Detailed information for compound 1046100

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.769 | Formula: C16H17ClN2O6
  • H donors: 1 H acceptors: 5 LogP: 3.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[Cl](=O)(=O)=O.COc1ccc(cc1)C(=O)C1CN=c2n(C1)cccc2
  • InChi: 1S/C16H16N2O2.ClHO4/c1-20-14-7-5-12(6-8-14)16(19)13-10-17-15-4-2-3-9-18(15)11-13;2-1(3,4)5/h2-9,13H,10-11H2,1H3;(H,2,3,4,5)
  • InChiKey: NHQJWOAWPQUCFT-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0073 0.0425 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0099 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0425 0.0486
Brugia malayi Pre-SET motif family protein 0.0128 0.0993 0.1135
Brugia malayi jmjC domain containing protein 0.0073 0.0425 0.0486
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0125
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0081 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0082
Onchocerca volvulus 0.0068 0.0383 0.0383
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0545 0.5228 0.5975
Brugia malayi hypothetical protein 0.0068 0.0383 0.0438
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0081 0.0091
Echinococcus granulosus jumonji domain containing 1A 0.0073 0.0425 0.059
Brugia malayi jmjC domain containing protein 0.0274 0.2473 0.2827
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0082
Schistosoma mansoni phosphatidylserine receptor 0.0073 0.0425 0.0614
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0371 0.0424
Loa Loa (eye worm) hypothetical protein 0.0085 0.055 0.0628
Plasmodium vivax hypothetical protein, conserved 0.0122 0.0924 0.9251
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.0574 0.0805
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0891 0.8749 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0073 0.0425 0.0614
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.0574 0.0805
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0081 0.001
Onchocerca volvulus Huntingtin homolog 0.0131 0.1022 0.1022
Brugia malayi chromobox protein homolog 3 0.0041 0.0099 0.0114
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0371 0.0424
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0993 0.1434
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3323 0.3274
Schistosoma mansoni hypothetical protein 0.0067 0.0371 0.0535
Echinococcus multilocularis lysine specific demethylase 5A 0.0272 0.2456 0.3531
Brugia malayi AF-10 protein 0.004 0.0091 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0081 0.0271
Echinococcus multilocularis jumonji domain containing 1A 0.0073 0.0425 0.059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0081 0.0016
Schistosoma mansoni hypothetical protein 0.004 0.0091 0.0132
Toxoplasma gondii PHD-finger domain-containing protein 0.0122 0.0924 0.9251
Schistosoma mansoni hypothetical protein 0.0067 0.0371 0.0535
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0933 0.1325
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0081 0.0093
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.004 0.0091 0.0559
Plasmodium vivax SET domain protein, putative 0.0128 0.0993 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0523 0.5009 0.7229
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3323 0.3274
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Onchocerca volvulus Glucosylceramidase homolog 0.0357 0.3323 0.3323
Onchocerca volvulus 0.0032 0.001 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0274 0.2473 0.3573
Echinococcus multilocularis peregrin 0.0122 0.0924 0.1312
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0081 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0371 0.0511
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.004 0.0091 0.0215
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2223 0.3194
Echinococcus multilocularis aminopeptidase N 0.0038 0.0071 0.0078
Onchocerca volvulus 0.0101 0.0714 0.0714
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3323 0.3274
Loa Loa (eye worm) hypothetical protein 0.0131 0.1022 0.1168
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.1463 0.1672
Echinococcus multilocularis lysine specific demethylase 6a 0.0073 0.0425 0.059
Plasmodium falciparum JmjC domain-containing protein, putative 0.0073 0.0425 0.4152
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0301 0.275 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.1848 0.2112
Brugia malayi Bromodomain containing protein 0.0122 0.0924 0.1056
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0616 0.5958 1
Schistosoma mansoni hypothetical protein 0.0145 0.1164 0.1682
Schistosoma mansoni hypothetical protein 0.0531 0.5086 0.7347
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.1022 0.1168
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0128 0.0993 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0993 0.1135
Schistosoma mansoni jun-related protein 0.0071 0.0408 0.0589
Brugia malayi hypothetical protein 0.0038 0.0071 0.0082
Echinococcus granulosus aminopeptidase N 0.0038 0.0071 0.0078
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0423 0.0354
Echinococcus multilocularis JmjC domain containing protein 4 0.0073 0.0425 0.059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0328 0.2782
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0202 0.0231
Schistosoma mansoni alpha glucosidase 0.0039 0.0081 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3323 0.3274
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2223 0.3194
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0486
Loa Loa (eye worm) jmjC domain-containing protein 0.0251 0.224 0.2561
Trichomonas vaginalis set domain proteins, putative 0.1014 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0523 0.5009 0.7229
Echinococcus granulosus leukotriene A 4 hydrolase 0.0711 0.6922 1
Echinococcus multilocularis jumonji domain containing protein 0.0169 0.1408 0.2013
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0486
Schistosoma mansoni alpha-glucosidase 0.015 0.1215 0.1756
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.1463 0.2092
Giardia lamblia Fructose-bisphosphate aldolase 0.0616 0.5958 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0122 0.0924 0.1312
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0301 0.275 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0074 0.0443 0.0616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Echinococcus multilocularis geminin 0.0531 0.5086 0.734
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0711 0.6922 0.7912
Loa Loa (eye worm) hypothetical protein 0.0122 0.0924 0.1056
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.5228 0.5193
Echinococcus granulosus phd:f box containing protein 0.0073 0.0425 0.059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Schistosoma mansoni chromobox protein 0.0072 0.0423 0.061
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0545 0.5228 0.5975
Brugia malayi Pre-SET motif family protein 0.0891 0.8749 1
Schistosoma mansoni hypothetical protein 0.0122 0.0924 0.1334
Echinococcus granulosus chromobox protein 1 0.0072 0.0423 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0099 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0081 0.001
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0933 0.1325
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0073 0.0425 1
Schistosoma mansoni hypothetical protein 0.0067 0.0371 0.0535
Schistosoma mansoni alpha-glucosidase 0.015 0.1215 0.1756
Treponema pallidum fructose-bisphosphate aldolase 0.0616 0.5958 0.5
Schistosoma mansoni chromobox protein 0.0072 0.0423 0.061
Echinococcus multilocularis chromobox protein 1 0.0072 0.0423 0.0586
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0131 0.006
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0073 0.0425 1
Onchocerca volvulus 0.0038 0.0071 0.0071
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0131 0.006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0938 0.1333
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.3518 0.3472
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0204 0.0234
Echinococcus granulosus JmjC domain containing protein 4 0.0073 0.0425 0.059
Onchocerca volvulus 0.014 0.1113 0.1113
Onchocerca volvulus Alhambra homolog 0.0122 0.0924 0.0924
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Schistosoma mansoni aminopeptidase A (M01 family) 0.0038 0.0071 0.0103
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0081 0.0271
Plasmodium falciparum phd finger protein, putative 0.0122 0.0924 1
Schistosoma mansoni hypothetical protein 0.0051 0.0204 0.0295
Onchocerca volvulus 0.0038 0.0071 0.0071
Brugia malayi jmjC domain containing protein 0.0073 0.0425 0.0486
Loa Loa (eye worm) hypothetical protein 0.0249 0.2223 0.2541
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0993 0.1434
Brugia malayi hypothetical protein 0.0038 0.0071 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0081 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.5228 0.5193
Brugia malayi Cytochrome P450 family protein 0.0051 0.0202 0.0231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0371 0.0511
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0071 0.0103
Brugia malayi PHD-finger family protein 0.0041 0.0109 0.0125
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0042 0.011 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.014 0.1113 0.1608
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1463 0.2092
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.004 0.0091 0.0559
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0081 0.0093
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0131 0.0131
Brugia malayi hypothetical protein 0.0131 0.1022 0.1168
Loa Loa (eye worm) hypothetical protein 0.0242 0.2146 0.2453
Echinococcus granulosus jumonji domain containing protein 0.0169 0.1408 0.2013
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.5228 0.5193
Schistosoma mansoni hypothetical protein 0.0438 0.4144 0.5987
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0071 0.0082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0399 0.0576
Schistosoma mansoni jumonji/arid domain-containing protein 0.0274 0.2473 0.3573
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0711 0.6922 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0038 0.0071 0.0078
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0423 0.0354
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0073 0.0425 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1463 0.2092
Loa Loa (eye worm) hypothetical protein 0.0041 0.0099 0.0114
Echinococcus multilocularis GPCR, family 2 0.0067 0.0371 0.0511
Schistosoma mansoni hypothetical protein 0.0067 0.0371 0.0535
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0074 0.0443 0.0616
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3323 0.3274
Onchocerca volvulus 0.0051 0.0204 0.0204
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0081 0.001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0128 0.0993 0.1412
Echinococcus multilocularis jun protein 0.0087 0.0574 0.0805
Trypanosoma brucei glucosidase, putative 0.0039 0.0081 0.0271
Loa Loa (eye worm) peptidase family M1 containing protein 0.0038 0.0071 0.0082
Toxoplasma gondii PHD-finger domain-containing protein 0.0122 0.0924 0.9251
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0081 0.0016
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0073 0.0425 0.3841
Loa Loa (eye worm) hypothetical protein 0.0212 0.1848 0.2112
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Echinococcus granulosus peregrin 0.0122 0.0924 0.1312
Schistosoma mansoni cpg binding protein 0.0033 0.0018 0.0026
Echinococcus granulosus geminin 0.0531 0.5086 0.734
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.1848 0.2112
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0081 0.001
Onchocerca volvulus Huntingtin homolog 0.0131 0.1022 0.1022
Schistosoma mansoni jumonji domain containing protein 0.0441 0.4176 0.6033
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Brugia malayi F/Y-rich N-terminus family protein 0.0054 0.0235 0.0268
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0371 0.0511
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0616 0.5958 1
Loa Loa (eye worm) PHD-finger family protein 0.0122 0.0924 0.1056
Brugia malayi Heterochromatin protein 1 0.0072 0.0423 0.0483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0371 0.0424
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3323 0.3274
Echinococcus granulosus lysine specific demethylase 6a 0.0073 0.0425 0.059
Schistosoma mansoni survival motor neuron protein 0.0051 0.0204 0.0295
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0371 0.0511
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0425 0.0486
Loa Loa (eye worm) jmjC domain-containing protein 0.0274 0.2473 0.2827
Loa Loa (eye worm) aminopeptidase N 0.0038 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0067 0.0371 0.0424
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.1848 0.2112
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0099 0.0099
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0423 0.0483
Schistosoma mansoni cpg binding protein 0.0033 0.0018 0.0026
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0071 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.3518 0.3472
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0081 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0082
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0081 0.001
Echinococcus granulosus chromobox protein 1 0.0072 0.0423 0.0586
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0071 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3323 0.3274
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.1463 0.1672
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.4144 0.5977
Echinococcus multilocularis chromobox protein 1 0.0072 0.0423 0.0586
Brugia malayi PHD-finger family protein 0.0122 0.0924 0.1056
Brugia malayi TATA binding protein associated factor 0.0038 0.0071 0.0082
Echinococcus granulosus jun protein 0.0087 0.0574 0.0805
Brugia malayi bZIP transcription factor family protein 0.0087 0.0574 0.0656
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0038 0.0071 0.0103
Echinococcus multilocularis phd:f box containing protein 0.0073 0.0425 0.059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0425 0.0486
Echinococcus granulosus dnaJ subfamily B 0.0438 0.4144 0.5977
Brugia malayi hypothetical protein 0.0249 0.2223 0.2541
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0711 0.6922 1
Schistosoma mansoni lipoxygenase 0.0122 0.0933 0.1347
Echinococcus multilocularis PHD finger protein rhinoceros 0.0122 0.0924 0.1312
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.1164 0.133
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0073 0.0425 0.3841
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.5958 0.5929
Brugia malayi jmjC domain containing protein 0.0523 0.5009 0.5725
Schistosoma mansoni hypothetical protein 0.0071 0.0408 0.0589
Brugia malayi hypothetical protein 0.0327 0.3013 0.3444
Schistosoma mansoni lipoxygenase 0.0086 0.0558 0.0806
Echinococcus granulosus lysine specific demethylase 5A 0.0274 0.2473 0.3556
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0301 0.275 0.5
Schistosoma mansoni phd/f-box containing protein 0.0073 0.0425 0.0614
Schistosoma mansoni protein phosphatase 2C 0.0073 0.0425 0.0614
Echinococcus granulosus GPCR family 2 0.0067 0.0371 0.0511
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0038 0.0071 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0993 0.1434
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0081 0.001
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0122 0.0924 0.1334
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0081 0.001
Plasmodium vivax JmjC domain containing protein 0.0073 0.0425 0.3841
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0425 0.0614
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.0993 0.1412
Schistosoma mansoni hypothetical protein 0.0531 0.5086 0.7347
Loa Loa (eye worm) hypothetical protein 0.0145 0.1164 0.133
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0091 0.0215
Leishmania major hypothetical protein, conserved 0.0073 0.0425 1
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.5228 0.5193
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.5228 0.5193
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0081 0.0104
Brugia malayi jmjC domain containing protein 0.0073 0.0425 0.0486
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.0993 0.1412
Onchocerca volvulus 0.0038 0.0071 0.0071
Loa Loa (eye worm) TATA binding protein associated factor 0.0038 0.0071 0.0082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0052 0.0217 0.0313
Plasmodium vivax hypothetical protein, conserved 0.0042 0.011 0.0422
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.5228 0.5193
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0071 0.0078

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 90 % Inhibition of bovine eNOS expressed in insect Sf9 cells assessed as residual activity at 100 uM by Griess assay relative to control ChEMBL. 19144449
Activity (binding) = 90 % Inhibition of rat recombinant nNOS expressed in insect Sf9 cells assessed as residual activity at 100 uM by Griess assay relative to control ChEMBL. 19144449
Activity (binding) = 100 % Inhibition of mouse iNOS expressed in insect Sf9 cells assessed as residual activity at 100 uM by Griess assay relative to control ChEMBL. 19144449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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