Detailed information for compound 1045263

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.275 | Formula: C17H22Cl2N2O
  • H donors: 1 H acceptors: 1 LogP: 5.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC(NCc1coc(n1)c1ccc(cc1Cl)Cl)C
  • InChi: 1S/C17H22Cl2N2O/c1-3-4-5-6-12(2)20-10-14-11-22-17(21-14)15-8-7-13(18)9-16(15)19/h7-9,11-12,20H,3-6,10H2,1-2H3
  • InChiKey: SBNSYUQDVQZGKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0422 0.3982
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0247 0.0347
Brugia malayi isocitrate dehydrogenase 0.0017 0.0023 0.0074
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0039 0.1455
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0243 1
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0606 0.7101 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0023 0.0843
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0023 0.0032
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0399 0.0498
Echinococcus granulosus pyruvate kinase 0.0018 0.0039 0.0049
Loa Loa (eye worm) hypothetical protein 0.0103 0.106 0.3458
Echinococcus multilocularis pyruvate kinase 0.0035 0.0243 0.0243
Brugia malayi hypothetical protein 0.0038 0.0276 0.0901
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1076 0.3509
Brugia malayi intermediate filament protein 0.0028 0.0158 0.0516
Schistosoma mansoni patched 1 0.0044 0.0355 0.0443
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0271 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.106 0.106
Schistosoma mansoni hypothetical protein 0.0043 0.0336 0.0419
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0422 0.3982
Schistosoma mansoni pyruvate kinase 0.0035 0.0243 0.0304
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0243 0.0793
Echinococcus granulosus pyruvate kinase 0.0035 0.0243 0.0304
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.1091 0.1091
Entamoeba histolytica hypothetical protein 0.0038 0.0276 0.2604
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2065 0.6738
Echinococcus granulosus lamin 0.0028 0.0158 0.0197
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0422 0.3982
Brugia malayi Melibiase family protein 0.007 0.0669 0.2183
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.022 0.0275
Leishmania major pyruvate kinase 0.0035 0.0243 0.4102
Brugia malayi Latrophilin receptor protein 2 0.0033 0.022 0.0719
Echinococcus multilocularis protein dispatched 1 0.005 0.043 0.043
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0355 0.1157
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1951 0.6365
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0355 0.0443
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0593 0.0835
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.159 0.1987
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0606 0.7101 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0271 1
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0422 0.7119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1076 0.3509
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0669 0.2183
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.159 0.159
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0039 0.0056
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0276 0.0345
Brugia malayi AMP-binding enzyme family protein 0.005 0.0422 0.1377
Loa Loa (eye worm) hypothetical protein 0.0033 0.022 0.0719
Toxoplasma gondii melibiase subfamily protein 0.0105 0.1091 0.1536
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0884
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1951 0.6365
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.1091 0.1364
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.022 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0422 0.0594
Echinococcus granulosus intermediate filament protein 0.0028 0.0158 0.0197
Brugia malayi AMP-binding enzyme family protein 0.005 0.0422 0.1377
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1079 0.1349
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.0023
Echinococcus multilocularis lamin 0.0028 0.0158 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0247 0.0347
Giardia lamblia Pyruvate kinase 0.0035 0.0243 1
Schistosoma mansoni lamin 0.0028 0.0158 0.0197
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.3065 1
Echinococcus multilocularis lamin dm0 0.0028 0.0158 0.0158
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0243 0.1246
Brugia malayi AMP-binding enzyme family protein 0.005 0.0422 0.1377
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0422 0.0594
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0606 0.7101 1
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.106 0.1325
Plasmodium falciparum pyruvate kinase 0.0035 0.0243 0.8973
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0422 0.0594
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0496
Schistosoma mansoni hypothetical protein 0.0071 0.068 0.085
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0593 0.0741
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.0023
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0593 0.0835
Schistosoma mansoni pyruvate kinase 0.0035 0.0243 0.0304
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0243 0.0342
Onchocerca volvulus 0.0028 0.0158 0.081
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.3065 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1076 0.3509
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0243 1
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0271 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0399 0.0498
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0593 0.0835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0399 0.0498
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0669 0.0836
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.022 0.0275
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.1951 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0158 0.0516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0399 0.0498
Loa Loa (eye worm) hypothetical protein 0.005 0.0422 0.1377
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0247 0.0347
Loa Loa (eye worm) hypothetical protein 0.0054 0.0474 0.1546
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0884
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.1091 0.1364
Loa Loa (eye worm) hypothetical protein 0.0044 0.0355 0.1157
Onchocerca volvulus 0.005 0.0422 0.2163
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0271 0.0382
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.068 0.2218
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.106 0.3458
Entamoeba histolytica hypothetical protein 0.0038 0.0276 0.2604
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0023 0.0939
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0422 0.0594
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.3065 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0158 0.0516
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0023 0.0032
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0243 1
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0243 0.0342
Loa Loa (eye worm) hypothetical protein 0.0071 0.068 0.2218
Schistosoma mansoni hypothetical protein 0.0043 0.0336 0.0419
Loa Loa (eye worm) hypothetical protein 0.007 0.0669 0.2183
Entamoeba histolytica hypothetical protein 0.0038 0.0276 0.2604
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.8001 0.8001
Echinococcus multilocularis pyruvate kinase 0.0027 0.0155 0.0155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0399 0.0399
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0023 0.0939
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0884
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0243 0.0793
Echinococcus granulosus microtubule associated protein 2 0.0681 0.8001 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.022 0.0719
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0399 0.13
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0004 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0276 0.0345
Brugia malayi CHE-14 protein 0.0044 0.0355 0.1157
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1951 0.6365
Echinococcus granulosus pyruvate kinase 0.0018 0.0039 0.0049
Schistosoma mansoni lamin 0.0028 0.0158 0.0197
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0884
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0243 0.0793
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0593 0.0741
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0271 0.0382
Onchocerca volvulus 0.0028 0.0158 0.081
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0023 0.0939
Loa Loa (eye worm) hypothetical protein 0.005 0.0422 0.1377
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0593 0.0835
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0422 0.1377
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.3509
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.3065 1
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.3065 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.1091 0.1364
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1951 0.6365
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0158 0.0516
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0243 0.1246
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.106 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0355 0.1157
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.3065 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0117 0.038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0117 0.038
Echinococcus granulosus pyruvate kinase 0.0018 0.0039 0.0049
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0023 0.0385
Echinococcus multilocularis pyruvate kinase 0.0018 0.0039 0.0039
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0243 0.0793
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0023 0.0939
Echinococcus multilocularis GPCR, family 2 0.0033 0.022 0.022
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0593 0.0741
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0023 0.0074
Schistosoma mansoni hypothetical protein 0.0033 0.022 0.0275
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0399 0.13
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0004 0.0005
Echinococcus granulosus pyruvate kinase 0.0035 0.0243 0.0304
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0793
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1951 0.6365
Echinococcus multilocularis pyruvate kinase 0.0018 0.0039 0.0039
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0355 0.0355
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0023 0.0029
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0243 0.8973
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0039 0.1455
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0422 0.7119
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0243 0.0793
Schistosoma mansoni hypothetical protein 0.0033 0.022 0.0275
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1951 0.6365
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0422 0.7119
Echinococcus granulosus lamin dm0 0.0028 0.0158 0.0197
Echinococcus multilocularis protein patched 0.0044 0.0355 0.0355
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0593 0.0835
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.8001 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0422 0.0594
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0276 0.0276
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0355 0.0443
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0422 0.0594
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0158 0.0516
Leishmania major pyruvate kinase 0.0035 0.0243 0.4102
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0243 0.0793
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0243 0.0342
Echinococcus granulosus GPCR family 2 0.0033 0.022 0.0275
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1951 0.6365
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0593 0.0593
Mycobacterium ulcerans hypothetical protein 0.005 0.0422 0.0594
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2065 0.6738
Echinococcus multilocularis pyruvate kinase 0.0018 0.0039 0.0039
Schistosoma mansoni intermediate filament proteins 0.0028 0.0158 0.0197
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0422 0.0594
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0023 0.0843
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0023 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.3065 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0243 0.0342
Echinococcus multilocularis musashi 0.0028 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0884
Echinococcus multilocularis expressed conserved protein 0.0097 0.0985 0.0985
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0422 0.0594
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0422 0.0594
Schistosoma mansoni hypothetical protein 0.0043 0.0336 0.0419
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0399 0.0399
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.1091 0.1364
Entamoeba histolytica hypothetical protein 0.0038 0.0276 0.2604
Schistosoma mansoni hypothetical protein 0.0038 0.0276 0.0345
Echinococcus granulosus expressed conserved protein 0.0097 0.0985 0.1231
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0023 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0023 0.0023
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0422 0.0594
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0669 0.0836
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.3065 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0023 0.0023
Schistosoma mansoni pyruvate kinase 0.0018 0.0039 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.022 0.022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0003 0.001
Schistosoma mansoni hypothetical protein 0.0043 0.0336 0.0419
Schistosoma mansoni hypothetical protein 0.0033 0.022 0.0275
Toxoplasma gondii pantoate-beta-alanine ligase 0.0606 0.7101 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.0023
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0117 0.1099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.022 0.0719
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0399 0.0498
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0247 0.0347
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.1091 0.1364
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0422 0.0594
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0243 0.0793
Echinococcus multilocularis pyruvate kinase 0.0035 0.0243 0.0243
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0593 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.1091 0.1091
Schistosoma mansoni hypothetical protein 0.0033 0.022 0.0275
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0243 0.1246

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.9 ug/ml DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro ChEMBL. No reference
IC50 = 3.47 ug/ml DNDI: Cytotoxicity against L929 mouse fibroblasts, 72 hour. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23
Trypanosoma brucei ChEMBL23
Trypanosoma brucei gambiense

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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