Detailed information for compound 104602

Basic information

Technical information
  • TDR Targets ID: 104602
  • Name: (4-bromophenyl)-[4-[(E)-4-[cyclopropyl(methyl )amino]but-2-enoxy]phenyl]methanone
  • MW: 400.309 | Formula: C21H22BrNO2
  • H donors: 0 H acceptors: 1 LogP: 4.83 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C1CC1)C/C=C/COc1ccc(cc1)C(=O)c1ccc(cc1)Br
  • InChi: 1S/C21H22BrNO2/c1-23(19-10-11-19)14-2-3-15-25-20-12-6-17(7-13-20)21(24)16-4-8-18(22)9-5-16/h2-9,12-13,19H,10-11,14-15H2,1H3/b3-2+
  • InChiKey: JAZMZJDLZUDIDG-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-bromophenyl)-[4-[(E)-4-(cyclopropyl-methylamino)but-2-enoxy]phenyl]methanone
  • (4-bromophenyl)-[4-[(E)-4-(cyclopropyl-methyl-amino)but-2-enoxy]phenyl]methanone
  • (4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE
  • R88

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillu Squalene-hopene cyclase Starlite/ChEMBL References
Homo sapiens lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma brucei lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania mexicana lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania donovani lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania braziliensis lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania major lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Candida albicans 2,3-oxidosqualene-lanosterol cyclase Get druggable targets OG5_127966 All targets in OG5_127966
Candida albicans 2,3-oxidosqualene-lanosterol cyclase Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma brucei gambiense lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma cruzi lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania infantum lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma cruzi lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear factor of activated T cells 5 0.0362 0.4098 0.4098
Entamoeba histolytica hypothetical protein 0.0042 0.0258 0.0261
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0097 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0676 0.7867 0.7997
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0214 0.2322 0.236
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0143 0.0143
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0034 0.0161 0.0163
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Plasmodium vivax proteasome subunit beta type-3, putative 0.0186 0.1982 0.2014
Brugia malayi Uncoordinated protein 44 0.0037 0.0197 0.0197
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0186 0.1982 0.2013
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.084 0.9838 0.9838
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0186 0.1982 0.1982
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0214 0.2322 0.2361
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0021 0.0009 0.0007
Giardia lamblia 20S proteasome alpha subunit 7 0.0193 0.2073 0.2106
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.018 0.1914 0.1945
Toxoplasma gondii proteasome 26S regulatory subunit 0.0021 0.0009 0.0009
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.004 0.0229 0.0229
Brugia malayi Proteasome subunit alpha type 1 0.0174 0.1846 0.1846
Entamoeba histolytica hypothetical protein 0.0042 0.0258 0.0261
Onchocerca volvulus 0.0039 0.0219 0.1054
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0037 0.0197 0.0197
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0108 0.0109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0143 0.0143
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0203 0.2194 0.2229
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0045 0.0288 0.0288
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0031 0.0127 0.0127
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Schistosoma mansoni hypothetical protein 0.0198 0.2133 0.2133
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0034 0.0159 0.0162
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0065 0.0533 0.0533
Giardia lamblia 20S proteasome alpha subunit 5 0.0203 0.2194 0.2229
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.003 0.0108 0.0109
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0143 0.0143
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0186 0.1982 0.2014
Trypanosoma brucei proteasome subunit beta type-5, putative 0.084 0.9838 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0222
Brugia malayi proteasome subunit beta type 2 0.0186 0.1982 0.1982
Brugia malayi 26S protease regulatory subunit 6A 0.0022 0.0016 0.0016
Echinococcus granulosus glycoprotein Antigen 5 0.0039 0.0219 0.0219
Toxoplasma gondii proteasome subunit beta type, putative 0.084 0.9838 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0214 0.2322 0.2361
Toxoplasma gondii SAC3/GANP family protein 0.003 0.0108 0.011
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0242 0.2663 0.2706
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0125 0.0127
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0031 0.0125 0.0126
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0197 0.2115 0.215
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0022 0.0016 0.0015
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0127 0.0129
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0016 0.0017
Giardia lamblia 20S proteasome alpha subunit 6 0.0191 0.2047 0.208
Mycobacterium leprae proteasome (beta subunit) PrcB 0.084 0.9838 1
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.009 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0245 0.2696 0.274
Trypanosoma brucei proteasome beta 6 subunit 0.0214 0.2322 0.236
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.003 0.0108 0.0108
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0022 0.0016 0.0017
Brugia malayi Trypsin family protein 0.0039 0.0219 0.0219
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0186 0.1982 0.2013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0143 0.0143
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0021 0.0001 0.0001
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0204 0.2206 0.2241
Schistosoma mansoni carbonic anhydrase-related 0.0065 0.0533 0.0533
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0021 0.0001 0.0001
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0184 0.1961 0.1992
Schistosoma mansoni hypothetical protein 0.0042 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0222
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0184 0.1961 0.1993
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0191 0.2047 0.2047
Loa Loa (eye worm) hypothetical protein 0.0221 0.2408 0.2447
Schistosoma mansoni proteasome regulatory subunit-related 0.0034 0.0161 0.0161
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0184 0.1961 0.1992
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.004 0.0236 0.0236
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0045 0.0288 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0143 0.0145
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0016 0.0016
Brugia malayi Probable 26S protease regulatory subunit 4 0.0021 0.0001 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0143 0.0143
Schistosoma mansoni coup transcription factor 0.0033 0.0143 0.0143
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.004 0.0229 0.0231
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0108 0.0108
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0315 0.3532 0.2296
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0242 0.2663 0.2707
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0204 0.2206 0.2241
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0175 0.1854 0.1884
Toxoplasma gondii hypothetical protein 0.0027 0.0081 0.0082
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0037 0.0199 0.0199
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.003 0.0108 0.011
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0021 0.0001 0.0001
Giardia lamblia Proteasome subunit beta type 5 precursor 0.084 0.9838 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0186 0.1982 0.2014
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0158 0.1653 0.1653
Leishmania major proteasome beta 3 subunit, putative 0.0186 0.1982 0.2014
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0186 0.1982 0.2013
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0197 0.2115 0.215
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0143 0.0143
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0192 0.2053 0.2087
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0186 0.1982 0.2013
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0108 0.0109
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0222
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.084 0.9838 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0203 0.2194 0.2194
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0143 0.0143
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0191 0.2047 0.2081
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0022 0.0016 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0143 0.0143
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.084 0.9838 1
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0127 0.0129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0143 0.0143
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0192 0.2059 0.2091
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0204 0.2206 0.2242
Leishmania major lanosterol synthase, putative 0.0474 0.5438 0.5527
Echinococcus granulosus adhesion regulating molecule 1 0.0097 0.0921 0.0921
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0143 0.0145
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.004 0.0236 0.0236
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0221 0.2408 0.2408
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0242 0.2663 0.2707
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0143 0.0689
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.004 0.0229 0.0229
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0001 0.0001
Echinococcus multilocularis enteropeptidase 0.0039 0.0219 0.0219
Echinococcus multilocularis proteasome subunit alpha type 6 0.0204 0.2206 0.2206
Brugia malayi small heat shock protein 0.0676 0.7867 0.7867
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0127 0.0128
Echinococcus granulosus proteasome prosome macropain 0.084 0.9838 0.9838
Toxoplasma gondii hypothetical protein 0.0065 0.0533 0.0542
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0016 0.0016
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0127 0.0129
Loa Loa (eye worm) PCI domain-containing protein 0.0034 0.0161 0.0163
Leishmania major proteasome beta 5 subunit, putative 0.084 0.9838 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0192 0.2053 0.2086
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.004 0.0236 0.0239
Plasmodium vivax proteasome subunit beta type-7, putative 0.0245 0.2696 0.2741
Onchocerca volvulus 0.0033 0.0143 0.0689
Brugia malayi steroid hormone receptor 0.0033 0.0143 0.0143
Entamoeba histolytica proteasome regulatory subunit, putative 0.004 0.0236 0.0239
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0159 0.0159
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0245 0.2696 0.274
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0159 0.0162
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0034 0.0159 0.0159
Onchocerca volvulus 0.0039 0.0219 0.1054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0143 0.0145
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0258 0.0258
Echinococcus granulosus netrin receptor unc 5 0.0037 0.0197 0.0197
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0143 0.0145
Giardia lamblia 26S protease regulatory subunit 6A 0.0022 0.0016 0.0015
Brugia malayi proteasome subunit alpha type 4 0.0175 0.1852 0.1852
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.084 0.9838 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0143 0.0143
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Brugia malayi nuclear receptor NHR-88 0.0033 0.0143 0.0143
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0045 0.0288 0.0288
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0192 0.2053 0.2053
Echinococcus granulosus death domain containing protein 0.0037 0.0197 0.0197
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0143 0.0143
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.003 0.0108 0.011
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.084 0.9838 1
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0193 0.2073 0.2108
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0186 0.1982 0.1982
Loa Loa (eye worm) hypothetical protein 0.0037 0.0197 0.02
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0192 0.2053 0.2086
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0203 0.2194 0.223
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0045 0.0288 0.0288
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0143 0.0143
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0031 0.0127 0.0127
Leishmania major proteasome beta-1 subunit, putative 0.0192 0.2059 0.2093
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0022 0.0016 0.0017
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0031 0.0127 0.0128
Echinococcus multilocularis carbonic anhydrase 0.0065 0.0533 0.0533
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.004 0.0236 0.024
Plasmodium vivax proteasome subunit beta type-1, putative 0.0214 0.2322 0.2361
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0127 0.0128
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0143 0.0143
Brugia malayi PCI domain containing protein 0.0031 0.0125 0.0125
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0192 0.2053 0.2086
Onchocerca volvulus 0.0021 0.0001 0.0007
Brugia malayi hypothetical protein 0.0042 0.0258 0.0258
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0037 0.0197 0.0197
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0016 0.0016
Schistosoma mansoni carbonic anhydrase 0.0065 0.0533 0.0533
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0022 0.0016 0.0015
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0184 0.1961 0.1993
Echinococcus granulosus Proteasome subunit alpha type 7 0.0242 0.2663 0.2663
Toxoplasma gondii proteasome subunit alpha1, putative 0.0204 0.2206 0.2242
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0245 0.2696 0.2741
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0175 0.1855 0.1855
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.084 0.9838 1
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0045 0.0288 0.0292
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0258 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0143 0.0143
Toxoplasma gondii peptidase, T1 family protein 0.0193 0.2073 0.2108
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0143 0.0143
Mycobacterium ulcerans proteasome PrcA 0.0158 0.1653 0.1492
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.004 0.0236 0.024
Brugia malayi Proteasome subunit alpha type 7-1 0.0242 0.2663 0.2663
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0222
Echinococcus granulosus carbonic anhydrase 0.0065 0.0533 0.0533
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0242 0.2663 0.2707
Leishmania major proteasome beta 2 subunit, putative 0.0245 0.2696 0.2741
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0192 0.2053 0.2086
Brugia malayi proteasome subunit alpha type 6 0.0204 0.2206 0.2206
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0221 0.2408 0.2408
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0184 0.1961 0.1961
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0186 0.1982 0.2014
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0203 0.2194 0.2194
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0186 0.1982 0.1982
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0034 0.0159 0.0162
Leishmania major proteasome alpha 7 subunit, putative 0.0242 0.2663 0.2707
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0031 0.0125 0.0126
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0031 0.0125 0.0125
Schistosoma mansoni ankyrin 23/unc44 0.0037 0.0197 0.0197
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0175 0.1855 0.1855
Toxoplasma gondii PCI domain-containing protein 0.0037 0.0202 0.0206
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0022 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0222
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0191 0.2047 0.208
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0186 0.1982 0.2013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0143 0.0143
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0022 0.0016 0.0016
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0187 0.1993 0.1993
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0045 0.0288 0.0292
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0222
Toxoplasma gondii proteasome subunit alpha type, putative 0.0192 0.2053 0.2087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Brugia malayi proteasome subunit alpha type 1 0.0191 0.2047 0.2047
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0021 0.0001 0.0001
Echinococcus granulosus proteasome subunit beta t family 0.0186 0.1982 0.1982
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0031 0.0127 0.0128
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0184 0.1961 0.1993
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0204 0.2206 0.2242
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0186 0.1982 0.1982
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0127 0.0129
Schistosoma mansoni hypothetical protein 0.0039 0.0219 0.0219
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0192 0.2053 0.2087
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.003 0.0115 0.0117
Brugia malayi proteasome subunit alpha type 3 0.0193 0.2073 0.2073
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0045 0.0288 0.0292
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0191 0.2047 0.2081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0143 0.0143
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.004 0.0236 0.024
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0127 0.0127
Trypanosoma cruzi lanosterol synthase, putative 0.0474 0.5438 0.5527
Loa Loa (eye worm) hypothetical protein 0.0065 0.0533 0.0542
Brugia malayi Trypsin family protein 0.0039 0.0219 0.0219
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.003 0.0108 0.011
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0193 0.2073 0.2108
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0197 0.2115 0.2115
Brugia malayi hypothetical protein 0.0039 0.0219 0.0219
Echinococcus granulosus Mastin 0.0039 0.0219 0.0219
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0242 0.2663 0.2706
Brugia malayi proteasome subunit alpha type 2 0.0197 0.2115 0.2115
Toxoplasma gondii proteasome subunit 0.0192 0.2059 0.2093
Trypanosoma brucei carbonic anhydrase-like protein 0.0175 0.1855 0.1885
Onchocerca volvulus 0.0039 0.0219 0.1054
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0001 0.0001
Brugia malayi Trypsin family protein 0.0039 0.0219 0.0219
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0158 0.1653 0.1679
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0125 0.0127
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0149 0.0149
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0037 0.0202 0.0206
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0034 0.0161 0.0163
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0065 0.0533 0.0533
Echinococcus multilocularis Ankyrin 0.0037 0.0199 0.0199
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0186 0.1982 0.2014
Giardia lamblia 20S proteasome alpha subunit 4 0.0242 0.2663 0.2706
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0023 0.0031 0.003
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0175 0.1855 0.1886
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0125 0.0127
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.004 0.0236 0.0236
Echinococcus granulosus proteasome subunit beta type 6 0.0192 0.2059 0.2059
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0034 0.0159 0.016
Echinococcus multilocularis adhesion regulating molecule 1 0.0097 0.0921 0.0921
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0037 0.0202 0.0204
Echinococcus granulosus proteasome subunit beta type 7 0.0854 1 1
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0031 0.0127 0.0127
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0191 0.2047 0.2081
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0037 0.0202 0.0202
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0034 0.0161 0.0161
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0108 0.011
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0022 0.0016 0.0016
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0016 0.0016
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0184 0.1961 0.1992
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0175 0.1855 0.1886
Echinococcus multilocularis carbonic anhydrase 0.0065 0.0533 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0143 0.0143
Brugia malayi ecdysteroid receptor 0.0033 0.0143 0.0143
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0045 0.0288 0.0291
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.004 0.0229 0.0233
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0021 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0143 0.0143
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.0016 0.0014
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.2073 0.2108
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.009 0.0834 0.0834
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0197 0.2115 0.2149
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0108 0.0109
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0191 0.2047 0.2047
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0143 0.0143
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0186 0.1982 0.1982
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0159 0.016
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0065 0.0533 0.0542
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0159 0.016
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0031 0.0127 0.0129
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0245 0.2696 0.2741
Toxoplasma gondii PCI domain-containing protein 0.004 0.0236 0.024
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0158 0.1653 0.5
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0034 0.0161 0.0162
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.004 0.0229 0.0233
Echinococcus multilocularis glycoprotein Antigen 5 0.0039 0.0219 0.0219
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0022 0.0016 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0143 0.0143
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0031 0.0127 0.0129
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0034 0.0161 0.0163
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0202 0.0206
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0214 0.2322 0.2322
Schistosoma mansoni multiubiquitin binding protein S5a 0.0022 0.0016 0.0016
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0031 0.0125 0.0127
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0192 0.2059 0.2093
Schistosoma mansoni hypothetical protein 0.0061 0.0479 0.0479
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0186 0.1982 0.2014
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0191 0.2047 0.208
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0021 0.0001 0.0001
Onchocerca volvulus 0.0021 0.0001 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0143 0.0143
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0203 0.2194 0.223
Plasmodium falciparum proteasome subunit beta type-4 0.0184 0.1961 0.1993
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0245 0.2696 0.274
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0037 0.0202 0.0202
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0191 0.2047 0.208
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0065 0.0533 0.0533
Brugia malayi Trypsin family protein 0.0039 0.0219 0.0219
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0203 0.2194 0.223
Loa Loa (eye worm) trypsin family protein 0.0039 0.0219 0.0222
Schistosoma mansoni hypothetical protein 0.0198 0.2133 0.2133
Schistosoma mansoni hypothetical protein 0.0065 0.0533 0.0533
Onchocerca volvulus 0.0039 0.0219 0.1054
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.004 0.0229 0.0229
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0016 0.0017
Schistosoma mansoni netrin receptor unc5 0.0037 0.0197 0.0197
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0037 0.0202 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0143 0.0143
Loa Loa (eye worm) proteasome subunit beta type 3 0.0186 0.1982 0.2014
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0016 0.0016
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0045 0.0288 0.0291
Plasmodium falciparum proteasome subunit beta type-5 0.084 0.9838 1
Schistosoma mansoni hypothetical protein 0.0031 0.0125 0.0125
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.2073 0.2108
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0191 0.2047 0.2047
Plasmodium falciparum carbonic anhydrase 0.0065 0.0533 0.0542
Onchocerca volvulus 0.0039 0.0219 0.1054
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0186 0.1982 0.2014
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0001 0.0001
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0184 0.1961 0.1993
Loa Loa (eye worm) hypothetical protein 0.003 0.0108 0.011
Entamoeba histolytica proteasome regulatory subunit, putative 0.0037 0.0202 0.0204
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0192 0.2053 0.2053
Echinococcus granulosus geminin 0.0198 0.2133 0.2133
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0159 0.0159
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0203 0.2194 0.2229
Echinococcus multilocularis proteasome subunit alpha type 2 0.0197 0.2115 0.2115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0039 0.0219 0.0219
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0022 0.0016 0.0017
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0197 0.2115 0.215
Leishmania major proteasome beta 2 subunit, putative 0.0186 0.1982 0.2014
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0022 0.0016 0.0017
Echinococcus multilocularis proteasome subunit beta type 6 0.0192 0.2059 0.2059
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0021 0.0001 0.0001
Brugia malayi nuclear hormone receptor 0.0033 0.0143 0.0143
Echinococcus multilocularis carbonic anhydrase 0.0065 0.0533 0.0533
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0193 0.2073 0.2106
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0204 0.2206 0.2206
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0127 0.0128
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0184 0.1961 0.1961
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0186 0.1982 0.2013
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.084 0.9838 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Toxoplasma gondii proteasome subunit alpha type, putative 0.0084 0.0762 0.0775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0143 0.0145
Brugia malayi Proteasome A-type and B-type family protein 0.084 0.9838 0.9838
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0143 0.0143
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0197 0.2115 0.215
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.004 0.0236 0.0236
Trypanosoma brucei proteasome alpha 7 subunit 0.0193 0.2073 0.2106
Onchocerca volvulus 0.0039 0.0219 0.1054
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0039 0.0219 0.0219
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0021 0.0001 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0143 0.0143
Trypanosoma brucei lanosterol synthase 0.0474 0.5438 0.5527
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0184 0.1961 0.1993
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0037 0.0202 0.0202
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0192 0.2059 0.2093
Toxoplasma gondii proteasome beta subunit 0.0186 0.1982 0.2014
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.003 0.0108 0.0108
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0245 0.2696 0.274
Entamoeba histolytica proteasome regulatory subunit, putative 0.0022 0.0016 0.0014
Echinococcus granulosus transmembrane protease serine 3 0.0039 0.0219 0.0219
Brugia malayi Proteasome A-type and B-type family protein 0.0184 0.1961 0.1961
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0214 0.2322 0.2361
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0191 0.2047 0.2081
Brugia malayi Trypsin-like protease protein 5 0.0039 0.0219 0.0219
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0184 0.1961 0.1993
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0192 0.2053 0.2053
Toxoplasma gondii heat shock protein hslv, putative 0.0158 0.1653 0.1681
Leishmania major carbonic anhydrase-like protein 0.0175 0.1855 0.1886
Entamoeba histolytica hypothetical protein 0.004 0.0229 0.0231
Trypanosoma cruzi lanosterol synthase, putative 0.0474 0.5438 0.5527
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0034 0.0159 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0143 0.0145
Loa Loa (eye worm) hypothetical protein 0.0037 0.0199 0.0202
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0197 0.2115 0.2149
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0065 0.0533 0.0533
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0143 0.0143
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0186 0.1982 0.1982
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0184 0.1961 0.1993
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0193 0.2073 0.2106
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0242 0.2663 0.2706
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0214 0.2322 0.2322
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0242 0.2663 0.2663
Loa Loa (eye worm) RPN-3 protein 0.004 0.0236 0.024
Brugia malayi proteasome subunit beta type 1 0.0214 0.2322 0.2322
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0159 0.0162
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0186 0.1982 0.1982
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0184 0.1961 0.1961
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0045 0.0288 0.0291
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0362 0.4098 0.4098
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0161 0.0162
Echinococcus granulosus carbonic anhydrase 0.0065 0.0533 0.0533
Plasmodium vivax proteasome subunit beta type-4, putative 0.0184 0.1961 0.1993
Leishmania major proteasome alpha 1 subunit, putative 0.0191 0.2047 0.2081
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0203 0.2194 0.2194
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0033 0.0149 0.015
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0021 0.0001 0.0001
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0031 0.0127 0.0127
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0127 0.0129
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0143 0.0143
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0037 0.0197 0.0197
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0192 0.2059 0.2093
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0184 0.1961 0.1993
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0242 0.2663 0.2707
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0245 0.2696 0.2741
Echinococcus granulosus proteasome subunit alpha type 6 0.0204 0.2206 0.2206
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0045 0.0288 0.0292
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0143 0.0143
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Loa Loa (eye worm) proteasome subunit beta type 2 0.0186 0.1982 0.2014
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0175 0.1855 0.1855
Brugia malayi proteasome subunit beta type 3 0.0186 0.1982 0.1982
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0143 0.0143
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0021 0.0001 0.0001
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.004 0.0236 0.0236
Toxoplasma gondii PCI domain-containing protein 0.0031 0.0125 0.0127
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0065 0.0533 0.0533
Schistosoma mansoni 26S proteasome subunit S9 0.0037 0.0202 0.0202
Leishmania major hypothetical protein, conserved 0.0051 0.0361 0.0367
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0202 0.0206
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0149 0.0149
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.004 0.0229 0.0233
Echinococcus granulosus carbonic anhydrase II 0.0175 0.1855 0.1855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0143 0.0145
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0197 0.0197
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0214 0.2322 0.2361
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0143 0.0143
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0204 0.2206 0.2241
Entamoeba histolytica hypothetical protein 0.0042 0.0258 0.0261
Leishmania major proteasome alpha 2 subunit, putative 0.0197 0.2115 0.215
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0031 0.0127 0.0127
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0175 0.1855 0.1886
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0158 0.1653 0.1681
Echinococcus multilocularis geminin 0.0198 0.2133 0.2133
Plasmodium vivax proteasome subunit beta type-6, putative 0.0192 0.2059 0.2093
Echinococcus granulosus Ankyrin 0.0037 0.0199 0.0199
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0854 1 1
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0203 0.2194 0.223
Loa Loa (eye worm) hypothetical protein 0.003 0.0108 0.011
Giardia lamblia 20S proteasome alpha subunit 1 0.0204 0.2206 0.2241
Loa Loa (eye worm) proteasome subunit beta type 1 0.0214 0.2322 0.2361
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0203 0.2194 0.2229
Echinococcus granulosus Proteasome subunit alpha beta 0.0193 0.2073 0.2073
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0204 0.2206 0.2242
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0039 0.0219 0.0219
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0203 0.2194 0.223
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0031 0.0127 0.0129
Leishmania major proteasome alpha 1 subunit, putative 0.0204 0.2206 0.2242
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0191 0.2047 0.2081
Trypanosoma cruzi 20S proteasome subunit 0.0186 0.1982 0.2014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0143 0.0143
Trypanosoma brucei proteasome beta 7 subunit 0.0184 0.1961 0.1992
Brugia malayi Protein kinase domain containing protein 0.0037 0.0197 0.0197
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0158 0.1653 0.1681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0143 0.0145
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0065 0.0533 0.0542
Entamoeba histolytica hypothetical protein 0.0042 0.0258 0.0261
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0108 0.0108
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0023 0.0031 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0258 0.0258
Schistosoma mansoni carbonic anhydrase-related 0.0065 0.0533 0.0533
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0193 0.2073 0.2108
Echinococcus multilocularis netrin receptor unc 5 0.0037 0.0197 0.0197
Giardia lamblia 20S proteasome alpha subunit 2 0.0197 0.2115 0.2149
Brugia malayi 26S proteasome subunit P45 family protein 0.0021 0.0001 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0143 0.0143
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0097 0.0921 0.0936
Schistosoma mansoni carbonic anhydrase-related 0.0065 0.0533 0.0533
Loa Loa (eye worm) carbonic anhydrase 3 0.0175 0.1855 0.1886
Loa Loa (eye worm) PAS-3 protein 0.0175 0.1852 0.1883
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0062 0.0494 0.2383
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Brugia malayi 20S proteasome alpha5 subunit 0.0203 0.2194 0.2194
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0219 0.0219
Leishmania major proteasome alpha 7 subunit, putative 0.0193 0.2073 0.2108
Onchocerca volvulus Netrin receptor homolog 0.0037 0.0197 0.0949
Brugia malayi Proteasome A-type and B-type family protein 0.0192 0.2059 0.2059
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0034 0.0161 0.0162
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0034 0.0159 0.016
Echinococcus granulosus subfamily T1A non peptidase ue 0.0203 0.2194 0.2194
Echinococcus multilocularis carbonic anhydrase II 0.0175 0.1855 0.1855
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0097 0.0921 0.0921
Onchocerca volvulus Notchless protein homolog 0.0193 0.2073 1
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0021 0.0001 0.0001
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0016 0.0016
Giardia lamblia 20S proteasome alpha subunit 3 0.0192 0.2053 0.2086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0143 0.0143
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0097 0.0921 0.0936
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0143 0.0689
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0242 0.2663 0.2663
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0158 0.1653 0.1681
Brugia malayi PCI domain containing protein 0.0034 0.0161 0.0161
Echinococcus multilocularis Mastin 0.0039 0.0219 0.0219
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0197 0.02
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0143 0.0143
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0127 0.0127
Trichomonas vaginalis 26S proteasome subunit, putative 0.0031 0.0125 0.0126
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0143 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0143 0.0143
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0242 0.2663 0.2663
Giardia lamblia Hypothetical protein 0.0037 0.0202 0.0204
Echinococcus granulosus carbonic anhydrase 0.0065 0.0533 0.0533
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0193 0.2073 0.2073
Toxoplasma gondii proteasome regulatory subunit 0.0031 0.0127 0.0129
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0021 0.0001 0.0001
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0037 0.0202 0.0204
Giardia lamblia Proteasome subunit beta type 3 0.0186 0.1982 0.2013
Mycobacterium ulcerans proteasome PrcB 0.084 0.9838 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0214 0.2322 0.2322
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0143 0.0143
Schistosoma mansoni 26S protease regulatory subunit 0.0021 0.0001 0.0001
Loa Loa (eye worm) proteasome regulatory particle 0.0037 0.0202 0.0206
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0186 0.1982 0.2013
Giardia lamblia Proteasome subunit beta type 1 0.0214 0.2322 0.236
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0034 0.0161 0.0161
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0051 0.0361 0.0367
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0143 0.0143
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0143 0.0143
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0034 0.0161 0.0163
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0204 0.2206 0.2242
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0219 0.0219
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0203 0.2194 0.223
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0204 0.2206 0.2242
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0214 0.2322 0.2361
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0045 0.0288 0.0288
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0001 0.0001
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0245 0.2696 0.2741
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0175 0.1855 0.1855
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0065 0.0533 0.0542
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0045 0.0288 0.0288
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.018 0.1914 0.1944
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0039 0.0219 0.0219
Brugia malayi Death domain containing protein 0.0037 0.0197 0.0197
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0192 0.2053 0.2087
Echinococcus granulosus proteasome subunit alpha type 2 0.0197 0.2115 0.2115
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0192 0.2059 0.2091
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0192 0.2059 0.2059
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0197 0.2115 0.215
Giardia lamblia Proteasome subunit beta type 2 0.0186 0.1982 0.2013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0143 0.0143
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.009 0.0834 0.0834
Echinococcus multilocularis proteasome (prosome, macropain) 0.084 0.9838 0.9838
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0022 0.0016 0.0015
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0186 0.1982 0.2014
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0127 0.0129
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0045 0.0288 0.0288
Leishmania major proteasome alpha 3 subunit, putative 0.0192 0.2053 0.2087
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0193 0.2073 0.2073
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0158 0.1653 0.1681
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0242 0.2663 0.2707
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0203 0.2194 0.2229
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0158 0.1653 0.1679
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0158 0.1653 0.1681
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0033 0.0149 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0145
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0192 0.2053 0.2087
Loa Loa (eye worm) proteasome Regulatory Particle 0.0034 0.0159 0.0162
Loa Loa (eye worm) PCI domain-containing protein 0.0031 0.0125 0.0127
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0039 0.0219 0.0219
Plasmodium vivax proteasome subunit beta type-5, putative 0.084 0.9838 1
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0192 0.2059 0.2093
Echinococcus multilocularis proteasome subunit beta type 7 0.0854 1 1
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0203 0.2194 0.223
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0184 0.1961 0.1993
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0242 0.2663 0.2663
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0192 0.2059 0.2091
Leishmania major proteasome beta 7 subunit, putative 0.0184 0.1961 0.1993
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0034 0.0161 0.0163
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0192 0.2059 0.2091
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Echinococcus multilocularis transmembrane protease serine 3 0.0039 0.0219 0.0219
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0031 0.0125 0.0125
Echinococcus granulosus enteropeptidase 0.0039 0.0219 0.0219
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0214 0.2322 0.236
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0219 0.0219
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0127 0.0129
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0108 0.0109
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0021 0.0001 0.0001
Brugia malayi Ubiquitin interaction motif family protein 0.0022 0.0016 0.0016
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0242 0.2663 0.2706
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0125 0.0126
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0143 0.0689
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0193 0.2073 0.2106

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.72 Inhibition of oxidosqualene cyclase ChEMBL. 17981368
IC50 (binding) = 18 nM Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius ChEMBL. 12747780
IC50 (binding) = 18 nM Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius ChEMBL. 12747780
IC50 (binding) = 19 nM Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomes ChEMBL. 12747780
IC50 (binding) = 19 nM Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomes ChEMBL. 12747780

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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