Detailed information for compound 104487

Basic information

Technical information
  • TDR Targets ID: 104487
  • Name: 3-[3-(4-fluoro-4-phenethylpiperidin-1-yl)prop yl]-5-(1,2,4-triazol-4-yl)-1H-indole
  • MW: 431.548 | Formula: C26H30FN5
  • H donors: 1 H acceptors: 2 LogP: 4.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC1(CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1)CCc1ccccc1
  • InChi: 1S/C26H30FN5/c27-26(11-10-21-5-2-1-3-6-21)12-15-31(16-13-26)14-4-7-22-18-28-25-9-8-23(17-24(22)25)32-19-29-30-20-32/h1-3,5-6,8-9,17-20,28H,4,7,10-16H2
  • InChiKey: WMPPKOCCVMTGGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[3-(4-fluoro-4-phenethyl-1-piperidyl)propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
  • 3-[3-(4-fluoro-4-phenethyl-1-piperidinyl)propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
  • 3-[3-(4-fluoro-4-phenethyl-piperidin-1-yl)propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
  • 3-[3-(4-fluoro-4-phenethyl-piperidino)propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
  • 3-[3-[4-fluoro-4-(2-phenylethyl)piperidin-1-yl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
  • 3-[3-[4-fluoro-4-(2-phenylethyl)-1-piperidyl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
  • 3-[3-[4-fluoro-4-(2-phenylethyl)-1-piperidinyl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi AT19640p 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 390 aa 335 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dro:myosuppressin receptor 0.0061 0.0685 0.0736
Schistosoma mansoni amine GPCR 0.0061 0.0685 0.0733
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0004 0.0006 0.0007
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0685 0.0736
Schistosoma mansoni hypothetical protein 0.0061 0.0685 0.0733
Echinococcus multilocularis 0.0004 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0004 0.0003 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0004 0.0006 0.0007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0061 0.0685 0.0733
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0006 0.0006
Onchocerca volvulus 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0132 0.1544 0.166
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0061 0.0685 0.0733
Leishmania major cytochrome p450-like protein 0.0004 0.0006 1
Mycobacterium ulcerans short chain dehydrogenase 0.0272 0.3217 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Brugia malayi Cytochrome P450 family protein 0.0004 0.0006 0.0006
Echinococcus multilocularis orexin receptor type 2 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus allatostatin A receptor 0.0061 0.0685 0.0736
Schistosoma mansoni hypothetical protein 0.0061 0.0685 0.0733
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0004 0.0006 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0004 0.0003 0.0004
Toxoplasma gondii cytochrome p450 superfamily protein 0.0004 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0418 0.4966 0.534
Echinococcus granulosus g protein coupled receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi follicle stimulating hormone receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) melatonin receptor type 1A 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus neuropeptide receptor A26 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Schistosoma mansoni hypothetical protein 0.0004 0.0006 0.0002
Schistosoma mansoni amine GPCR 0.0061 0.0685 0.0733
Onchocerca volvulus 0.0132 0.1544 0.1657
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0685 0.0733
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0004 0.0006 0.0007
Loa Loa (eye worm) dehydrogenase 0.0004 0.0003 0.0004
Trypanosoma cruzi cytochrome P450, putative 0.0004 0.0006 1
Schistosoma mansoni neuropeptide receptor 0.0061 0.0685 0.0733
Echinococcus granulosus oxidoreductase 0.0004 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0685 0.0736
Trypanosoma cruzi cytochrome P450, putative 0.0004 0.0006 1
Schistosoma mansoni biogenic amine receptor 0.0061 0.0685 0.0733
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0004 0.0006 0.0007
Echinococcus granulosus hypothetical protein 0.0004 0.0003 0.0004
Onchocerca volvulus 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus g-protein coupled receptor 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0132 0.1544 0.1657
Brugia malayi Serotonin receptor 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0061 0.0685 0.0733
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0685 0.0736
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0685 0.0736
Schistosoma mansoni NADH dehydrogenase subunit 1 0.004 0.0443 0.0473
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0779 0.93 1
Echinococcus granulosus neuropeptide receptor 0.0061 0.0685 0.0736
Echinococcus granulosus 7TM GPCR rhodopsin 0.0061 0.0685 0.0736
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0685 0.0736
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0132 0.1544 0.166
Echinococcus multilocularis sodium and chloride dependent glycine 0.0132 0.1544 0.166
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0685 0.0733
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0685 0.0733
Onchocerca volvulus 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi Dehydrogenases, short chain protein 2 0.0004 0.0003 0.0004
Echinococcus granulosus G protein coupled receptor 139 0.0061 0.0685 0.0736
Onchocerca volvulus 0.004 0.0443 0.0473
Brugia malayi Dopamine receptor protein 1 0.0061 0.0685 0.0736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Echinococcus multilocularis conserved hypothetical protein 0.0004 0.0003 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0685 0.0736
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.015 0.1759 0.5463
Loa Loa (eye worm) hypothetical protein 0.0418 0.4966 0.534
Brugia malayi dehydrogenases, short chain protein 9 0.0004 0.0003 0.0004
Echinococcus granulosus sodium and chloride dependent glycine 0.0132 0.1544 0.166
Onchocerca volvulus 0.0061 0.0685 0.0733
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0061 0.0685 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0004 0.0006 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0132 0.1544 0.1657
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0004 0.0006 0.0007
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0004 0.0006 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0685 0.0736
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0004 0.0006 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0685 0.0736
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0004 0.0006 1
Brugia malayi neuropeptide F receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Schistosoma mansoni hypothetical protein 0.015 0.1759 0.1888
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Brugia malayi Melatonin receptor type 1A 0.0061 0.0685 0.0736
Giardia lamblia NADPH oxidoreductase, putative 0.0838 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0418 0.4966 0.534
Echinococcus multilocularis allatostatin A receptor 0.0061 0.0685 0.0736
Brugia malayi neuropeptide F receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0006 0.0006
Schistosoma mansoni growth hormone secretagogue receptor 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Echinococcus granulosus hypothetical protein 0.0061 0.0685 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0003 0.0004
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0209 0.2467 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0004 0.0006 0.0007
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0004 0.0006 0.0007
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0004 0.0006 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0685 0.0736
Trypanosoma brucei cytochrome P450, putative 0.0004 0.0006 1
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0004 0.0003 0.0004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0132 0.1544 0.166
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Schistosoma mansoni sodium-dependent amino acid transporter 0.0132 0.1544 0.1657
Onchocerca volvulus 0.0061 0.0685 0.0733
Brugia malayi putative neuropeptide receptor NPR1 0.0061 0.0685 0.0736
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0004 0.0003 0.0004
Schistosoma mansoni neuropeptide receptor 0.0061 0.0685 0.0733
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0004 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Echinococcus granulosus g protein coupled receptor 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Echinococcus granulosus neuropeptide receptor 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus multilocularis retinol dehydrogenase 11 0.0004 0.0003 0.0004
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0132 0.1544 0.166
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Loa Loa (eye worm) hypothetical protein 0.0779 0.93 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0061 0.0685 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Echinococcus granulosus WW domain containing oxidoreductase 0.0004 0.0003 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0628 0.7491 0.749
Echinococcus multilocularis G protein coupled receptor 139 0.0061 0.0685 0.0736
Brugia malayi hypothetical protein 0.0004 0.0003 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Echinococcus granulosus peptide allatostatin:somatostatin 0.0061 0.0685 0.0736
Mycobacterium tuberculosis Probable oxidoreductase 0.0272 0.3217 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0004 0.0006 0.0007
Echinococcus multilocularis oxidoreductase 0.0004 0.0003 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0004 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0003 0.0004
Brugia malayi Dopamine receptor protein 2 0.0061 0.0685 0.0736
Loa Loa (eye worm) solute carrier family 6 member 4 0.0779 0.93 1
Onchocerca volvulus 0.004 0.0443 0.0473
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0132 0.1544 0.1657
Echinococcus multilocularis sex peptide receptor 0.0061 0.0685 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Loa Loa (eye worm) cytochrome P450 0.0004 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0004 0.0006 0.0006
Onchocerca volvulus 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0132 0.1544 0.166
Loa Loa (eye worm) hypothetical protein 0.0779 0.93 1
Mycobacterium leprae putative cytochrome p450 0.0004 0.0006 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0685 0.0733
Echinococcus granulosus tachykinin peptides receptor 99D 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Echinococcus granulosus biogenic amine 5HT receptor 0.0061 0.0685 0.0736
Echinococcus granulosus neuropeptide s receptor 0.0061 0.0685 0.0736
Brugia malayi Retinol dehydrogenase 12 0.0004 0.0003 0.0004
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Echinococcus granulosus fmrfamide receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis serotonin transporter 0.0779 0.93 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0004 0.0003 0.0004
Schistosoma mansoni adenoreceptor 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0132 0.1544 0.166
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0061 0.0685 0.0733
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0004 0.0006 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0132 0.1544 0.1657
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0004 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi hypothetical protein 0.0004 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0132 0.1544 0.166
Schistosoma mansoni biogenic amine receptor 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi Dopamine receptor 0.0061 0.0685 0.0736
Echinococcus granulosus retinol dehydrogenase 11 0.0004 0.0003 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0685 0.0736
Echinococcus granulosus g protein coupled receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0685 0.0736
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Brugia malayi G protein-coupled receptor 0.0061 0.0685 0.0736
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0004 0.0003 0.0004
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0838 1 1
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0209 0.2467 0.2465
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0209 0.2467 0.2465
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0132 0.1544 0.166
Echinococcus multilocularis neuropeptide receptor A26 0.0061 0.0685 0.0736
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0779 0.93 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Brugia malayi NADH dehydrogenase subunit 1, identical 0.004 0.0443 0.0476
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0004 0.0006 0.0007
Brugia malayi larval opioid receptor 0.0061 0.0685 0.0736
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Brugia malayi Serotonin receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0132 0.1544 0.1657
Brugia malayi Cytochrome P450 family protein 0.0004 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0004 0.0006 0.0007
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0132 0.1544 0.1657
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0004 0.0006 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0132 0.1544 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0004 0.0006 0.0007
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0838 1 1
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.004 0.0443 0.0476
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0685 0.0736
Treponema pallidum sodium- and chloride- dependent transporter 0.0779 0.93 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Onchocerca volvulus 0.0779 0.93 1
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0004 0.0006 0.0007
Schistosoma mansoni cytochrome P450 0.0004 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Giardia lamblia NADPH oxidoreductase, putative 0.0838 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0061 0.0685 0.0736
Loa Loa (eye worm) CYP4Cod1 0.0004 0.0006 0.0006
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0209 0.2467 0.2465
Echinococcus multilocularis dro:myosuppressin receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus orexin receptor type 2 0.0061 0.0685 0.0736
Schistosoma mansoni alpha-1 adrenergic receptor 0.0061 0.0685 0.0733
Schistosoma mansoni amine GPCR 0.0061 0.0685 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus granulosus sodium and chloride dependent glycine 0.0132 0.1544 0.166
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0685 0.0736
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0004 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0004 0.0003 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.0061 0.0685 0.0736
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0061 0.0685 0.0736
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0685 0.0736
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Schistosoma mansoni hypothetical protein 0.0061 0.0685 0.0733
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0132 0.1544 0.1657
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0061 0.0685 0.0733
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0061 0.0685 0.0733
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0003 0.0004
Onchocerca volvulus 0.0061 0.0685 0.0733
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0004 0.0006 0.0007
Brugia malayi G-protein coupled receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0004 0.0003 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Onchocerca volvulus 0.0061 0.0685 0.0733
Onchocerca volvulus 0.0061 0.0685 0.0733
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0132 0.1544 0.166
Plasmodium falciparum transporter, putative 0.0132 0.1544 1
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0004 0.0006 0.0007
Brugia malayi G-protein coupled receptor 0.0061 0.0685 0.0736
Mycobacterium ulcerans formate hydrogenlyase HycD 0.004 0.0443 0.1368
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0004 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.015 0.1759 1
Brugia malayi NADH dehydrogenase subunit 1 0.004 0.0443 0.0476
Schistosoma mansoni sodium/chloride dependent transporter 0.0132 0.1544 0.1657
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0132 0.1544 0.166
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0418 0.4966 0.5338
Brugia malayi G protein-coupled receptor F59B2.13 0.0061 0.0685 0.0736
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0003 0.0004
Brugia malayi cytochrome P450 0.0004 0.0006 0.0006
Schistosoma mansoni opsin-like receptor 0.0061 0.0685 0.0733
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0004 0.0006 0.0007
Echinococcus multilocularis retinol dehydrogenase 13 0.0004 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0004 0.0006 0.0007
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0004 0.0003 0.0004
Schistosoma mansoni amine GPCR 0.0061 0.0685 0.0733
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0061 0.0685 0.0736
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0004 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Loa Loa (eye worm) dehydrogenase 0.0004 0.0003 0.0004
Echinococcus multilocularis retinol dehydrogenase 11 0.0004 0.0003 0.0004
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0209 0.2467 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0132 0.1544 0.1657
Schistosoma mansoni neuropeptide receptor 0.0061 0.0685 0.0733
Schistosoma mansoni myosin xvIII 0.0061 0.0685 0.0733
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis neuropeptide s receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0061 0.0685 0.0733
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0004 0.0006 1
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Brugia malayi hypothetical protein 0.0132 0.1544 0.166
Echinococcus granulosus cytochrome P450 2K1 0.0004 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0004 0.0006 0.0007
Brugia malayi putative neuropeptide receptor 0.0061 0.0685 0.0736
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0685 0.0733
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0132 0.1544 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Echinococcus granulosus retinol dehydrogenase 11 0.0004 0.0003 0.0004
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0006 0.0006
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0004 0.0006 0.0007
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0132 0.1544 0.166
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0132 0.1544 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0132 0.1544 0.166
Toxoplasma gondii hypothetical protein 0.0132 0.1544 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1544 0.166
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0061 0.0685 0.0736
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Echinococcus multilocularis serotonin receptor 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Schistosoma mansoni neuropeptide receptor 0.0061 0.0685 0.0733
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0061 0.0685 0.0733
Mycobacterium leprae Conserved hypothetical protein 0.0004 0.0006 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0004
Brugia malayi Tachykinin-like peptides receptor 99D 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus multilocularis steroid dehydrogenase 0.0004 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0004 0.0006 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0132 0.1544 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0132 0.1544 0.166
Brugia malayi GnHR receptor homolog 0.0061 0.0685 0.0736
Schistosoma mansoni opsin-like receptor 0.0061 0.0685 0.0733
Schistosoma mansoni biogenic amine (5HT) receptor 0.0061 0.0685 0.0733
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0132 0.1544 0.166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0004 0.0006 0.0007
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0838 1 1
Plasmodium vivax amine transporter, putative 0.0132 0.1544 1
Toxoplasma gondii hypothetical protein 0.0132 0.1544 1
Echinococcus granulosus NADH dehydrogenase subunit 1 0.015 0.1759 0.1891
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0004 0.0006 0.0007
Onchocerca volvulus 0.0061 0.0685 0.0733
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.015 0.1759 0.5463
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2467 0.2465
Loa Loa (eye worm) norepinephrine transporter 0.0779 0.93 1
Brugia malayi AKH receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus 7tm_1 domain containing protein 0.0061 0.0685 0.0736
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0004 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus granulosus serotonin receptor 0.0061 0.0685 0.0736
Brugia malayi RE15519p 0.0061 0.0685 0.0736
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0004 0.0006 0.0007
Brugia malayi ORL1-like opioid receptor 0.0061 0.0685 0.0736
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0061 0.0685 0.0736
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0004 0.0003 0.0004
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0004 0.0003 0.0004
Echinococcus granulosus hypothetical protein 0.0004 0.0003 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Leishmania major cytochrome p450-like protein 0.0004 0.0006 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0779 0.93 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0061 0.0685 0.0733
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0061 0.0685 0.0733
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0132 0.1544 0.1657
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0004 0.0006 0.0007
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0004 0.0006 0.0007
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0004 0.0006 0.0007
Brugia malayi oxidoreductase 0.0004 0.0003 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0685 0.0736
Schistosoma mansoni opsin-like receptor 0.0061 0.0685 0.0733
Schistosoma mansoni neuropeptide f receptor 76f 0.0061 0.0685 0.0733
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0004 0.0006 0.0007
Echinococcus granulosus serotonin transporter 0.0779 0.93 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0004 0.0006 0.0007
Echinococcus granulosus steroid dehydrogenase 0.0004 0.0003 0.0004
Echinococcus multilocularis sodium and chloride dependent glycine 0.0132 0.1544 0.166
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Echinococcus multilocularis steroid dehydrogenase 0.0004 0.0003 0.0004
Schistosoma mansoni biogenic amine receptor 0.0061 0.0685 0.0733
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Echinococcus multilocularis somatostatin receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Echinococcus multilocularis g-protein coupled receptor 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0685 0.0733
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Entamoeba histolytica hypothetical protein 0.0209 0.2467 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0685 0.0736
Echinococcus granulosus neuropeptide FF receptor 2 0.0061 0.0685 0.0736
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0004 0.0006 0.0007
Loa Loa (eye worm) serotonin transporter b 0.0779 0.93 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0061 0.0685 0.0736
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0061 0.0685 0.0736
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0003 0.0004
Onchocerca volvulus 0.0061 0.0685 0.0733
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0373 0.4431 0.4765
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Trichomonas vaginalis modulator of drug activity B, putative 0.0209 0.2467 0.2465
Echinococcus granulosus somatostatin receptor 0.0061 0.0685 0.0736
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0061 0.0685 0.0736
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0685 0.0736
Echinococcus multilocularis neuropeptide FF receptor 2 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0061 0.0685 0.0733
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0004 0.0006 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0132 0.1544 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0061 0.0685 0.0733
Echinococcus multilocularis G-protein coupled receptor, putative 0.0061 0.0685 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Schistosoma mansoni histamine h1 receptor 0.0061 0.0685 0.0733
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0685 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0838 1 1
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Loa Loa (eye worm) oxidoreductase 0.0004 0.0003 0.0004
Plasmodium falciparum amino acid transporter, putative 0.0132 0.1544 1
Schistosoma mansoni amine GPCR 0.0061 0.0685 0.0733
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0132 0.1544 0.166
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0003 0.0004
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.004 0.0443 0.1368
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0685 0.0736
Brugia malayi sulfakinin receptor protein 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0061 0.0685 0.0733
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0132 0.1544 0.166
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0061 0.0685 0.0736
Brugia malayi dehydrogenases, short chain protein 2 0.0004 0.0003 0.0004
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0132 0.1544 0.166
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0004 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0132 0.1544 0.166
Brugia malayi Cytochrome P450 family protein 0.0004 0.0006 0.0006
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0132 0.1544 0.166
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Onchocerca volvulus 0.0061 0.0685 0.0733
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0004 0.0003 0.0004
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0132 0.1544 0.1657
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0003 0.0004
Schistosoma mansoni sodium/chloride dependent transporter 0.0132 0.1544 0.1657
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0061 0.0685 0.0736
Brugia malayi hypothetical protein 0.004 0.0443 0.0476
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0061 0.0685 0.0736
Echinococcus granulosus sex peptide receptor 0.0061 0.0685 0.0736
Leishmania major cytochrome p450-like protein 0.0004 0.0006 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0004 0.0006 0.0007
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0004 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0061 0.0685 0.0736
Brugia malayi hypothetical protein 0.0061 0.0685 0.0736
Schistosoma mansoni sodium/chloride dependent transporter 0.0779 0.93 1
Echinococcus multilocularis serotonin receptor 0.0061 0.0685 0.0736

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 nM Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells ChEMBL. 10377215
IC50 (binding) = 2 nM Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells ChEMBL. 10377215
IC50 (binding) = 49 nM Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells ChEMBL. 10377215
IC50 (binding) = 49 nM Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells ChEMBL. 10377215
Selectivity (binding) = 25 Selectivity towards 5-HT1D and to that of 5-HT1B in CHO cells ChEMBL. 10377215

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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