Detailed information for compound 104603

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 631.742 | Formula: C33H37N5O6S
  • H donors: 3 H acceptors: 6 LogP: 2.33 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1CC(N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@@H](C(=O)N(Cc1ccccc1)C)Cc1ccc(cc1)NS(=O)(=O)C
  • InChi: 1S/C33H37N5O6S/c1-36-21-27(26-11-7-8-12-29(26)36)32(41)38-20-25(39)18-30(38)31(40)34-28(33(42)37(2)19-23-9-5-4-6-10-23)17-22-13-15-24(16-14-22)35-45(3,43)44/h4-16,21,25,28,30,35,39H,17-20H2,1-3H3,(H,34,40)/t25-,28-,30?/m1/s1
  • InChiKey: ORVVGMWWQBVVHF-UPKZMJGNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Neurokinin 1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus thyrotropin releasing hormone receptor Neurokinin 1 receptor   407 aa 341 aa 22.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Neurokinin 1 receptor   407 aa 373 aa 23.1 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Neurokinin 1 receptor   407 aa 339 aa 20.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Neurokinin 1 receptor   407 aa 341 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major proteasome beta 2 subunit, putative 0.0178 0.1979 0.2015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0227
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0176 0.1959 0.1994
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0167 0.1849 0.1883
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0172 0.1912 0.1947
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0235 0.2697 0.2746
Echinococcus granulosus proteasome subunit alpha type 6 0.0196 0.2202 0.2202
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0262 0.0262
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0205 0.2318 0.236
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0148 0.0148
Echinococcus granulosus death domain containing protein 0.0035 0.0201 0.0201
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0183 0.2044 0.2082
Onchocerca volvulus 0.0037 0.0223 0.1076
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0036 0.0207 0.021
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0148 0.0148
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0167 0.1849 0.1849
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0148 0.0148
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0043 0.0291 0.0291
Toxoplasma gondii PCI domain-containing protein 0.0039 0.024 0.0245
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.003 0.013 0.0133
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0165 0.0168
Schistosoma mansoni carbonic anhydrase-related 0.0062 0.0535 0.0535
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.002 0.0007 0.0007
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.003 0.0132 0.0132
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0152 0.1653 0.1683
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0195 0.219 0.223
Entamoeba histolytica hypothetical protein 0.004 0.0262 0.0267
Echinococcus multilocularis proteasome subunit alpha type 2 0.0188 0.2112 0.2112
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.0006 0.0006
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.003 0.0132 0.0135
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0036 0.0203 0.0203
Plasmodium vivax proteasome subunit beta type-1, putative 0.0205 0.2318 0.236
Echinococcus multilocularis proteasome subunit alpha type 6 0.0196 0.2202 0.2202
Echinococcus multilocularis proteasome subunit beta type 7 0.082 1 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0035 0.0201 0.0201
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0195 0.219 0.219
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0028 0.0113 0.0113
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0195 0.219 0.219
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0188 0.2112 0.2112
Plasmodium vivax proteasome subunit beta type-6, putative 0.0184 0.2056 0.2093
Schistosoma mansoni hypothetical protein 0.0037 0.0223 0.0223
Echinococcus multilocularis adhesion regulating molecule 1 0.0093 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0062 0.0535 0.0545
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0178 0.1979 0.2015
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0148 0.0148
Brugia malayi Uncoordinated protein 44 0.0035 0.0201 0.0201
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0188 0.2112 0.215
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0152 0.1653 0.1683
Loa Loa (eye worm) hypothetical protein 0.0093 0.092 0.0937
Toxoplasma gondii kringle domain-containing protein 0.002 0.0006 0.0006
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0039 0.024 0.0245
Leishmania major proteasome beta 2 subunit, putative 0.0235 0.2697 0.2746
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0032 0.0165 0.0168
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0039 0.024 0.0245
Giardia lamblia 20S proteasome alpha subunit 4 0.0232 0.2656 0.2705
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0205 0.2318 0.236
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0232 0.2656 0.2705
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0196 0.2202 0.2242
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0148 0.015
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0176 0.1959 0.1994
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0185 0.207 0.2108
Plasmodium falciparum proteasome subunit beta type-4 0.0176 0.1959 0.1994
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0043 0.0291 0.0297
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0032 0.0165 0.0168
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0235 0.2697 0.2746
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0154
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0178 0.1979 0.2015
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Toxoplasma gondii PCI domain-containing protein 0.003 0.013 0.0133
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.003 0.0132 0.0135
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0148 0.0148
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.002 0.0007 0.0007
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0195 0.219 0.223
Echinococcus granulosus carbonic anhydrase 0.0062 0.0535 0.0535
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0178 0.1979 0.1979
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0176 0.1959 0.1994
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0148 0.0148
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0806 0.982 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Brugia malayi Proteasome A-type and B-type family protein 0.0806 0.982 0.982
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0176 0.1959 0.1994
Schistosoma mansoni carbonic anhydrase 0.0062 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0227
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0167 0.1849 0.1883
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0132 0.0135
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.003 0.0132 0.0135
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.002 0.0007 0.0007
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0184 0.2056 0.2093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0535 0.0545
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0195 0.219 0.223
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Toxoplasma gondii peptidase, T1 family protein 0.0185 0.207 0.2108
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0038 0.0233 0.0237
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0185 0.207 0.2108
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0036 0.0207 0.021
Plasmodium vivax proteasome subunit beta type-4, putative 0.0176 0.1959 0.1994
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0346 0.4077 0.4077
Echinococcus granulosus transmembrane protease serine 3 0.0037 0.0223 0.0223
Giardia lamblia 26S protease regulatory subunit 6B 0.002 0.0007 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0148 0.0148
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0183 0.2044 0.2082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0227
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0176 0.1959 0.1994
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0205 0.2318 0.236
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0183 0.2044 0.2082
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Brugia malayi Proteasome A-type and B-type family protein 0.0176 0.1959 0.1959
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0232 0.2656 0.2705
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Giardia lamblia 20S proteasome alpha subunit 6 0.0183 0.2044 0.2082
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0178 0.1979 0.2015
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0028 0.0113 0.0115
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0043 0.0291 0.0291
Echinococcus granulosus proteasome subunit alpha type 2 0.0188 0.2112 0.2112
Echinococcus granulosus Ankyrin 0.0036 0.0203 0.0203
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0195 0.219 0.223
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0048 0.0364 0.0371
Plasmodium falciparum proteasome subunit beta type-5 0.0806 0.982 1
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0043 0.0291 0.0291
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.013 0.0133
Giardia lamblia 20S proteasome alpha subunit 7 0.0185 0.207 0.2108
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0148 0.0148
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0178 0.1979 0.2015
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Brugia malayi Death domain containing protein 0.0035 0.0201 0.0201
Echinococcus granulosus enteropeptidase 0.0037 0.0223 0.0223
Schistosoma mansoni netrin receptor unc5 0.0035 0.0201 0.0201
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0038 0.0233 0.0233
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0021 0.0021
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0176 0.1959 0.1994
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0028 0.0113 0.0115
Leishmania major hypothetical protein, conserved 0.002 0.0006 0.0006
Plasmodium falciparum carbonic anhydrase 0.0062 0.0535 0.0545
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0178 0.1979 0.2015
Brugia malayi proteasome subunit beta type 3 0.0178 0.1979 0.1979
Onchocerca volvulus 0.0037 0.0223 0.1076
Schistosoma mansoni multiubiquitin binding protein S5a 0.0021 0.0021 0.0021
Giardia lamblia Proteasome subunit beta type 2 0.0178 0.1979 0.2015
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0183 0.2044 0.2044
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0148 0.0148
Brugia malayi Trypsin family protein 0.0037 0.0223 0.0223
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0021 0.0021 0.0021
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0188 0.2112 0.215
Brugia malayi proteasome subunit alpha type 2 0.0188 0.2112 0.2112
Echinococcus multilocularis proteasome subunit beta type 6 0.0184 0.2056 0.2056
Echinococcus multilocularis Ankyrin 0.0036 0.0203 0.0203
Leishmania major proteasome alpha 2 subunit, putative 0.0188 0.2112 0.215
Loa Loa (eye worm) PCI domain-containing protein 0.0032 0.0165 0.0168
Giardia lamblia 20S proteasome alpha subunit 2 0.0188 0.2112 0.215
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0183 0.205 0.205
Toxoplasma gondii proteasome subunit 0.0184 0.2056 0.2093
Schistosoma mansoni hypothetical protein 0.003 0.013 0.013
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0043 0.0291 0.0291
Trypanosoma cruzi 20S proteasome subunit 0.0178 0.1979 0.2015
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0156
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.003 0.0132 0.0135
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0148 0.0148
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0183 0.2044 0.2082
Toxoplasma gondii heat shock protein hslv, putative 0.0152 0.1653 0.1683
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0152 0.1653 0.1683
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0148 0.0148
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0152 0.1653 0.1683
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0232 0.2656 0.2705
Echinococcus granulosus subfamily T1A non peptidase ue 0.0195 0.219 0.219
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0032 0.0164 0.0167
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0176 0.1959 0.1994
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0184 0.2056 0.2093
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0183 0.205 0.2088
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.082 1 1
Echinococcus multilocularis geminin 0.0189 0.2125 0.2125
Schistosoma mansoni hypothetical protein 0.0211 0.2398 0.2398
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0176 0.1959 0.1994
Echinococcus granulosus glycoprotein Antigen 5 0.0037 0.0223 0.0223
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0019 0.0000019404 0.0000019759
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0806 0.982 1
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.003 0.013 0.013
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0232 0.2656 0.2656
Onchocerca volvulus Notchless protein homolog 0.0185 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Trypanosoma brucei proteasome beta 6 subunit 0.0205 0.2318 0.236
Brugia malayi PCI domain containing protein 0.003 0.013 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0022 0.0037 0.0037
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0037 0.0223 0.0223
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.003 0.0132 0.0135
Loa Loa (eye worm) trypsin family protein 0.0037 0.0223 0.0227
Brugia malayi Proteasome A-type and B-type family protein 0.0184 0.2056 0.2056
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0036 0.0207 0.021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0227
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0148 0.0148
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0032 0.0164 0.0164
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0196 0.2202 0.2242
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0223 0.0223
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0032 0.0164 0.0167
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0043 0.0291 0.0297
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0148 0.0148
Schistosoma mansoni 26S protease regulatory subunit 6b 0.002 0.0007 0.0007
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0235 0.2697 0.2746
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.002 0.0007 0.0007
Brugia malayi proteasome subunit alpha type 4 0.0167 0.185 0.185
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0032 0.0164 0.0164
Echinococcus multilocularis carbonic anhydrase 0.0062 0.0535 0.0535
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0196 0.2202 0.2242
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0205 0.2318 0.2318
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0043 0.0291 0.0297
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0195 0.219 0.223
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0183 0.205 0.2088
Onchocerca volvulus 0.0037 0.0223 0.1076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0201 0.0201
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0043 0.0291 0.0297
Leishmania major carbonic anhydrase-like protein 0.0167 0.1849 0.1883
Loa Loa (eye worm) hypothetical protein 0.0062 0.0535 0.0545
Echinococcus granulosus proteasome prosome macropain 0.0806 0.982 0.982
Plasmodium vivax proteasome subunit beta type-3, putative 0.0178 0.1979 0.2015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0148 0.0148
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0184 0.2056 0.2056
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0185 0.207 0.2108
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0185 0.207 0.2108
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0183 0.2044 0.2044
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0152 0.1653 0.1653
Toxoplasma gondii proteasome subunit alpha type, putative 0.008 0.0763 0.0777
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0185 0.207 0.2108
Entamoeba histolytica 19S cap proteasome S2 subunit 0.002 0.0014 0.0014
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.002 0.0007 0.0007
Echinococcus granulosus geminin 0.0189 0.2125 0.2125
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0007 0.0007
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.002 0.0007 0.0007
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0032 0.0164 0.0167
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0032 0.0154 0.0156
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0232 0.2656 0.2705
Echinococcus granulosus adhesion regulating molecule 1 0.0093 0.092 0.092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0148 0.015
Echinococcus multilocularis carbonic anhydrase 0.0062 0.0535 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0148 0.0148
Giardia lamblia 20S proteasome alpha subunit 3 0.0183 0.205 0.2088
Schistosoma mansoni carbonic anhydrase-related 0.0062 0.0535 0.0535
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.003 0.0132 0.0132
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0185 0.207 0.207
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0232 0.2656 0.2705
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0207
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.003 0.0132 0.0135
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.003 0.0132 0.0135
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0148 0.0148
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0148 0.0148
Echinococcus granulosus netrin receptor unc 5 0.0035 0.0201 0.0201
Brugia malayi Trypsin family protein 0.0037 0.0223 0.0223
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0148 0.0148
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0036 0.0207 0.021
Giardia lamblia Proteasome subunit beta type 1 0.0205 0.2318 0.236
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0176 0.1959 0.1959
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0148 0.0148
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.0006 0.0006
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0036 0.0207 0.0207
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0178 0.1979 0.1979
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0806 0.982 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0205 0.2318 0.236
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.002 0.0007 0.0007
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0183 0.205 0.205
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0178 0.1979 0.2015
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.003 0.0132 0.0135
Giardia lamblia 20S proteasome alpha subunit 1 0.0196 0.2202 0.2242
Brugia malayi 20S proteasome alpha5 subunit 0.0195 0.219 0.219
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0195 0.219 0.223
Brugia malayi proteasome subunit alpha type 3 0.0185 0.207 0.207
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0195 0.219 0.223
Giardia lamblia Hypothetical protein 0.0036 0.0207 0.021
Entamoeba histolytica hypothetical protein 0.004 0.0262 0.0267
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0028 0.0113 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0148 0.015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0062 0.0535 0.0535
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0152 0.1653 0.1683
Leishmania major proteasome beta 7 subunit, putative 0.0176 0.1959 0.1994
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0148 0.0148
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0036 0.0207 0.0207
Schistosoma mansoni 26S proteasome subunit S9 0.0036 0.0207 0.0207
Trypanosoma brucei proteasome alpha 7 subunit 0.0185 0.207 0.2108
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0184 0.2056 0.2093
Schistosoma mansoni carbonic anhydrase-related 0.0062 0.0535 0.0535
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0021 0.0021 0.0022
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.024 0.0245
Onchocerca volvulus 0.0037 0.0223 0.1076
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0184 0.2056 0.2093
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0032 0.0164 0.0167
Schistosoma mansoni coup transcription factor 0.0031 0.0148 0.0148
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0184 0.2056 0.2093
Loa Loa (eye worm) PAS-3 protein 0.0167 0.185 0.1884
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0043 0.0291 0.0297
Echinococcus multilocularis carbonic anhydrase II 0.0167 0.1849 0.1849
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.002 0.0014 0.0014
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0195 0.219 0.223
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0086 0.0835 0.0835
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0059 0.0497 0.2398
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.002 0.0007 0.0007
Brugia malayi steroid hormone receptor 0.0031 0.0148 0.0148
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0032 0.0165 0.0165
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0806 0.982 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0184 0.2056 0.2093
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0038 0.0233 0.0237
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0235 0.2697 0.2746
Echinococcus multilocularis carbonic anhydrase 0.0062 0.0535 0.0535
Brugia malayi 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.003 0.013 0.0133
Toxoplasma gondii proteasome regulatory subunit 0.003 0.0132 0.0135
Brugia malayi small heat shock protein 0.0646 0.7823 0.7823
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0806 0.982 1
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0196 0.2202 0.2242
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.002 0.0007 0.0007
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0037 0.0223 0.0223
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0039 0.024 0.024
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0148 0.0713
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0032 0.0165 0.0168
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0032 0.0164 0.0164
Leishmania major proteasome alpha 7 subunit, putative 0.0232 0.2656 0.2705
Loa Loa (eye worm) proteasome Regulatory Particle 0.0032 0.0164 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0148 0.0148
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0039 0.024 0.024
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0183 0.205 0.2088
Schistosoma mansoni hypothetical protein 0.0189 0.2125 0.2125
Brugia malayi nuclear receptor NHR-88 0.0031 0.0148 0.0148
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0178 0.1979 0.2015
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0185 0.207 0.2108
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0806 0.982 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0036 0.0207 0.0207
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0028 0.0113 0.0115
Brugia malayi Trypsin-like protease protein 5 0.0037 0.0223 0.0223
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.003 0.0132 0.0132
Brugia malayi nuclear hormone receptor 0.0031 0.0148 0.0148
Brugia malayi hypothetical protein 0.004 0.0262 0.0262
Leishmania major proteasome beta-1 subunit, putative 0.0184 0.2056 0.2093
Echinococcus multilocularis netrin receptor unc 5 0.0035 0.0201 0.0201
Echinococcus multilocularis proteasome (prosome, macropain) 0.0806 0.982 0.982
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0032 0.0164 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0148 0.015
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0152 0.1653 0.1683
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0006 0.0006
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0196 0.2202 0.2242
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0028 0.0113 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0148 0.0148
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.003 0.0132 0.0135
Echinococcus granulosus Mastin 0.0037 0.0223 0.0223
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0007 0.0007
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0038 0.0233 0.0237
Onchocerca volvulus 0.0037 0.0223 0.1076
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0028 0.0113 0.0115
Leishmania major proteasome alpha 1 subunit, putative 0.0183 0.2044 0.2082
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0021 0.0022 0.0022
Toxoplasma gondii hypothetical protein 0.0062 0.0535 0.0545
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.003 0.013 0.0133
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0148 0.0148
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0043 0.0291 0.0297
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0195 0.219 0.223
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0167 0.1849 0.1849
Plasmodium vivax proteasome subunit beta type-7, putative 0.0235 0.2697 0.2746
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0232 0.2656 0.2656
Entamoeba histolytica proteasome regulatory subunit, putative 0.0021 0.0021 0.0021
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0038 0.0233 0.0237
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0148 0.0148
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0148 0.0148
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0183 0.2044 0.2082
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0178 0.1979 0.1979
Brugia malayi proteasome subunit beta type 2 0.0178 0.1979 0.1979
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.013 0.0133
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0188 0.2112 0.215
Loa Loa (eye worm) proteasome subunit beta type 3 0.0178 0.1979 0.2015
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0152 0.1653 0.5
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0178 0.1979 0.1979
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0021 0.0021
Brugia malayi PCI domain containing protein 0.0032 0.0165 0.0165
Onchocerca volvulus 0.002 0.0007 0.0034
Mycobacterium ulcerans proteasome PrcB 0.0806 0.982 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0115
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.003 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0148 0.0148
Loa Loa (eye worm) RPT-2 protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0031 0.0148 0.0713
Toxoplasma gondii proteasome subunit beta type, putative 0.0806 0.982 1
Schistosoma mansoni hypothetical protein 0.0189 0.2125 0.2125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0148 0.0148
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0183 0.2044 0.2044
Toxoplasma gondii SAC3/GANP family protein 0.0028 0.0113 0.0115
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0007 0.0007
Leishmania major proteasome beta 5 subunit, putative 0.0806 0.982 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0227
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0028 0.0113 0.0115
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0037 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0006
Echinococcus multilocularis enteropeptidase 0.0037 0.0223 0.0223
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0038 0.0233 0.0233
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0205 0.2318 0.236
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0232 0.2656 0.2656
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0148 0.0713
Echinococcus granulosus nuclear factor of activated T cells 5 0.0346 0.4077 0.4077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0148 0.015
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0086 0.0835 0.0835
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0183 0.205 0.2088
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0196 0.2202 0.2242
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0211 0.2398 0.2398
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0028 0.0113 0.0115
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0806 0.982 1
Toxoplasma gondii proteasome 26S regulatory subunit 0.002 0.0014 0.0014
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0196 0.2202 0.2202
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0205 0.2318 0.2318
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0232 0.2656 0.2705
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0088
Giardia lamblia 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Brugia malayi Trypsin family protein 0.0037 0.0223 0.0223
Brugia malayi Ubiquitin interaction motif family protein 0.0021 0.0021 0.0021
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0183 0.2044 0.2082
Onchocerca volvulus 0.002 0.0006 0.0027
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0806 0.982 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0062 0.0535 0.0535
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0021 0.0022 0.0022
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.003 0.0132 0.0132
Trichomonas vaginalis 26S proteasome subunit, putative 0.003 0.013 0.0133
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.003 0.013 0.0133
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0188 0.2112 0.215
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0262 0.0262
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0148 0.0148
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0168 0.1853 0.1887
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.0006 0.0006
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0176 0.1959 0.1994
Brugia malayi Kringle domain containing protein 0.002 0.0006 0.0006
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0196 0.2202 0.2242
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.002 0.0007 0.0007
Echinococcus granulosus carbonic anhydrase 0.0062 0.0535 0.0535
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0178 0.1979 0.2015
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0148 0.0148
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.004 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0164 0.0167
Trypanosoma brucei proteasome beta 7 subunit 0.0176 0.1959 0.1994
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0039 0.024 0.0245
Loa Loa (eye worm) proteasome subunit beta type 1 0.0205 0.2318 0.236
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0183 0.205 0.2088
Schistosoma mansoni ankyrin 23/unc44 0.0035 0.0201 0.0201
Leishmania major proteasome beta 3 subunit, putative 0.0178 0.1979 0.2015
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0178 0.1979 0.2015
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0806 0.982 1
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Brugia malayi ecdysteroid receptor 0.0031 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0032 0.0165 0.0168
Loa Loa (eye worm) hypothetical protein 0.0646 0.7823 0.7966
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.002 0.0007 0.0007
Leishmania major proteasome alpha 1 subunit, putative 0.0196 0.2202 0.2242
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0235 0.2697 0.2746
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.024 0.024
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0093 0.092 0.092
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0152 0.1653 0.1683
Echinococcus granulosus proteasome subunit beta type 6 0.0184 0.2056 0.2056
Loa Loa (eye worm) carbonic anhydrase 3 0.0167 0.1849 0.1883
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) RPN-3 protein 0.0039 0.024 0.0245
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0205 0.2318 0.236
Brugia malayi 26S proteasome subunit P45 family protein 0.002 0.0007 0.0007
Loa Loa (eye worm) proteasome subunit beta type 2 0.0178 0.1979 0.2015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0148 0.015
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0148 0.0148
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0148 0.0148
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0188 0.2112 0.215
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0195 0.219 0.223
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0148 0.015
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0043 0.0291 0.0291
Brugia malayi 26S proteasome regulatory subunit rpn11 0.003 0.0132 0.0132
Loa Loa (eye worm) proteasome 26S subunit 0.0019 0.0000019404 0.0000019759
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0039 0.024 0.024
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0035 0.0201 0.0201
Toxoplasma gondii hypothetical protein 0.0026 0.0086 0.0088
Onchocerca volvulus 0.0037 0.0223 0.1076
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0021 0.0022 0.0022
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0178 0.1979 0.2015
Brugia malayi hypothetical protein 0.0037 0.0223 0.0223
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0178 0.1979 0.1979
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.003 0.0132 0.0135
Plasmodium vivax proteasome subunit beta type-5, putative 0.0806 0.982 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0195 0.219 0.223
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0028 0.0113 0.0113
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0032 0.0164 0.0164
Echinococcus granulosus carbonic anhydrase 0.0062 0.0535 0.0535
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.003 0.013 0.013
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0062 0.0535 0.0535
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0032 0.0164 0.0167
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Brugia malayi Protein kinase domain containing protein 0.002 0.0006 0.0006
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0183 0.205 0.2088
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0032 0.0165 0.0168
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0178 0.1979 0.2015
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.002 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0038 0.0233 0.0237
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0148 0.0148
Echinococcus granulosus Proteasome subunit alpha type 7 0.0232 0.2656 0.2656
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0148 0.015
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0029 0.012 0.0122
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0035 0.0201 0.0201
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0032 0.0165 0.0165
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.013 0.0133
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0205 0.2318 0.2318
Echinococcus multilocularis Mastin 0.0037 0.0223 0.0223
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.015
Mycobacterium ulcerans proteasome PrcA 0.0152 0.1653 0.149
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0032 0.0165 0.0168
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0037 0.0223 0.0223
Echinococcus multilocularis transmembrane protease serine 3 0.0037 0.0223 0.0223
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0232 0.2656 0.2656
Brugia malayi Protein kinase domain containing protein 0.0035 0.0201 0.0201
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0179 0.199 0.199
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0176 0.1959 0.1994
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.002 0.0007 0.0007
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0183 0.205 0.2088
Echinococcus granulosus tissue type plasminogen activator 0.002 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0148 0.0148
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0195 0.219 0.219
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0043 0.0291 0.0291
Leishmania major proteasome alpha 3 subunit, putative 0.0183 0.205 0.2088
Giardia lamblia Proteasome subunit beta type 3 0.0178 0.1979 0.2015
Entamoeba histolytica proteasome regulatory subunit, putative 0.0036 0.0207 0.021
Schistosoma mansoni proteasome regulatory subunit-related 0.0032 0.0165 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0148 0.0148
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.003 0.0132 0.0135
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0093 0.092 0.0937
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0032 0.0165 0.0168
Echinococcus granulosus proteasome subunit beta t family 0.0178 0.1979 0.1979
Onchocerca volvulus Netrin receptor homolog 0.0035 0.0201 0.0972
Loa Loa (eye worm) proteasome regulatory particle 0.0036 0.0207 0.021
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0086 0.0835 0.0835
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0032 0.0164 0.0167
Echinococcus granulosus proteasome subunit beta type 7 0.082 1 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0113 0.0115
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0021 0.0021
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0167 0.1849 0.1883
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.003 0.0132 0.0135
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0039 0.024 0.0245
Brugia malayi proteasome subunit alpha type 1 0.0183 0.2044 0.2044
Toxoplasma gondii PCI domain-containing protein 0.0036 0.0207 0.021
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0062 0.0535 0.0535
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0176 0.1959 0.1994
Brugia malayi Proteasome subunit alpha type 7-1 0.0232 0.2656 0.2656
Brugia malayi Proteasome subunit alpha type 1 0.0167 0.1844 0.1844
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0062 0.0535 0.0535
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0148 0.0148
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0148 0.0148
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0176 0.1959 0.1994
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0021 0.0022 0.0022
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0028 0.0113 0.0113
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0062 0.0535 0.0545
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0188 0.2112 0.215
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0028 0.0113 0.0113
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.003 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0148 0.0148
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0021 0.0022 0.0022
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0185 0.207 0.2108
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0043 0.0291 0.0297
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0184 0.2056 0.2093
Entamoeba histolytica hypothetical protein 0.004 0.0262 0.0267
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0148 0.0148
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0021 0.0022 0.0022
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0178 0.1979 0.1979
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Toxoplasma gondii proteasome beta subunit 0.0178 0.1979 0.2015
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0176 0.1959 0.1959
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0021 0.0022 0.0022
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0196 0.2202 0.2242
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.002 0.0007 0.0007
Plasmodium vivax proteasome subunit beta type-2, putative 0.0178 0.1979 0.2015
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.003 0.0132 0.0132
Echinococcus granulosus carbonic anhydrase II 0.0167 0.1849 0.1849
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0036 0.0207 0.021
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0183 0.2044 0.2082
Brugia malayi Trypsin family protein 0.0037 0.0223 0.0223
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0148 0.0713
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0038 0.0233 0.0233
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0183 0.205 0.205
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0022 0.0037 0.0037
Leishmania major proteasome alpha 7 subunit, putative 0.0185 0.207 0.2108
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0043 0.0291 0.0297
Toxoplasma gondii proteasome subunit alpha type, putative 0.0183 0.205 0.2088
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0006 0.0006
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.003 0.0132 0.0135
Echinococcus multilocularis glycoprotein Antigen 5 0.0037 0.0223 0.0223
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0178 0.1979 0.2015
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0036 0.0207 0.021
Trypanosoma brucei carbonic anhydrase-like protein 0.0167 0.1849 0.1883
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0183 0.2044 0.2082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0227
Schistosoma mansoni 26S protease regulatory subunit 0.002 0.0007 0.0007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0223 0.0223
Brugia malayi proteasome subunit beta type 1 0.0205 0.2318 0.2318
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0188 0.2112 0.215
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0028 0.0113 0.0115
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0185 0.207 0.2108
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0185 0.207 0.207
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0037 0.0223 0.0223
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0235 0.2697 0.2746
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0115
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0062 0.0535 0.0535
Brugia malayi Probable 26S protease regulatory subunit 4 0.002 0.0007 0.0007
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0058 0.0482 0.0482
Entamoeba histolytica hypothetical protein 0.004 0.0262 0.0267
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0035 0.0201 0.0205
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0184 0.2056 0.2093
Onchocerca volvulus 0.002 0.0007 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0223 0.0223
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0232 0.2656 0.2705
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0227
Leishmania major hypothetical protein, conserved 0.0048 0.0364 0.0371
Loa Loa (eye worm) hypothetical protein 0.0211 0.2398 0.2442
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0148 0.0148
Echinococcus granulosus Proteasome subunit alpha beta 0.0185 0.207 0.207
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0148 0.0148
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0093 0.092 0.092
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0235 0.2697 0.2746
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0167 0.1849 0.1849
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0806 0.982 0.982
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0262 0.0262
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.024 0.024
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0172 0.1912 0.1947
Toxoplasma gondii proteasome subunit alpha1, putative 0.0196 0.2202 0.2242
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0232 0.2656 0.2705
Giardia lamblia 20S proteasome alpha subunit 5 0.0195 0.219 0.223
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0178 0.1979 0.1979
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0178 0.1979 0.2015
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0154 0.0154
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0232 0.2656 0.2705
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.003 0.013 0.0133
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0205 0.2318 0.236
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0176 0.1959 0.1959
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0235 0.2697 0.2746
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0183 0.205 0.2088
Brugia malayi proteasome subunit alpha type 6 0.0196 0.2202 0.2202
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0148 0.0148
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0022 0.0022
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0167 0.1849 0.1849
Loa Loa (eye worm) hypothetical protein 0.0035 0.0201 0.0205
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.003 0.0132 0.0135
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0032 0.0164 0.0167

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 25.3 nM In vitro binding affinity against substance P receptor using [3H]-SP as radioligand in guinea pig lung membrane ChEMBL. 7518002
IC50 (binding) = 25.3 nM In vitro binding affinity against substance P receptor using [3H]-SP as radioligand in guinea pig lung membrane ChEMBL. 7518002
Inhibition (functional) = 0 % In vivo inhibitory activity against airway edema induced by Substance P at a dose 100 mg/kg administered orally ChEMBL. 7518002
Inhibition (functional) 0 % In vivo inhibitory activity against airway edema induced by Substance P at a dose 10 mg/kg administered orally ;ND=Not determined ChEMBL. 7518002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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