Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutathione reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | glutathione reductase | 522 aa | 545 aa | 25.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.4785 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.062 | 0.1295 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.9197 | 0.9197 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.4785 | 0.4785 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.1134 | 0.2369 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.4785 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.4785 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.1134 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1134 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0136 | 0.9197 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.4785 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.062 | 0.1295 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.1134 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.4785 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1134 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.1134 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0026 | 0.1134 | 0.1134 |
Leishmania major | trypanothione reductase | 0.0076 | 0.4785 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.4785 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0026 | 0.1134 | 0.1233 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 0.4785 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.1134 | 0.1134 |
Brugia malayi | glutathione reductase | 0.0076 | 0.4785 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.4785 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.4785 | 0.5203 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.4785 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0136 | 0.9197 | 0.9197 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.1134 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.1134 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.1134 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.1134 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 0.4785 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.1134 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.1134 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.4785 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23 mM | Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry | ChEMBL. | 20430631 |
IC50 (binding) | = 14.2 uM | Inhibition of human erythrocyte glutathione reductase | ChEMBL. | 19447620 |
IC50 (binding) | = 181 uM | Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry | ChEMBL. | 20430631 |
Ki (binding) | = 45.2 mM | Noncompetitive inhibition of human carbonic anhydrase 1 esterase activity by Lineweaver-Burke plot analysis | ChEMBL. | 20430631 |
Ki (binding) | = 21.9 uM | Inhibition of human erythrocyte glutathione reductase | ChEMBL. | 19447620 |
Ki (binding) | = 267.2 uM | Noncompetitive inhibition of human carbonic anhydrase 2 esterase activity by Lineweaver-Burke plot analysis | ChEMBL. | 20430631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.