Detailed information for compound 1045234

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 272.385 | Formula: C17H24N2O
  • H donors: 1 H acceptors: 1 LogP: 3.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(CNCc1coc(n1)c1ccc(cc1)C)CC
  • InChi: 1S/C17H24N2O/c1-4-14(5-2)10-18-11-16-12-20-17(19-16)15-8-6-13(3)7-9-15/h6-9,12,14,18H,4-5,10-11H2,1-3H3
  • InChiKey: WYOCFGNUIULETL-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0072 0.0189 0.0281
Echinococcus granulosus muscleblind protein 0.0174 0.0823 0.1226
Schistosoma mansoni rho gtpase activating protein 0.0072 0.0189 0.0281
Echinococcus granulosus oxysterol binding protein 9 0.0072 0.0189 0.0281
Echinococcus multilocularis geminin 0.0165 0.0772 0.115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Trichomonas vaginalis centaurin/arf, putative 0.0072 0.0189 0.0189
Echinococcus granulosus nervana 2 0.1036 0.6189 0.9222
Onchocerca volvulus Protein melted homolog 0.0072 0.0189 0.2856
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0072 0.0189 0.7147
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0007 0.0008
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0148 0.0661 0.0661
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0084 0.0264 0.0264
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0084 0.0264 1
Echinococcus multilocularis Glutaredoxin protein 5 0.1036 0.6189 0.9222
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Schistosoma mansoni vav2 0.0072 0.0189 0.0281
Brugia malayi glutathione reductase 0.0055 0.0084 0.0084
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0007 0.0007
Schistosoma mansoni goodpasture antigen-binding protein 0.0072 0.0189 0.0281
Echinococcus multilocularis Rho GTPase activating protein 24 0.0072 0.0189 0.0281
Brugia malayi Muscleblind-like protein 0.0174 0.0823 0.0823
Trypanosoma brucei protein kinase, putative 0.0084 0.0264 0.0264
Echinococcus multilocularis Pleckstrin y 0.0072 0.0189 0.0281
Brugia malayi Oxysterol binding protein 0.0072 0.0189 0.0189
Echinococcus granulosus Pleckstrin y 0.0072 0.0189 0.0281
Onchocerca volvulus 0.0072 0.0189 0.2856
Schistosoma mansoni syntrophin 0.0072 0.0189 0.0281
Schistosoma mansoni serine/threonine kinase 0.054 0.3106 0.4628
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0072 0.0189 0.0189
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0124 0.0185
Entamoeba histolytica p21-activated kinase 0.0084 0.0264 0.0257
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Mycobacterium tuberculosis Probable reductase 0.0125 0.0523 0.2902
Echinococcus granulosus Pleckstrin y 0.0072 0.0189 0.0281
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0177 0.671
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0072 0.0189 0.0189
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0528 0.3031 0.3031
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.054 0.3106 0.4628
Brugia malayi MAX-1A 0.0072 0.0189 0.0189
Trichomonas vaginalis AGC family protein kinase 0.054 0.3106 0.3106
Trypanosoma cruzi hypothetical protein 0.0072 0.0189 0.0281
Trypanosoma cruzi hypothetical protein 0.0072 0.0189 0.0281
Leishmania major trypanothione reductase 0.0055 0.0084 0.3187
Trypanosoma cruzi PH domain containing protein, putative 0.0072 0.0189 0.0281
Toxoplasma gondii Oxysterol-binding protein 0.0072 0.0189 0.0198
Trypanosoma cruzi Protein kinase B 0.112 0.6711 1
Echinococcus multilocularis GRB2 associated binding protein 3 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Trichomonas vaginalis protein transport protein sec7, putative 0.0072 0.0189 0.0189
Schistosoma mansoni microtubule-associated protein tau 0.0796 0.4699 0.7002
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0072 0.0189 0.0182
Loa Loa (eye worm) hypothetical protein 0.054 0.3106 0.3106
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0072 0.0189 0.0281
Trichomonas vaginalis hypothetical protein 0.0072 0.0189 0.0189
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.257 0.383
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Trichomonas vaginalis AGC family protein kinase 0.0612 0.3553 0.3553
Echinococcus granulosus myotubularin protein 13 0.0072 0.0189 0.0281
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0007 0.0007
Echinococcus granulosus DCC interacting protein 13 beta 0.0072 0.0189 0.0281
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0177 0.0264
Onchocerca volvulus outspread protein homolog 0.0072 0.0189 0.2856
Toxoplasma gondii phosphatidylinositol transfer protein 0.0072 0.0189 0.0198
Leishmania major hypothetical protein, conserved 0.0072 0.0189 0.7147
Echinococcus multilocularis dynamin 1 0.0072 0.0189 0.0281
Entamoeba histolytica PH domain containing protein kinase, putative 0.112 0.6711 0.6709
Trichomonas vaginalis AGC family protein kinase 0.1648 1 1
Entamoeba histolytica protein kinase, putative 0.1576 0.9553 0.9553
Echinococcus multilocularis pleckstrin y domain containing family A 0.0072 0.0189 0.0281
Echinococcus granulosus microtubule associated protein 2 0.0796 0.4699 0.7002
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Entamoeba histolytica protein kinase, putative 0.0084 0.0264 0.0257
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0523 0.2902
Loa Loa (eye worm) inositol-1 0.0043 0.0007 0.0007
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0124 0.0124
Loa Loa (eye worm) rho-GTPase-activating 0.0072 0.0189 0.0189
Echinococcus multilocularis Protein kinase C, brain isozyme 0.054 0.3106 0.4628
Loa Loa (eye worm) uncoordinated protein 104 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.0124 0.4705
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0072 0.0189 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Echinococcus multilocularis nervana 2 0.1036 0.6189 0.9222
Plasmodium falciparum calcium-dependent protein kinase 7 0.0084 0.0264 0.0291
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0084 0.0264 0.0264
Brugia malayi Plekhf2 protein 0.0072 0.0189 0.0189
Trypanosoma cruzi hypothetical protein 0.0072 0.0189 0.0281
Echinococcus multilocularis tumor protein p63 0.0356 0.1958 0.2917
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Schistosoma mansoni zinc finger protein 0.0072 0.0189 0.0281
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.1048 0.6264 0.9334
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0072 0.0189 0.0281
Schistosoma mansoni hypothetical protein 0.0072 0.0189 0.0281
Trichomonas vaginalis protein transport protein sec7, putative 0.0072 0.0189 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Trypanosoma cruzi PH domain containing protein, putative 0.0072 0.0189 0.0281
Trichomonas vaginalis centaurin alpha, putative 0.0072 0.0189 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.054 0.3106 0.4628
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0072 0.0189 0.0169
Brugia malayi Oxysterol-binding protein 0.0072 0.0189 0.0189
Trypanosoma brucei PH domain containing protein, putative 0.0072 0.0189 0.0189
Entamoeba histolytica protein kinase, putative 0.0084 0.0264 0.0257
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0072 0.0189 0.0189
Echinococcus multilocularis serine:threonine protein kinase N2 0.054 0.3106 0.4628
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0177 0.0264
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0072 0.0189 0.0281
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.061 0.3385
Brugia malayi Protein kinase domain containing protein 0.054 0.3106 0.3106
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0072 0.0189 0.0169
Leishmania major protein kinase, putative 0.0084 0.0264 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0677 0.3957 0.6242
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0084 0.0125
Schistosoma mansoni hypothetical protein 0.0072 0.0189 0.0281
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0072 0.0189 0.2856
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.257 0.383
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0264 0.0257
Onchocerca volvulus 0.0072 0.0189 0.2856
Echinococcus granulosus neuropeptide s receptor 0.0454 0.257 0.383
Entamoeba histolytica hypothetical protein 0.0072 0.0189 0.0182
Brugia malayi hypothetical protein 0.0148 0.0661 0.0661
Echinococcus multilocularis protein kinase c iota type 0.054 0.3106 0.4628
Brugia malayi TBC domain containing protein 0.0072 0.0189 0.0189
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0072 0.0189 0.0189
Loa Loa (eye worm) PH domain-containing protein 0.0072 0.0189 0.0189
Echinococcus granulosus cytohesin 1 0.0072 0.0189 0.0281
Echinococcus multilocularis muscleblind protein 1 0.0174 0.0823 0.1226
Plasmodium vivax PH domain containing protein 0.0072 0.0189 0.0301
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0084 0.0467
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0124 0.0185
Echinococcus multilocularis Pleckstrin y 0.0072 0.0189 0.0281
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0264 0.0257
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.054 0.3106 0.3106
Trypanosoma cruzi hypothetical protein 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.1648 1 1
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0084 0.0264 0.0393
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0084 0.0264 0.0276
Brugia malayi Variant SH3 domain containing protein 0.0072 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0072 0.0189 0.0281
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0177 0.0984
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0072 0.0189 0.0189
Echinococcus granulosus pdz domain containing protein 0.0072 0.0189 0.0281
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Echinococcus multilocularis oxysterol binding protein 1 0.0072 0.0189 0.0281
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.054 0.3106 0.3106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Brugia malayi probable spectrin beta chain 0.0072 0.0189 0.0189
Echinococcus granulosus Protein kinase C brain isozyme 0.054 0.3106 0.4628
Echinococcus granulosus serine:threonine protein kinase N2 0.054 0.3106 0.4628
Trichomonas vaginalis AGC family protein kinase 0.1648 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Echinococcus multilocularis Ras associated and pleckstrin y 0.0072 0.0189 0.0281
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0072 0.0189 0.0281
Toxoplasma gondii AGC kinase 0.1576 0.9553 1
Echinococcus multilocularis myotubularin protein 13 0.0072 0.0189 0.0281
Echinococcus granulosus oxysterol binding protein 3 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Echinococcus granulosus tumor protein p63 0.0356 0.1958 0.2917
Schistosoma mansoni serine/threonine-protein kinase 0.112 0.6711 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0124 0.0185
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0165 0.0772 0.115
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Toxoplasma gondii hypothetical protein 0.0072 0.0189 0.0198
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0072 0.0189 0.0281
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0189 0.0301
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.054 0.3106 0.4628
Schistosoma mansoni goodpasture antigen-binding protein 0.0072 0.0189 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0124 0.0124
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1036 0.6189 0.9222
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Echinococcus granulosus serine threonine protein kinase nrc 0.1048 0.6264 0.9334
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0007 0.5
Plasmodium falciparum PH domain-containing protein, putative 0.0072 0.0189 0.0169
Onchocerca volvulus Putative zinc finger protein 0.0072 0.0189 0.2856
Trypanosoma cruzi PH domain containing protein, putative 0.0072 0.0189 0.0281
Echinococcus granulosus Rho GTPase activating protein 24 0.0072 0.0189 0.0281
Brugia malayi Pleckstrin Homology Domain 0.0072 0.0189 0.0189
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0072 0.0189 0.0189
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0072 0.0189 0.0182
Trichomonas vaginalis centaurin gamma, putative 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Echinococcus multilocularis pdz domain containing protein 0.0072 0.0189 0.0281
Schistosoma mansoni myotubularin-related protein 0.0072 0.0189 0.0281
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0084 0.0264 0.0264
Entamoeba histolytica protein kinase, putative 0.0084 0.0264 0.0257
Echinococcus multilocularis DCC interacting protein 13 beta 0.0072 0.0189 0.0281
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0066 0.0099
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Treponema pallidum fructose-bisphosphate aldolase 0.0677 0.3957 0.5
Entamoeba histolytica ARF GTPase activating protein, putative 0.0072 0.0189 0.0182
Brugia malayi Hr1 repeat family protein 0.054 0.3106 0.3106
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0072 0.0189 0.0169
Echinococcus multilocularis protein kinase c epsilon type 0.054 0.3106 0.4628
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Echinococcus multilocularis rac serine:threonine kinase 0.112 0.6711 1
Brugia malayi hypothetical protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0072 0.0189 0.0281
Echinococcus granulosus dynamin 1 0.0072 0.0189 0.0281
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Trypanosoma cruzi hypothetical protein 0.0072 0.0189 0.0281
Brugia malayi Uncoordinated protein 104 0.0072 0.0189 0.0189
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.0124 0.0185
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0084 0.0125
Echinococcus multilocularis actin binding protein anillin 0.0072 0.0189 0.0281
Echinococcus multilocularis serine:threonine protein kinase N2 0.054 0.3106 0.4628
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0073 0.0109
Entamoeba histolytica protein kinase, putative 0.1648 1 1
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0072 0.0189 0.2856
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.054 0.3106 0.4628
Echinococcus multilocularis calcium dependent secretion activator 1 0.0072 0.0189 0.0281
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Trypanosoma brucei protein kinase, putative 0.0061 0.0124 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0073 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0523 0.2902
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0072 0.0189 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0124 0.0185
Brugia malayi Syntrophin-1 0.0072 0.0189 0.0189
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0331 0.1801 1
Entamoeba histolytica hypothetical protein 0.0084 0.0264 0.0257
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0072 0.0189 0.0281
Trichomonas vaginalis alpha chimerin, putative 0.0072 0.0189 0.0189
Echinococcus granulosus serine/threonine protein kinase 0.112 0.6711 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0072 0.0189 0.0281
Echinococcus multilocularis muscleblind protein 0.0174 0.0823 0.1226
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0072 0.0189 0.0281
Trypanosoma brucei rac serine-threonine kinase, putative 0.1648 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Entamoeba histolytica PH domain containing protein kinase, putative 0.112 0.6711 0.6709
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0084 0.0264 0.0264
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0072 0.0189 0.0281
Entamoeba histolytica PH domain containing protein 0.0072 0.0189 0.0182
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0084 0.0125
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.0124 0.0185
Echinococcus multilocularis oxysterol binding protein 3 0.0072 0.0189 0.0281
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.1048 0.6264 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0523 0.2902
Brugia malayi Thioredoxin reductase 0.0055 0.0084 0.0084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0177 0.0984
Echinococcus granulosus geminin 0.0165 0.0772 0.115
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0331 0.1801 1
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0007 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0072 0.0189 0.0281
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Onchocerca volvulus 0.0072 0.0189 0.2856
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0084 0.0264 0.0393
Toxoplasma gondii AtPH1 family protein 0.0072 0.0189 0.0198
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0124 0.0124
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0177 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0177 0.0984
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.1391 0.7722
Echinococcus granulosus Oxysterol binding protein 11 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.054 0.3106 0.3106
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Brugia malayi Cadps2 protein 0.0072 0.0189 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.054 0.3106 0.4628
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0007 0.0011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0523 0.2902
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0084 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0073 0.0109
Entamoeba histolytica protein kinase 2, putative 0.1048 0.6264 0.6262
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0084 0.0264 0.0393
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0072 0.0189 0.0281
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0124 0.0185
Trypanosoma cruzi NIMA-related kinase, putative 0.0084 0.0264 0.0393
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0007 0.0011
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1036 0.6189 0.9222
Trypanosoma brucei trypanothione reductase 0.0055 0.0084 0.0084
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0084 0.0264 0.0393
Loa Loa (eye worm) hypothetical protein 0.0174 0.0823 0.0823
Leishmania major folate/biopterin transporter, putative 0.0084 0.0264 1
Entamoeba histolytica hypothetical protein, conserved 0.0072 0.0189 0.0182
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0084 0.0264 1
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0084 0.0264 0.0393
Schistosoma mansoni dynamin 0.0072 0.0189 0.0281
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0523 0.2902
Entamoeba histolytica protein kinase, putative 0.1648 1 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0084 0.0264 0.0393
Echinococcus granulosus protein kinase c epsilon type 0.054 0.3106 0.4628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0073 0.0109
Leishmania major serine/threonine-protein kinase a, putative 0.0084 0.0264 1
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0084 0.0264 0.0393
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Onchocerca volvulus 0.0052 0.0066 0.1003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0177 0.0264
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.054 0.3106 0.4628
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0124 0.0124
Entamoeba histolytica hypothetical protein 0.0072 0.0189 0.0182
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0072 0.0189 0.0281
Trypanosoma cruzi PH domain containing protein, putative 0.0072 0.0189 0.0281
Schistosoma mansoni serine/threonine protein kinase 0.054 0.3106 0.4628
Brugia malayi PH domain containing protein 0.0072 0.0189 0.0189
Trichomonas vaginalis centaurin beta, putative 0.0072 0.0189 0.0189
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0331 0.1801 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0072 0.0189 0.0301
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Echinococcus granulosus nervana 2 0.1036 0.6189 0.9222
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.061 0.3385
Echinococcus multilocularis nervana 2 0.1036 0.6189 0.9222
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0523 0.2902
Onchocerca volvulus 0.0148 0.0661 1
Trypanosoma cruzi hypothetical protein 0.0072 0.0189 0.0281
Giardia lamblia Kinase, AGC PKA 0.1048 0.6264 1
Toxoplasma gondii hypothetical protein 0.0072 0.0189 0.0198
Loa Loa (eye worm) AGC/PKN protein kinase 0.054 0.3106 0.3106
Echinococcus multilocularis oxysterol binding protein 9 0.0072 0.0189 0.0281
Schistosoma mansoni serine/threonine protein kinase 0.054 0.3106 0.4628
Loa Loa (eye worm) AGC/NDR protein kinase 0.054 0.3106 0.3106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.061 0.3385
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0072 0.0189 0.0281
Echinococcus granulosus oxysterol binding protein 1 0.0072 0.0189 0.0281
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.0124 0.4705
Trichomonas vaginalis centaurin/arf, putative 0.0072 0.0189 0.0189
Schistosoma mansoni dynamin 0.0072 0.0189 0.0281
Echinococcus granulosus NDR protein kinase 0.054 0.3106 0.4628
Schistosoma mansoni serine/threonine protein kinase 0.054 0.3106 0.4628
Loa Loa (eye worm) hypothetical protein 0.0174 0.0823 0.0823
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Brugia malayi MAP kinase sur-1 0.0061 0.0124 0.0124
Loa Loa (eye worm) oxysterol binding protein 0.0072 0.0189 0.0189
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.1048 0.6264 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0124 0.0185
Trichomonas vaginalis AGC family protein kinase 0.1648 1 1
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Echinococcus multilocularis Oxysterol binding protein 11 0.0072 0.0189 0.0281
Brugia malayi protein kinase C II. 0.054 0.3106 0.3106
Entamoeba histolytica PH domain containing protein 0.0072 0.0189 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0073 0.0109
Schistosoma mansoni serine/threonine-protein kinase 0.112 0.6711 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Schistosoma mansoni inositol monophosphatase 0.0043 0.0007 0.0011
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0264 0.0257
Echinococcus granulosus Pleckstrin y 0.0072 0.0189 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Echinococcus multilocularis Pleckstrin y 0.0072 0.0189 0.0281
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.054 0.3106 0.3106
Loa Loa (eye worm) AGC/AKT protein kinase 0.1648 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0084 0.0264 0.0264
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0264 0.0257
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0084 0.0264 0.0393
Brugia malayi Dynamin 0.0072 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0072 0.0189 0.0182
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.1576 0.9553 0.9553
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0072 0.0189 0.0301
Echinococcus granulosus Glutaredoxin protein 5 0.1036 0.6189 0.9222
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0007 0.004
Echinococcus granulosus pleckstrin y domain containing family A 0.0072 0.0189 0.0281
Onchocerca volvulus 0.0072 0.0189 0.2856
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.054 0.3106 0.3106
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0072 0.0189 0.0281
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0072 0.0189 0.0189
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0072 0.0189 0.0189
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0934 0.5554 0.8276
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0073 0.0073
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0072 0.0189 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) syntrophin-1 0.0072 0.0189 0.0189
Schistosoma mansoni growth factor receptor-bound protein 0.0072 0.0189 0.0281
Brugia malayi Inositol-1 0.0043 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.054 0.3106 0.4628
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.257 0.383
Schistosoma mansoni centaurin alpha 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.054 0.3106 0.4628
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Echinococcus granulosus GRB2 associated binding protein 3 0.0072 0.0189 0.0281
Leishmania major protein kinase, putative 0.0084 0.0264 1
Loa Loa (eye worm) glutathione reductase 0.0055 0.0084 0.0084
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0007 0.0011
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0124 0.0185
Trypanosoma cruzi NIMA-related kinase, putative 0.0084 0.0264 0.0393
Schistosoma mansoni oxysterol-binding protein 1 0.0072 0.0189 0.0281
Echinococcus granulosus protein kinase C gamma type 0.054 0.3106 0.4628
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0072 0.0189 0.0182
Plasmodium vivax glutathione reductase, putative 0.0055 0.0084 0.0134
Echinococcus multilocularis cytohesin 1 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0072 0.0189 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Entamoeba histolytica hypothetical protein 0.0072 0.0189 0.0182
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0072 0.0189 0.0189
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.061 0.3385
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.1048 0.6264 0.9334
Schistosoma mansoni oxysterol-binding protein 1 0.0072 0.0189 0.0281
Brugia malayi Dynamin 0.0072 0.0189 0.0189
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0177 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Echinococcus multilocularis microtubule associated protein 2 0.0796 0.4699 0.7002
Entamoeba histolytica PH domain containing protein 0.0072 0.0189 0.0182
Echinococcus multilocularis serine threonine protein kinase 0.054 0.3106 0.4628
Echinococcus multilocularis serine:threonine protein kinase 38 0.054 0.3106 0.4628
Loa Loa (eye worm) Plekhf2 protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.054 0.3106 0.3106
Onchocerca volvulus 0.0072 0.0189 0.2856
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0072 0.0189 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.054 0.3106 0.4628
Brugia malayi Variant SH3 domain containing protein 0.0072 0.0189 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Trichomonas vaginalis AGC family protein kinase 0.1648 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Echinococcus granulosus calcium dependent secretion activator 1 0.0072 0.0189 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Schistosoma mansoni inositol monophosphatase 0.0043 0.0007 0.0011
Entamoeba histolytica hypothetical protein 0.0072 0.0189 0.0182
Brugia malayi Cytohesin 3 0.0072 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.054 0.3106 0.3106
Echinococcus granulosus protein kinase c iota type 0.054 0.3106 0.4628
Trichomonas vaginalis AGC family protein kinase 0.1648 1 1
Toxoplasma gondii protein kinase domain-containing protein 0.0084 0.0264 0.0276
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Schistosoma mansoni zinc finger protein 0.0072 0.0189 0.0281
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.054 0.3106 0.4628
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0072 0.0189 0.0182
Onchocerca volvulus 0.0072 0.0189 0.2856
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1048 0.6264 0.9334
Plasmodium falciparum oxysterol-binding protein, putative 0.0072 0.0189 0.0169
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Trypanosoma cruzi hypothetical protein 0.0072 0.0189 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0189 0.0189
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.0124 0.013
Loa Loa (eye worm) cytohesin 3 0.0072 0.0189 0.0189
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0072 0.0189 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Schistosoma mansoni hypothetical protein 0.0165 0.0772 0.115
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0072 0.0189 0.0189
Onchocerca volvulus 0.0072 0.0189 0.2856
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0677 0.3957 0.3952
Entamoeba histolytica hypothetical protein 0.0084 0.0264 0.0257
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0124 0.0124
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0084 0.0264 0.0421
Schistosoma mansoni atypical protein kinase C 0.054 0.3106 0.4628
Brugia malayi p70 ribosomal S6 kinase beta 0.1576 0.9553 0.9553
Loa Loa (eye worm) hypothetical protein 0.0072 0.0189 0.0189
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0072 0.0189 0.0182
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0084 0.0264 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0073 0.0109
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0072 0.0189 0.0169
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0072 0.0189 0.0281
Entamoeba histolytica protein kinase, putative 0.054 0.3106 0.3101
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0177 0.0984
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0072 0.0189 0.0281
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0072 0.0189 0.0182
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0264 0.0264
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0072 0.0189 0.0281
Echinococcus granulosus beta 1 syntrophin 0.0072 0.0189 0.0281
Trypanosoma cruzi rac serine-threonine kinase, putative 0.112 0.6711 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0073 0.0073
Trichomonas vaginalis AGC family protein kinase 0.1648 1 1
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0072 0.0189 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0073 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0677 0.3957 0.3957
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0007 0.0275
Toxoplasma gondii thioredoxin reductase 0.0055 0.0084 0.0088
Trichomonas vaginalis kinesin light chain, putative 0.0072 0.0189 0.0189
Entamoeba histolytica protein kinase, putative 0.0084 0.0264 0.0257
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0072 0.0189 0.0189
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0677 0.3957 0.3952
Entamoeba histolytica protein kinase, putative 0.0084 0.0264 0.0257
Echinococcus multilocularis beta 1 syntrophin 0.0072 0.0189 0.0281
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0072 0.0189 0.0189

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 19 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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