayi jmjC domain containing protein 0.0066 0.0596 0.2003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0207 0.0712
Loa Loa (eye worm) hypothetical protein 0.0081 0.0766 0.263
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0039 0.0039
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0052
Schistosoma mansoni hypothetical protein 0.0081 0.0766 0.0748
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.1104
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0894 0.0877
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.2858 1
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0019 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0207 0.066
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0019 0.0009
Mycobacterium ulcerans lipase LipD 0.0041 0.0321 0.1523
Brugia malayi jmjC domain containing protein 0.0017 0.0039 0.0077
Schistosoma mansoni lamin 0.0027 0.016 0.0141
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1411 0.4817
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0071 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0207 0.066
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0957 0.0957
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0262 0.0849
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0596 0.0578
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0255 0.2743 0.9421
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0207 0.3462
Entamoeba histolytica protein kinase, putative 0.0092 0.0894 0.2288
Schistosoma mansoni tar DNA-binding protein 0.027 0.2911 0.2898
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0056
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0894 1
Brugia malayi hypothetical protein 0.0015 0.0019 0.0009
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0019 0.0065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Brugia malayi nuclear receptor NHR-67 0.0015 0.0019 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0207 0.0207
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0321 0.0303
Loa Loa (eye worm) hypothetical protein 0.0092 0.0889 0.3053
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0207 0.0207
Mycobacterium tuberculosis Conserved protein 0.0041 0.0321 0.09
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0583 0.0583
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0028 0.0028
Loa Loa (eye worm) TAR-binding protein 0.027 0.2911 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0071 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0766 0.0766
Onchocerca volvulus 0.0041 0.0321 0.5555
Loa Loa (eye worm) intermediate filament protein 0.0027 0.016 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0207 0.0712
Schistosoma mansoni transient receptor potential channel 0.0098 0.0957 0.094
Brugia malayi jmjC domain containing protein 0.0017 0.0039 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.2743 0.9418
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0583 0.0583
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0039 0.002
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0207 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.1717 1
Leishmania major hypothetical protein, conserved 0.0041 0.0321 0.3303
Brugia malayi jmjC domain containing protein 0.0017 0.0039 0.0077
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.1201 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0207 0.066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0207 0.0712
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0207 0.066
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0019 0.0009
Schistosoma mansoni tar DNA-binding protein 0.027 0.2911 0.2898
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0133
Onchocerca volvulus 0.0027 0.016 0.2594
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0321 0.09
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0207 0.0189
Brugia malayi hypothetical protein 0.0017 0.0039 0.0078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0207 0.0712
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0321 0.0845
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0766 0.2589
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0321 0.09
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0207 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0207 0.066
Loa Loa (eye worm) DR-78 0.0015 0.0019 0.0065
Brugia malayi hypothetical protein 0.0017 0.0039 0.0078
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.017 0.1778 0.1762
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0039 0.0134
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1247 0.4283
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0134
Mycobacterium ulcerans beta-lactamase 0.0041 0.0321 0.1523
Brugia malayi nuclear receptor NHR-88 0.0015 0.0019 0.0009
Brugia malayi steroid hormone receptor 0.0031 0.0207 0.066
Echinococcus multilocularis dnaJ subfamily B 0.0895 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0071 0.0373
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.1104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0154 0.0531
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0039 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0039 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0207 0.0207
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0019 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0039 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0207 0.0712
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0957 0.094
Loa Loa (eye worm) hypothetical protein 0.0174 0.1828 0.6278
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0134
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0262 0.0262
Brugia malayi Protein kinase domain containing protein 0.0092 0.0894 0.3033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0321 0.1523
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0039 0.0133
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0556 0.0556
Loa Loa (eye worm) beta-lactamase 0.0041 0.0321 0.1104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0207 0.066
Brugia malayi nuclear receptor RXR 0.0015 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.1362 0.1346
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0207 0.0207
Echinococcus granulosus intermediate filament protein 0.0027 0.016 0.016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0134
Brugia malayi jmjC domain containing protein 0.0017 0.0039 0.0077
Brugia malayi intermediate filament protein 0.0027 0.016 0.0496
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0028 0.0028
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0071 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1411 0.1395
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0894 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0174 0.1828 0.1812
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0894 1
Echinococcus granulosus cpg binding protein 0.0066 0.0604 0.0604
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0019 0.0009
Schistosoma mansoni hypothetical protein 0.0081 0.0766 0.0748
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.016
Echinococcus granulosus dual specificity 0.0092 0.0894 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0039 0.0039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0207 0.0207
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0207 0.0712
Brugia malayi RNA recognition motif domain containing protein 0.027 0.2911 1
Echinococcus multilocularis dual specificity 0.0092 0.0894 0.0894
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0321 0.3303
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0019 0.0019
Schistosoma mansoni lamin 0.0027 0.016 0.0141
Schistosoma mansoni tar DNA-binding protein 0.027 0.2911 0.2898
Echinococcus granulosus lamin dm0 0.0027 0.016 0.016
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0321 0.0321
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.1717 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1411 0.1411
Echinococcus multilocularis tar DNA binding protein 0.027 0.2911 0.2911
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0321 0.0845
Loa Loa (eye worm) hypothetical protein 0.0092 0.0889 0.3053
Loa Loa (eye worm) hypothetical protein 0.0033 0.0225 0.0774
Loa Loa (eye worm) hypothetical protein 0.0061 0.0546 0.1875
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0321 0.09
Brugia malayi hypothetical protein 0.0015 0.0019 0.0009
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0079 0.0079
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0262 0.0262
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0207 0.0207
Onchocerca volvulus 0.0041 0.0321 0.5555
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0766 0.263
Schistosoma mansoni tar DNA-binding protein 0.027 0.2911 0.2898
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0583 0.0583
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0596 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0207 0.066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0207 0.066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1411 0.1395
Schistosoma mansoni intermediate filament proteins 0.0027 0.016 0.0141
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0901
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0321 0.1053
Schistosoma mansoni cpg binding protein 0.0063 0.0563 0.0545
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0019 0.0019
Brugia malayi CXXC zinc finger family protein 0.0063 0.0563 0.1889
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0766 0.0766
Brugia malayi nuclear receptor NHR-88 0.0031 0.0207 0.066
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0207 0.066
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0019 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0071 0.0244
Echinococcus multilocularis musashi 0.0027 0.016 0.016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0071 0.0071
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.016
Brugia malayi beta-lactamase family protein 0.0041 0.0321 0.1053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0207 0.0712
Brugia malayi nuclear hormone receptor 0.0015 0.0019 0.0009
Brugia malayi nuclear receptor RXR 0.0017 0.0039 0.0078
Brugia malayi MH2 domain containing protein 0.0123 0.1247 0.425
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0028 0.0028
Brugia malayi RNA binding protein 0.027 0.2911 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0583 0.0583
Trichomonas vaginalis esterase, putative 0.0041 0.0321 0.0845
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.1104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1411 0.1411
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.1717 0.5908
Schistosoma mansoni hypothetical protein 0.0081 0.0766 0.0748
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0028 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0068 0.0179
Entamoeba histolytica hypothetical protein 0.0092 0.0894 0.2288
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0321 1
Brugia malayi ecdysteroid receptor 0.0031 0.0207 0.066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1411 0.1411
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0321 0.1104
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0019 0.0019
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0894 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0039 0.0133
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0321 0.3303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.1104
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0207 0.0207
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.3671 1
Echinococcus multilocularis geminin 0.017 0.1778 0.1778
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0321 0.09
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0039 0.002
Echinococcus granulosus geminin 0.017 0.1778 0.1778
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0134
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0321 0.09
Schistosoma mansoni coup transcription factor 0.0031 0.0207 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0207 0.0207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0321 0.1523
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0894 0.3072
Schistosoma mansoni cpg binding protein 0.0066 0.0604 0.0586
Mycobacterium tuberculosis Conserved protein 0.0041 0.0321 0.09
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0207 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0207 0.066
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0207 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0321 0.3303
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0207 0.0207
Brugia malayi TAR-binding protein 0.027 0.2911 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0071 0.0071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0019 0.0019
Echinococcus multilocularis GPCR, family 2 0.0081 0.0766 0.0766
Schistosoma mansoni transient receptor potential channel 0.0065 0.0583 0.0565
Schistosoma mansoni hypothetical protein 0.0895 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.027 0.2911 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0207 0.066
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0207 0.0189
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0207 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0207 0.066
Brugia malayi beta-lactamase family protein 0.0041 0.0321 0.1053
Brugia malayi conserved hypotetical protein 0.0015 0.0019 0.0009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0563 0.1935
Loa Loa (eye worm) hypothetical protein 0.0098 0.0957 0.3288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.092 0.092
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0321 0.0845
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0071 0.0373
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0019 0.0019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.3671 1
Schistosoma mansoni tar DNA-binding protein 0.027 0.2911 0.2898
Echinococcus granulosus GPCR family 2 0.0081 0.0766 0.0766
Schistosoma mansoni cpg binding protein 0.0066 0.0604 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0207 0.066
Giardia lamblia Fructose-bisphosphate aldolase 0.0337 0.3671 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0321 0.0845
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.1104
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0207 0.3462
Echinococcus multilocularis cpg binding protein 0.0066 0.0604 0.0604
Echinococcus granulosus phd:f box containing protein 0.0017 0.0039 0.0039
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0207 0.066
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.055
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0596 0.0578
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.2743 0.9418
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0321 0.09
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.016 0.055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0039 0.0133
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0321 0.09
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0207 0.0712
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 0.113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1411 0.1411
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0071 0.0242
Brugia malayi ecdysone receptor 0.0015 0.0019 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0207 0.0207
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0019 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0766 0.2589
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0133
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0207 0.0207
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0207 0.3462
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0556 0.0556
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0207 0.0189
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0207 0.0207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0712
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0207 0.0189
Entamoeba histolytica protein kinase, putative 0.0092 0.0894 0.2288
Echinococcus granulosus tar DNA binding protein 0.027 0.2911 0.2911
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0065
Brugia malayi tailless protein 0.0015 0.0019 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.3671 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0134
Brugia malayi nuclear hormone receptor 0.0031 0.0207 0.066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0207 0.066
Echinococcus multilocularis lamin dm0 0.0027 0.016 0.016
Mycobacterium tuberculosis Conserved protein 0.0041 0.0321 0.09
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0207 0.0207
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0321 0.0845
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0556 0.0556
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0019 0.0019
Brugia malayi jmjC domain containing protein 0.0062 0.0556 0.1863
Onchocerca volvulus 0.0063 0.0563 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0019 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0207 0.0189
Toxoplasma gondii ABC1 family protein 0.0041 0.0321 0.2432
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0957 0.0957
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0039 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.1104

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.25 ug/ml DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro ChEMBL. No reference
Inhibition (functional) = 78 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense
Trypanosoma brucei ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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