Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.865 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.865 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.865 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.865 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0137 | 0.0122 | 0.0044 |
Brugia malayi | thymidylate synthase | 0.0209 | 0.0206 | 0.0206 |
Echinococcus multilocularis | dihydrofolate reductase | 0.865 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.357 | 0.4105 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0209 | 0.0206 | 0.0206 |
Brugia malayi | Dihydrofolate reductase | 0.865 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0209 | 0.0206 | 0.0206 |
Brugia malayi | hypothetical protein | 0.01 | 0.0078 | 0.0078 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.357 | 0.4105 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.357 | 0.4105 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.01 | 0.0078 | 0.271 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.865 | 1 | 1 |
Onchocerca volvulus | 0.0209 | 0.0206 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.357 | 0.4105 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.357 | 0.4105 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0281 | 0.0289 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0209 | 0.0206 | 0.0085 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0209 | 0.0206 | 0.0128 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0209 | 0.0206 | 0.0206 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.865 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0281 | 0.0289 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0209 | 0.0206 | 0.0206 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.865 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0209 | 0.0206 | 0.0085 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.357 | 0.4105 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0281 | 0.0289 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 15 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.