Detailed information for compound 104414

Basic information

Technical information
  • TDR Targets ID: 104414
  • Name: (2S)-3-(1H-indol-3-yl)-2-[(4-methoxybenzoyl)a mino]propanoic acid
  • MW: 338.357 | Formula: C19H18N2O4
  • H donors: 3 H acceptors: 3 LogP: 2.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C19H18N2O4/c1-25-14-8-6-12(7-9-14)18(22)21-17(19(23)24)10-13-11-20-16-5-3-2-4-15(13)16/h2-9,11,17,20H,10H2,1H3,(H,21,22)(H,23,24)/t17-/m0/s1
  • InChiKey: IUJUDKHYWKXAIY-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-3-(1H-indol-3-yl)-2-[[(4-methoxyphenyl)-oxomethyl]amino]propanoic acid
  • (2S)-3-(1H-indol-3-yl)-2-[(4-methoxyphenyl)carbonylamino]propanoic acid
  • (2S)-3-(1H-indol-3-yl)-2-(p-anisoylamino)propionic acid
  • (2S)-3-(1H-indol-3-yl)-2-[(4-methoxybenzoyl)amino]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0009 0.0076 0.0238
Echinococcus granulosus expressed conserved protein 0.0066 0.1674 0.2536
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0389 0.088
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0153 0.4137 0.6268
Brugia malayi calpain 5 0.0007 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0055 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0627 0.1418
Brugia malayi glutathione reductase 0.0019 0.0345 0.0356
Loa Loa (eye worm) hypothetical protein 0.0021 0.0422 0.0423
Schistosoma mansoni amidase 0.0041 0.0983 0.2226
Chlamydia trachomatis dihydrofolate reductase 0.0163 0.4416 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0153 0.4137 0.6268
Echinococcus multilocularis disintegrin and metalloproteinase 0.0007 0.0013 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0389 0.0589
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0055 0.0091
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0055 0.0083
Mycobacterium tuberculosis Hypothetical protein 0.0021 0.0424 0.0959
Echinococcus granulosus protein kinase C gamma type 0.0018 0.0337 0.0511
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0015 0.0234 0.0354
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0087 0.009
Echinococcus granulosus disintegrin and metalloproteinase 0.0007 0.0013 0.0019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0011 0.0114 0.036
Trypanosoma brucei trypanothione reductase 0.0019 0.0345 0.1088
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0087 0.0072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0114 0.0173
Echinococcus granulosus calpain 7 C02 family 0.0009 0.0076 0.0114
Brugia malayi Carboxyl transferase domain containing protein 0.0034 0.0768 0.0792
Toxoplasma gondii thioredoxin reductase 0.0019 0.0345 0.1088
Loa Loa (eye worm) hypothetical protein 0.0029 0.0627 0.0634
Onchocerca volvulus 0.001 0.0087 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0011 0.0114 0.036
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0087 0.0132
Plasmodium falciparum replication factor C subunit 1, putative 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Brugia malayi Niemann-Pick C1 protein precursor 0.007 0.1794 0.1849
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0389 0.0401
Schistosoma mansoni coup transcription factor 0.002 0.0389 0.0881
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0069 0.1777 0.4024
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0114 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Schistosoma mansoni topbp1 0.0007 0.0015 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0015 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0389 0.0389
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0422 0.133
Schistosoma mansoni hypothetical protein 0.0029 0.0635 0.1437
Brugia malayi conserved hypotetical protein 0.001 0.0087 0.009
Echinococcus granulosus thioredoxin glutathione reductase 0.0019 0.0352 0.0533
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0389 0.0589
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0007 0.0015 0.0015
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0043 0.1021 0.2313
Schistosoma mansoni nuclear receptor 0.001 0.0087 0.0197
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0033 0.0743 0.0766
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0002
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0041 0.0983 0.1489
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0015 0.0221
Loa Loa (eye worm) hypothetical protein 0.0011 0.0119 0.011
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0087 0.009
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0055 0.0124
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0627 0.139
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0119 0.3171 1
Brugia malayi Pax transcription activation domain interacting protein 0.0007 0.0015 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0389 0.0589
Schistosoma mansoni fatty-acid amide hydrolase 0.0041 0.0983 0.2226
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0119 0.0123
Schistosoma mansoni calpain-7 (C02 family) 0.0009 0.0076 0.0171
Brugia malayi nuclear receptor NHR-88 0.001 0.0087 0.009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0009 0.0076 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0389 0.0401
Schistosoma mansoni calpain C (C02 family) 0.0009 0.0076 0.0171
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0009 0.0076 0.0238
Brugia malayi DKFZp564C0469 protein 0.0007 0.0015 0.0015
Brugia malayi hypothetical protein 0.0011 0.0119 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Brugia malayi amidase 0.0041 0.0983 0.1013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0047 0.1156 0.2617
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0153 0.4137 0.4258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0087 0.0132
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0035 0.0803 0.253
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Toxoplasma gondii ATPase, AAA family protein 0.0007 0.0015 0.0046
Brugia malayi hypothetical protein 0.001 0.0087 0.009
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0055 0.0124
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0007 0.0015 0.0084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0055 0.0124
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0055 0.0124
Brugia malayi nuclear hormone receptor 0.035 0.9698 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0055 0.0124
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0033 0.0743 0.1125
Echinococcus granulosus FTZ F1 alpha 0.002 0.0389 0.0589
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0627 0.3493
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0055 0.0056
Onchocerca volvulus 0.0035 0.081 0.0796
Brugia malayi topoisomerase 0.0007 0.0015 0.0015
Echinococcus granulosus adam 0.0012 0.0158 0.0239
Mycobacterium ulcerans thymidylate synthase 0.0045 0.1092 0.2473
Onchocerca volvulus 0.002 0.0389 0.0375
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0627 0.139
Schistosoma mansoni hypothetical protein 0.0029 0.0635 0.1437
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Brugia malayi nuclear receptor NHR-88 0.002 0.0389 0.0401
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0627 0.3493
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0055 0.0822
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0013 0.0193 0.0607
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0034 0.0768 0.078
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0389 0.0589
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.0055 0.0091
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0055 0.0083
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0114 0.036
Toxoplasma gondii pyruvate carboxylase 0.0013 0.0193 0.0607
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Echinococcus granulosus fatty acid amide hydrolase 1 0.0041 0.0983 0.1489
Echinococcus multilocularis calpain 0.0009 0.0076 0.0114
Trypanosoma brucei unspecified product 0.0009 0.0064 0.0201
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0163 0.4416 1
Brugia malayi hypothetical protein 0.0007 0.0015 0.0015
Echinococcus multilocularis adam 0.0012 0.0158 0.0239
Schistosoma mansoni thyroid hormone receptor 0.002 0.0389 0.0881
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0009 0.0076 0.0238
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0009 0.0076 0.0238
Echinococcus granulosus sterol regulatory element binding protein 0.003 0.0666 0.1008
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0007 0.0013 0.0019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0389 0.0881
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0055 0.0124
Loa Loa (eye worm) hypothetical protein 0.034 0.9428 0.9721
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0389 0.088
Loa Loa (eye worm) DR-78 0.001 0.0087 0.0077
Echinococcus multilocularis replication factor c subunit 1 0.0007 0.0015 0.0022
Echinococcus granulosus calpain 0.0009 0.0076 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0389 0.0401
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0627 0.1975
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0035 0.0803 0.253
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0043 0.1021 0.2287
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0035 0.0803 0.1215
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0013 0.0193 1
Echinococcus granulosus Protein patched homolog 1 0.003 0.0666 0.1008
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0055 0.0822
Loa Loa (eye worm) hypothetical protein 0.0021 0.0425 0.0425
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0055 0.0172
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0119 0.3171 1
Schistosoma mansoni topbp1 0.0007 0.0015 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0424 0.6366
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Trypanosoma brucei acetyl-CoA carboxylase 0.0035 0.0803 0.253
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0021 0.0401 0.0607
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0163 0.4416 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0055 0.0056
Loa Loa (eye worm) dihydrofolate reductase 0.0163 0.4416 0.4546
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0389 0.0389
Echinococcus granulosus dihydrofolate reductase 0.0163 0.4416 0.669
Loa Loa (eye worm) hypothetical protein 0.0041 0.0983 0.1002
Echinococcus multilocularis thymidylate synthase 0.0045 0.1092 0.1654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0389 0.0389
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0114 0.036
Chlamydia trachomatis biotin carboxylase 0.0012 0.0158 0.0357
Brugia malayi calpain family protein 1 0.0024 0.0502 0.0518
Loa Loa (eye worm) thioredoxin reductase 0.0019 0.0345 0.0343
Loa Loa (eye worm) hypothetical protein 0.0011 0.0119 0.011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0389 0.0589
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0627 0.0646
Loa Loa (eye worm) nuclear receptor nhr-7B 0.035 0.9698 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0019 0.0345 0.0781
Brugia malayi ecdysone receptor 0.001 0.0087 0.009
Echinococcus granulosus calpain A 0.0009 0.0076 0.0114
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0114 0.0173
Loa Loa (eye worm) glutathione reductase 0.0019 0.0345 0.0343
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0627 0.1418
Loa Loa (eye worm) hypothetical protein 0.0029 0.0627 0.0634
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0055 0.0056
Loa Loa (eye worm) hypothetical protein 0.0008 0.0055 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.1877 0.425
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0119 0.027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0019 0.0352 0.0533
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0087 0.0197
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0627 0.1418
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0055 0.0172
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0025 0.0533 0.0808
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0087 0.0132
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0041 0.0983 0.1489
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0009 0.0076 0.0238
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0013 0.0193 0.0436
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0389 0.0401
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0389 0.0881
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0119 0.3171 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0298 0.0294
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0055 0.0172
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0627 0.1418
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0389 0.0375
Onchocerca volvulus 0.0008 0.0055 0.004
Loa Loa (eye worm) hypothetical protein 0.007 0.1794 0.1839
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.081 0.1834
Schistosoma mansoni Mername-AA248 (C02 family) 0.001 0.0089 0.0201
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0422 0.133
Echinococcus multilocularis hypothetical protein 0.0009 0.0076 0.0114
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0389 0.0589
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0037 0.0856 0.0871
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0007 0.0013 0.0019
Schistosoma mansoni nuclear receptor 0.001 0.0087 0.0197
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0119 0.3171 1
Brugia malayi nuclear hormone receptor 0.002 0.0389 0.0401
Mycobacterium tuberculosis Probable oxidoreductase 0.0047 0.1156 0.2617
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0627 0.1975
Echinococcus multilocularis RNA directed DNA polymerase 0.0015 0.0234 0.0354
Onchocerca volvulus 0.0008 0.0055 0.004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0389 0.0589
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0087 0.0077
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0055 0.0124
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.003 0.0666 0.0674
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0055 0.0172
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0163 0.4416 1
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0025 0.053 0.1671
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0389 0.0589
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0055 0.0172
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0013 0.0193 0.0607
Brugia malayi calpain 7 0.0009 0.0076 0.0078
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0033 0.0743 0.1125
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0013 0.0193 0.0436
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0055 0.0172
Echinococcus multilocularis dihydrofolate reductase 0.0163 0.4416 0.669
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0389 0.0589
Loa Loa (eye worm) hypothetical protein 0.0021 0.0422 0.0423
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0045 0.1092 0.2448
Brugia malayi hypothetical protein 0.0012 0.0158 0.0163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0422 0.0955
Brugia malayi CHE-14 protein 0.003 0.0666 0.0686
Loa Loa (eye worm) hypothetical protein 0.0011 0.0119 0.011
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0007 0.0013 0.0028
Loa Loa (eye worm) calpain 0.0009 0.0076 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0389 0.0401
Chlamydia trachomatis DNA ligase 0.0007 0.0015 0.0033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0422 0.0955
Echinococcus multilocularis protein dispatched 1 0.0034 0.0785 0.1189
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0389 0.0589
Brugia malayi nuclear receptor RXR 0.001 0.0087 0.009
Leishmania major acetyl-CoA carboxylase, putative 0.0035 0.0803 0.253
Schistosoma mansoni pyruvate carboxylase 0.0013 0.0193 0.0436
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0043 0.1021 0.2313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0119 0.011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0087 0.0132
Brugia malayi nuclear receptor NHR-67 0.001 0.0087 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0627 0.1975
Trypanosoma brucei calpain-like protein, putative 0.0009 0.0076 0.0238
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0114 0.0173
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0007 0.0015 0.0046
Echinococcus granulosus RNA directed DNA polymerase 0.0015 0.0234 0.0354
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.0055 0.0091
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0035 0.0803 0.1215
Onchocerca volvulus 0.0015 0.0244 0.0229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0244 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0666 1
Mycobacterium tuberculosis Probable reductase 0.0043 0.1021 0.2313
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0062 0.1574 0.2385
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0087 0.0077
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0055 0.0124
Schistosoma mansoni calpain (C02 family) 0.0009 0.0076 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0389 0.0401
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0033 0.0743 0.1682
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0119 0.0181
Schistosoma mansoni nuclear hormone receptor 0.002 0.0389 0.0881
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0015 0.0221
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0013 0.0193 0.0436
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0013 0.0193 0.0436
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0087 0.0132
Onchocerca volvulus 0.0045 0.1092 0.1079
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0114 0.0258
Echinococcus multilocularis expressed conserved protein 0.0066 0.1674 0.2536
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0389 0.0589
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0401 0.0908
Echinococcus multilocularis tumor protein p63 0.024 0.6601 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0015 0.0221
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0011 0.0114 0.036
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0389 0.0401
Trypanosoma brucei calpain-like protein, putative 0.0009 0.0076 0.0238
Mycobacterium tuberculosis Probable dehydrogenase 0.0043 0.1021 0.2313
Loa Loa (eye worm) hypothetical protein 0.0015 0.0234 0.0228
Plasmodium vivax replication factor C subunit 1, putative 0.0007 0.0015 0.0046
Schistosoma mansoni hypothetical protein 0.0029 0.0635 0.1437
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0389 0.0881
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0055 0.0172
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0013 0.0193 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0389 0.0389
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0389 0.0389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.1877 0.2843
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0055 0.0172
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0119 0.3171 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0389 0.0589
Mycobacterium ulcerans hypothetical protein 0.0029 0.0627 0.1418
Echinococcus multilocularis calpain 5 0.001 0.0089 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0422 0.0423
Brugia malayi Nuclear hormone receptor E75 0.001 0.0087 0.009
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0045 0.1092 0.2473
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0015 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0389 0.0401
Brugia malayi ecdysteroid receptor 0.002 0.0389 0.0401
Loa Loa (eye worm) thymidylate synthase 0.0045 0.1092 0.1114
Trypanosoma brucei calpain-like protein, putative 0.0009 0.0076 0.0238
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0627 0.1418
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0627 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0389 0.0401
Brugia malayi nuclear receptor RXR 0.0011 0.0119 0.0123
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0021 0.0424 0.1336
Trypanosoma cruzi FHA domain containing protein, putative 0.0007 0.0015 0.0046
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0013 0.0193 0.0607
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0011 0.0114 0.036
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0389 0.0401
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0087 0.0132
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0025 0.053 0.1671
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0055 0.0124
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0025 0.0533 0.1207
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0119 0.0181
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0389 0.0881
Echinococcus multilocularis protein patched 0.003 0.0666 0.1008
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0012 0.0158 0.0357
Brugia malayi Nuclear hormone receptor E75 0.001 0.0087 0.009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0119 0.011
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0055 0.0172
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0055 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0627 0.1418
Echinococcus multilocularis calpain A 0.0025 0.0533 0.0808
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0055 0.0172
Brugia malayi dihydrofolate reductase family protein 0.0163 0.4416 0.4553
Loa Loa (eye worm) hypothetical protein 0.0008 0.0055 0.0044
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.007 0.1794 1
Brugia malayi isocitrate dehydrogenase 0.0011 0.0114 0.0118
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0114 0.0173
Schistosoma mansoni zinc finger protein 0.001 0.0087 0.0197
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0389 0.0401
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0007 0.0015 0.0046
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0119 0.3171 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Echinococcus multilocularis calpain family protein 1, d 0.0018 0.0322 0.0487
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0013 0.0193 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0422 0.0423
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0389 0.0589
Trypanosoma brucei antigen, putative 0.0009 0.0076 0.0238
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0389 0.0589
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0007 0.0013 0.0028
Brugia malayi calpain family protein 1 0.0024 0.0502 0.0518
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0345 0.1088
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0114 0.036
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0055 0.0044
Brugia malayi hypothetical protein 0.001 0.0087 0.009
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0044 0.1047 0.1586
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0389 0.0401
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0055 0.0124
Entamoeba histolytica hypothetical protein 0.0007 0.0015 0.0084
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0055 0.0124
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0002
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0055 0.0124
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0044 0.1047 0.1586
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0087 0.009
Loa Loa (eye worm) calpain family protein 1 0.0024 0.0502 0.0505
Loa Loa (eye worm) hypothetical protein 0.0029 0.0627 0.0634
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0114 0.0173
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0055 0.0124
Plasmodium vivax glutathione reductase, putative 0.0019 0.0345 0.1088
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0087 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Brugia malayi Dihydrofolate reductase 0.0163 0.4416 0.4553
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0015 0.0221
Schistosoma mansoni patched 1 0.003 0.0666 0.1507
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Brugia malayi hypothetical protein 0.0021 0.0424 0.0437
Echinococcus granulosus Protein kinase C brain isozyme 0.0021 0.0401 0.0607
Schistosoma mansoni dihydroceramide desaturase 0.0007 0.0013 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0055 0.0056
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0119 0.027
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0055 0.0124
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Brugia malayi hypothetical protein 0.0011 0.0119 0.0123
Trypanosoma cruzi acetyl-CoA carboxylase 0.0022 0.0427 0.1347
Schistosoma mansoni acetyl-CoA carboxylase 0.0035 0.0803 0.1817
Echinococcus multilocularis sterol regulatory element binding protein 0.003 0.0666 0.1008
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0087 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0389 0.0401
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0047 0.1156 0.2592
Plasmodium falciparum thioredoxin reductase 0.0019 0.0345 0.1088
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0389 0.0401
Mycobacterium ulcerans pyruvate carboxylase 0.0013 0.0193 0.0436
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0013 0.0193 0.0291
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0047 0.1156 0.2617
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0389 0.0589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0389 0.088
Onchocerca volvulus 0.0008 0.0055 0.004
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0055 0.0172
Echinococcus granulosus calpain 5 0.001 0.0089 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0389 0.088
Echinococcus granulosus fatty acid amide hydrolase 1 0.0041 0.0983 0.1489
Echinococcus granulosus calpain A 0.0025 0.0533 0.0808
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0627 0.1418
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0071 0.1824 0.4131
Echinococcus multilocularis Niemann Pick C1 protein 0.007 0.1794 0.2717
Brugia malayi Thioredoxin reductase 0.0019 0.0345 0.0356
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0627 0.0646
Loa Loa (eye worm) hypothetical protein 0.0035 0.081 0.0823
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0087 0.009
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0087 0.0197
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0013 0.0193 0.0291
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0013 0.0193 0.0404
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0119 0.011
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.2642 0.4002
Schistosoma mansoni nuclear hormone receptor 0.001 0.0087 0.0197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0627 0.1418
Schistosoma mansoni hypothetical protein 0.0029 0.0635 0.1437
Loa Loa (eye worm) hypothetical protein 0.003 0.0666 0.0674
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0627 0.3493
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0114 0.0173
Loa Loa (eye worm) oxidoreductase 0.0008 0.0055 0.0044
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0055 0.0172
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0013 0.0193 0.0436
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0015 0.0249 0.0244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0422 0.0423
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0055 0.0124
Brugia malayi steroid hormone receptor 0.002 0.0389 0.0401
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0389 0.0389
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.2642 0.4002
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0119 0.0123
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0009 0.0076 0.0238
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0114 0.0118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0502 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0389 0.0401
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0389 0.0589
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0627 0.1418
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0025 0.0533 0.0808
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0055 0.0124
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0022 0.0049
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0055 0.0172
Echinococcus multilocularis serine threonine protein kinase 0.0018 0.0337 0.0511
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0087 0.0132
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0153 0.4137 0.4266
Schistosoma mansoni DNA ligase IV 0.0007 0.0015 0.0033
Giardia lamblia Replication factor C, subunit 1 0.0007 0.0015 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0025 0.0533 0.1207
Plasmodium vivax calpain, putative 0.0009 0.0076 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0055 0.0124
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0055 0.0306
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0153 0.4137 0.9369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0389 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0389 0.0401
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0013 0.0193 0.0436
Brugia malayi Protein kinase c protein 2 0.0018 0.0313 0.0322
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0055 0.0056
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0055 0.0124
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0114 0.036
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0389 0.0881
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0015 0.0221
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0043 0.1021 0.2313
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0114 0.036
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0007 0.0015 0.0033
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0011 0.0114 0.0258
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0055 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Plasmodium vivax thioredoxin reductase, putative 0.0019 0.0345 0.1088
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0007 0.0015 0.0046
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0043 0.1021 0.2313
Schistosoma mansoni calpain-7 (C02 family) 0.0009 0.0076 0.0171
Schistosoma mansoni dihydrofolate reductase 0.0163 0.4416 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0389 0.0881
Treponema pallidum DNA ligase (lig) 0.0007 0.0015 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0007 0.0015 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0013 0.0193 0.0436
Brugia malayi thymidylate synthase 0.0045 0.1092 0.1126
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0087 0.0132
Schistosoma mansoni nuclear hormone receptor 0.001 0.0087 0.0197
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0401 0.0908
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0087 0.0132
Leishmania major trypanothione reductase 0.0019 0.0345 0.1088
Loa Loa (eye worm) hypothetical protein 0.002 0.0389 0.0389
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0389 0.0375
Echinococcus multilocularis calpain 7 (C02 family) 0.0009 0.0076 0.0114
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0007 0.0015 0.0766
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0015 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0015 0.0221
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0055 0.0124
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0045 0.1092 0.2473
Schistosoma mansoni chromosome transmission fidelity factor 0.0007 0.0015 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Loa Loa (eye worm) hypothetical protein 0.0146 0.3935 0.405
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0015 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0077
Echinococcus multilocularis adam 17 protease 0.0069 0.1777 0.2692
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0024 0.0502 0.1137
Plasmodium falciparum glutathione reductase 0.0019 0.0345 0.1088
Brugia malayi tailless protein 0.001 0.0087 0.009
Echinococcus granulosus Niemann Pick C1 protein 0.007 0.1794 0.2717
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0009 0.0076 0.0238
Brugia malayi hypothetical protein 0.0007 0.0015 0.0015
Onchocerca volvulus 0.0029 0.0627 0.0612
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0087 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0322 0.0319
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0389 0.0881
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0422 0.0955
Echinococcus granulosus replication factor c subunit 1 0.0007 0.0015 0.0022
Onchocerca volvulus 0.001 0.0087 0.0072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0389 0.0881
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0055 0.0124
Loa Loa (eye worm) calpain family protein 1 0.0018 0.0322 0.0319
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0389 0.0881
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0055 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0055 0.0124
Echinococcus granulosus adam 17 protease 0.0076 0.1972 0.2988
Trypanosoma brucei calpain-like protein, putative 0.0009 0.0076 0.0238
Leishmania major carboxylase, putative 0.0013 0.0193 0.0607
Echinococcus granulosus thymidylate synthase 0.0045 0.1092 0.1654
Onchocerca volvulus 0.0008 0.0055 0.004
Echinococcus multilocularis nibrin 0.0007 0.0015 0.0022
Brugia malayi Disintegrin family protein 0.0007 0.0013 0.0013
Echinococcus granulosus tumor protein p63 0.024 0.6601 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0087 0.0197
Echinococcus granulosus nibrin 0.0007 0.0015 0.0022

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 178 uM Inhibitory activity against association of LFA-1 with intercellular adhesion molecule 1 ChEMBL. 15080978
IC50 (binding) = 178 uM Inhibitory activity against association of LFA-1 with intercellular adhesion molecule 1 ChEMBL. 15080978

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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