TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 519.493 | Formula: C28H21F4N5O
H donors: 4 H acceptors: 2 LogP: 4.97 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: NCc1ccc(cc1)c1cnc2c(c1)c(c[nH]2)c1cccc(c1)NC(=O)Nc1ccc(cc1F)C(F)(F)F
InChi: 1S/C28H21F4N5O/c29-24-12-20(28(30,31)32)8-9-25(24)37-27(38)36-21-3-1-2-18(10-21)23-15-35-26-22(23)11-19(14-34-26)17-6-4-16(13-33)5-7-17/h1-12,14-15H,13,33H2,(H,34,35)(H2,36,37,38)
InChiKey: RDNOLDWOMGZBPI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 8	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase 10	Starlite/ChEMBL	References
Homo sapiens	spleen tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	Starlite/ChEMBL	References
Homo sapiens	conserved helix-loop-helix ubiquitous kinase	Starlite/ChEMBL	References
Homo sapiens	LYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	insulin-like growth factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K04440 c-Jun N-terminal kinase, putative	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma japonicum	ko:K05855 spleen tyrosine kinase, putative	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus granulosus	c-Jun N-terminal kinases	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma japonicum	IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Brugia malayi	Stress-activated protein kinase jnk-1	Get druggable targets OG5_129677	All targets in OG5_129677
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus granulosus	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855
Echinococcus granulosus	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	c Jun NH2 terminal kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma japonicum	ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	TK/INSR protein kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K04527 insulin receptor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative	Get druggable targets OG5_131855	All targets in OG5_131855
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0122	0.0666	0.0666
Schistosoma mansoni	retinoic acid receptor RXR	0.0122	0.0666	0.1191
Schistosoma mansoni	tyrosine kinase	0.0161	0.0919	0.1643
Schistosoma mansoni	tyrosine kinase	0.0075	0.0361	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0293	0.0304
Schistosoma mansoni	RAR-like nuclear receptor	0.0122	0.0666	0.1191
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0021	0.0012	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0293	0.0304
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0064	0.0293	0.061
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0058	0.0248	0.0444
Loa Loa (eye worm)	nuclear hormone receptor	0.0058	0.0248	0.0258
Brugia malayi	Nuclear hormone receptor E75	0.0058	0.0248	0.0248
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0058	0.0248	0.0444
Brugia malayi	Nuclear hormone receptor E75	0.0058	0.0248	0.0248
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0122	0.0666	0.1191
Onchocerca volvulus	Protein ultraspiracle homolog	0.0122	0.0666	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0122	0.0666	0.1191
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0122	0.0666	0.0692
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0058	0.0248	0.0258
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0058	0.0248	0.0444
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0122	0.0666	0.1387
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0064	0.0293	0.0524
Schistosoma mansoni	tyrosine kinase	0.0071	0.0333	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0161	0.0919	0.0919
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.0248	0.0444
Brugia malayi	hypothetical protein	0.0064	0.0293	0.0293
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0122	0.0666	0.0692
Schistosoma mansoni	tyrosine kinase	0.0071	0.0333	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0293	0.0304
Brugia malayi	ecdysone receptor	0.0058	0.0248	0.0248
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.1504	0.9627	1
Schistosoma mansoni	nuclear hormone receptor	0.0058	0.0248	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0293	0.0304
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0122	0.0666	0.1387
Schistosoma mansoni	tyrosine kinase	0.0261	0.1565	0.2797
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0161	0.0919	0.1914
Echinococcus granulosus	insulin receptor	0.0161	0.0919	0.1914
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0557	0.3488	0.6235
Brugia malayi	Furin-like cysteine rich region family protein	0.0075	0.0361	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0122	0.0666	0.0666
Brugia malayi	Stress-activated protein kinase jnk-1	0.0557	0.3488	0.3488
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0058	0.0248	0.0517
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0122	0.0666	0.1387
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0122	0.0666	0.1387
Schistosoma mansoni	thyroid hormone receptor	0.0882	0.5594	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0122	0.0666	0.0666
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0122	0.0666	0.0666
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0058	0.0248	0.0444
Schistosoma mansoni	tyrosine kinase	0.0075	0.0361	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0293	0.0304
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0122	0.0666	0.1191
Schistosoma mansoni	nuclear hormone receptor	0.0058	0.0248	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0122	0.0666	0.1191
Schistosoma mansoni	tyrosine kinase	0.0071	0.0333	0.0595
Echinococcus multilocularis	tyrosine protein kinase shark	0.0271	0.1633	0.292
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0882	0.5594	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0122	0.0666	0.1191
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0122	0.0666	0.1191
Echinococcus granulosus	nuclear receptor nhr 48	0.0058	0.0248	0.0517
Echinococcus granulosus	c-Jun N-terminal kinases	0.0557	0.3488	0.7262
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0058	0.0248	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0122	0.0666	0.0666
Echinococcus multilocularis	FTZ F1 alpha	0.0122	0.0666	0.1191
Brugia malayi	steroid hormone receptor	0.0122	0.0666	0.0666
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0122	0.0666	0.1191
Brugia malayi	ecdysteroid receptor	0.0122	0.0666	0.0666
Brugia malayi	hypothetical protein	0.0058	0.0248	0.0248
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0058	0.0248	0.0517
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0064	0.0293	0.0524
Brugia malayi	tailless protein	0.0058	0.0248	0.0248
Loa Loa (eye worm)	DR-78	0.0058	0.0248	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0122	0.0666	0.0692
Schistosoma mansoni	tyrosine kinase	0.0271	0.1633	0.292
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Schistosoma mansoni	nuclear receptor	0.0058	0.0248	0.0444
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0075	0.0361	0.0751
Brugia malayi	Steroid receptor seven-up type 2	0.0122	0.0666	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0122	0.0666	0.0666
Brugia malayi	hypothetical protein	0.0058	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor-like 1	0.1504	0.9627	0.9627
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0122	0.0666	0.1191
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0058	0.0248	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0122	0.0666	0.1191
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0122	0.0666	0.0692
Echinococcus granulosus	epidermal growth factor receptor	0.0075	0.0361	0.0751
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0122	0.0666	0.0666
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0122	0.0666	0.1191
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0122	0.0666	0.0692
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0122	0.0666	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0434	0.0451
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0122	0.0666	0.0666
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.076	0.4803	1
Loa Loa (eye worm)	hypothetical protein	0.1498	0.9582	0.9954
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0058	0.0248	0.0248
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0058	0.0248	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Schistosoma mansoni	hypothetical protein	0.076	0.4803	0.8586
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0122	0.0666	0.1387
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0058	0.0248	0.0248
Echinococcus multilocularis	epidermal growth factor receptor	0.0075	0.0361	0.0644
Echinococcus multilocularis	nuclear receptor nhr 48	0.0058	0.0248	0.0444
Brugia malayi	photoreceptor-specific nuclear receptor	0.0122	0.0666	0.0666
Echinococcus granulosus	epidermal growth factor receptor	0.0075	0.0361	0.0751
Brugia malayi	nuclear receptor NHR-67	0.0058	0.0248	0.0248
Brugia malayi	nuclear hormone receptor	0.0058	0.0248	0.0248
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0064	0.0293	0.0524
Schistosoma mansoni	nuclear receptor	0.0058	0.0248	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0122	0.0666	0.0666
Schistosoma mansoni	zinc finger protein	0.0058	0.0248	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0122	0.0666	0.0666
Brugia malayi	nuclear hormone receptor	0.0122	0.0666	0.0666
Brugia malayi	conserved hypotetical protein	0.0058	0.0248	0.0248
Brugia malayi	orphan nuclear receptor NR2E1	0.0058	0.0248	0.0248
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0122	0.0666	0.0692
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0122	0.0666	0.1191
Brugia malayi	Protein kinase domain containing protein	0.009	0.0461	0.0461
Echinococcus multilocularis	ecdysone induced protein 78C	0.0122	0.0666	0.1191
Schistosoma mansoni	tyrosine kinase	0.0075	0.0361	0.0644
Echinococcus granulosus	thyroid hormone receptor alpha	0.0058	0.0248	0.0517
Loa Loa (eye worm)	steroid hormone receptor	0.0122	0.0666	0.0692
Echinococcus multilocularis		0.0021	0.0009	0.0016
Echinococcus granulosus	FTZ F1 alpha	0.0122	0.0666	0.1387
Echinococcus granulosus	ecdysone induced protein 78C	0.0122	0.0666	0.1387
Loa Loa (eye worm)	TK/INSR protein kinase	0.0161	0.0919	0.0955
Schistosoma mansoni	thyroid hormone receptor	0.0882	0.5594	1
Brugia malayi	Nuclear hormone receptor-like 1	0.1504	0.9627	0.9627
Onchocerca volvulus	Bile acid receptor homolog	0.0122	0.0666	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Schistosoma mansoni	coup transcription factor	0.0122	0.0666	0.1191
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0122	0.0666	0.1191
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.0248	0.0517
Brugia malayi	nuclear receptor RXR	0.0058	0.0248	0.0248
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0122	0.0666	0.1387
Schistosoma mansoni	nuclear receptor nhr-48	0.0058	0.0248	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0122	0.0666	0.0666
Brugia malayi	nuclear receptor NHR-88	0.0058	0.0248	0.0248
Echinococcus multilocularis	epidermal growth factor receptor	0.0075	0.0361	0.0644
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0557	0.3488	0.3623
Echinococcus granulosus	tyrosine protein kinase shark	0.0271	0.1633	0.3401
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Brugia malayi	nuclear receptor NHR-88	0.0122	0.0666	0.0666
Schistosoma mansoni	nuclear hormone receptor	0.0122	0.0666	0.1191
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0058	0.0248	0.0258
Schistosoma mansoni	tyrosine kinase	0.0161	0.0919	0.1643
Echinococcus multilocularis	insulin receptor	0.0161	0.0919	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0122	0.0666	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0666	0.0692
Brugia malayi	nuclear receptor RXR	0.0064	0.0293	0.0293
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0075	0.0361	0.0375
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0161	0.0919	0.1643
Brugia malayi	hypothetical protein	0.0064	0.0293	0.0293
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0122	0.0666	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0248	0.0258
Schistosoma mansoni	serine/threonine protein kinase	0.0557	0.3488	0.6235
Brugia malayi	nuclear hormone receptor family member odr-7	0.0058	0.0248	0.0248
Onchocerca volvulus		0.0122	0.0666	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0122	0.0666	0.0692
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0122	0.0666	0.0666
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0122	0.0666	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.076	0.4803	0.8586

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 32 nM	Inhibition of IKK1	ChEMBL.	19394223
IC50 (binding)	= 40 nM	Inhibition of LYN	ChEMBL.	19394223
IC50 (binding)	= 50 nM	Inhibition of GST-tagged human IGF1R expressed in Sf9-baculovirus system	ChEMBL.	19394223
IC50 (binding)	= 79 nM	Inhibition of IKK2	ChEMBL.	19394223
IC50 (binding)	= 79 nM	Inhibition of JNK1	ChEMBL.	19394223
IC50 (binding)	= 80 nM	Inhibition of SYK	ChEMBL.	19394223
IC50 (binding)	= 250 nM	Inhibition of JNK3	ChEMBL.	19394223

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL551024

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1045099